DE69303413D1 - 2-substituierte-tertiäre-Carbinolderivate als antivirale Arzneimittel - Google Patents
2-substituierte-tertiäre-Carbinolderivate als antivirale ArzneimittelInfo
- Publication number
- DE69303413D1 DE69303413D1 DE69303413T DE69303413T DE69303413D1 DE 69303413 D1 DE69303413 D1 DE 69303413D1 DE 69303413 T DE69303413 T DE 69303413T DE 69303413 T DE69303413 T DE 69303413T DE 69303413 D1 DE69303413 D1 DE 69303413D1
- Authority
- DE
- Germany
- Prior art keywords
- tertiary
- substituted
- antiviral drugs
- carbinol derivatives
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/861,058 US5258518A (en) | 1992-04-01 | 1992-04-01 | 2-substituted tertiary carbinol derivatives of deoxynojirimycin |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69303413D1 true DE69303413D1 (de) | 1996-08-08 |
DE69303413T2 DE69303413T2 (de) | 1997-01-09 |
Family
ID=25334759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69303413T Expired - Fee Related DE69303413T2 (de) | 1992-04-01 | 1993-03-31 | 2-substituierte-tertiäre-Carbinolderivate als antivirale Arzneimittel |
Country Status (9)
Country | Link |
---|---|
US (7) | US5258518A (de) |
EP (1) | EP0566556B1 (de) |
JP (1) | JP3210772B2 (de) |
AT (1) | ATE139998T1 (de) |
CA (1) | CA2093078C (de) |
DE (1) | DE69303413T2 (de) |
DK (1) | DK0566556T3 (de) |
ES (1) | ES2090948T3 (de) |
GR (1) | GR3021228T3 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5451679A (en) * | 1994-03-08 | 1995-09-19 | G. D. Searle & Co. | 2-chloro and 2-bromo derivatives of 1,5-iminosugars |
DK0817775T3 (da) * | 1995-03-30 | 2001-11-19 | Pfizer | Quinazolinderivater |
US5840711A (en) * | 1995-06-21 | 1998-11-24 | University Of Kentucky Research Foundation | Compositions containing lithium inorganic salts and anti-viral drugs and method of treating viral infections such as acquired immunodeficiency syndrome |
US20030100532A1 (en) | 1997-02-14 | 2003-05-29 | Gary S. Jacob | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections |
DE69821520T2 (de) * | 1997-11-10 | 2004-12-16 | G.D. Searle & Co., Chicago | Verwendung von alkylierten iminozuckern zur behandlung von multipler medikamentenresistenz |
US6689759B1 (en) | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
ATE331515T1 (de) | 1998-02-12 | 2006-07-15 | Searle Llc | Verwendung von n-substituirten-1,5-dideoxy-1,5- imino-d-glucitolen zur behandlung von hepatitis infektionen |
EP1173161A2 (de) | 1999-02-12 | 2002-01-23 | G.D. SEARLE & CO. | Verwendung von glucamin derivaten zur behandlung von hepatitis infektionen |
DE60039729D1 (de) | 1999-02-12 | 2008-09-11 | United Therapeutics Corp | N-(8,8,8-Trifluorooctyl)-1,5-dideoxy-1,5-imino-D-glucitol zur Behandlung von Hepatitis-Virus-Infektionen |
EP2027137B1 (de) * | 2005-06-08 | 2015-02-18 | Amicus Therapeutics, Inc. | Aufreinigung von imino- und aminozuckern |
BRPI0613221A2 (pt) * | 2005-06-08 | 2010-12-28 | Amicus Therapeutics Inc | furanose cristalina e método para produzir uma furanose cristalina |
EP1888610A1 (de) * | 2005-06-08 | 2008-02-20 | Amicus Therapeutics, Inc. | Stabilisierung von mit triflatgruppen versehenen verbindungen |
JP6166150B2 (ja) * | 2013-10-29 | 2017-07-19 | アルプス電気株式会社 | 受光装置 |
EP3318277A1 (de) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitoren der glucosylceramidsynthase zur behandlung von motoneuronerkrankungen |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
GB2020278B (en) * | 1978-05-03 | 1983-02-23 | Nippon Shinyaku Co Ltd | Moranoline dervitives |
US4182763A (en) * | 1978-05-22 | 1980-01-08 | Mead Johnson & Company | Buspirone anti-anxiety method |
DE2848117A1 (de) * | 1978-11-06 | 1980-05-14 | Bayer Ag | Derivate des 2-hydroxymethyl-3,4,5- trihydroxy-piperidins, ihre herstellung und verwendung zur beeinflussung des kohlenhydrat- und fettstoffwechsels |
DE3007078A1 (de) * | 1980-02-26 | 1981-09-10 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung |
US4632992A (en) * | 1981-02-09 | 1986-12-30 | Pfizer Inc. | Intermediates for preparing pirbuterol and analogs |
DE3620645A1 (de) * | 1985-12-20 | 1987-07-02 | Bayer Ag | 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung |
ATE126696T1 (de) * | 1985-12-23 | 1995-09-15 | Hutchinson Fred Cancer Res | Regulierung der retroviralen replikation, infektion und pathogenese. |
DE3611841A1 (de) * | 1986-04-09 | 1987-10-15 | Bayer Ag | Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten |
EP0282618A1 (de) * | 1987-03-18 | 1988-09-21 | Vereniging Het Nederlands Kanker Instituut | 1-Deoxynojirimycin als Anti-HIV-Therapeutikum |
JPS6461459A (en) * | 1987-08-28 | 1989-03-08 | Nippon Shinyaku Co Ltd | Moranoline derivative |
US4999360A (en) * | 1987-12-21 | 1991-03-12 | Monsanto Company | Method of inhibiting virus |
US4849430A (en) * | 1988-03-09 | 1989-07-18 | Monsanto Company | Method of inhibiting virus |
US4861892A (en) * | 1988-02-12 | 1989-08-29 | G. D. Searle & Co. | Method for synthesis of deoxymannojirimycin |
US5144037A (en) * | 1988-11-03 | 1992-09-01 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-d-glucitol derivatives |
US5003072A (en) * | 1988-11-03 | 1991-03-26 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-D-glucitol derivatives |
US4957926A (en) * | 1988-12-22 | 1990-09-18 | Monsanto Company | Method of treating herpesviruses |
US5011829A (en) * | 1989-06-02 | 1991-04-30 | G. D. Searle & Co. | Pharmaceutical composition and method of inhibiting virus |
US5175168A (en) * | 1989-07-27 | 1992-12-29 | Monsanto Company | Intermediates for 1,2-dideoxy-2-fluoronojirimycin |
US5026713A (en) * | 1989-08-29 | 1991-06-25 | Monsanto Company | 1,3-dideoxy-3-fluoronojirimycin which inhibits glycosidase activity |
US5025021A (en) * | 1989-07-27 | 1991-06-18 | Monsanto Company | 1,2-dideoxy-2-fluoronojirimycin as glycosidase inhibitors |
ES2036512T3 (es) * | 1989-07-27 | 1996-03-01 | Monsanto Co | Compuestos de piperidina con actividad inhibidora de las glicosidasas. |
US5218121A (en) * | 1989-08-29 | 1993-06-08 | Monsanto Company | Synthesis of 1,3-dideoxy-3-fluoronojirimycin |
US5130320A (en) * | 1989-08-29 | 1992-07-14 | Monsanto Company | Glycosidase inhibiting 1,3-dideoxy-3-fluoronojirimycin |
US5030638A (en) * | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
DE4009561A1 (de) * | 1990-03-24 | 1991-09-26 | Bayer Ag | Neue desoxynojirimycinderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
US5273981A (en) * | 1990-10-18 | 1993-12-28 | Monsanto Company | Intramolecular carbamate derivative of 2,3-Di-O-blocked-1,4-dideoxy-4-fluoro-nojirimycins |
US5128347A (en) * | 1990-10-18 | 1992-07-07 | Monsanto Company | Glycosidase inhibiting 1,4-dideoxy-4-fluoronojirimycin |
US5216168A (en) * | 1992-04-01 | 1993-06-01 | G. D. Searle & Co. | 2- and 3- amino and azido derivatives of 1,5-iminosugars |
US5331096A (en) * | 1992-04-01 | 1994-07-19 | G. D. Searle & Co. | 2- and 3-sulfur derivatives of 1,5-iminosugars |
US5206251A (en) * | 1992-04-01 | 1993-04-27 | G. D. Searle & Co. | 2- and 3- amino and azido derivatives of 1,5-iminosugars |
-
1992
- 1992-04-01 US US07/861,058 patent/US5258518A/en not_active Expired - Lifetime
-
1993
- 1993-03-31 EP EP93870060A patent/EP0566556B1/de not_active Expired - Lifetime
- 1993-03-31 CA CA002093078A patent/CA2093078C/en not_active Expired - Fee Related
- 1993-03-31 JP JP10973393A patent/JP3210772B2/ja not_active Expired - Fee Related
- 1993-03-31 AT AT93870060T patent/ATE139998T1/de not_active IP Right Cessation
- 1993-03-31 DK DK93870060.6T patent/DK0566556T3/da active
- 1993-03-31 ES ES93870060T patent/ES2090948T3/es not_active Expired - Lifetime
- 1993-03-31 DE DE69303413T patent/DE69303413T2/de not_active Expired - Fee Related
- 1993-07-12 US US08/089,919 patent/US5350854A/en not_active Expired - Fee Related
-
1994
- 1994-01-19 US US08/375,024 patent/US5502193A/en not_active Expired - Fee Related
- 1994-07-08 US US08/272,723 patent/US5530132A/en not_active Expired - Fee Related
- 1994-08-23 US US08/294,296 patent/US5523406A/en not_active Expired - Fee Related
-
1996
- 1996-06-05 US US08/659,692 patent/US5639882A/en not_active Expired - Fee Related
- 1996-06-05 US US08/658,775 patent/US5637707A/en not_active Expired - Fee Related
- 1996-10-02 GR GR960402582T patent/GR3021228T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2090948T3 (es) | 1996-10-16 |
JPH06279408A (ja) | 1994-10-04 |
DE69303413T2 (de) | 1997-01-09 |
CA2093078C (en) | 2005-02-22 |
US5530132A (en) | 1996-06-25 |
DK0566556T3 (da) | 1996-08-19 |
EP0566556A1 (de) | 1993-10-20 |
US5637707A (en) | 1997-06-10 |
EP0566556B1 (de) | 1996-07-03 |
US5258518A (en) | 1993-11-02 |
US5502193A (en) | 1996-03-26 |
GR3021228T3 (en) | 1997-01-31 |
US5350854A (en) | 1994-09-27 |
ATE139998T1 (de) | 1996-07-15 |
JP3210772B2 (ja) | 2001-09-17 |
US5523406A (en) | 1996-06-04 |
CA2093078A1 (en) | 1993-10-02 |
US5639882A (en) | 1997-06-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |