DE69320742T2 - Faseroptischer sensor und verfahren zum nachweis eines organischen analyten in einer flüssigen oder dampfförmigen probe - Google Patents

Faseroptischer sensor und verfahren zum nachweis eines organischen analyten in einer flüssigen oder dampfförmigen probe

Info

Publication number
DE69320742T2
DE69320742T2 DE69320742T DE69320742T DE69320742T2 DE 69320742 T2 DE69320742 T2 DE 69320742T2 DE 69320742 T DE69320742 T DE 69320742T DE 69320742 T DE69320742 T DE 69320742T DE 69320742 T2 DE69320742 T2 DE 69320742T2
Authority
DE
Germany
Prior art keywords
vapored
analytic
sample
organic
detecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69320742T
Other languages
English (en)
Other versions
DE69320742D1 (de
Inventor
David Walt
Steven Barnard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tufts University
Original Assignee
Tufts University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts University filed Critical Tufts University
Publication of DE69320742D1 publication Critical patent/DE69320742D1/de
Application granted granted Critical
Publication of DE69320742T2 publication Critical patent/DE69320742T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6434Optrodes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706Reagent provision
    • G01N2021/773Porous polymer jacket; Polymer matrix with indicator
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7793Sensor comprising plural indicators
DE69320742T 1992-04-20 1993-04-12 Faseroptischer sensor und verfahren zum nachweis eines organischen analyten in einer flüssigen oder dampfförmigen probe Expired - Fee Related DE69320742T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/870,949 US5244813A (en) 1991-01-25 1992-04-20 Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
PCT/US1993/003448 WO1993021513A1 (en) 1992-04-20 1993-04-12 Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample

Publications (2)

Publication Number Publication Date
DE69320742D1 DE69320742D1 (de) 1998-10-08
DE69320742T2 true DE69320742T2 (de) 1999-03-04

Family

ID=25356393

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69320742T Expired - Fee Related DE69320742T2 (de) 1992-04-20 1993-04-12 Faseroptischer sensor und verfahren zum nachweis eines organischen analyten in einer flüssigen oder dampfförmigen probe

Country Status (6)

Country Link
US (1) US5244813A (de)
EP (1) EP0590145B1 (de)
JP (1) JPH06508694A (de)
CA (1) CA2111838A1 (de)
DE (1) DE69320742T2 (de)
WO (1) WO1993021513A1 (de)

Families Citing this family (178)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320814A (en) * 1991-01-25 1994-06-14 Trustees Of Tufts College Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample
US5525520A (en) * 1992-09-01 1996-06-11 Martin Marietta Energy Systems, Inc. Photo-activated luminescence sensor and method of detecting trichloroethylene and related volatile organochloride compounds
US5416879A (en) * 1993-03-29 1995-05-16 World Precision Instruments, Inc. Apparatus and method for measuring light absorption in small aqueous fluid samples
IT1265878B1 (it) * 1993-07-06 1996-12-12 Consiglio Nazionale Ricerche Metodo per l'immobilizzazione di supporti vetrosi all'estremita' di fibre ottiche di plastica o di vetro per la realizzazione di sensori
US5445795A (en) * 1993-11-17 1995-08-29 The United States Of America As Represented By The United States Department Of Energy Volatile organic compound sensing devices
US5512490A (en) * 1994-08-11 1996-04-30 Trustees Of Tufts College Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns
US6596522B2 (en) 1997-05-08 2003-07-22 The Regents Of The University Of California Detection of transmembrane potentials by optical methods
US5661035A (en) * 1995-06-07 1997-08-26 The Regents Of The University Of California Voltage sensing by fluorescence resonance energy transfer
US6342379B1 (en) 1995-06-07 2002-01-29 The Regents Of The University Of California Detection of transmembrane potentials by optical methods
US5567622A (en) * 1995-07-05 1996-10-22 The Aerospace Corporation Sensor for detection of nitrogen dioxide and nitrogen tetroxide
US5814524A (en) * 1995-12-14 1998-09-29 Trustees Of Tufts College Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
US7041510B2 (en) 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
ES2288760T3 (es) * 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US6387707B1 (en) * 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US7144119B2 (en) * 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
GB9700745D0 (en) 1997-01-15 1997-03-05 Univ Strathclyde Furfuraldehyde detector
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7622294B2 (en) * 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US6406845B1 (en) 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
EP1003904B1 (de) * 1997-05-23 2007-07-11 BioArray Solutions Ltd. Farbkodierung und in situ abfrage von matrix-gekoppelten chemischen verbindungen
DE19734618A1 (de) * 1997-08-09 1999-02-11 Boehringer Mannheim Gmbh Analysevorrichtung zur in vivo-Analyse im Körper eines Patienten
DE69802954T4 (de) * 1997-10-02 2003-11-20 Siemens Canada Ltd Verfahren zur temperatur-korrektur und untersystem für eine anordnung zur verdampfungsleck-detektion von fahrzeugen
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US6098454A (en) * 1998-02-06 2000-08-08 Zellweger Uster, Inc. Subsampling fiber testing system
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
US8198096B2 (en) * 1998-05-05 2012-06-12 Massachusetts Institute Of Technology Emissive polymers and devices incorporating these polymers
EP1080162B1 (de) 1998-05-05 2004-03-10 Massachusetts Institute Of Technology Lichtemittierende polymere und vorrichtungen, die diese enthalten
US20050147534A1 (en) * 1998-05-05 2005-07-07 Massachusetts Institute Of Technology Emissive sensors and devices incorporating these sensors
US6780617B2 (en) 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
EP1090293B2 (de) 1998-06-24 2019-01-23 Illumina, Inc. Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel
US7799521B2 (en) * 1998-06-24 2010-09-21 Chen & Chen, Llc Thermal cycling
CA2301153C (en) * 1998-06-24 2008-08-26 Chen & Chen, Llc Fluid sample testing system
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6608671B2 (en) 1998-07-17 2003-08-19 Vertex Pharmaceuticals (San Diego) Llc Detector and screening device for ion channels
US6349160B2 (en) 1998-07-24 2002-02-19 Aurora Biosciences Corporation Detector and screening device for ion channels
US6406668B1 (en) 1998-08-03 2002-06-18 University Of Iowa Research Foundation Sensing array and sensor structure
GB9818766D0 (en) * 1998-08-28 1998-10-21 Johnson Matthey Plc Improvements in sensors
US6035705A (en) * 1998-09-01 2000-03-14 Marathon Ashland Petroleum Llc Method for characterization of fuels
US6285807B1 (en) * 1998-11-16 2001-09-04 Trustees Of Tufts College Fiber optic sensor for long-term analyte measurements in fluids
US7510841B2 (en) * 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
JP4454155B2 (ja) 1999-01-08 2010-04-21 アプライド バイオシステムズ, エルエルシー 化学種を接触させるためのファイバーアレイならびにファイバーアレイを使用および作製する方法
US20050026209A1 (en) * 1999-01-08 2005-02-03 Vann Charles S. Optical fiber bundle for detecting binding of chemical species
US7595189B2 (en) * 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
US6490030B1 (en) 1999-01-18 2002-12-03 Verification Technologies, Inc. Portable product authentication device
US6846460B1 (en) 1999-01-29 2005-01-25 Illumina, Inc. Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US20030215821A1 (en) * 1999-04-20 2003-11-20 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
EP1190100B1 (de) 1999-05-20 2012-07-25 Illumina, Inc. Kombinatorische entschlüsselung von zufallsnukleinsäurearrays
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6132958A (en) * 1999-05-27 2000-10-17 The Rockefeller University Fluorescent bead for determining the temperature of a cell and methods of use thereof
US7022517B1 (en) 1999-07-16 2006-04-04 Board Of Regents, The University Of Texas System Method and apparatus for the delivery of samples to a chemical sensor array
EP1204859B1 (de) 1999-07-16 2006-11-22 The Board Of Regents, The University Of Texas System Verfahren und vorrichtung zur zuführung von proben zu einer chemischen sensormatrix
DK1218545T3 (da) 1999-08-18 2012-02-20 Illumina Inc Fremgangsmåder til fremstilling af oligonukleotidopløsninger
AU2246601A (en) 1999-08-30 2001-04-10 Illumina, Inc. Methods for improving signal detection from an array
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6975944B1 (en) * 1999-09-28 2005-12-13 Alpha Mos Method and apparatus for monitoring materials used in electronics
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
WO2001055702A1 (en) 2000-01-31 2001-08-02 Board Of Regents, The University Of Texas System Portable sensor array system
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
EP1255865B1 (de) 2000-02-07 2007-04-18 Illumina, Inc. Nukleinsäure Nachweisverfahren mit universellem Priming
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US6913884B2 (en) * 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
EP1990428B1 (de) 2000-02-07 2010-12-22 Illumina, Inc. Nukleinsäuredetektionsverfahren mit universellem Priming
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7361488B2 (en) * 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
AU2001239760B2 (en) * 2000-02-10 2005-11-24 Illumina, Inc. Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
US6770441B2 (en) * 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
EP1257668B1 (de) 2000-02-16 2008-10-29 Illumina, Inc. Parallele genotypisierung mehrerer patientenproben
US6649416B1 (en) * 2000-02-18 2003-11-18 Trustees Of Tufts College Intelligent electro-optical sensor array and method for analyte detection
US6362006B1 (en) * 2000-03-13 2002-03-26 General Electric Company Rapid parallel determination of non-volatile analytes in complex combinatorial samples
US6485962B1 (en) 2000-04-05 2002-11-26 Echo Technologies Methods for signal enhancement in optical microorganism sensors
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
ES2259666T3 (es) 2000-06-21 2006-10-16 Bioarray Solutions Ltd Analisis molecular de multiples analitos usando series de particulas aleatorias con especificidad de aplicacion.
JP3699339B2 (ja) * 2000-07-17 2005-09-28 財団法人鉄道総合技術研究所 地盤中に含まれる有害イオンの簡易検出方法および簡易検出装置
US6783814B2 (en) 2000-08-21 2004-08-31 Massachusetts Institute Of Technology Polymers with high internal free volume
AU2001288751A1 (en) * 2000-09-05 2002-03-22 Illumina, Inc. Cellular arrays comprising encoded cells
US7057704B2 (en) * 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
EP1320744A2 (de) * 2000-09-19 2003-06-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und verfahren zur analyse von fluiden
US20030045005A1 (en) 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
US20040018491A1 (en) * 2000-10-26 2004-01-29 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20030003436A1 (en) * 2001-02-05 2003-01-02 Willson C. Grant Use of mesoscale self-assembly and recognition to effect delivery of sensing reagent for arrayed sensors
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
JP4513085B2 (ja) 2001-09-11 2010-07-28 アイキューム インク 試料の容器
US7096053B2 (en) 2001-10-02 2006-08-22 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Internal biochemical sensing device
US20050267326A1 (en) * 2001-10-02 2005-12-01 Alfred E. Mann Institute For Biomedical Eng. At The University Of Southern California Percutaneous chemical sensor based on fluorescence resonant energy transfer (FRET)
EP2722395B1 (de) 2001-10-15 2018-12-19 Bioarray Solutions Ltd Gemultiplexte Analyse polymorphischer Stellen durch gleichzeitige Abfrage und enzymvermittelte Detektion
US7462325B2 (en) * 2001-11-30 2008-12-09 Nomadics, Inc. Luminescent polymer particles
US6741365B2 (en) 2001-12-12 2004-05-25 Artel, Inc. Photometric calibration of liquid volumes
US20030148391A1 (en) * 2002-01-24 2003-08-07 Salafsky Joshua S. Method using a nonlinear optical technique for detection of interactions involving a conformational change
US7499806B2 (en) 2002-02-14 2009-03-03 Illumina, Inc. Image processing in microsphere arrays
AU2003228711C1 (en) 2002-04-26 2010-01-07 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
AU2003269913A1 (en) * 2002-07-15 2004-02-02 Massachusetts Institute Of Technology Emissive, high charge transport polymers
AU2003260116A1 (en) * 2002-08-28 2004-03-19 Mabgen L.L.C. Selecting therapeutic human monoclonal antibodies from disease-specific libraries
US7595883B1 (en) * 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
WO2006086578A1 (en) * 2002-10-02 2006-08-17 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Internal biochemical sensing device
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US20040121337A1 (en) * 2002-12-19 2004-06-24 Nomadics, Inc. Luminescent polymers and methods of use thereof
US7887752B2 (en) 2003-01-21 2011-02-15 Illumina, Inc. Chemical reaction monitor
EP2574400B1 (de) 2003-02-05 2016-09-28 Iquum, Inc. Probenverarbeitung
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
WO2004097371A2 (en) * 2003-04-25 2004-11-11 Board Of Regents, The University Of Texas System System and method for the detection of analytes
US7651850B2 (en) * 2003-05-16 2010-01-26 Board Of Regents, The University Of Texas System Image and part recognition technology
US9317922B2 (en) 2003-05-16 2016-04-19 Board Of Regents The University Of Texas System Image and part recognition technology
US7148066B2 (en) * 2003-08-01 2006-12-12 Glotell Products, Inc. Dye solutions for use in methods to detect the prior evaporation of anhydrous ammonia and the production of illict drugs
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
ES2375962T3 (es) 2003-09-22 2012-03-07 Bioarray Solutions Ltd Polielectrolito inmovilizado en superficie con múltiples grupos funcionales capaces de unirse covalentemente a biomoléculas.
EP1692298A4 (de) 2003-10-28 2008-08-13 Bioarray Solutions Ltd Optimierung der genexpressionsanalyse unter verwendung immobilisierter fängersonden
ES2533876T3 (es) 2003-10-29 2015-04-15 Bioarray Solutions Ltd Análisis multiplexado de ácidos nucleicos mediante fragmentación de ADN bicatenario
US7787923B2 (en) * 2003-11-26 2010-08-31 Becton, Dickinson And Company Fiber optic device for sensing analytes and method of making same
US7496392B2 (en) * 2003-11-26 2009-02-24 Becton, Dickinson And Company Fiber optic device for sensing analytes
US20050148003A1 (en) * 2003-11-26 2005-07-07 Steven Keith Methods of correcting a luminescence value, and methods of determining a corrected analyte concentration
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US7846676B2 (en) * 2004-07-19 2010-12-07 Cell Biosciences, Inc. Methods and devices for analyte detection
US7935479B2 (en) 2004-07-19 2011-05-03 Cell Biosciences, Inc. Methods and devices for analyte detection
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US8617819B2 (en) 2004-09-17 2013-12-31 Massachusetts Institute Of Technology Polymers for analyte detection
WO2006047038A1 (en) * 2004-09-28 2006-05-04 Trustees Of Tufts College Apparatus and method for cell migration assays
US8329390B2 (en) * 2004-10-21 2012-12-11 Anaspec Incorporated Detection of transmembrane potentials using N,N,N′-trialkyl thiobarbituric acid-derived polymethine oxonols
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
EP1910824A4 (de) 2005-05-31 2012-11-21 Labnow Inc Verfahren und zusammensetzungen in zusammenhang mit der erstellung und verwendung eines weissen blutbildes
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
WO2007035864A2 (en) 2005-09-20 2007-03-29 Cell Biosciences, Inc. Electrophoresis standards, methods and kits
US20070147738A1 (en) * 2005-12-12 2007-06-28 Xingwei Wang Intrinsic fabry-perot structure with micrometric tip
US8003405B2 (en) * 2005-12-16 2011-08-23 Artel, Inc. Calibrating dispensing device performance for complex and/or non-aqueous liquids
US7772008B2 (en) * 2006-01-06 2010-08-10 Artel, Inc. Method and apparatus for determining liquid volume
US8460879B2 (en) * 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US20080017512A1 (en) * 2006-07-24 2008-01-24 Bordunov Andrei V Coatings for capillaries capable of capturing analytes
US8158437B2 (en) * 2006-08-04 2012-04-17 Massachusetts Institute Of Technology Luminescent detection of hydrazine and hydrazine derivatives
US7998747B2 (en) * 2006-09-15 2011-08-16 Artel, Inc. Quantitative dual-dye photometric method for determining dilution impact
US7704751B2 (en) * 2006-09-18 2010-04-27 3M Innovative Properties Company Polymeric fluorescent chemical sensor
US8283423B2 (en) 2006-09-29 2012-10-09 Massachusetts Institute Of Technology Polymer synthetic technique
US8802447B2 (en) 2006-10-05 2014-08-12 Massachusetts Institute Of Technology Emissive compositions with internal standard and related techniques
US20090215189A1 (en) * 2006-10-27 2009-08-27 Massachusetts Institute Of Technology Sensor of species including toxins and chemical warfare agents
ES2556627T3 (es) * 2007-08-30 2016-01-19 Trustees Of Tufts College Métodos para determinar la concentración de un analito en solución
US8393198B2 (en) * 2008-01-09 2013-03-12 OronoSpectral Solutions, Inc. Apparatus and method for determining analyte content in a fluid
US10107782B2 (en) 2008-01-25 2018-10-23 ProteinSimple Method to perform limited two dimensional separation of proteins and other biologicals
US7791716B2 (en) * 2008-04-07 2010-09-07 Artel, Inc. System and method for liquid delivery evaluation using solutions with multiple light absorbance spectral features
US8404158B2 (en) 2008-04-07 2013-03-26 Artel, Inc. System and method for liquid delivery evaluation using solutions with multiple light absorbance spectral features
FR2933703B1 (fr) * 2008-07-11 2012-08-17 Commissariat Energie Atomique Detecteurs nanoporeux de composes aromatiques monocycliques et autres polluants
US9182406B2 (en) * 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100075862A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
JP2010195750A (ja) * 2009-02-27 2010-09-09 Osaka Municipal Technical Research Institute 両親媒性物質、界面活性剤、および、界面活性剤の使用方法
EP2404162B1 (de) 2009-03-03 2017-12-27 Access Medical System Co., Ltd. Nachweissystem und verfahren für hochsensitive fluoreszenztests
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
GB0915150D0 (en) * 2009-09-01 2009-10-07 Intelisys Ltd In-borehole gas monitor apparatus and method
ES2544635T3 (es) 2010-03-01 2015-09-02 Quanterix Corporation Métodos para extender el rango dinámico en ensayos para la detección de moléculas o partículas
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) * 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
FR2965918B1 (fr) * 2010-10-08 2013-01-18 IFP Energies Nouvelles Dispositif optique de detection de polluants dans un fluide et methode utilisant un tel dispositif
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
AU2012230899A1 (en) 2011-03-21 2013-10-10 Biodesy, Llc Classification of kinase inhibitors using nonlinear optical techniques
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
CN103608675B (zh) 2011-04-20 2015-07-22 万迈医疗仪器有限公司 发光聚合物循环扩增
US9568431B2 (en) 2012-04-16 2017-02-14 Access Medical Systems, Ltd. Luminescent immunoassays for quantitating analytes having a wide concentration range
WO2013155634A1 (en) 2012-04-19 2013-10-24 Jiaqi Wu Dual wavelength isoelectric focusing for determining drug load in antibody drug conjugates
EP2743681A1 (de) * 2012-12-13 2014-06-18 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Fluoreszenzdetektorsystem zur Detektion eines aromatischen Kohlenwasserstoffs
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
US9766206B2 (en) 2013-09-27 2017-09-19 ProteinSimple Apparatus, systems, and methods for capillary electrophoresis
WO2016106286A1 (en) 2014-12-23 2016-06-30 Biodesy, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
CN106053687B (zh) * 2016-08-18 2018-10-23 安徽瑞思威尔科技有限公司 一种固态发酵产物中香味物质的检测方法
US10309901B2 (en) * 2017-02-17 2019-06-04 International Business Machines Corporation Water-sensitive fluorophores for moisture content evaluation in hygroscopic polymers
JP7106612B2 (ja) * 2020-10-01 2022-07-26 株式会社東芝 蛍光発光可能な膜、および分子検出装置

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929561A (en) * 1985-08-08 1990-05-29 Regents Of The University Of California Absorption-emission optrode and methods of use thereof
US4798738A (en) * 1986-10-10 1989-01-17 Cardiovascular Devices, Inc. Micro sensor
US4842783A (en) * 1987-09-03 1989-06-27 Cordis Corporation Method of producing fiber optic chemical sensors incorporating photocrosslinked polymer gels
US4994396A (en) * 1987-12-14 1991-02-19 The Dow Chemical Company Method for measuring the concentration or partial pressure of oxygen
US5000901A (en) * 1988-07-25 1991-03-19 Abbott Laboratories Fiber-optic physiological probes
US5096671A (en) * 1989-03-15 1992-03-17 Cordis Corporation Fiber optic chemical sensors incorporating electrostatic coupling
US5152287A (en) * 1990-08-15 1992-10-06 Cordis Corporation Cross-linked fluorinated polymers for use in gas sensors

Also Published As

Publication number Publication date
US5244813A (en) 1993-09-14
EP0590145B1 (de) 1998-09-02
EP0590145A4 (en) 1994-08-24
DE69320742D1 (de) 1998-10-08
WO1993021513A1 (en) 1993-10-28
CA2111838A1 (en) 1993-10-28
EP0590145A1 (de) 1994-04-06
JPH06508694A (ja) 1994-09-29

Similar Documents

Publication Publication Date Title
DE69320742T2 (de) Faseroptischer sensor und verfahren zum nachweis eines organischen analyten in einer flüssigen oder dampfförmigen probe
DE69816339D1 (de) Chromatographische vorrichtung und verfahren zum nachweis eines analyts in einer vollblutprobe
DE69430152T2 (de) Verfahren und Vorrichtung zum Messen von Glukoseverwandten Substanzen
DE69331067T2 (de) Verfahren und vorrichtung zum nachweis von nukleinsäure oder analysen unter verwendung der internen totalreflexion
DE69311841T3 (de) Verfahren und Vorrichtung zum Ziehen von optischen Fasern
DE69840657D1 (de) Verfahren zum Nachweis eines Restanalyts in einer Probe
DE69319843D1 (de) Verfahren und Apparat zum Nachweis biologischer Aktivitäten in einer Probe
DE69420593D1 (de) Verfahren und Vorrichtung zum Erfassen von seismischen Signalen
DE69413042D1 (de) Verfahren und vorrichtung zum feststellen der verschiebung eines gegenstandes
DE69418982D1 (de) Verfahren und Vorrichtung zum Überwachen und Auswerten von Sensorsignalen
DE69122972D1 (de) SENSOR UND VERFAHREN ZUM BESTIMMEN EINER KöRPERLICHEN EIGENSCHAFT EINES BLATTES
DE69308011D1 (de) Verfahren und Vorrichtung zum Erkennen von Reifenfehlern
DE69213531T2 (de) Verfahren und Vorrichtung zum Beobachten einer biologischen Probe
DE68906889D1 (de) Vorrichtung und verfahren zum aufspueren von fehlern in optischen fasern.
DE68914411D1 (de) Vorrichtung und Verfahren zum Testen einer flüssigen Probe.
DE69308203D1 (de) Verfahren und Vorrichtung zum Erkennen von Reifenfehlern
DE69019070D1 (de) Gerät und Verfahren zum Nachweis von Fehlern auf einer lichtbeugenden Oberfläche.
DE3676651D1 (de) Verfahren und vorrichtung zum ermitteln der abmessungen eines laenglichen pruefobjektes.
DE69400302D1 (de) Verfahren und Vorrichtung zum Nachweis unregelmässiger Bereiche einer optischen Faser
DE69419570T2 (de) Vorrichtung und Verfahren zum Nachweis einer Flüssigkeit und/oder einer Phasenveränderung
DE59306219D1 (de) Verfahren und vorrichtung zum nachweis von oberflächenplasmonen
DE69225170D1 (de) Verfahren und Gerät zum Zusammenbau und zur Prüfung von Glasfasersteckern
DE69425656D1 (de) Verfahren und anordnung zur entnahme einer probe
DE69214471D1 (de) Vorrichtung und Verfahren zum Messen einer Probe
DE69210434T2 (de) Ein kolorimetrisches Verfahren und Reagenz zum Nachweis von Lithium in einer Testprobe

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee