DE69328776T2 - Rekonstruiertes knorpelgewebe - Google Patents
Rekonstruiertes knorpelgewebeInfo
- Publication number
- DE69328776T2 DE69328776T2 DE69328776T DE69328776T DE69328776T2 DE 69328776 T2 DE69328776 T2 DE 69328776T2 DE 69328776 T DE69328776 T DE 69328776T DE 69328776 T DE69328776 T DE 69328776T DE 69328776 T2 DE69328776 T2 DE 69328776T2
- Authority
- DE
- Germany
- Prior art keywords
- cartilage tissue
- reconstituted
- reconstructed
- reconstructed cartilage
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3612—Cartilage, synovial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3633—Extracellular matrix [ECM]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/3654—Cartilage, e.g. meniscus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/835,831 US5326357A (en) | 1992-03-18 | 1992-03-18 | Reconstituted cartridge tissue |
PCT/CA1993/000111 WO1993019168A1 (en) | 1992-03-18 | 1993-03-18 | Reconstituted cartilage tissue |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69328776D1 DE69328776D1 (de) | 2000-07-06 |
DE69328776T2 true DE69328776T2 (de) | 2000-11-09 |
Family
ID=25270583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69328776T Expired - Fee Related DE69328776T2 (de) | 1992-03-18 | 1993-03-18 | Rekonstruiertes knorpelgewebe |
Country Status (12)
Country | Link |
---|---|
US (1) | US5326357A (de) |
EP (1) | EP0631619B1 (de) |
JP (1) | JP3587305B2 (de) |
AT (1) | ATE193550T1 (de) |
AU (1) | AU677953B2 (de) |
CA (1) | CA2131904C (de) |
DE (1) | DE69328776T2 (de) |
DK (1) | DK0631619T3 (de) |
ES (1) | ES2146611T3 (de) |
GR (1) | GR3034190T3 (de) |
PT (1) | PT631619E (de) |
WO (1) | WO1993019168A1 (de) |
Families Citing this family (108)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5904717A (en) * | 1986-01-28 | 1999-05-18 | Thm Biomedical, Inc. | Method and device for reconstruction of articular cartilage |
US5902741A (en) * | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
CA2175049A1 (en) * | 1993-10-28 | 1995-05-04 | Timothy Ringeisen | Improved process and device for treating and healing a bone void |
US5763416A (en) | 1994-02-18 | 1998-06-09 | The Regent Of The University Of Michigan | Gene transfer into bone cells and tissues |
US5962427A (en) | 1994-02-18 | 1999-10-05 | The Regent Of The University Of Michigan | In vivo gene transfer methods for wound healing |
US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
US6074840A (en) | 1994-02-18 | 2000-06-13 | The Regents Of The University Of Michigan | Recombinant production of latent TGF-beta binding protein-3 (LTBP-3) |
US20020193338A1 (en) * | 1994-02-18 | 2002-12-19 | Goldstein Steven A. | In vivo gene transfer methods for wound healing |
US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
US5723331A (en) * | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
US5981825A (en) * | 1994-05-13 | 1999-11-09 | Thm Biomedical, Inc. | Device and methods for in vivo culturing of diverse tissue cells |
US5906827A (en) * | 1994-06-03 | 1999-05-25 | Creative Biomolecules, Inc. | Matrix for the manufacture of autogenous replacement body parts |
US5716404A (en) * | 1994-12-16 | 1998-02-10 | Massachusetts Institute Of Technology | Breast tissue engineering |
GB9503492D0 (en) | 1995-02-22 | 1995-04-12 | Ed Geistlich S Hne A G F R Che | Chemical product |
EP0735135A3 (de) * | 1995-03-31 | 1997-12-29 | DIZG Deutsches Institüt für Zell- und Gewebeersatz gGmbH | Zellschichten und Transportsystem für Zellschichten |
US5904716A (en) * | 1995-04-26 | 1999-05-18 | Gendler; El | Method for reconstituting cartilage tissue using demineralized bone and product thereof |
DE19540487A1 (de) * | 1995-10-20 | 1997-04-24 | Olaf Schultz | Zellinteraktionssystem zur Induktion künstlicher Gewebe |
US20020111695A1 (en) * | 1995-11-06 | 2002-08-15 | Mount Sinai Hospital Corporation | Reconstituted mineralized cartilage tissue |
AU7274696A (en) | 1995-11-06 | 1997-05-29 | Mount Sinai Hospital Corporation | Reconstituted mineralized cartilage tissue |
WO1997045147A1 (en) * | 1996-05-28 | 1997-12-04 | 1218122 Ontario Inc. | Resorbable implant biomaterial made of condensed calcium phosphate particles |
ATE250666T1 (de) * | 1996-06-04 | 2003-10-15 | Sulzer Orthopedics Ltd | Verfahren zur herstellung von knorpelgewebe und von implantaten |
US6569172B2 (en) * | 1996-08-30 | 2003-05-27 | Verigen Transplantation Service International (Vtsi) | Method, instruments, and kit for autologous transplantation |
US5989269A (en) | 1996-08-30 | 1999-11-23 | Vts Holdings L.L.C. | Method, instruments and kit for autologous transplantation |
CA2285382C (en) * | 1997-04-04 | 2008-03-25 | Barnes-Jewish Hospital | Neocartilage and methods of use |
EP0989855A4 (de) * | 1997-05-13 | 2002-06-12 | Osiris Therapeutics Inc | Regeneration von knorpel bei osteoarthritis mittels menschlicher mesenchymaler stammzellen |
ES2320603T3 (es) | 1997-07-30 | 2009-05-25 | Emory University | Sistemas de expresion, vectores, adn, proteinas de mineralizacion osea novedosos. |
US7923250B2 (en) | 1997-07-30 | 2011-04-12 | Warsaw Orthopedic, Inc. | Methods of expressing LIM mineralization protein in non-osseous cells |
US20050186283A1 (en) | 1997-10-10 | 2005-08-25 | Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie | Collagen carrier of therapeutic genetic material, and method |
US8858981B2 (en) | 1997-10-10 | 2014-10-14 | Ed. Geistlich Soehne Fuer Chemistrie Industrie | Bone healing material comprising matrix carrying bone-forming cells |
US9034315B2 (en) | 1997-10-10 | 2015-05-19 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Cell-charged multi-layer collagen membrane |
US6378527B1 (en) * | 1998-04-08 | 2002-04-30 | Chondros, Inc. | Cell-culture and polymer constructs |
US6835377B2 (en) | 1998-05-13 | 2004-12-28 | Osiris Therapeutics, Inc. | Osteoarthritis cartilage regeneration |
YU12201A (sh) | 1998-08-14 | 2005-06-10 | Verigen Transplantation Service International (Vtsi) Ag. | Metodi, instrumenti i materijali za transplantaciju ćelija hondrocita |
US6482401B1 (en) | 1998-12-23 | 2002-11-19 | Naturopathic Laboratories International, Inc. | Composition for the relief of joint pain and myofascial pain and method of preparing same |
US6197061B1 (en) * | 1999-03-01 | 2001-03-06 | Koichi Masuda | In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage |
WO2000073417A1 (en) | 1999-05-27 | 2000-12-07 | The Research Foundation Of State University Of New York | In vitro cell culture device including cartilage and methods of using the same |
US6179840B1 (en) | 1999-07-23 | 2001-01-30 | Ethicon, Inc. | Graft fixation device and method |
US20020095157A1 (en) | 1999-07-23 | 2002-07-18 | Bowman Steven M. | Graft fixation device combination |
JP2003512110A (ja) * | 1999-10-15 | 2003-04-02 | マウント・シナイ・ホスピタル | 組織形成のための合成基材 |
US6623963B1 (en) | 1999-12-20 | 2003-09-23 | Verigen Ag | Cellular matrix |
CA2405345C (en) | 2000-04-25 | 2012-09-18 | Osiris Therapeutics, Inc. | Joint repair using mesenchymal stem cells |
WO2002000142A2 (en) * | 2000-06-29 | 2002-01-03 | Mount Sinai Hospital | Intervertebral disc |
IL137460A0 (en) * | 2000-07-24 | 2001-07-24 | Yeda Res & Dev | Identifying antigen clusters for monitoring a global state of an immune system |
AU2007203472B2 (en) * | 2000-07-29 | 2011-07-14 | Smith & Nephew Plc | Tissue implant for cartilage repair |
US9452238B2 (en) | 2000-07-29 | 2016-09-27 | Smith & Nephew LLP | Tissue implant |
JP2002233567A (ja) * | 2000-12-06 | 2002-08-20 | Mitsuo Ochi | 移植用組織等価物及びその製造方法 |
US6599323B2 (en) * | 2000-12-21 | 2003-07-29 | Ethicon, Inc. | Reinforced tissue implants and methods of manufacture and use |
CA2365376C (en) * | 2000-12-21 | 2006-03-28 | Ethicon, Inc. | Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
US6852330B2 (en) * | 2000-12-21 | 2005-02-08 | Depuy Mitek, Inc. | Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
US20020127265A1 (en) * | 2000-12-21 | 2002-09-12 | Bowman Steven M. | Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
CA2438047A1 (en) * | 2001-02-14 | 2002-08-22 | Hildegard M. Kramer | Biocompatible fleece for hemostasis and tissue engineering |
US6713085B2 (en) | 2001-04-27 | 2004-03-30 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Method and membrane for mucosa regeneration |
US8227240B2 (en) * | 2001-08-14 | 2012-07-24 | The Washington University | Systems for screening pharmaceutical chemicals |
AU2002356043A1 (en) * | 2001-08-14 | 2003-03-03 | Washington University In St. Louis | Systems and methods for screening pharmaceutical chemicals |
US7476257B2 (en) * | 2001-09-15 | 2009-01-13 | Rush University Medical Center | Methods to engineer stratified cartilage tissue |
EP1437147B1 (de) * | 2001-09-25 | 2012-06-27 | National Institute for Environmental Studies | Verfahren zur herstellung einer grundmembran |
US20030165473A1 (en) * | 2001-11-09 | 2003-09-04 | Rush-Presbyterian-St. Luke's Medical Center | Engineered intervertebral disc tissue |
CA2412012C (en) | 2001-11-20 | 2011-08-02 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage |
US20030138873A1 (en) * | 2002-01-22 | 2003-07-24 | Koichi Masuda | Tissue engineered cartilage for drug discovery |
JP2005516972A (ja) * | 2002-01-22 | 2005-06-09 | ファイザー・インク | 血栓疾患の治療のためのtafi−a阻害剤として使用される3−(イミダゾリル)−2−アミノプロピオン酸 |
US7931687B2 (en) * | 2002-05-13 | 2011-04-26 | Articular Engineering, Llc | Tissue engineered osteochondral implant |
US20050069572A1 (en) * | 2002-10-09 | 2005-03-31 | Jennifer Elisseeff | Multi-layered polymerizing hydrogels for tissue regeneration |
US7824701B2 (en) * | 2002-10-18 | 2010-11-02 | Ethicon, Inc. | Biocompatible scaffold for ligament or tendon repair |
US20040078090A1 (en) * | 2002-10-18 | 2004-04-22 | Francois Binette | Biocompatible scaffolds with tissue fragments |
CN100412188C (zh) * | 2003-02-21 | 2008-08-20 | Uab研究基金会 | 生物活性天然生物基质组合物 |
US8197837B2 (en) | 2003-03-07 | 2012-06-12 | Depuy Mitek, Inc. | Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof |
DE10312144B4 (de) * | 2003-03-13 | 2006-12-14 | Technische Universität Dresden | Trägermaterial für die Gewebe- und Zellkultur und die Herstellung von Implantatmaterialien |
JP4676679B2 (ja) * | 2003-04-02 | 2011-04-27 | 帝人株式会社 | 人工軟骨 |
US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US7488348B2 (en) | 2003-05-16 | 2009-02-10 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US8226715B2 (en) | 2003-06-30 | 2012-07-24 | Depuy Mitek, Inc. | Scaffold for connective tissue repair |
US10583220B2 (en) | 2003-08-11 | 2020-03-10 | DePuy Synthes Products, Inc. | Method and apparatus for resurfacing an articular surface |
GB0320691D0 (en) * | 2003-09-04 | 2003-10-01 | Smith & Nephew | Use of joint lining cells for articular cartilage repair |
US20050074744A1 (en) * | 2003-10-02 | 2005-04-07 | Dibenedetto Peter | Assays for evaluating anti-osteoarthritic activity |
DE10349722A1 (de) | 2003-10-23 | 2005-06-16 | Beschorner, Katharina, Dr. | Zusammensetzung zur Arthrose-/Arthritisbehandlung, insbesondere von Gelenken |
US7316822B2 (en) | 2003-11-26 | 2008-01-08 | Ethicon, Inc. | Conformable tissue repair implant capable of injection delivery |
US7901461B2 (en) | 2003-12-05 | 2011-03-08 | Ethicon, Inc. | Viable tissue repair implants and methods of use |
WO2005058207A1 (en) | 2003-12-11 | 2005-06-30 | Isto Technologies, Inc. | Particulate cartilage system |
US11395865B2 (en) * | 2004-02-09 | 2022-07-26 | DePuy Synthes Products, Inc. | Scaffolds with viable tissue |
US20060275273A1 (en) * | 2004-02-20 | 2006-12-07 | Seyedin Mitchell S | Intervertebral Disc Repair, Methods and Devices Therefor |
WO2005081870A2 (en) * | 2004-02-20 | 2005-09-09 | Isto Technologies, Inc. | Intervertebral disc repair, methods and devices therefor |
US8221780B2 (en) | 2004-04-20 | 2012-07-17 | Depuy Mitek, Inc. | Nonwoven tissue scaffold |
US8137686B2 (en) | 2004-04-20 | 2012-03-20 | Depuy Mitek, Inc. | Nonwoven tissue scaffold |
US8657881B2 (en) * | 2004-04-20 | 2014-02-25 | Depuy Mitek, Llc | Meniscal repair scaffold |
US7273756B2 (en) * | 2004-10-01 | 2007-09-25 | Isto Technologies, Inc. | Method for chondrocyte expansion with phenotype retention |
US8017394B2 (en) * | 2004-10-01 | 2011-09-13 | Isto Technologies, Inc. | Method for chondrocyte expansion with phenotype retention |
US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
JP4044579B2 (ja) * | 2005-08-02 | 2008-02-06 | 株式会社Pgリサーチ | 人工軟骨組織 |
EP1916964A4 (de) | 2005-08-26 | 2015-11-04 | Zimmer Inc | Implantate und verfahren zur behebung, ersetzung und behandlung von gelenkkrankheiten |
WO2007032404A1 (ja) * | 2005-09-16 | 2007-03-22 | St. Marianna University, School Of Medicine | 再生医療用バイオマテリアル |
WO2007035778A2 (en) | 2005-09-19 | 2007-03-29 | Histogenics Corporation | Cell-support matrix and a method for preparation thereof |
EP1764117A1 (de) | 2005-09-20 | 2007-03-21 | Zimmer GmbH | Implantat zur Wiederherstellung von Knorpeldefekten und Verfahren zu seiner Herstellung |
US7544141B2 (en) * | 2006-07-18 | 2009-06-09 | Gm Global Technology Operations, Inc. | Transmission device with selectable motor connections |
US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
AU2008240191B2 (en) | 2007-04-12 | 2013-09-19 | Zimmer, Inc. | Compositions and methods for tissue repair |
WO2009111069A1 (en) | 2008-03-05 | 2009-09-11 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
CN102099458A (zh) | 2008-06-05 | 2011-06-15 | 威斯康星医学院公司 | 用于高通量试验的三维组织 |
SG11201500189PA (en) | 2012-07-11 | 2015-03-30 | Osiris Therapeutics Inc | Porated cartilage products |
US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
US10195044B2 (en) | 2013-07-12 | 2019-02-05 | Sinai Health System | Intervertebral disc implant |
WO2015101988A1 (en) | 2013-12-31 | 2015-07-09 | Yeda Research And Development Co. Ltd. | Diagnosis of systemic lupus erythematosus using oligonucleotides antigens |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
US9238090B1 (en) | 2014-12-24 | 2016-01-19 | Fettech, Llc | Tissue-based compositions |
US11047855B2 (en) | 2015-03-01 | 2021-06-29 | Immunarray Ltd. | Diagnosis of systemic lupus erythematosus using protein, peptide and oligonucleotide antigens |
US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3703575A (en) * | 1970-12-23 | 1972-11-21 | Heinrich Thiele | Reconstructed cartilaginous tissue and method of implanting it into the human or animal body |
US4356261A (en) * | 1980-04-22 | 1982-10-26 | Rush-Presbyterian-St. Luke's Medical Center | Anti-invasion factor containing cultures |
IL68218A (en) * | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
US4757017A (en) * | 1984-09-14 | 1988-07-12 | Mcw Research Foundation, Inc. | In vitro cell culture system |
US5041138A (en) * | 1986-11-20 | 1991-08-20 | Massachusetts Institute Of Technology | Neomorphogenesis of cartilage in vivo from cell culture |
US5037656A (en) * | 1986-12-04 | 1991-08-06 | Millipore Corporation | Porous membrane having hydrophilic and cell growth promotions surface and process |
US4846835A (en) * | 1987-06-15 | 1989-07-11 | Grande Daniel A | Technique for healing lesions in cartilage |
US5053050A (en) * | 1988-04-29 | 1991-10-01 | Samuel Itay | Compositions for repair of cartilage and bone |
US4904259A (en) * | 1988-04-29 | 1990-02-27 | Samuel Itay | Compositions and methods for repair of cartilage and bone |
US4996154A (en) * | 1989-05-04 | 1991-02-26 | Millipore Corporation | Method for growing cellular tissue |
-
1992
- 1992-03-18 US US07/835,831 patent/US5326357A/en not_active Expired - Lifetime
-
1993
- 1993-03-18 WO PCT/CA1993/000111 patent/WO1993019168A1/en active IP Right Grant
- 1993-03-18 EP EP93907686A patent/EP0631619B1/de not_active Expired - Lifetime
- 1993-03-18 AT AT93907686T patent/ATE193550T1/de not_active IP Right Cessation
- 1993-03-18 AU AU38816/93A patent/AU677953B2/en not_active Ceased
- 1993-03-18 DE DE69328776T patent/DE69328776T2/de not_active Expired - Fee Related
- 1993-03-18 PT PT93907686T patent/PT631619E/pt unknown
- 1993-03-18 ES ES93907686T patent/ES2146611T3/es not_active Expired - Lifetime
- 1993-03-18 CA CA002131904A patent/CA2131904C/en not_active Expired - Fee Related
- 1993-03-18 JP JP51613193A patent/JP3587305B2/ja not_active Expired - Fee Related
- 1993-03-18 DK DK93907686T patent/DK0631619T3/da active
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2000
- 2000-08-14 GR GR20000401884T patent/GR3034190T3/el not_active IP Right Cessation
Also Published As
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JP3587305B2 (ja) | 2004-11-10 |
CA2131904A1 (en) | 1993-09-30 |
EP0631619B1 (de) | 2000-05-31 |
PT631619E (pt) | 2000-09-29 |
AU3881693A (en) | 1993-10-21 |
DE69328776D1 (de) | 2000-07-06 |
EP0631619A1 (de) | 1995-01-04 |
ATE193550T1 (de) | 2000-06-15 |
WO1993019168A1 (en) | 1993-09-30 |
ES2146611T3 (es) | 2000-08-16 |
DK0631619T3 (da) | 2000-10-09 |
GR3034190T3 (en) | 2000-11-30 |
US5326357A (en) | 1994-07-05 |
CA2131904C (en) | 2007-10-16 |
JPH07505620A (ja) | 1995-06-22 |
AU677953B2 (en) | 1997-05-15 |
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