DE69329825T2 - Zweiphasenmatrix für ein abgabesystem zur verzögerten arzneistofffreisetzung - Google Patents

Zweiphasenmatrix für ein abgabesystem zur verzögerten arzneistofffreisetzung

Info

Publication number
DE69329825T2
DE69329825T2 DE69329825T DE69329825T DE69329825T2 DE 69329825 T2 DE69329825 T2 DE 69329825T2 DE 69329825 T DE69329825 T DE 69329825T DE 69329825 T DE69329825 T DE 69329825T DE 69329825 T2 DE69329825 T2 DE 69329825T2
Authority
DE
Germany
Prior art keywords
phase
delivery system
delayed release
medicinal products
phase matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69329825T
Other languages
English (en)
Other versions
DE69329825D1 (de
Inventor
Tsung-Min Hsu
Tung Fen Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc
Application granted granted Critical
Publication of DE69329825D1 publication Critical patent/DE69329825D1/de
Publication of DE69329825T2 publication Critical patent/DE69329825T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
DE69329825T 1992-10-05 1993-10-05 Zweiphasenmatrix für ein abgabesystem zur verzögerten arzneistofffreisetzung Expired - Lifetime DE69329825T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95663592A 1992-10-05 1992-10-05
US08/056,076 US5989586A (en) 1992-10-05 1993-04-30 Two-phase matrix for sustained release drug delivery device
PCT/US1993/009510 WO1994007468A1 (en) 1992-10-05 1993-10-05 Two-phase matrix for sustained release drug delivery device

Publications (2)

Publication Number Publication Date
DE69329825D1 DE69329825D1 (de) 2001-02-08
DE69329825T2 true DE69329825T2 (de) 2001-06-13

Family

ID=26734946

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69329825T Expired - Lifetime DE69329825T2 (de) 1992-10-05 1993-10-05 Zweiphasenmatrix für ein abgabesystem zur verzögerten arzneistofffreisetzung

Country Status (14)

Country Link
US (2) US5989586A (de)
EP (1) EP0662822B1 (de)
JP (1) JPH08504757A (de)
CN (1) CN1089469A (de)
AT (1) ATE198420T1 (de)
AU (1) AU5321194A (de)
CA (1) CA2145631C (de)
DE (1) DE69329825T2 (de)
DK (1) DK0662822T3 (de)
ES (1) ES2155073T3 (de)
GR (1) GR3035626T3 (de)
PT (1) PT662822E (de)
TW (1) TW252919B (de)
WO (1) WO1994007468A1 (de)

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Publication number Publication date
EP0662822B1 (de) 2001-01-03
EP0662822A1 (de) 1995-07-19
CA2145631A1 (en) 1994-04-14
ES2155073T3 (es) 2001-05-01
US5989586A (en) 1999-11-23
PT662822E (pt) 2001-04-30
ATE198420T1 (de) 2001-01-15
DE69329825D1 (de) 2001-02-08
CA2145631C (en) 2004-02-10
GR3035626T3 (en) 2001-06-29
CN1089469A (zh) 1994-07-20
US5840336A (en) 1998-11-24
AU5321194A (en) 1994-04-26
DK0662822T3 (da) 2001-01-29
JPH08504757A (ja) 1996-05-21
EP0662822A4 (de) 1996-08-07
WO1994007468A1 (en) 1994-04-14
TW252919B (de) 1995-08-01

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