DE69333622D1 - Neuartige, biologisch aktive polypeptide, ihre herstellung und diese polypeptide enthaltende pharmazeutische zusammensetzung - Google Patents

Neuartige, biologisch aktive polypeptide, ihre herstellung und diese polypeptide enthaltende pharmazeutische zusammensetzung

Info

Publication number
DE69333622D1
DE69333622D1 DE69333622T DE69333622T DE69333622D1 DE 69333622 D1 DE69333622 D1 DE 69333622D1 DE 69333622 T DE69333622 T DE 69333622T DE 69333622 T DE69333622 T DE 69333622T DE 69333622 D1 DE69333622 D1 DE 69333622D1
Authority
DE
Germany
Prior art keywords
polypeptides
innovative
production
pharmaceutical composition
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69333622T
Other languages
English (en)
Other versions
DE69333622T2 (de
Inventor
Reinhard Fleer
Alain Fournier
Jean-Dominique Guitton
Gerard Jung
Patrice Yeh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novozymes Biopharma DK AS
Original Assignee
Delta Biotechnology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delta Biotechnology Ltd filed Critical Delta Biotechnology Ltd
Publication of DE69333622D1 publication Critical patent/DE69333622D1/de
Application granted granted Critical
Publication of DE69333622T2 publication Critical patent/DE69333622T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B69/00—Unpacking of articles or materials, not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
DE69333622T 1992-01-31 1993-01-28 Neuartige, biologisch aktive polypeptide, ihre herstellung und diese polypeptide enthaltende pharmazeutische zusammensetzung Expired - Lifetime DE69333622T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9201064 1992-01-31
FR9201064A FR2686899B1 (fr) 1992-01-31 1992-01-31 Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
PCT/FR1993/000085 WO1993015199A1 (fr) 1992-01-31 1993-01-28 Nouveaux polypeptides biologiquement actifs, leur preparation et composition pharmaceutique les contenant

Publications (2)

Publication Number Publication Date
DE69333622D1 true DE69333622D1 (de) 2004-10-21
DE69333622T2 DE69333622T2 (de) 2005-10-27

Family

ID=9426190

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69333622T Expired - Lifetime DE69333622T2 (de) 1992-01-31 1993-01-28 Neuartige, biologisch aktive polypeptide, ihre herstellung und diese polypeptide enthaltende pharmazeutische zusammensetzung

Country Status (13)

Country Link
US (12) US5876969A (de)
EP (2) EP0624195B1 (de)
JP (3) JPH07503368A (de)
AT (1) ATE276361T1 (de)
CA (1) CA2126091C (de)
DE (1) DE69333622T2 (de)
DK (1) DK0624195T3 (de)
ES (1) ES2230541T3 (de)
FI (1) FI120355B (de)
FR (1) FR2686899B1 (de)
NO (2) NO325486B1 (de)
PT (1) PT624195E (de)
WO (1) WO1993015199A1 (de)

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DK0624195T3 (da) 2005-01-17
US20060105429A1 (en) 2006-05-18
US20040086977A1 (en) 2004-05-06
EP0624195A1 (de) 1994-11-17
PT624195E (pt) 2004-12-31
US6972322B2 (en) 2005-12-06
US5876969A (en) 1999-03-02
EP1449921A3 (de) 2006-01-11
EP0624195B1 (de) 2004-09-15
US6686179B2 (en) 2004-02-03
ATE276361T1 (de) 2004-10-15
US7081354B2 (en) 2006-07-25
FI120355B (fi) 2009-09-30
NO942839L (no) 1994-09-22
US20030036172A1 (en) 2003-02-20
US6987006B2 (en) 2006-01-17
US20050239167A1 (en) 2005-10-27
EP1449921A2 (de) 2004-08-25
FI943563A (fi) 1994-07-29
US20030036171A1 (en) 2003-02-20
US6989365B2 (en) 2006-01-24
DE69333622T2 (de) 2005-10-27
US20030082747A1 (en) 2003-05-01
CA2126091C (en) 2008-03-11
NO942839D0 (no) 1994-07-29
FI943563A0 (fi) 1994-07-29
CA2126091A1 (fr) 1993-08-05
US20020151011A1 (en) 2002-10-17
FR2686899A1 (fr) 1993-08-06
US7410779B2 (en) 2008-08-12
US7056701B2 (en) 2006-06-06
US7094577B2 (en) 2006-08-22
US20030036170A1 (en) 2003-02-20
US7833521B2 (en) 2010-11-16
WO1993015199A1 (fr) 1993-08-05
FR2686899B1 (fr) 1995-09-01
NO20064159L (no) 1994-09-22
NO325486B1 (no) 2008-05-13
JPH07503368A (ja) 1995-04-13
US20030022308A1 (en) 2003-01-30
ES2230541T3 (es) 2005-05-01
JP2003235589A (ja) 2003-08-26
US20040086976A1 (en) 2004-05-06
US7435410B2 (en) 2008-10-14
US20090176276A1 (en) 2009-07-09
US7041478B2 (en) 2006-05-09
JP2007306939A (ja) 2007-11-29

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