DE69328523T2 - Immobilisierung eines chemischen spezies in einer vernetzten matrix - Google Patents

Immobilisierung eines chemischen spezies in einer vernetzten matrix

Info

Publication number
DE69328523T2
DE69328523T2 DE69328523T DE69328523T DE69328523T2 DE 69328523 T2 DE69328523 T2 DE 69328523T2 DE 69328523 T DE69328523 T DE 69328523T DE 69328523 T DE69328523 T DE 69328523T DE 69328523 T2 DE69328523 T2 DE 69328523T2
Authority
DE
Germany
Prior art keywords
chemical
coupling compound
matrix
specie
reactive groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69328523T
Other languages
English (en)
Other versions
DE69328523D1 (de
Inventor
Gustaf Swan
William Josephson
John Swanson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Surmodics Inc
Original Assignee
Surmodics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Surmodics Inc filed Critical Surmodics Inc
Publication of DE69328523D1 publication Critical patent/DE69328523D1/de
Application granted granted Critical
Publication of DE69328523T2 publication Critical patent/DE69328523T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0006—Organic membrane manufacture by chemical reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0093—Chemical modification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
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    • B01D67/0081—After-treatment of organic or inorganic membranes
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    • B01D67/00931—Chemical modification by introduction of specific groups after membrane formation, e.g. by grafting
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    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
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    • B01D69/14—Dynamic membranes
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    • B01D69/1411—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes containing dispersed material in a continuous matrix
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    • B01D71/06—Organic material
    • B01D71/28—Polymers of vinyl aromatic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01D71/28—Polymers of vinyl aromatic compounds
    • B01D71/283—Polyvinylpyridine
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/40—Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
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    • B01D71/06—Organic material
    • B01D71/40—Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
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    • B01D—SEPARATION
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    • B01D71/06—Organic material
    • B01D71/52—Polyethers
    • B01D71/521—Aliphatic polyethers
    • B01D71/5211—Polyethylene glycol or polyethyleneoxide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/087—Acrylic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
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    • A—HUMAN NECESSITIES
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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    • A—HUMAN NECESSITIES
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/813—Carrier is a saccharide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y10S530/816—Attached to the carrier via a bridging agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y10S530/817—Entrapped within the carrier, e.g. gel, hollow fibre
DE69328523T 1992-02-13 1993-02-11 Immobilisierung eines chemischen spezies in einer vernetzten matrix Expired - Fee Related DE69328523T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83520692A 1992-02-13 1992-02-13
PCT/US1993/001248 WO1993016176A1 (en) 1992-02-13 1993-02-11 Immobilization of chemical species in crosslinked matrices

Publications (2)

Publication Number Publication Date
DE69328523D1 DE69328523D1 (de) 2000-06-08
DE69328523T2 true DE69328523T2 (de) 2000-09-21

Family

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Family Applications (1)

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DE69328523T Expired - Fee Related DE69328523T2 (de) 1992-02-13 1993-02-11 Immobilisierung eines chemischen spezies in einer vernetzten matrix

Country Status (9)

Country Link
US (1) US5563056A (de)
EP (1) EP0585436B1 (de)
JP (1) JP3455217B2 (de)
AT (1) ATE192487T1 (de)
AU (2) AU3664693A (de)
CA (1) CA2107683C (de)
DE (1) DE69328523T2 (de)
ES (1) ES2145044T3 (de)
WO (1) WO1993016176A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11766506B2 (en) 2016-03-04 2023-09-26 Mirus Llc Stent device for spinal fusion
US11779685B2 (en) 2014-06-24 2023-10-10 Mirus Llc Metal alloys for medical devices

Families Citing this family (198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639376A (en) * 1994-01-10 1997-06-17 Hemasure, Inc. Process for simultaneously removing leukocytes and methylene blue from plasma
WO1995018665A1 (en) * 1994-01-10 1995-07-13 Hemasure, Inc. Device and process for removing leukocytes and viral inactivating agents from blood
RU2066551C1 (ru) * 1994-03-23 1996-09-20 Институт нефтехимического синтеза РАН Способ получения инсулинсодержащих полимерных гидрогелей
AUPM771094A0 (en) * 1994-08-26 1994-09-22 Orphean Nominees Pty Ltd Food holder
US5803925A (en) * 1995-01-17 1998-09-08 Allergan IOL insertion apparatus with covalently bonded lubricant
WO1996022062A1 (en) * 1995-01-17 1996-07-25 Allergan Iol insertion apparatus and method for using same
US6004583A (en) * 1995-03-22 1999-12-21 Orex Pharmaceutical Development Corp. Protein-containing polymer composition for oral administration
US6782886B2 (en) 1995-04-05 2004-08-31 Aerogen, Inc. Metering pumps for an aerosolizer
US6205999B1 (en) 1995-04-05 2001-03-27 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
WO1996037165A1 (en) * 1995-05-26 1996-11-28 Bsi Corporation Method and implantable article for promoting endothelialization
US5804318A (en) * 1995-10-26 1998-09-08 Corvita Corporation Lubricious hydrogel surface modification
US5714360A (en) * 1995-11-03 1998-02-03 Bsi Corporation Photoactivatable water soluble cross-linking agents containing an onium group
US5916585A (en) * 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
US6143037A (en) * 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US6283975B1 (en) 1996-07-10 2001-09-04 Allergan Sales, Inc. IOL insertion apparatus and method for making and using same
US5716364A (en) * 1996-07-10 1998-02-10 Allergan IOL insertion apparatus and method for making and using same
US6083230A (en) * 1997-07-30 2000-07-04 Allergan Method for making IOL insertion apparatus
US5853744A (en) * 1996-08-20 1998-12-29 Regents Of The University Of Minnesota Solid-phase method for attaching a biomolecule to a substrate surface with a photoreactive crosslinking agent
US6039940A (en) * 1996-10-28 2000-03-21 Ballard Medical Products Inherently antimicrobial quaternary amine hydrogel wound dressings
US6800278B1 (en) 1996-10-28 2004-10-05 Ballard Medical Products, Inc. Inherently antimicrobial quaternary amine hydrogel wound dressings
US6576752B1 (en) 1997-02-14 2003-06-10 Isis Pharmaceuticals, Inc. Aminooxy functionalized oligomers
AU781125B2 (en) * 1997-04-04 2005-05-05 Board Of Regents Of The University Of Nebraska, The Methods and materials for making and using transgenic dicamba-degrading organisms
US7105724B2 (en) 1997-04-04 2006-09-12 Board Of Regents Of University Of Nebraska Methods and materials for making and using transgenic dicamba-degrading organisms
US6146771A (en) 1997-07-01 2000-11-14 Terumo Cardiovascular Systems Corporation Process for modifying surfaces using the reaction product of a water-insoluble polymer and a polyalkylene imine
US6121027A (en) * 1997-08-15 2000-09-19 Surmodics, Inc. Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups
US6506895B2 (en) * 1997-08-15 2003-01-14 Surmodics, Inc. Photoactivatable nucleic acids
US5858653A (en) * 1997-09-30 1999-01-12 Surmodics, Inc. Reagent and method for attaching target molecules to a surface
US6762019B2 (en) * 1997-09-30 2004-07-13 Surmodics, Inc. Epoxide polymer surfaces
US6465178B2 (en) * 1997-09-30 2002-10-15 Surmodics, Inc. Target molecule attachment to surfaces
US20030040790A1 (en) 1998-04-15 2003-02-27 Furst Joseph G. Stent coating
US20020099438A1 (en) * 1998-04-15 2002-07-25 Furst Joseph G. Irradiated stent coating
DE19818360C2 (de) * 1998-04-24 2000-05-31 Suisse Electronique Microtech Dextranbeschichtete Oberfläche
WO1999055396A1 (en) 1998-04-27 1999-11-04 Surmodics, Inc. Bioactive agent release coating
EP1080162B1 (de) 1998-05-05 2004-03-10 Massachusetts Institute Of Technology Lichtemittierende polymere und vorrichtungen, die diese enthalten
US20050147534A1 (en) * 1998-05-05 2005-07-07 Massachusetts Institute Of Technology Emissive sensors and devices incorporating these sensors
US8198096B2 (en) * 1998-05-05 2012-06-12 Massachusetts Institute Of Technology Emissive polymers and devices incorporating these polymers
US7967855B2 (en) 1998-07-27 2011-06-28 Icon Interventional Systems, Inc. Coated medical device
US8070796B2 (en) * 1998-07-27 2011-12-06 Icon Interventional Systems, Inc. Thrombosis inhibiting graft
US6183516B1 (en) * 1998-10-08 2001-02-06 Sulzer Orthopedics Inc. Method for improved bonding of prosthetic devices to bone
US6514768B1 (en) * 1999-01-29 2003-02-04 Surmodics, Inc. Replicable probe array
US20030148360A1 (en) * 1999-01-29 2003-08-07 Surmodics, Inc. Replicable probe array
JP4505871B2 (ja) * 1999-04-07 2010-07-21 株式会社ジェイ・エム・エス 抗血栓性ムコ多糖処理した血流接触医療用部材、および該血流接触医療用部材の製造法
US6716445B2 (en) * 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
US6340465B1 (en) 1999-04-12 2002-01-22 Edwards Lifesciences Corp. Lubricious coatings for medical devices
DE60038010T2 (de) * 1999-04-12 2009-03-05 Cornell Research Foundation, Inc. Hydrogel-formendes system mit hydrophoben und hydrophilen komponenten
US6174683B1 (en) * 1999-04-26 2001-01-16 Biocept, Inc. Method of making biochips and the biochips resulting therefrom
US6664061B2 (en) 1999-06-25 2003-12-16 Amersham Biosciences Ab Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
US6372813B1 (en) * 1999-06-25 2002-04-16 Motorola Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays
US6780980B1 (en) * 1999-06-30 2004-08-24 Centre Suisse D'electronique Et De Microtechnique S.A. Process for the modification of surface
JP2001037472A (ja) * 1999-07-28 2001-02-13 Bio Quest:Kk 三次元細胞培養基材及びそれを用いた細胞培養方法
US6309660B1 (en) 1999-07-28 2001-10-30 Edwards Lifesciences Corp. Universal biocompatible coating platform for medical devices
US6248111B1 (en) 1999-08-06 2001-06-19 Allergan Sales, Inc. IOL insertion apparatus and methods for using same
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
US7220276B1 (en) 2000-03-06 2007-05-22 Surmodics, Inc. Endovascular graft coatings
US6410643B1 (en) 2000-03-09 2002-06-25 Surmodics, Inc. Solid phase synthesis method and reagent
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US6543443B1 (en) 2000-07-12 2003-04-08 Aerogen, Inc. Methods and devices for nebulizing fluids
US6783814B2 (en) 2000-08-21 2004-08-31 Massachusetts Institute Of Technology Polymers with high internal free volume
ES2189602B1 (es) * 2000-10-11 2004-08-01 Universidad De Murcia Procedimiento para la inmovilizacion de un ligando sobre un soporte.
EP1202062B1 (de) * 2000-10-31 2007-02-28 Micronas GmbH Gemusterte Polymeroberflächen geeignet für Biokonjugationen und Verfahren zu ihrer Herstellung
US6546927B2 (en) 2001-03-13 2003-04-15 Aerogen, Inc. Methods and apparatus for controlling piezoelectric vibration
US6550472B2 (en) 2001-03-16 2003-04-22 Aerogen, Inc. Devices and methods for nebulizing fluids using flow directors
US20040253634A1 (en) * 2001-04-10 2004-12-16 Denong Wang Novel microarrays and methods of use thereof
US6554201B2 (en) 2001-05-02 2003-04-29 Aerogen, Inc. Insert molded aerosol generator and methods
US6732944B2 (en) 2001-05-02 2004-05-11 Aerogen, Inc. Base isolated nebulizing device and methods
US6444318B1 (en) * 2001-07-17 2002-09-03 Surmodics, Inc. Self assembling monolayer compositions
US7195913B2 (en) * 2001-10-05 2007-03-27 Surmodics, Inc. Randomly ordered arrays and methods of making and using
WO2003030879A1 (en) * 2001-10-05 2003-04-17 Surmodics, Inc. Particle immobilized coatings and uses thereof
AU2002353997A1 (en) * 2001-11-01 2003-05-12 Rensselaer Polytechnic Institute In vitro metabolic engineering on microscale devices
US7462325B2 (en) * 2001-11-30 2008-12-09 Nomadics, Inc. Luminescent polymer particles
US7348055B2 (en) 2001-12-21 2008-03-25 Surmodics, Inc. Reagent and method for providing coatings on surfaces
US7677467B2 (en) 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
CA2472644C (en) 2002-01-07 2013-11-05 Aerogen, Inc. Devices and methods for nebulizing fluids for inhalation
ES2603067T3 (es) 2002-01-15 2017-02-23 Novartis Ag Métodos y sistemas para hacer funcionar un generador de aerosol
US20040033546A1 (en) 2002-04-10 2004-02-19 The Trustees Of Columbia University In The City Of New York Novel microarrays and methods of use thereof
EP1509259B1 (de) 2002-05-20 2016-04-20 Novartis AG Gerät zur bereitstellung eines aerosols für die medizinische behandlung und verfahren
DE10223310A1 (de) * 2002-05-24 2003-12-11 Biotronik Mess & Therapieg Verfahren zum Beschichten von Implantaten mit einer Polysaccharid-Lage
US7097850B2 (en) 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
AU2003269913A1 (en) * 2002-07-15 2004-02-02 Massachusetts Institute Of Technology Emissive, high charge transport polymers
US8016881B2 (en) 2002-07-31 2011-09-13 Icon Interventional Systems, Inc. Sutures and surgical staples for anastamoses, wound closures, and surgical closures
US7628917B2 (en) 2002-09-03 2009-12-08 Whatman, Inc. Porous composite membrane and method for making the same
US7045366B2 (en) * 2003-09-12 2006-05-16 Ciphergen Biosystems, Inc. Photocrosslinked hydrogel blend surface coatings
AU2003270601A1 (en) * 2002-09-13 2004-04-30 Ciphergen Biosystems, Inc. Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays
US20060292701A1 (en) * 2002-09-13 2006-12-28 Ciphergen Biosystems Inc. Photocrosslinked hydrogel blend surface coatings
US20040111144A1 (en) * 2002-12-06 2004-06-10 Lawin Laurie R. Barriers for polymeric coatings
FR2848847B1 (fr) * 2002-12-18 2005-10-14 Coletica Composition cosmetique ou dermopharmaceutique comprenant une enzyme insoluble en milieu aqueux, ainsi que ses utilisations
US7166451B1 (en) * 2003-02-24 2007-01-23 The Ohio State University Immobilization of enzyme on a fibrous matrix
US20040209360A1 (en) * 2003-04-18 2004-10-21 Keith Steven C. PVA-based polymer coating for cell culture
DE10328815A1 (de) * 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Beschichtungssystem für Implantate zur Erhöhung der Gewebsverträglichkeit
DE10329296B4 (de) * 2003-06-24 2007-07-12 Leibniz-Institut Für Polymerforschung Dresden E.V. Beschichtungssystem für Biomaterialien
DE10330900B4 (de) * 2003-07-01 2006-09-14 Leibniz-Institut Für Polymerforschung Dresden E.V. Biomaterial mit einem modularen Beschichtungssystem zur Anwendung in Medizinprodukten mit direktem Blutkontakt
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
GB0319929D0 (en) * 2003-08-26 2003-09-24 Suisse Electronique Microtech Yarn and textile products
US7309593B2 (en) * 2003-10-01 2007-12-18 Surmodics, Inc. Attachment of molecules to surfaces
CN101052672A (zh) * 2004-03-17 2007-10-10 伯乐实验室有限公司 光交联的水凝胶共混物表面涂层
CA2559741A1 (en) * 2004-03-26 2005-10-20 Surmodics, Inc. A medical article having a bioactive agent-releasing component with photoreactive groups
EP1732619A1 (de) * 2004-03-26 2006-12-20 SurModics, Inc. Zusammensetzung und verfahren zur herstellung von biokompatiblen oberflächen
CN1964748A (zh) 2004-04-06 2007-05-16 苏莫迪克斯公司 用于生物活性剂的涂料组合物
US7946291B2 (en) 2004-04-20 2011-05-24 Novartis Ag Ventilation systems and methods employing aerosol generators
JP5026956B2 (ja) * 2004-05-12 2012-09-19 サーモディクス，インコーポレイティド 医療用具のための天然生分解性多糖コーティング
US20050281857A1 (en) * 2004-05-25 2005-12-22 Heyer Toni M Methods and reagents for preparing biomolecule-containing coatings
WO2006002112A1 (en) * 2004-06-18 2006-01-05 Surmodics, Inc. Devices, articles, coatings, and methods for controlled active agent release
US8617819B2 (en) 2004-09-17 2013-12-31 Massachusetts Institute Of Technology Polymers for analyte detection
US8377461B2 (en) 2004-12-06 2013-02-19 Surmodics, Inc. Multifunctional medical articles
WO2006084238A2 (en) * 2005-02-04 2006-08-10 Molecular Imaging Corporation Probe and method of making a probe using crosslinker compositions as chemical and biological sensors
US7540995B2 (en) 2005-03-03 2009-06-02 Icon Medical Corp. Process for forming an improved metal alloy stent
JP5335244B2 (ja) 2005-03-03 2013-11-06 アイコン メディカル コーポレーション 改良された金属合金を用いた医療用部材
US9107899B2 (en) 2005-03-03 2015-08-18 Icon Medical Corporation Metal alloys for medical devices
WO2006110197A2 (en) 2005-03-03 2006-10-19 Icon Medical Corp. Polymer biodegradable medical device
US20060200048A1 (en) * 2005-03-03 2006-09-07 Icon Medical Corp. Removable sheath for device protection
CA2600711C (en) * 2005-03-15 2014-07-08 Surmodics, Inc. Compliant polymeric coatings for insertable medical articles
CA2563253A1 (en) * 2005-04-06 2006-10-12 Surmodics, Inc. Bioactive coating compositions for medical devices
JP5064383B2 (ja) 2005-05-25 2012-10-31 エアロジェン，インコーポレイテッド 振動システムと方法
US20070048759A1 (en) * 2005-06-10 2007-03-01 Dan Luo Detection of target molecules with labeled nucleic acid detection molecules
US7772393B2 (en) 2005-06-13 2010-08-10 Innovative Surface Technologies, Inc. Photochemical crosslinkers for polymer coatings and substrate tie-layer
JP5908664B2 (ja) * 2005-07-20 2016-04-26 サーモディクス，インコーポレイティド ポリマーコーティング及び細胞接着方法
US8663673B2 (en) 2005-07-29 2014-03-04 Surmodics, Inc. Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
US20070148246A1 (en) * 2005-08-11 2007-06-28 Dan Luo Nucleic Acid-Based Matrixes
US20100136614A1 (en) * 2005-10-18 2010-06-03 Dan Luo Dendrimer-like modular delivery vector
US8486621B2 (en) * 2005-08-11 2013-07-16 Cornell Research Foundation, Inc. Nucleic acid-based matrixes
US20070048249A1 (en) 2005-08-24 2007-03-01 Purdue Research Foundation Hydrophilized bactericidal polymers
JP5139301B2 (ja) * 2005-09-21 2013-02-06 サーモディクス，インコーポレイティド 生分解性天然多糖を含む被膜及び器具
EP1926504B1 (de) * 2005-09-21 2010-01-13 SurModics, Inc. In situ okklusionszusammensetzungen mit natürlichen biologisch abbaubaren polysacchariden
GB2433505A (en) * 2005-12-20 2007-06-27 Sharp Kk Capture agents for binding a ligand
GB2433591A (en) * 2005-12-20 2007-06-27 Sharp Kk Method for functionalising a hydrophobic substrate
GB2433506A (en) * 2005-12-20 2007-06-27 Sharp Kk A method of producing a multimeric capture agent
US8158437B2 (en) * 2006-08-04 2012-04-17 Massachusetts Institute Of Technology Luminescent detection of hydrazine and hydrazine derivatives
DE102006037724A1 (de) * 2006-08-11 2008-02-14 Merck Patent Gmbh Verwendung von Ascorbinsäurederivaten zur Funktionalisierung von Matrices
US20080063627A1 (en) * 2006-09-12 2008-03-13 Surmodics, Inc. Tissue graft materials containing biocompatible agent and methods of making and using same
WO2008039749A2 (en) * 2006-09-25 2008-04-03 Surmodics, Inc. Multi-layered coatings and methods for controlling elution of active agents
US8283423B2 (en) 2006-09-29 2012-10-09 Massachusetts Institute Of Technology Polymer synthetic technique
US8802447B2 (en) 2006-10-05 2014-08-12 Massachusetts Institute Of Technology Emissive compositions with internal standard and related techniques
US20090215189A1 (en) * 2006-10-27 2009-08-27 Massachusetts Institute Of Technology Sensor of species including toxins and chemical warfare agents
US20100255581A1 (en) * 2007-06-22 2010-10-07 Innovative Surface Technologies, Inc. Stimuli responsive nanofibers
CA2691541A1 (en) 2007-06-22 2008-12-31 Innovative Surface Technologies, Inc. Nanofibers containing latent reactive groups
US20090123519A1 (en) * 2007-11-12 2009-05-14 Surmodics, Inc. Swellable hydrogel matrix and methods
US8936811B2 (en) * 2008-05-07 2015-01-20 Surmodics, Inc. Device coated with glycogen particles comprising nucleic acid complexes
US20120040397A1 (en) * 2008-08-05 2012-02-16 Dan Luo Photo-Crosslinked Nucleic Acid Hydrogels
CA2734410A1 (en) 2008-09-05 2010-03-11 Innovative Surface Technologies, Inc. Photoactivatable crosslinker compositions for surface modification
EP2391215A4 (de) * 2009-01-28 2013-10-30 Smartcells Inc Bindungsstellenmodifizierte lectine und ihre verwendung
PE20120583A1 (es) 2009-01-28 2012-05-19 Smartcells Inc Sistemas basados en conjugados para entrega farmacologica controlada
EP2391216A4 (de) * 2009-01-28 2013-06-19 Smartcells Inc Exogen ausgelöste stoffe mit verzögerter freisetzung und ihre verwendung
CA2750269A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Crystalline insulin-conjugates
AU2010208305A1 (en) * 2009-01-28 2011-09-08 Smartcells, Inc. Synthetic conjugates and uses thereof
US8691983B2 (en) 2009-03-03 2014-04-08 Innovative Surface Technologies, Inc. Brush polymer coating by in situ polymerization from photoreactive surface
WO2010107520A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
WO2010107519A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Terminally-functionalized conjugates and uses thereof
CA2716502C (en) 2009-05-15 2015-06-16 Interface Biologics, Inc. Antithrombogenic hollow fiber membranes and filters
US20110144373A1 (en) * 2009-12-10 2011-06-16 Surmodics, Inc. Water-soluble degradable photo-crosslinker
JP5152212B2 (ja) * 2010-01-30 2013-02-27 株式会社ジェイ・エム・エス 血流接触医療用部材、および該血流接触医療用部材の製造法
US8398916B2 (en) 2010-03-04 2013-03-19 Icon Medical Corp. Method for forming a tubular medical device
WO2011131222A1 (en) * 2010-04-19 2011-10-27 Invatec S.P.A. Photoactivated polymeric material and its use for the preparation of medical devices
EP2588156B1 (de) 2010-06-29 2014-08-13 SurModics, Inc. Fluorierte polymere und schmiermittelbeschichtungen
WO2012015681A2 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
EP2598522A4 (de) 2010-07-28 2014-11-12 Smartcells Inc Rekombinante lektine, bindungsstellenmodifizierte lektine und anwendungen davon
WO2012015692A2 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
TWI707926B (zh) 2010-07-30 2020-10-21 瑞士商愛爾康公司 可易於使用之聚矽氧水凝膠隱形鏡片
US8722076B2 (en) 2010-09-30 2014-05-13 Surmodics, Inc. Photochrome- or near IR dye-coupled polymeric matrices for medical articles
US10315987B2 (en) 2010-12-13 2019-06-11 Surmodics, Inc. Photo-crosslinker
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
US20120171769A1 (en) 2010-12-30 2012-07-05 Mcgonigle Joseph S Cell attachment coatings and methods
US20140127517A1 (en) * 2011-07-15 2014-05-08 Jason J. Locklin Compounds, methods of making, and methods of use
JP6017572B2 (ja) 2011-10-12 2016-11-02 ノバルティス アーゲー コーティングによるｕｖ吸収性眼用レンズの製造方法
US10501791B2 (en) 2011-10-14 2019-12-10 President And Fellows Of Harvard College Sequencing by structure assembly
US10227639B2 (en) 2011-12-22 2019-03-12 President And Fellows Of Harvard College Compositions and methods for analyte detection
US11021737B2 (en) 2011-12-22 2021-06-01 President And Fellows Of Harvard College Compositions and methods for analyte detection
EP2838577B1 (de) 2012-04-02 2019-02-27 SurModics, Inc. Hydrophile polymerbeschichtungen für medizinische artikel mit einem visualisierungsteil
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
WO2014004997A1 (en) 2012-06-29 2014-01-03 Surmodics, Inc. Cell attachment coatings and methods using phosphorous-containing photoreagent
US9629945B2 (en) 2012-12-12 2017-04-25 Surmodics, Inc. Stilbene-based reactive compounds, polymeric matrices formed therefrom, and articles visualizable by fluorescence
WO2014095690A1 (en) 2012-12-17 2014-06-26 Novartis Ag Method for making improved uv-absorbing ophthalmic lenses
US10138509B2 (en) 2013-03-12 2018-11-27 President And Fellows Of Harvard College Method for generating a three-dimensional nucleic acid containing matrix
EP3052134B1 (de) 2013-10-04 2021-05-05 Merck Sharp & Dohme Corp. Auf glucose reagierende insulinkonjugate
US20160251646A1 (en) 2013-10-12 2016-09-01 Innovative Surface Technologies, Inc. Tissue scaffolds for electrically excitable cells
US9708087B2 (en) 2013-12-17 2017-07-18 Novartis Ag Silicone hydrogel lens with a crosslinked hydrophilic coating
US10179932B2 (en) 2014-07-11 2019-01-15 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
KR20230048175A (ko) 2014-08-15 2023-04-10 더 존스 홉킨스 유니버시티 조직 복원용 복합 재료
EP3186070B1 (de) 2014-08-26 2019-09-25 Novartis AG Verfahren zum auftragen einer stabilen beschichtung auf silikonhydrogelkontaktlinsen
WO2016037239A1 (en) * 2014-09-12 2016-03-17 Heart Research Institute Ltd Medical devices with reduced thrombogenicity
FR3029784B1 (fr) 2014-12-16 2016-12-30 Oreal Procede cosmetique pour attenuer les rides
ES2919964T3 (es) 2015-08-17 2022-07-29 Univ Johns Hopkins Material compuesto que se forma in situ para la restauración de tejido
MX2018005611A (es) 2015-11-03 2018-11-09 Harvard College Metodo y aparato para la formacion de imagenes volumetricas de una matriz tridimensional que contiene acido nucleico.
EP3391101B1 (de) 2015-12-15 2020-07-08 Alcon Inc. Verfahren zum auftragen einer stabilen beschichtung auf silikonhydrogelkontaktlinsen
CN109415761B (zh) 2016-04-25 2022-09-20 哈佛学院董事及会员团体 用于原位分子检测的杂交链反应方法
CN109983125A (zh) 2016-08-31 2019-07-05 哈佛学院董事及会员团体 生成用于通过荧光原位测序检测的核酸序列文库的方法
CN109923216A (zh) 2016-08-31 2019-06-21 哈佛学院董事及会员团体 将生物分子的检测组合到使用荧光原位测序的单个试验的方法
CN110167995B (zh) 2016-10-18 2022-07-01 界面生物公司 具有表面改性大分子的塑化pvc混合物和由其制成的制品
CN109789167A (zh) 2017-04-14 2019-05-21 哈佛学院董事及会员团体 用于产生细胞衍生的微丝网络的方法
WO2018218150A1 (en) 2017-05-26 2018-11-29 President And Fellows Of Harvard College Systems and methods for high-throughput image-based screening
WO2018222622A1 (en) 2017-05-27 2018-12-06 Poly Group LLC Dispersible antimicrobial complex and coatings therefrom
EP3638740A1 (de) 2017-06-16 2020-04-22 Poly Group LLC Polymeres antimikrobielles tensid
US11029446B2 (en) 2017-12-13 2021-06-08 Alcon Inc. Method for producing MPS-compatible water gradient contact lenses
US20210402061A1 (en) 2018-05-09 2021-12-30 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery
BR112020022853A2 (pt) 2018-05-09 2021-02-23 The Johns Hopkins University população de microesferas, formulação, biomaterial, kit, método para realizar um procedimento, complexo de microesferas
EP3836967A4 (de) * 2018-07-30 2022-06-15 ReadCoor, LLC Verfahren und systeme zur probenverarbeitung oder -analyse
US20230285641A1 (en) 2022-03-09 2023-09-14 Surmodics Coatings, LLC Thromboresistant coatings, coated devices, and methods

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975350A (en) * 1972-08-02 1976-08-17 Princeton Polymer Laboratories, Incorporated Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles
US3959078A (en) * 1973-05-18 1976-05-25 Midwest Research Institute Enzyme immobilization with a thermochemical-photochemical bifunctional agent
US4007089A (en) * 1975-04-30 1977-02-08 Nelson Research & Development Company Method for binding biologically active compounds
US4722906A (en) * 1982-09-29 1988-02-02 Bio-Metric Systems, Inc. Binding reagents and methods
DE3435744C2 (de) * 1984-09-28 1986-08-07 Organogen Medizinisch-Molekularbiologische Forschungsgesellschaft mbH, 6900 Heidelberg Trägermaterial zur Verwendung für Immunbestimmungen
US4979959A (en) * 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
US5024742A (en) * 1988-02-24 1991-06-18 Cedars-Sinai Medical Center Method of crosslinking amino acid containing polymers using photoactivatable chemical crosslinkers
DE3856430T2 (de) * 1988-07-22 2001-05-03 Surmodics Inc Herstellung von polymeren oberflächen
JPH02108489A (ja) * 1988-10-17 1990-04-20 Fanuc Ltd 多関節型レーザロボットの手首機構
CA2066660C (en) * 1989-09-15 2002-07-30 Cary Reich Method for achieving epithelialization of synthetic lenses
EP0484472B1 (de) * 1990-04-12 1997-07-16 SIGRIST, Hans, Dr. Verfahren zur lichtinduzierten immobilisierung von biomolekülen an chemisch "inerten" oberflächen

Cited By (2)

* Cited by examiner, † Cited by third party
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US11779685B2 (en) 2014-06-24 2023-10-10 Mirus Llc Metal alloys for medical devices
US11766506B2 (en) 2016-03-04 2023-09-26 Mirus Llc Stent device for spinal fusion

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CA2107683C (en) 2004-07-20
DE69328523D1 (de) 2000-06-08
EP0585436B1 (de) 2000-05-03
US5563056A (en) 1996-10-08
JP3455217B2 (ja) 2003-10-14
EP0585436A1 (de) 1994-03-09
AU1482797A (en) 1997-06-26
JPH06506959A (ja) 1994-08-04
ES2145044T3 (es) 2000-07-01
ATE192487T1 (de) 2000-05-15
AU716543B2 (en) 2000-02-24
CA2107683A1 (en) 1993-08-14
AU3664693A (en) 1993-09-03
WO1993016176A1 (en) 1993-08-19
EP0585436A4 (de) 1994-03-30

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