DE69330643T2 - Monoklonaler antikörper, welcher spezifisch an vaskularisiertes tumorendothelium bindet und verwendungen davon - Google Patents

Monoklonaler antikörper, welcher spezifisch an vaskularisiertes tumorendothelium bindet und verwendungen davon

Info

Publication number
DE69330643T2
DE69330643T2 DE69330643T DE69330643T DE69330643T2 DE 69330643 T2 DE69330643 T2 DE 69330643T2 DE 69330643 T DE69330643 T DE 69330643T DE 69330643 T DE69330643 T DE 69330643T DE 69330643 T2 DE69330643 T2 DE 69330643T2
Authority
DE
Germany
Prior art keywords
dothelium
glycoprotein
monoclonal antibody
specifically binds
vascularized tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69330643T
Other languages
English (en)
Other versions
DE69330643D1 (de
Inventor
Pilar Garin-Chesa
Wolfgang J Rettig
Lloyd J Old
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sloan Kettering Institute for Cancer Research
Ludwig Institute for Cancer Research New York
Memorial Sloan Kettering Cancer Center
Original Assignee
Sloan Kettering Institute for Cancer Research
Ludwig Institute for Cancer Research New York
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Institute for Cancer Research, Ludwig Institute for Cancer Research New York, Memorial Sloan Kettering Cancer Center filed Critical Sloan Kettering Institute for Cancer Research
Publication of DE69330643D1 publication Critical patent/DE69330643D1/de
Application granted granted Critical
Publication of DE69330643T2 publication Critical patent/DE69330643T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855Proteins from animals other than mammals or birds
    • Y10S530/857Fish; fish eggs; shell fish; crustacea
DE69330643T 1992-11-13 1993-11-09 Monoklonaler antikörper, welcher spezifisch an vaskularisiertes tumorendothelium bindet und verwendungen davon Expired - Lifetime DE69330643T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/976,405 US5342757A (en) 1992-11-13 1992-11-13 Monoclonal antibodies which specifically binds to endosialin, a 165 Kd glycoprotein found on tumor vascular endothelium, and uses thereof
PCT/US1993/010773 WO1994011023A1 (en) 1992-11-13 1993-11-09 Monoclonal antibody which specifically binds to tumor vascular endothelium and uses thereof

Publications (2)

Publication Number Publication Date
DE69330643D1 DE69330643D1 (de) 2001-09-27
DE69330643T2 true DE69330643T2 (de) 2002-07-04

Family

ID=25524065

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69330643T Expired - Lifetime DE69330643T2 (de) 1992-11-13 1993-11-09 Monoklonaler antikörper, welcher spezifisch an vaskularisiertes tumorendothelium bindet und verwendungen davon

Country Status (12)

Country Link
US (2) US5342757A (de)
EP (1) EP0673255B1 (de)
JP (1) JP3541296B2 (de)
AT (1) ATE204480T1 (de)
AU (1) AU671884B2 (de)
CA (1) CA2149120C (de)
DE (1) DE69330643T2 (de)
DK (1) DK0673255T3 (de)
ES (1) ES2161751T3 (de)
GR (1) GR3036906T3 (de)
PT (1) PT673255E (de)
WO (1) WO1994011023A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749853B1 (en) * 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
US6093399A (en) * 1992-03-05 2000-07-25 Board Of Regents, The University Of Texas System Methods and compositions for the specific coagulation of vasculature
US5877289A (en) * 1992-03-05 1999-03-02 The Scripps Research Institute Tissue factor compositions and ligands for the specific coagulation of vasculature
US5776427A (en) * 1992-03-05 1998-07-07 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
US6004554A (en) * 1992-03-05 1999-12-21 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
US6004555A (en) * 1992-03-05 1999-12-21 Board Of Regents, The University Of Texas System Methods for the specific coagulation of vasculature
US6036955A (en) * 1992-03-05 2000-03-14 The Scripps Research Institute Kits and methods for the specific coagulation of vasculature
US5965132A (en) * 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
ATE327330T1 (de) * 1994-03-08 2006-06-15 Sloan Kettering Inst Cancer Rekombinante humanisierte antikörper gegen fb5
US5536641A (en) * 1994-05-17 1996-07-16 Memorial Sloane Kittering Cancer Center Monoclonal antibody specific for vascular endothelial cell antigen endoglyx-1 and uses thereof for detection of, and isolation of, vascular endothelial cells
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
EA200001007A1 (ru) 1998-03-31 2001-04-23 Дюпон Фармасьютикалз Компани Фармацевтические препараты для визуализации ангиогенных расстройств
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US6524553B2 (en) 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6511649B1 (en) 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
AU2371400A (en) 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company Vitronectin receptor antagonist pharmaceuticals
JP2002532440A (ja) 1998-12-18 2002-10-02 デュポン ファーマシューティカルズ カンパニー ビトロネクチン受容体拮抗剤薬剤
US6794518B1 (en) * 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
EP1307557A2 (de) * 2000-08-02 2003-05-07 The Johns Hopkins University Expressionsmuster von endothelzellen
US7731648B2 (en) 2001-07-25 2010-06-08 Aduro Biotech Magnetic nanoscale particle compositions, and therapeutic methods related thereto
US7951061B2 (en) 2001-07-25 2011-05-31 Allan Foreman Devices for targeted delivery of thermotherapy, and methods related thereto
US7074175B2 (en) 2001-07-25 2006-07-11 Erik Schroeder Handy Thermotherapy via targeted delivery of nanoscale magnetic particles
US6997863B2 (en) 2001-07-25 2006-02-14 Triton Biosystems, Inc. Thermotherapy via targeted delivery of nanoscale magnetic particles
EP2365004B1 (de) * 2002-06-21 2016-01-06 Johns Hopkins University School of Medicine Membranassoziierte Tumorendothel-Marker
JP4928259B2 (ja) * 2003-03-04 2012-05-09 キリンホールディングス株式会社 内皮細胞特異的抗体およびその使用
CA2590583A1 (en) * 2004-12-03 2006-06-08 Morphotek, Inc. Use of endosialin binding proteins to isolate endosialin positive cells
AU2006241235B2 (en) * 2005-04-22 2012-04-05 Eisai, Inc. Antibodies with immune effector activity and that internalize in endosialin-positive cells
PL2137217T3 (pl) 2007-04-05 2014-08-29 Eisai Inc Sposoby hamowania wiązania endosialiny z ligandami
WO2010118203A2 (en) * 2009-04-09 2010-10-14 Morphotek, Inc. Endosialin binding molecules
SE535982C2 (sv) * 2009-12-15 2013-03-19 Theravac Pharmaceuticals Ab Ett nytt vaccin som angriper tumörkärl som ett effektivt redskap i tumörterapi
EP2621946A1 (de) 2010-09-29 2013-08-07 Morphotek, Inc. Manipulierte humanes endosialin-exprimierende nager
EP3543258B1 (de) * 2012-03-30 2023-09-13 Eisai R&D Management Co., Ltd. Diagnostische tem-1-antikörper

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE327330T1 (de) * 1994-03-08 2006-06-15 Sloan Kettering Inst Cancer Rekombinante humanisierte antikörper gegen fb5

Also Published As

Publication number Publication date
WO1994011023A1 (en) 1994-05-26
JP3541296B2 (ja) 2004-07-07
DK0673255T3 (da) 2001-12-10
EP0673255B1 (de) 2001-08-22
JPH08505764A (ja) 1996-06-25
US5437865A (en) 1995-08-01
DE69330643D1 (de) 2001-09-27
CA2149120C (en) 2005-09-27
EP0673255A4 (de) 1996-08-21
PT673255E (pt) 2002-02-28
ATE204480T1 (de) 2001-09-15
US5342757A (en) 1994-08-30
EP0673255A1 (de) 1995-09-27
AU671884B2 (en) 1996-09-12
CA2149120A1 (en) 1994-05-26
ES2161751T3 (es) 2001-12-16
AU5596594A (en) 1994-06-08
GR3036906T3 (en) 2002-01-31

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