DE69324645T2 - Verfahren zur Herstellung von Hepatitis Antigenen und Impfstoffen - Google Patents

Verfahren zur Herstellung von Hepatitis Antigenen und Impfstoffen

Info

Publication number
DE69324645T2
DE69324645T2 DE69324645T DE69324645T DE69324645T2 DE 69324645 T2 DE69324645 T2 DE 69324645T2 DE 69324645 T DE69324645 T DE 69324645T DE 69324645 T DE69324645 T DE 69324645T DE 69324645 T2 DE69324645 T2 DE 69324645T2
Authority
DE
Germany
Prior art keywords
vaccines
production
carried out
hepatitis antigens
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69324645T
Other languages
English (en)
Other versions
DE69324645D1 (de
Inventor
Bernard Fanget
Alain Francon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur SA
Original Assignee
Pasteur Merieux Serum et Vaccines SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Merieux Serum et Vaccines SA filed Critical Pasteur Merieux Serum et Vaccines SA
Application granted granted Critical
Publication of DE69324645D1 publication Critical patent/DE69324645D1/de
Publication of DE69324645T2 publication Critical patent/DE69324645T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
    • C12N2770/32422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
    • C12N2770/32434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines
DE69324645T 1992-10-14 1993-10-07 Verfahren zur Herstellung von Hepatitis Antigenen und Impfstoffen Expired - Lifetime DE69324645T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9212285A FR2696748B1 (fr) 1992-10-14 1992-10-14 Procédé de préparation d'antigènes et de vaccins de l'hépatite A (HAV).

Publications (2)

Publication Number Publication Date
DE69324645D1 DE69324645D1 (de) 1999-06-02
DE69324645T2 true DE69324645T2 (de) 1999-12-30

Family

ID=9434534

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69324645T Expired - Lifetime DE69324645T2 (de) 1992-10-14 1993-10-07 Verfahren zur Herstellung von Hepatitis Antigenen und Impfstoffen

Country Status (10)

Country Link
US (1) US5731187A (de)
EP (1) EP0593339B1 (de)
JP (1) JP3724821B2 (de)
AT (1) ATE179428T1 (de)
CA (1) CA2108292C (de)
DE (1) DE69324645T2 (de)
DK (1) DK0593339T3 (de)
ES (1) ES2132204T3 (de)
FR (1) FR2696748B1 (de)
GR (1) GR3030636T3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6908598A (en) * 1996-10-29 1998-05-22 Smithkline Beecham Biologicals (Sa) Purification of respiratory syncytial virus antigens
DE69737364T2 (de) * 1996-12-13 2007-11-29 Schering Corp. Methoden zur virus-reinigung
US6544769B1 (en) 1996-12-13 2003-04-08 Schering Corporation Compostions comprising viruses and methods for concentrating virus preparations
US6261823B1 (en) 1996-12-13 2001-07-17 Schering Corporation Methods for purifying viruses
CA2482512C (en) * 2002-04-30 2011-09-20 Oncolytics Biotech Inc. Improved viral purification methods
JPWO2006011580A1 (ja) * 2004-07-27 2008-05-01 ジェノミディア株式会社 ウイルスエンベロープの精製方法
US7901921B2 (en) * 2004-10-22 2011-03-08 Oncolytics Biotech Inc. Viral purification methods
EP3121268B1 (de) 2015-07-23 2018-12-26 Grifols, S.A. Verfahren zur reinigung eines in-vitro-hergestellten virus und clearance-assay für das virus
EP3695849A1 (de) * 2019-02-13 2020-08-19 Mediagnost Gesellschaft für Forschung und Herstellung von Diagnostika GmbH Verfahren zur extraktion eines antigens des hepatitis-a-virus (hav) aus einer zellkultur
KR102277089B1 (ko) * 2019-12-19 2021-07-14 에스케이바이오사이언스(주) A형 간염 바이러스의 제조방법 및 상기의 방법에 따라 제조된 a형 간염 바이러스

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ225583A (en) * 1987-08-06 1991-07-26 Merck & Co Inc Process for purifying hepatitis a virions (hav)
JPH0761955B2 (ja) * 1988-04-28 1995-07-05 国立予防衛生研究所長 凍結乾燥ａ型肝炎ワクチン
CA2047041A1 (en) * 1990-07-18 1992-01-19 John A. Lewis Process for purification of hepatitis-a virus capsids
IT1248075B (it) * 1991-06-18 1995-01-05 Sclavo Spa Processo per la purificazione del virus dell'epatite a (hav), virus cosi` purificato e composizioni vaccinali che lo contengono.

Also Published As

Publication number Publication date
US5731187A (en) 1998-03-24
JP3724821B2 (ja) 2005-12-07
CA2108292C (en) 2005-04-12
GR3030636T3 (en) 1999-10-29
FR2696748B1 (fr) 1994-12-30
DK0593339T3 (da) 1999-11-08
EP0593339B1 (de) 1999-04-28
ES2132204T3 (es) 1999-08-16
DE69324645D1 (de) 1999-06-02
ATE179428T1 (de) 1999-05-15
EP0593339A1 (de) 1994-04-20
CA2108292A1 (en) 1994-04-15
FR2696748A1 (fr) 1994-04-15
JPH06279317A (ja) 1994-10-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition