DE69320096T2 - Verabreichungssystem für Östradiol - Google Patents
Verabreichungssystem für ÖstradiolInfo
- Publication number
- DE69320096T2 DE69320096T2 DE69320096T DE69320096T DE69320096T2 DE 69320096 T2 DE69320096 T2 DE 69320096T2 DE 69320096 T DE69320096 T DE 69320096T DE 69320096 T DE69320096 T DE 69320096T DE 69320096 T2 DE69320096 T2 DE 69320096T2
- Authority
- DE
- Germany
- Prior art keywords
- estradiol
- adhesive
- progestin
- solvent
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 title abstract 5
- 229960005309 estradiol Drugs 0.000 title abstract 5
- 229930182833 estradiol Natural products 0.000 title abstract 5
- 239000000853 adhesive Substances 0.000 abstract 4
- 230000001070 adhesive effect Effects 0.000 abstract 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 2
- 239000011505 plaster Substances 0.000 abstract 2
- 239000000583 progesterone congener Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 229920002367 Polyisobutene Polymers 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 238000002657 hormone replacement therapy Methods 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 230000035699 permeability Effects 0.000 abstract 1
- 229920000058 polyacrylate Polymers 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 150000004671 saturated fatty acids Chemical class 0.000 abstract 1
- 238000007910 systemic administration Methods 0.000 abstract 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 abstract 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH148792 | 1992-05-08 | ||
US08/358,897 US5665377A (en) | 1992-05-08 | 1994-12-19 | Administration system for estradiol |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69320096D1 DE69320096D1 (de) | 1998-09-10 |
DE69320096T2 true DE69320096T2 (de) | 1998-12-10 |
Family
ID=25687798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69320096T Expired - Fee Related DE69320096T2 (de) | 1992-05-08 | 1993-05-07 | Verabreichungssystem für Östradiol |
Country Status (11)
Country | Link |
---|---|
US (1) | US5665377A (de) |
EP (1) | EP0569338B1 (de) |
JP (1) | JP2960832B2 (de) |
AT (1) | ATE169213T1 (de) |
AU (1) | AU670273B2 (de) |
CA (1) | CA2095789C (de) |
DE (1) | DE69320096T2 (de) |
DK (1) | DK0569338T3 (de) |
ES (1) | ES2121975T3 (de) |
NZ (1) | NZ247549A (de) |
ZA (1) | ZA933180B (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5474783A (en) * | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
DE4400770C1 (de) * | 1994-01-13 | 1995-02-02 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges Pflaster zur Abgabe von Estradiol mit mindestens einem Penetrationsverstärker, Verfahren zu seiner Herstellung und seine Verwendung |
JP3534775B2 (ja) * | 1995-06-07 | 2004-06-07 | オーソ―マクニール ファーマシューティカル,インコーポレイテッド | 17−デアセチルノルゲスチマートを単独でまたはエストロゲンと組み合わせて投与するための経皮パッチおよび方法 |
US5910403A (en) * | 1997-05-15 | 1999-06-08 | The Regents Of University Of California | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
US6692763B1 (en) | 1998-11-19 | 2004-02-17 | The Regents Of The University Of California | Methods for treating postmenopausal women using ultra-low doses of estrogen |
US5891868A (en) * | 1997-11-21 | 1999-04-06 | Kaiser Foundation Health Plan, Inc. | Methods for treating postmenopausal women using ultra-low doses of estrogen |
FR2776191B1 (fr) * | 1998-03-23 | 2002-05-31 | Theramex | Composition hormonale topique a effet systemique |
GB9828480D0 (en) * | 1998-12-24 | 1999-02-17 | Dermatech Limited | Transdermal drug delivery system |
WO2000053226A1 (fr) * | 1999-03-11 | 2000-09-14 | Saitama Daiichi Pharmaceutical Co., Ltd. | Compositions facilitant l'absorption cutanee |
DE10019171A1 (de) * | 2000-04-07 | 2001-10-18 | Schering Ag | Zusammensetzungen zur Verwendung als Penetrationsverstärker in transdermalen Formulierungen für hoch lipophile Wirkstoffe |
US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
US20040092494A9 (en) * | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
US7001587B2 (en) * | 2001-10-24 | 2006-02-21 | The Regents Of The University Of California | Measurement of protein synthesis rates in humans and experimental systems by use of isotopically labeled water |
DE10159120B4 (de) * | 2001-12-01 | 2006-08-17 | Lts Lohmann Therapie-Systeme Ag | Steroidhormonhaltige transdermale therapeutische Systeme enthaltend Propylenglycolmonocaprylat und seine Verwendung |
CA2475924C (en) * | 2002-02-12 | 2016-03-29 | The Regents Of The University Of California | Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation |
WO2004011426A2 (en) * | 2002-07-30 | 2004-02-05 | The Regents Of The University Of California | Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry |
WO2004021863A2 (en) * | 2002-09-04 | 2004-03-18 | The Regents Of The University Of California | Methods for measuring rates of replication and death of nfectious microbial agents in an infected host organism |
DK1546373T3 (da) | 2002-09-13 | 2009-03-30 | Univ California | Fremgangsmåder til måling af hastigheder af revers cholesteroltransport in vivo som et indeks for antiatherogenese |
US20070248540A1 (en) * | 2002-09-16 | 2007-10-25 | The Regents Of The University Of California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
SG152922A1 (en) * | 2002-11-04 | 2009-06-29 | Univ California | Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body |
AU2004220541B2 (en) | 2003-03-12 | 2009-03-26 | Epitome Pharmaceuticals Limited | Rapidly absorbing lipophilic skin compositions and uses therefor |
US7858607B2 (en) * | 2003-03-14 | 2010-12-28 | Mamchur Stephen A | System for use by compounding pharmacists to produce hormone replacement medicine customized for each consumer |
US7262020B2 (en) * | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
EP1682102A2 (de) * | 2003-09-10 | 2006-07-26 | Noven Pharmaceuticals, Inc. | Mehrschichtige transdermale arzneimittelabgabevorrichtung |
RU2356580C2 (ru) * | 2003-10-28 | 2009-05-27 | Новен Фармасьютикалз, Инк | Композиции и способы, обеспечивающие контролируемую потерю лекарственных средств и доставку в системах трансдермальной доставки лекарственных средств |
US20050202406A1 (en) | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
TW200538738A (en) | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
AU2005222430A1 (en) * | 2004-03-11 | 2005-09-22 | The Regents Of University Of California | Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients |
US20050238577A1 (en) * | 2004-03-29 | 2005-10-27 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
WO2006041911A2 (en) | 2004-10-08 | 2006-04-20 | Noven Pharmaceuticals, Inc. | Device transdermal administration of drugs including acrylic polymers |
WO2006041907A2 (en) | 2004-10-08 | 2006-04-20 | Noven Pharmaceuticals, Inc. | Transdermal delivery of estradiol |
US20060251576A1 (en) * | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
TW200711660A (en) | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
AU2006299833B2 (en) | 2005-10-12 | 2012-04-12 | Besins Healthcare Luxembourg Sarl | Improved testosterone gel and method of use |
US8231906B2 (en) | 2008-07-10 | 2012-07-31 | Noven Pharmaceuticals, Inc. | Transdermal estrogen device and delivery |
US20130032163A1 (en) * | 2011-08-03 | 2013-02-07 | Nail Couture L.A. Llc | System and method for nail foil application |
WO2013036885A1 (en) | 2011-09-08 | 2013-03-14 | The Regents Of The University Of California | Metabolic flux measurement, imaging and microscopy |
US20140353486A1 (en) | 2011-12-07 | 2014-12-04 | Glaxosmithkline Llc | Methods for determining total body skeletal muscle mass |
US9134319B2 (en) | 2013-03-15 | 2015-09-15 | The Regents Of The University Of California | Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5843368B2 (ja) * | 1980-10-30 | 1983-09-27 | 日東電工株式会社 | 消炎鎮痛貼付剤 |
US4626539A (en) * | 1984-08-10 | 1986-12-02 | E. I. Dupont De Nemours And Company | Trandermal delivery of opioids |
US4818540A (en) * | 1985-02-25 | 1989-04-04 | Rutgers, The State University Of New Jersey | Transdermal fertility control system and process |
US4764381A (en) * | 1985-12-06 | 1988-08-16 | Key Pharmaceuticals, Inc. | Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol |
US5145682A (en) * | 1986-05-30 | 1992-09-08 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for postmenopausal syndrome treatment and process for administration |
US5023084A (en) * | 1986-12-29 | 1991-06-11 | Rutgers, The State University Of New Jersey | Transdermal estrogen/progestin dosage unit, system and process |
US4816258A (en) * | 1987-02-26 | 1989-03-28 | Alza Corporation | Transdermal contraceptive formulations |
US4994267A (en) * | 1988-03-04 | 1991-02-19 | Noven Pharmaceuticals, Inc. | Transdermal acrylic multipolymer drug delivery system |
DE58909570D1 (de) * | 1988-10-27 | 1996-02-22 | Schering Ag | Mittel zur transdermalen applikation enthaltend gestoden |
CA2004203A1 (en) * | 1988-12-01 | 1990-06-01 | Sharad K. Govil | Compositions for transdermal delivery of estradiol |
DE3933460A1 (de) * | 1989-10-06 | 1991-04-18 | Lohmann Therapie Syst Lts | Oestrogenhaltiges wirkstoffpflaster |
AR246186A1 (es) * | 1989-11-17 | 1994-07-29 | Beta Pharm Co | Procedimiento para fabricar un dispositivo para administrar estradiol por via transdermica. |
US5122382A (en) * | 1990-10-29 | 1992-06-16 | Alza Corporation | Transdermal contraceptive formulations, methods and devices |
-
1993
- 1993-04-28 JP JP5102325A patent/JP2960832B2/ja not_active Expired - Fee Related
- 1993-05-05 NZ NZ247549A patent/NZ247549A/en unknown
- 1993-05-06 ZA ZA933180A patent/ZA933180B/xx unknown
- 1993-05-07 DK DK93810336T patent/DK0569338T3/da not_active Application Discontinuation
- 1993-05-07 AU AU38459/93A patent/AU670273B2/en not_active Ceased
- 1993-05-07 EP EP93810336A patent/EP0569338B1/de not_active Expired - Lifetime
- 1993-05-07 AT AT93810336T patent/ATE169213T1/de not_active IP Right Cessation
- 1993-05-07 ES ES93810336T patent/ES2121975T3/es not_active Expired - Lifetime
- 1993-05-07 DE DE69320096T patent/DE69320096T2/de not_active Expired - Fee Related
- 1993-05-07 CA CA002095789A patent/CA2095789C/en not_active Expired - Fee Related
-
1994
- 1994-12-19 US US08/358,897 patent/US5665377A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2095789A1 (en) | 1993-11-09 |
JPH0614986A (ja) | 1994-01-25 |
DE69320096D1 (de) | 1998-09-10 |
JP2960832B2 (ja) | 1999-10-12 |
AU670273B2 (en) | 1996-07-11 |
EP0569338B1 (de) | 1998-08-05 |
ATE169213T1 (de) | 1998-08-15 |
EP0569338A1 (de) | 1993-11-10 |
CA2095789C (en) | 2002-12-03 |
ES2121975T3 (es) | 1998-12-16 |
AU3845993A (en) | 1993-11-11 |
US5665377A (en) | 1997-09-09 |
NZ247549A (en) | 1995-12-21 |
DK0569338T3 (da) | 1999-05-03 |
ZA933180B (en) | 1994-06-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE169213T1 (de) | Verabreichungssystem für östradiol | |
US4863738A (en) | Skin permeation enhancer compositions using glycerol monooleate | |
DE3870504D1 (de) | Transdermale therapeutische systeme fuer wirkstoffkombinationen. | |
KR940013496A (ko) | 경피투여시스템 | |
PT96028A (pt) | Processo para a preparacao de um sistema terapeutico transdermico contendo 17-(ciclopropil-metil)-alfa-(1,1-dimetil-etil)-4,5-epoxi-18,19-di-hidro-3-hidroxi-6-metoxi-alfa-metil-6,14-etenomorfinano-7-metanol(buprenorfinal) como ingrediente activo | |
CA2227538A1 (en) | Hormone patch | |
GB2156215B (en) | Percutaneous absorption type adhesive pharmaceutical preparation | |
KR900005969A (ko) | 게스토덴을 함유하는 경피 투여용 제제 | |
ATE164769T1 (de) | Pflaster mit hohem gehalt an weichmachenden inhaltsstoffen | |
KR20000070178A (ko) | 호르몬 방출용 트랜스더멀 치료 시스템 | |
IL106512A (en) | Plaster for the transdermal application of steroid hormones and process for the preparation thereof | |
GB1216908A (en) | Medicated adhesive tape | |
ES2198584T3 (es) | Parche para aplicacion transdermica de pergolid. | |
CA2183544A1 (en) | Desogestrel-containing transdermal application agent | |
ATE240722T1 (de) | Transdermales abgabesystem, das ein östrogen enthält | |
JPS56140927A (en) | Medical member | |
KR920700704A (ko) | pH-조절된 조건하 약리학적 화합물 투여용 개선된 경피체계 | |
KR930023040A (ko) | 에스트라디올의 경피 투여용 접착 플라스터 및 그 제조 방법 | |
IL81540A0 (en) | Dermal and transdermal patches having a discontinuous pattern adhesive layer | |
JP3002491B2 (ja) | 経皮吸収製剤 | |
CA2144441A1 (en) | Dexpanthenol-containing plaster for the transdermal application of steroid hormones |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |