DE69332976D1 - Digitale analytische nachweisvorrichtung - Google Patents

Digitale analytische nachweisvorrichtung

Info

Publication number
DE69332976D1
DE69332976D1 DE69332976T DE69332976T DE69332976D1 DE 69332976 D1 DE69332976 D1 DE 69332976D1 DE 69332976 T DE69332976 T DE 69332976T DE 69332976 T DE69332976 T DE 69332976T DE 69332976 D1 DE69332976 D1 DE 69332976D1
Authority
DE
Germany
Prior art keywords
analyte
analyte particles
sample
digital
optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69332976T
Other languages
English (en)
Other versions
DE69332976T2 (de
Inventor
Fritz Allen
Thomas Niemczyk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acrogen Inc
Original Assignee
Acrogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acrogen Inc filed Critical Acrogen Inc
Publication of DE69332976D1 publication Critical patent/DE69332976D1/de
Application granted granted Critical
Publication of DE69332976T2 publication Critical patent/DE69332976T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G01N15/1433
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00Scenes; Scene-specific elements
    • G06V20/60Type of objects
    • G06V20/69Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695Preprocessing, e.g. image segmentation
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/10Segmentation; Edge detection
    • G06T7/11Region-based segmentation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10056Microscopic image
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10064Fluorescence image
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30024Cell structures in vitro; Tissue sections in vitro

Landscapes

  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Multimedia (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE69332976T 1992-07-23 1993-07-16 Digitale analytische nachweisvorrichtung Expired - Lifetime DE69332976T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/918,357 US5329461A (en) 1992-07-23 1992-07-23 Digital analyte detection system
US918357 1992-07-23
PCT/US1993/006707 WO1994002831A1 (en) 1992-07-23 1993-07-16 Digital analyte detection system

Publications (2)

Publication Number Publication Date
DE69332976D1 true DE69332976D1 (de) 2003-06-18
DE69332976T2 DE69332976T2 (de) 2004-05-19

Family

ID=25440250

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332976T Expired - Lifetime DE69332976T2 (de) 1992-07-23 1993-07-16 Digitale analytische nachweisvorrichtung

Country Status (6)

Country Link
US (2) US5329461A (de)
EP (1) EP0651879B1 (de)
JP (1) JP3954089B2 (de)
AT (1) ATE240515T1 (de)
DE (1) DE69332976T2 (de)
WO (1) WO1994002831A1 (de)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3076118B2 (ja) * 1991-11-27 2000-08-14 シスメックス株式会社 粒子計数方法
US5329461A (en) * 1992-07-23 1994-07-12 Acrogen, Inc. Digital analyte detection system
US6327031B1 (en) * 1998-09-18 2001-12-04 Burstein Technologies, Inc. Apparatus and semi-reflective optical system for carrying out analysis of samples
US5722470A (en) * 1995-11-09 1998-03-03 Glaxo Group Limited Bead dispensing device and methods
US5771310A (en) * 1996-12-30 1998-06-23 Shriners Hospitals For Children Method and apparatus for recording three-dimensional topographies
CA2255599C (en) * 1996-04-25 2006-09-05 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US20050214827A1 (en) * 1996-07-08 2005-09-29 Burstein Technologies, Inc. Assay device and method
US5978519A (en) * 1996-08-06 1999-11-02 Xerox Corporation Automatic image cropping
JP2962234B2 (ja) * 1996-08-07 1999-10-12 日本電気株式会社 半導体デバイスの寄生MIM構造箇所解析法及びSi半導体デバイスの寄生MIM構造箇所解析法
WO1998011258A1 (en) 1996-09-16 1998-03-19 University Of Utah Research Foundation Method and apparatus for analysis of chromatographic migration patterns
US7094609B2 (en) 1996-09-20 2006-08-22 Burstein Technologies, Inc. Spatially addressable combinatorial chemical arrays in encoded optical disk format
US6449562B1 (en) * 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
DE69731629T2 (de) * 1997-09-11 2005-11-03 Randox Laboratories Ltd., Crumlin Verfahren und Gerät zur Bildanalyse
US20030153023A1 (en) * 1999-05-13 2003-08-14 Starzl Timothy W. Enumeration method of analyte detection
US6151973A (en) * 1999-01-29 2000-11-28 Glaxo Wellcome Inc. Bead picking apparatus and method
US6355934B1 (en) 1999-02-26 2002-03-12 Packard Biochip Technologies Imaging system for an optical scanner
JP2002543370A (ja) * 1999-02-26 2002-12-17 ジーエスアイ・ルモニクス,インコーポレイテッド 光学スキャナ用の画像形成システム
DE19923822A1 (de) 1999-05-19 2000-11-23 Zeiss Carl Jena Gmbh Scannende Anordnung, vorzugsweise zur Erfassung von Fluoreszenzlicht
EP1221038A4 (de) * 1999-07-21 2004-09-08 Applera Corp Arbeitsplatz zum nachweis von lumineszenz
US6888951B1 (en) 1999-08-23 2005-05-03 Nagaoka & Co., Ltd. Methods and apparatus for analyzing operational and analyte data acquired from optical disc
US20050069956A1 (en) * 1999-11-22 2005-03-31 Michael Seul Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US7892854B2 (en) 2000-06-21 2011-02-22 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US20040038241A1 (en) * 2000-07-26 2004-02-26 Martin Glennsbjerg Spatially resolved enzyme-linked assay
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
US6937323B2 (en) * 2000-11-08 2005-08-30 Burstein Technologies, Inc. Interactive system for analyzing biological samples and processing related information and the use thereof
EP1410386A2 (de) * 2000-11-09 2004-04-21 Burstein Technologies, Inc. Plattenlaufwerkssystem und verfahren zur verwendung mit bio-platten
AU2002241602A1 (en) * 2000-11-16 2002-06-11 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
AU2002239289A1 (en) * 2000-11-22 2002-06-03 Burstein Technologies, Inc. Apparatus and methods for separating agglutinants and disperse particles
WO2002046762A2 (en) * 2000-12-08 2002-06-13 Burstein Technologies, Inc. Optical disc assemblies for performing assays
US6760298B2 (en) * 2000-12-08 2004-07-06 Nagaoka & Co., Ltd. Multiple data layer optical discs for detecting analytes
WO2002056311A2 (en) * 2001-01-11 2002-07-18 Burstein Technologies Inc Optical disc analysis system including related methods for biological and medical imaging
CA2439307A1 (en) * 2001-02-23 2002-09-06 Genicon Sciences Corporation Methods for providing extended dynamic range in analyte assays
US20020171838A1 (en) * 2001-05-16 2002-11-21 Pal Andrew Attila Variable sampling control for rendering pixelization of analysis results in a bio-disc assembly and apparatus relating thereto
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US7141416B2 (en) * 2001-07-12 2006-11-28 Burstein Technologies, Inc. Multi-purpose optical analysis optical bio-disc for conducting assays and various reporting agents for use therewith
US7221632B2 (en) * 2001-07-12 2007-05-22 Burstein Technologies, Inc. Optical disc system and related detecting methods for analysis of microscopic structures
WO2003010563A2 (en) * 2001-07-24 2003-02-06 Burstein Technologies, Inc. Magnetic assisted detection of magnetic beads using optical disc drives
US6750457B2 (en) * 2001-08-29 2004-06-15 Becton Dickinson And Company System for high throughput analysis
US20030129665A1 (en) * 2001-08-30 2003-07-10 Selvan Gowri Pyapali Methods for qualitative and quantitative analysis of cells and related optical bio-disc systems
WO2003021222A2 (en) * 2001-08-31 2003-03-13 Burstein Technologies, Inc. Capture layer assemblies for cellular assays including related optical analysis discs and methods
WO2003023354A2 (en) * 2001-09-07 2003-03-20 Burstein Technologies, Inc. Optical bio-disc systems for nuclear morphology based identification
WO2003023571A2 (en) * 2001-09-12 2003-03-20 Burstein Technologies, Inc. Methods for differential cell counts including related apparatus and software for performing same
KR20040068122A (ko) 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 공동 검색과 효소-매개된 탐지에 의한 다형성 좌위의 다중분석
EP1438566A2 (de) * 2001-10-24 2004-07-21 Burstein Technologies, Inc. Optische analysiervorrichtung für biologische platten
US20080094974A1 (en) * 2001-11-09 2008-04-24 Burstein Technologies, Inc. Optical disc system and related detecting methods for analysis of microscopic structures
AU2002352735A1 (en) * 2001-11-20 2003-06-10 Burstein Technologies, Inc. Optical bio-discs and microfluidic devices for analysis of cells
US7365849B2 (en) * 2001-12-27 2008-04-29 Taiwan Unison Biotechnology, Inc. Portable, scanning and analyzing apparatus
US20040246252A1 (en) * 2002-01-14 2004-12-09 Morrow Jesse James Method and apparatus for visualizing data
CA2471018A1 (en) * 2002-01-28 2003-08-07 Burstein Technologies, Inc. Methods and apparatus for logical triggering of an optical bio-disc
US20050003459A1 (en) * 2002-01-30 2005-01-06 Krutzik Siegfried Richard Multi-purpose optical analysis disc for conducting assays and related methods for attaching capture agents
AU2003209372B2 (en) 2002-01-31 2009-02-19 Burstein Technologies, Inc. Method for triggering through disc grooves and related optical analysis discs and system
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
CA2956645A1 (en) 2003-07-12 2005-03-31 David A. Goldberg Sensitive and rapid biodetection
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
CA2539824C (en) 2003-09-22 2015-02-03 Xinwen Wang Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
AU2004286252A1 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
US20050089916A1 (en) * 2003-10-28 2005-04-28 Xiongwu Xia Allele assignment and probe selection in multiplexed assays of polymorphic targets
WO2005045060A2 (en) 2003-10-29 2005-05-19 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded dna
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
EP2061901A2 (de) * 2006-10-31 2009-05-27 Noxxon Pharma AG Verfahren zum nachweis eines einzel- oder doppelsträngigen nukleinsäuremoleküls
US8244021B2 (en) * 2006-12-20 2012-08-14 Ventana Medical Systems, Inc. Quantitative, multispectral image analysis of tissue specimens stained with quantum dots
US20080243865A1 (en) * 2007-03-28 2008-10-02 Oracle International Corporation Maintaining global state of distributed transaction managed by an external transaction manager for clustered database systems
EP2201374B1 (de) 2007-08-30 2015-10-07 Trustees Of Tufts College Verfahren zur bestimmung der konzentration eines analyten in lösung
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100075862A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
US8581927B2 (en) * 2008-11-04 2013-11-12 Beckman Coulter, Inc. Multidimensional particle analysis data cluster reconstruction
DK200801722A (en) 2008-12-05 2010-06-06 Unisensor As Optical sectioning of a sample and detection of particles in a sample
AU2010327159B2 (en) 2009-12-04 2013-10-10 Unisensor A/S System and method for time-related microscopy of biological organisms
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8415171B2 (en) * 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
EP2542890B1 (de) 2010-03-01 2015-05-06 Quanterix Corporation Verfahren zur erweiterung des dynamischen bereichs bei tests für den nachweis von molekülen oder partikeln
KR20130054240A (ko) 2010-03-04 2013-05-24 유니센서 에이/에스 가요성 샘플 컨테이너
US8767069B2 (en) * 2010-06-30 2014-07-01 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device using light distribution
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
WO2012122314A2 (en) 2011-03-07 2012-09-13 Accelr8 Technology Corporation Rapid cell purification systems
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
WO2014145036A1 (en) * 2013-03-15 2014-09-18 The Trustees Of Princeton University Rapid and sensitive analyte measurement assay
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
US10656149B2 (en) * 2013-03-15 2020-05-19 The Trustees Of Princeton University Analyte detection enhancement by targeted immobilization, surface amplification, and pixelated reading and analysis
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
WO2015066006A2 (en) 2013-10-29 2015-05-07 Idexx Laboratories, Inc. Method and device for detecting bacteria and determining the concentration thereof in a liquid sample
WO2015080964A1 (en) * 2013-11-27 2015-06-04 Cirtemo, Lld Optical analysis system and process
KR102136645B1 (ko) * 2014-03-04 2020-07-22 삼성전자주식회사 검사장치 및 그 제어방법
CN107532991A (zh) 2015-03-10 2018-01-02 迈克必斯生物系统公司 用于分选和处理分析物的方法、系统和装置
US10023895B2 (en) 2015-03-30 2018-07-17 Accelerate Diagnostics, Inc. Instrument and system for rapid microogranism identification and antimicrobial agent susceptibility testing
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
US10718003B2 (en) * 2015-12-31 2020-07-21 Roche Molecular Systems, Inc. Detecting an analyte in a flash and glow reaction
US11317834B2 (en) 2017-08-14 2022-05-03 Senseonics, Incorporated Systems, apparatus, and methods for discriminating optical signals
EP4001890A4 (de) * 2019-07-19 2023-08-02 Hitachi High-Tech Corporation Teilchenmengenmessgerät

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853987A (en) * 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US4201763A (en) * 1975-10-09 1980-05-06 Bio-Rad Laboratories, Inc. Solid phase immunofluorescent assay method
US4295199A (en) * 1979-10-22 1981-10-13 Bio-Rad Laboratories, Inc. Automatic fluorometer and data processor for performing fluorescent immunoassays
US4271123A (en) * 1979-10-22 1981-06-02 Bio-Rad Laboratories, Inc. Automated system for performing fluorescent immunoassays
US4612614A (en) * 1980-09-12 1986-09-16 International Remote Imaging Systems, Inc. Method of analyzing particles in a fluid sample
US4393466A (en) * 1980-09-12 1983-07-12 International Remote Imaging Systems Method of analyzing particles in a dilute fluid sample
US4720804A (en) * 1984-08-08 1988-01-19 Moore Sidney D Electrically addressable opto-electronic indicator for making dynamic evaluations of microscopic or larger subjects
CA1228811A (en) * 1983-05-05 1987-11-03 Robert G. Pergolizzi Assay method utilizing polynucleotide sequences
US4672040A (en) * 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
US4704255A (en) * 1983-07-15 1987-11-03 Pandex Laboratories, Inc. Assay cartridge
FR2558172B1 (fr) * 1984-01-16 1986-06-13 Inst Nat Sante Rech Med Sonde contenant un acide nucleique modifie et reconnaissance par des anticorps specifiques et utilisation de cette sonde et de ces anticorps specifiques pour detecter et caracteriser une sequence d'adn homologue
AU3844485A (en) * 1984-02-09 1985-08-15 Enzo Biochem Inc. Heterologous detection of cabeled dna
CA1260372A (en) * 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
US4722840A (en) * 1984-09-12 1988-02-02 Chiron Corporation Hybrid particle immunogens
FI844027A (fi) * 1984-10-12 1986-04-13 Labsystems Oy Immunologiskt bestaemningsfoerfarande.
US4775619A (en) * 1984-10-16 1988-10-04 Chiron Corporation Polynucleotide determination with selectable cleavage sites
GB8507706D0 (en) * 1985-03-25 1985-05-01 Genetics Int Inc Magnetic nucleic acid sequences
US4824776A (en) * 1985-07-25 1989-04-25 Molecular Biosystems, Inc. Method for increasing the sensitivity of nucleic acid hybridization assays
US4769776A (en) * 1985-08-30 1988-09-06 Hitachi, Ltd. Apparatus for measuring the concentration of filamentous microorganisms in a mixture including microorganisms
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US4882269A (en) * 1985-12-13 1989-11-21 Princeton University Amplified hybridization assay
US4758727A (en) * 1986-02-12 1988-07-19 Ohio State University Research Foundation Method and apparatus for the measurement of low-level laser-induced fluorescence
US4968602A (en) * 1986-03-05 1990-11-06 Molecular Diagnostics, Inc. Solution-phase single hybridization assay for detecting polynucleotide sequences
US4925785A (en) * 1986-03-07 1990-05-15 Biotechnica Diagnostics, Inc. Nucleic acid hybridization assays
NO162946C (no) * 1987-08-21 1990-03-14 Otto Soerensen Anordning for magnetisk separasjon av celler.
US4855930A (en) * 1987-03-27 1989-08-08 Chimerix Corporation Method and appartatus for improved time-resolved fluorescence spectroscopy
IL85551A0 (en) * 1987-04-01 1988-08-31 Miles Inc Rapid hybridization assay and reagent system used therein
US4988618A (en) * 1987-11-16 1991-01-29 Gene-Trak Systems Magnetic separation device and methods for use in heterogeneous assays
NO164622C (no) * 1988-05-11 1990-10-24 Tore Lindmo Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.
WO1990002205A1 (en) * 1988-08-25 1990-03-08 Angenics, Inc. Detection of nucleic acid sequences using particle agglutination
CA2049042A1 (en) * 1989-03-10 1990-09-11 Mark L. Collins Preventing interference with affinity capture schemes
US5162990A (en) * 1990-06-15 1992-11-10 The United States Of America As Represented By The United States Navy System and method for quantifying macrophage phagocytosis by computer image analysis
USH1183H (en) * 1991-12-19 1993-05-04 Laser scanner method for determining number and size of particles
US5329461A (en) * 1992-07-23 1994-07-12 Acrogen, Inc. Digital analyte detection system

Also Published As

Publication number Publication date
US5329461A (en) 1994-07-12
ATE240515T1 (de) 2003-05-15
WO1994002831A1 (en) 1994-02-03
EP0651879B1 (de) 2003-05-14
JP3954089B2 (ja) 2007-08-08
DE69332976T2 (de) 2004-05-19
EP0651879A1 (de) 1995-05-10
JPH07509314A (ja) 1995-10-12
US5488567A (en) 1996-01-30
EP0651879A4 (de) 1995-08-23

Similar Documents

Publication Publication Date Title
ATE240515T1 (de) Digitale analytische nachweisvorrichtung
EP0284630B1 (de) Verfahren zur Erfassung von Fehlern in Oberflächen
EP0569718A3 (de)
DK0941465T3 (da) Fremgangsmåde til at skelne og detektere partikler i en sonde ved identifikation af tidsopløste signalafsnit,optiske råsignaler fra en sonde på basis af detektion af enkeltfotoner
DE69331188T2 (de) Vorrichtung und verfahren zur molekularen charakterisierung
NO974597L (no) Fremgangsmåte og apparat for kvantitativ partikkelbestemmelse i fluider
DE59310263D1 (de) Verfahren zur Bestimmung von Stoffen und/oder deren Eigenschaften und Gerät hierfür
EP0360126A3 (de) Verfahren zum Betrieb eines optischen Rauchmelders sowie Rauchmelder zur Durchführung des Verfahrens
ATE215694T1 (de) Verfahren zur charakterisierung von proben unter verwendung statistischer zwischendaten
EP0903572A3 (de) Vorrichtung zur Detektion der Verschmutzung eines Fensters
EP0760477A3 (de) Vorrichtung und Verfahren zur Messung eines streuenden Mediums
EP0046058A2 (de) Einrichtung zur Kontrolle einer Materialbahn
FR2433179A1 (fr) Systeme de detection et de classification des criques de surfaces metalliques
SE9400849D0 (sv) Anordning och förfarande för detektering av defekter i virke
DE69903015D1 (de) Verfahren und vorrichtung zum positionabhängigen abtasten mit normalisierter geschwindigkeit
KR920008470A (ko) 박류 용융물의 유량 측정방법 및 장치
ATE123196T1 (de) Vorrichtung und verfahren zur bewegungsdetektion in einem videosignal.
JP2995124B2 (ja) 寸法測定装置
DE69518504T2 (de) Detektion von verunreinigungen in metallagglomeraten
JPS57164657A (en) Image analyzing method and device
KR910010155A (ko) 폭 측정장치
FR2652896B1 (fr) Procede et dispositif de detection de cliquetis.
ATE104781T1 (de) Vorrichtung zur pruefung von muenzen.
FR2603706B1 (fr) Systeme de traitement de signaux issus d'un dispositif de detection de rayonnements et sonde de detection de rayonnements, comportant ce systeme
JPH08247730A (ja) 寸法測定装置のエッジ検出方法

Legal Events

Date Code Title Description
8364 No opposition during term of opposition