DE69330643D1 - Monoklonaler antikörper, welcher spezifisch an vaskularisiertes tumorendothelium bindet und verwendungen davon - Google Patents

Monoklonaler antikörper, welcher spezifisch an vaskularisiertes tumorendothelium bindet und verwendungen davon

Info

Publication number
DE69330643D1
DE69330643D1 DE69330643T DE69330643T DE69330643D1 DE 69330643 D1 DE69330643 D1 DE 69330643D1 DE 69330643 T DE69330643 T DE 69330643T DE 69330643 T DE69330643 T DE 69330643T DE 69330643 D1 DE69330643 D1 DE 69330643D1
Authority
DE
Germany
Prior art keywords
dothelium
glycoprotein
monoclonal antibody
specifically binds
vascularized tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69330643T
Other languages
English (en)
Other versions
DE69330643T2 (de
Inventor
Pilar Garin-Chesa
Wolfgang J Rettig
Lloyd J Old
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sloan Kettering Institute for Cancer Research
Ludwig Institute for Cancer Research New York
Memorial Sloan Kettering Cancer Center
Original Assignee
Sloan Kettering Institute for Cancer Research
Ludwig Institute for Cancer Research New York
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Institute for Cancer Research, Ludwig Institute for Cancer Research New York, Memorial Sloan Kettering Cancer Center filed Critical Sloan Kettering Institute for Cancer Research
Application granted granted Critical
Publication of DE69330643D1 publication Critical patent/DE69330643D1/de
Publication of DE69330643T2 publication Critical patent/DE69330643T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/857—Fish; fish eggs; shell fish; crustacea
DE69330643T 1992-11-13 1993-11-09 Monoklonaler antikörper, welcher spezifisch an vaskularisiertes tumorendothelium bindet und verwendungen davon Expired - Lifetime DE69330643T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/976,405 US5342757A (en) 1992-11-13 1992-11-13 Monoclonal antibodies which specifically binds to endosialin, a 165 Kd glycoprotein found on tumor vascular endothelium, and uses thereof
PCT/US1993/010773 WO1994011023A1 (en) 1992-11-13 1993-11-09 Monoclonal antibody which specifically binds to tumor vascular endothelium and uses thereof

Publications (2)

Publication Number Publication Date
DE69330643D1 true DE69330643D1 (de) 2001-09-27
DE69330643T2 DE69330643T2 (de) 2002-07-04

Family

ID=25524065

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69330643T Expired - Lifetime DE69330643T2 (de) 1992-11-13 1993-11-09 Monoklonaler antikörper, welcher spezifisch an vaskularisiertes tumorendothelium bindet und verwendungen davon

Country Status (12)

Country Link
US (2) US5342757A (de)
EP (1) EP0673255B1 (de)
JP (1) JP3541296B2 (de)
AT (1) ATE204480T1 (de)
AU (1) AU671884B2 (de)
CA (1) CA2149120C (de)
DE (1) DE69330643T2 (de)
DK (1) DK0673255T3 (de)
ES (1) ES2161751T3 (de)
GR (1) GR3036906T3 (de)
PT (1) PT673255E (de)
WO (1) WO1994011023A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036955A (en) * 1992-03-05 2000-03-14 The Scripps Research Institute Kits and methods for the specific coagulation of vasculature
US6749853B1 (en) * 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
US5877289A (en) * 1992-03-05 1999-03-02 The Scripps Research Institute Tissue factor compositions and ligands for the specific coagulation of vasculature
US6004555A (en) * 1992-03-05 1999-12-21 Board Of Regents, The University Of Texas System Methods for the specific coagulation of vasculature
ES2193143T3 (es) * 1992-03-05 2003-11-01 Univ Texas Uso de inmunoconjugados para la diagnosis y/o terapia de tumores vascularizaos.
US5965132A (en) 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US6093399A (en) * 1992-03-05 2000-07-25 Board Of Regents, The University Of Texas System Methods and compositions for the specific coagulation of vasculature
US5776427A (en) * 1992-03-05 1998-07-07 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
DK0746613T3 (da) * 1994-03-08 2006-09-25 Sloan Kettering Inst Cancer Rekombinante humaniserede antistoffer mod FB5
US5536641A (en) * 1994-05-17 1996-07-16 Memorial Sloane Kittering Cancer Center Monoclonal antibody specific for vascular endothelial cell antigen endoglyx-1 and uses thereof for detection of, and isolation of, vascular endothelial cells
CN1295578A (zh) 1998-03-31 2001-05-16 杜邦药品公司 用于血管生成性疾病成像的药物
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
US6524553B2 (en) * 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US6511649B1 (en) * 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en) * 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
CA2349333A1 (en) 1998-12-18 2000-06-22 Du Pont Pharmaceuticals Company Vitronectin receptor antagonist pharmaceuticals
US6794518B1 (en) 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
WO2000035492A2 (en) 1998-12-18 2000-06-22 Du Pont Pharmaceuticals Company Vitronectin receptor antagonist pharmaceuticals
CA2416732C (en) * 2000-08-02 2016-02-09 Brad St. Croix Endothelial cell expression patterns
US7951061B2 (en) 2001-07-25 2011-05-31 Allan Foreman Devices for targeted delivery of thermotherapy, and methods related thereto
US7074175B2 (en) 2001-07-25 2006-07-11 Erik Schroeder Handy Thermotherapy via targeted delivery of nanoscale magnetic particles
US7731648B2 (en) 2001-07-25 2010-06-08 Aduro Biotech Magnetic nanoscale particle compositions, and therapeutic methods related thereto
US6997863B2 (en) 2001-07-25 2006-02-14 Triton Biosystems, Inc. Thermotherapy via targeted delivery of nanoscale magnetic particles
WO2004001004A2 (en) * 2002-06-21 2003-12-31 Johns Hopkins University School Of Medicine Membrane associated tumor endothelium markers
BRPI0409575A (pt) * 2003-03-04 2006-04-18 Kirin Brewery anticorpos especìficos às células endoteliais e usos dos mesmos
EP1819736B1 (de) * 2004-12-03 2010-08-04 Morphotek, Inc. Verwendung von endosialinbindenden proteinen zum isolieren endosialinpositiver zellen
JP2008538700A (ja) * 2005-04-22 2008-11-06 モルフォテック、インク． 免疫エフェクター活性を有するエンドシアリン細胞に内部移行する抗体
LT2620451T (lt) * 2007-04-05 2017-01-10 Morphotek, Inc. Endosialino prijungimo prie ligandų slopinimo būdai
US20100260769A1 (en) * 2009-04-09 2010-10-14 Morphotek, Inc. Endosialin binding molecules
SE535982C2 (sv) * 2009-12-15 2013-03-19 Theravac Pharmaceuticals Ab Ett nytt vaccin som angriper tumörkärl som ett effektivt redskap i tumörterapi
US20130305396A1 (en) 2010-09-29 2013-11-14 Luigi Grasso Engineered human endosialin-expressing rodents
JP6285414B2 (ja) * 2012-03-30 2018-02-28 モルフォテック， インコーポレイテッド Ｔｅｍ−１診断用抗体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0746613T3 (da) * 1994-03-08 2006-09-25 Sloan Kettering Inst Cancer Rekombinante humaniserede antistoffer mod FB5

Also Published As

Publication number Publication date
PT673255E (pt) 2002-02-28
EP0673255A1 (de) 1995-09-27
JP3541296B2 (ja) 2004-07-07
JPH08505764A (ja) 1996-06-25
CA2149120C (en) 2005-09-27
CA2149120A1 (en) 1994-05-26
EP0673255B1 (de) 2001-08-22
DE69330643T2 (de) 2002-07-04
AU671884B2 (en) 1996-09-12
EP0673255A4 (de) 1996-08-21
ATE204480T1 (de) 2001-09-15
DK0673255T3 (da) 2001-12-10
AU5596594A (en) 1994-06-08
US5342757A (en) 1994-08-30
US5437865A (en) 1995-08-01
ES2161751T3 (es) 2001-12-16
GR3036906T3 (en) 2002-01-31
WO1994011023A1 (en) 1994-05-26

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