DE69320476T2 - Erythromycinderivate - Google Patents

Erythromycinderivate

Info

Publication number: DE69320476T2
Authority: DE; Germany
Prior art keywords: represents hydrogen; lower alkyl; represent; pair; different
Prior art date: 1992-05-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69320476T

Other languages

English (en)

Other versions

DE69320476D1 (en

Inventor

Hiroshi Koga

Tsutomu Sato

Hisanori Takanashi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Chugai Pharmaceutical Co Ltd

Original Assignee

Chugai Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-05-26

Filing date

1993-05-26

Publication date

1999-03-25

1993-05-26 Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd

1998-09-24 Publication of DE69320476D1 publication Critical patent/DE69320476D1/de

1999-03-25 Application granted granted Critical

1999-03-25 Publication of DE69320476T2 publication Critical patent/DE69320476T2/de

2013-05-27 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 2
239000001257 hydrogen Substances 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
210000004051 gastric juice Anatomy 0.000 abstract 1
210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
230000001737 promoting effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

DE69320476T 1992-05-26 1993-05-26 Erythromycinderivate Expired - Lifetime DE69320476T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP13382892		1992-05-26
PCT/JP1993/000702 WO1993024509A1 (en)	1992-05-26	1993-05-26	Erythromycin derivative

Publications (2)

Publication Number	Publication Date
DE69320476D1 DE69320476D1 (en)	1998-09-24
DE69320476T2 true DE69320476T2 (de)	1999-03-25

Family

ID=15113997

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69320476T Expired - Lifetime DE69320476T2 (de)	1992-05-26	1993-05-26	Erythromycinderivate

Country Status (21)

Country	Link
US (1)	US5658888A (de)
EP (1)	EP0643068B1 (de)
JP (1)	JP3068367B2 (de)
KR (1)	KR100226311B1 (de)
CN (1)	CN1036199C (de)
AT (1)	ATE169927T1 (de)
AU (1)	AU659740B2 (de)
CA (1)	CA2117883C (de)
DE (1)	DE69320476T2 (de)
DK (1)	DK0643068T3 (de)
ES (1)	ES2120499T3 (de)
HK (1)	HK1009969A1 (de)
HR (1)	HRP930926B1 (de)
IL (1)	IL105810A (de)
MY (1)	MY113693A (de)
SG (1)	SG52785A1 (de)
SI (1)	SI9300281B (de)
TW (1)	TW240230B (de)
WO (1)	WO1993024509A1 (de)
YU (1)	YU48771B (de)
ZA (1)	ZA933679B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2007204490A (ja) *	1995-08-03	2007-08-16	Chugai Pharmaceut Co Ltd	エリスロマイシン誘導体の製造方法
ZA966601B (en) *	1995-08-03	1997-02-19	Chugai Pharmaceutical Co Ltd	Process for producing erythromycin derivatives.
US6077943A (en) *	1996-03-01	2000-06-20	Takeda Chemical Industries, Ltd.	Method of producing erythromycin derivative
WO1998003531A1 (fr) *	1996-07-24	1998-01-29	Chugai Seiyaku Kabushiki Kaisha	Derives d'erythromycine
WO1998023629A1 (fr) *	1996-11-26	1998-06-04	Chugai Seiyaku Kabushiki Kaisha	Composes de macrolides comportant une chaine a 13 elements, medicament les contenant et leur procede de preparation
US5780605A (en) *	1997-09-08	1998-07-14	Abbott Laboratories	6,9-bridged erythromycin derivatives
JP2003523347A (ja) *	2000-02-18	2003-08-05	コーサンバイオサイエンシーズ，インコーポレイテッド	モチライド化合物
WO2003079972A2 (en)	2002-02-22	2003-10-02	New River Parmaceuticals Inc.	Active agent delivery systems and methods for protecting and administering active agents
AU8257701A (en) *	2000-09-01	2002-03-13	Chugai Pharmaceutical Co Ltd	Process for producing erythromycin derivative
TWI286139B (en)	2000-10-12	2007-09-01	Chugai Pharmaceutical Co Ltd	Erythromycin derivative having novel crystal structures and processes for their production
DE60206921T2 (de) *	2001-06-13	2006-07-20	Ube Industries, Ltd., Ube	Verfahren zur herstellung von erythromycinverbindungen
TW200302830A (en) *	2002-01-11	2003-08-16	Chugai Pharmaceutical Co Ltd	Anhydrate/hydrate of an erythromycin derivative and processes for preparing said anhydrate/hydrate
US20040010035A1 (en) *	2002-07-15	2004-01-15	Ciociola Arthur A.	Gastrointestinal compositions
NZ537395A (en) *	2002-07-10	2006-11-30	Warner Lambert Co	Combination of an allosteric inhibitor or matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib
US6986901B2 (en) *	2002-07-15	2006-01-17	Warner-Lambert Company Llc	Gastrointestinal compositions
JP4796300B2 (ja) *	2002-08-29	2011-10-19	ファイザーインコーポレイテッド	モチライド化合物
AR043050A1 (es) *	2002-09-26	2005-07-13	Rib X Pharmaceuticals Inc	Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
CA2517970A1 (en) *	2003-03-05	2004-09-16	Rib-X Pharmaceuticals, Inc.	Bifunctional heterocyclic compounds and methods of making and using the same
JP4928261B2 (ja)	2003-06-18	2012-05-09	トランザイム・ファーマ・インコーポレイテッド	モチリン受容体の大環状拮抗薬
US20050113319A1 (en) *	2003-08-26	2005-05-26	Christopher Carreras	11-Deoxy-6,9-ether erythromycin compounds
US7407941B2 (en) *	2003-08-26	2008-08-05	Pfizer, Inc.	N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US20070149463A1 (en) *	2003-10-30	2007-06-28	Oyelere Adegboyega K	Bifunctional macrolide heterocyclic compounds and methods of making and using the same
JP2007512256A (ja) *	2003-11-18	2007-05-17	リブ−エックスファーマシューティカルズ，インコーポレイテッド	二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法
US7211568B2 (en) *	2003-12-18	2007-05-01	Kosan Biosciences Incorporated	9-Desoxoerythromycin compounds as prokinetic agents
US8202843B2 (en) *	2004-02-27	2012-06-19	Rib-X Pharmaceuticals, Inc.	Macrocyclic compounds and methods of making and using the same
TW200633714A (en) *	2004-12-28	2006-10-01	Chugai Pharmaceutical Co Ltd	Drugs for the treatment and/or prophylaxis of gastroparesis symptom
US7582611B2 (en) *	2005-05-24	2009-09-01	Pfizer Inc.	Motilide compounds
US8470985B2 (en)	2005-08-24	2013-06-25	Rib-X Pharmaceuticals, Inc.	Triazole compounds and methods of making and using the same
WO2007025098A2 (en)	2005-08-24	2007-03-01	Rib-X Pharmaceuticals, Inc.	Triazole compounds and methods of making and using the same
US20070135362A1 (en) *	2005-12-08	2007-06-14	Yaoquan Liu	Method for demethylating the 3'-dimethylamino group of erythromycin compounds
CA2662897C (en)	2006-09-11	2017-11-07	Tranzyme Pharma, Inc.	Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
CA2670482C (en) *	2006-12-05	2011-10-11	Pfizer Inc.	Motilide polymorphs
US20080287371A1 (en) *	2007-05-17	2008-11-20	Tranzyme Pharma Inc.	Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60218321A (ja) *	1984-04-13	1985-11-01	Satoshi Omura	消化管収縮運動促進剤
JPS6187625A (ja) *	1984-10-05	1986-05-06	Satoshi Omura	消化管収縮運動促進剤
JPH0759513B2 (ja) *	1985-08-31	1995-06-28	北里研究所（社団法人）	消化管収縮運動促進剤
US5008249A (en) *	1985-08-31	1991-04-16	Kitasato Kenkyusho	Therapeutic method of stimulating digestive tract contractile motion in mammals
EP0215355B1 (de) *	1985-08-31	1994-04-06	Kitasato Kenkyusho	Erythromycinderivat und Verfahren zu dessen Herstellung
KR0179379B1 (ko) *	1992-01-21	1999-04-01	찰스 엠.브록	4"-데옥시에리트로마이신 유도체

1993
- 1993-05-19 MY MYPI93000927A patent/MY113693A/en unknown
- 1993-05-24 HR HR930926A patent/HRP930926B1/xx not_active IP Right Cessation
- 1993-05-25 TW TW082104109A patent/TW240230B/zh active
- 1993-05-25 YU YU36693A patent/YU48771B/sh unknown
- 1993-05-25 SI SI9300281A patent/SI9300281B/sl not_active IP Right Cessation
- 1993-05-25 IL IL10581093A patent/IL105810A/en not_active IP Right Cessation
- 1993-05-26 AU AU40897/93A patent/AU659740B2/en not_active Ceased
- 1993-05-26 CA CA002117883A patent/CA2117883C/en not_active Expired - Fee Related
- 1993-05-26 JP JP5124514A patent/JP3068367B2/ja not_active Expired - Fee Related
- 1993-05-26 CN CN93106467A patent/CN1036199C/zh not_active Expired - Fee Related
- 1993-05-26 ES ES93910399T patent/ES2120499T3/es not_active Expired - Lifetime
- 1993-05-26 SG SG1996009490A patent/SG52785A1/en unknown
- 1993-05-26 ZA ZA933679A patent/ZA933679B/xx unknown
- 1993-05-26 EP EP93910399A patent/EP0643068B1/de not_active Expired - Lifetime
- 1993-05-26 DK DK93910399T patent/DK0643068T3/da active
- 1993-05-26 KR KR1019940704274A patent/KR100226311B1/ko not_active IP Right Cessation
- 1993-05-26 US US08/318,814 patent/US5658888A/en not_active Expired - Lifetime
- 1993-05-26 WO PCT/JP1993/000702 patent/WO1993024509A1/ja active IP Right Grant
- 1993-05-26 DE DE69320476T patent/DE69320476T2/de not_active Expired - Lifetime
- 1993-05-26 AT AT93910399T patent/ATE169927T1/de not_active IP Right Cessation
1998
- 1998-09-24 HK HK98110895A patent/HK1009969A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP3068367B2 (ja)	2000-07-24
IL105810A0 (en)	1993-09-22
EP0643068A4 (de)	1995-08-02
ATE169927T1 (de)	1998-09-15
TW240230B (de)	1995-02-11
HRP930926B1 (en)	2000-10-31
MY113693A (en)	2002-05-31
CA2117883C (en)	2003-10-21
WO1993024509A1 (en)	1993-12-09
YU48771B (sh)	1999-12-27
ZA933679B (en)	1993-12-21
CA2117883A1 (en)	1993-12-09
US5658888A (en)	1997-08-19
SG52785A1 (en)	1998-09-28
ES2120499T3 (es)	1998-11-01
CN1036199C (zh)	1997-10-22
DE69320476D1 (en)	1998-09-24
YU36693A (sh)	1996-07-24
DK0643068T3 (da)	1999-02-08
CN1081184A (zh)	1994-01-26
EP0643068A1 (de)	1995-03-15
KR100226311B1 (ko)	1999-10-15
HRP930926A2 (en)	1995-02-28
IL105810A (en)	1998-12-27
AU659740B2 (en)	1995-05-25
JPH0656873A (ja)	1994-03-01
HK1009969A1 (en)	1999-09-10
SI9300281B (en)	2001-02-28
SI9300281A (sl)	1993-12-31
AU4089793A (en)	1993-12-30
KR950701640A (ko)	1995-04-28
EP0643068B1 (de)	1998-08-19

Legal Events

Date	Code	Title	Description
1999-09-16	8364	No opposition during term of opposition

Publication	Publication Date	Title
DE69320476T2 (de)	1999-03-25	Erythromycinderivate
DK0934950T3 (da)	2002-07-29	Tetrapeptidderivat
DE69127457T2 (de)	1998-01-22	6-0-methylerythromycin a-derivat
DK0585155T3 (da)	1997-06-09	Trifluormethylketon-peptidderivater med HLE-inhiberende aktivitet, deres fremstilling og farmaceutiske præparater
NO180011C (no)	1997-01-29	Cykliske fruktopyranosesulfitter og -sulfater med antikonvulsiv effekt, farmasöytiske preparater inneholdende slike forbindelser samt mellomprodukter
EP0324387A3 (en)	1990-06-13	Composition for treatment of ischemic disorder in organs
FR2614618B1 (fr)	1989-07-07	Derives heterocycliques polycycliques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire
DE68929368D1 (de)	2002-02-21	Cephemderivate und Verfahren zu ihrer Herstellung
ATE159258T1 (de)	1997-11-15	4-desoxy-4-epipodophyllotoxinderivate oder deren pharmazeutisch akzeptierbaren salze
MX9206093A (es)	1993-04-01	Derivado de oxazolidona
DE69400817D1 (de)	1996-12-05	9a-N-(N'-Carbamoyl)-und 9a-N-(N'Thiocarbamoyl)-Derivate von 9-Deoxo-9a-aza-9a-homoerythromycin A
DE3866012D1 (de)	1991-12-12	Antiarrhythmische heilmittel.
ES8503354A1 (es)	1985-02-16	Un procedimiento de preparacion de nuevos derivados de carbapenem.
ATE90685T1 (de)	1993-07-15	Disaccharidderivate.
DK540589A (da)	1990-05-01	Pyrrolidinderivater
ES8400436A1 (es)	1983-10-16	Un procedimiento para la preparacion de nuevos derivados de 2-fenotiazinsulfonamida.