DE69401109T2 - Selektive vernetzung von hemoglobin mittels oxidierten, ringgeöffneten sacchariden - Google Patents

Selektive vernetzung von hemoglobin mittels oxidierten, ringgeöffneten sacchariden

Info

Publication number
DE69401109T2
DE69401109T2 DE69401109T DE69401109T DE69401109T2 DE 69401109 T2 DE69401109 T2 DE 69401109T2 DE 69401109 T DE69401109 T DE 69401109T DE 69401109 T DE69401109 T DE 69401109T DE 69401109 T2 DE69401109 T2 DE 69401109T2
Authority
DE
Germany
Prior art keywords
hemoglobin
saccharide
tri
reaction
oxidized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69401109T
Other languages
English (en)
Other versions
DE69401109D1 (de
Inventor
Diana Pliura
Lawrence Wong
Song Er
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hemosol Inc
Original Assignee
Hemosol Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemosol Inc filed Critical Hemosol Inc
Publication of DE69401109D1 publication Critical patent/DE69401109D1/de
Application granted granted Critical
Publication of DE69401109T2 publication Critical patent/DE69401109T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
DE69401109T 1993-03-16 1994-03-11 Selektive vernetzung von hemoglobin mittels oxidierten, ringgeöffneten sacchariden Expired - Fee Related DE69401109T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3183093A 1993-03-16 1993-03-16
PCT/CA1994/000140 WO1994021682A1 (en) 1993-03-16 1994-03-11 Selective crosslinking of hemoglobins by oxidized, ring-opened saccharides

Publications (2)

Publication Number Publication Date
DE69401109D1 DE69401109D1 (de) 1997-01-23
DE69401109T2 true DE69401109T2 (de) 1997-05-28

Family

ID=21861634

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69401109T Expired - Fee Related DE69401109T2 (de) 1993-03-16 1994-03-11 Selektive vernetzung von hemoglobin mittels oxidierten, ringgeöffneten sacchariden

Country Status (13)

Country Link
US (2) US5532352A (de)
EP (1) EP0646130B1 (de)
JP (1) JP2594241B2 (de)
KR (1) KR100306000B1 (de)
CN (1) CN1046292C (de)
AT (1) ATE146189T1 (de)
AU (1) AU668294B2 (de)
CA (1) CA2131455C (de)
DE (1) DE69401109T2 (de)
DK (1) DK0646130T3 (de)
ES (1) ES2095751T3 (de)
NZ (1) NZ262349A (de)
WO (1) WO1994021682A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE503711C2 (sv) * 1994-12-14 1996-08-12 Medicarb Ab Flerstegsförfarande för beläggning av en intraokulär lins
US5952470A (en) * 1995-06-07 1999-09-14 Biopure Corporation Method for separating unmodified hemoglobin from cross-linked hemoglobin
US5891506A (en) * 1996-08-09 1999-04-06 Medtronic, Inc. Oxidative method for attachment of glycoproteins or glycopeptides to surfaces of medical devices
DE69727241D1 (de) * 1996-08-27 2004-02-19 Hemosol Inc Gesteigerte stimulation der erythropoesis
US5917020A (en) * 1997-01-15 1999-06-29 Kluger; Ronald H. Bis-tetrameric hemoglobin and reagents for its production
DE69831248T2 (de) 1997-02-28 2006-04-13 The Regents Of The University Of California, Oakland Verfahren und zusammensetzungen zur optimierung des sauerstofftransportes in zellfreien systemen
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
CA2233725A1 (en) 1998-03-31 1999-09-30 Hemosol Inc. Hemoglobin-hydroxyethyl starch complexes
CA2266174A1 (en) 1999-03-18 2000-09-18 Hemosol Inc. Hemoglobin-antioxidant conjugates
DE19933275A1 (de) * 1999-07-14 2001-01-18 Fresenius Ag Verwendung von Hämoglobin-Derivaten zur Bestimmung des Plasma- und/oder Blutvolumens
US6894150B1 (en) * 1999-10-01 2005-05-17 Ross Walden Tye Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin
US6500809B1 (en) 1999-11-12 2002-12-31 Neuron Therapeutics, Inc. Hyperoncotic artificial cerebrospinal fluid and method of treating neural tissue edema therewith
DE10031742A1 (de) * 2000-06-29 2002-01-17 Sanguibio Tech Ag Verfahren zur Herstellung künstlicher Sauerstoffträger aus kovalent vernetzten Hämoglobinen mit verbesserten funktionellen Eigenschaften durch Vernetzung in Anwesenheit chemisch nicht reagierender Effektoren der Sauerstoffaffinität der Hämoglobine
DE10112825A1 (de) 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
US20030153491A1 (en) * 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20050164915A1 (en) * 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
DE10209822A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
PL217085B1 (pl) 2002-09-11 2014-06-30 Fresenius Kabi Gmbh Koniugat hydroksyalkiloskrobi i polipeptydu, sposób wytwarzania koniugatu hydroksyalkiloskrobi i polipeptydu, zastosowanie koniugatu hydroksyalkiloskrobi i polipeptydu oraz kompozycja farmaceutyczna koniugatu hydroksyalkiloskrobi i polipeptydu
AU2003273413A1 (en) 2002-10-08 2004-05-04 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
US7135554B1 (en) * 2004-01-27 2006-11-14 Biopure Corporation Method of forming a polymerized hemoglobin solution from stabilized hemoglobin
DE202005021885U1 (de) 2004-03-11 2011-03-03 Fresenius Kabi Deutschland Gmbh Hydroxyalkylstärke-Protein-Konjugate, durch reduktive Aminierung hergestellt
WO2006108047A2 (en) * 2005-04-05 2006-10-12 Biopure Corporation Oxygenated polymerized hemoglobin solutions and their uses for tissue visualization
US7494974B2 (en) * 2006-10-24 2009-02-24 Ikor, Inc. Carboxymethylated cross-linked tetrameric hemoglobin
US7504377B2 (en) * 2006-10-23 2009-03-17 Ikor, Inc. Nitric oxide-blocked cross-linked tetrameric hemoglobin
EP2070950A1 (de) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkylstärkederivate und deren Herstellungsverfahren
US20140260586A1 (en) * 2013-03-14 2014-09-18 Schlumberger Technology Corporation Method to perform rapid formation fluid analysis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
JPH0645681B2 (ja) * 1986-02-05 1994-06-15 美浜 久春 修飾ヘム
DE3636590A1 (de) * 1986-10-28 1988-05-26 Braun Melsungen Ag Blutersatzmittel
GB8710598D0 (en) * 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
FR2640141B1 (fr) * 1988-12-14 1993-04-16 Merieux Inst Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
US5234903A (en) * 1989-11-22 1993-08-10 Enzon, Inc. Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
CZ281912B6 (cs) * 1990-11-29 1997-03-12 The Upjohn Company Směs hemoglobinu síťovaného imidoesterem a způso b její výroby
FR2680369B1 (fr) * 1991-08-14 1993-11-05 Pasteur Merieux Serums Vaccins Derives d'hemoglobine humaine, leur procede de preparation, produits en derivant et utilisation de ces derives et produits.
US5399671A (en) * 1992-11-18 1995-03-21 Kluger; Ronald Specifically crosslinked hemoglobin with free functionality

Also Published As

Publication number Publication date
NZ262349A (en) 1996-05-28
JP2594241B2 (ja) 1997-03-26
CN1046292C (zh) 1999-11-10
CN1105800A (zh) 1995-07-26
US5770727A (en) 1998-06-23
DK0646130T3 (da) 1997-06-02
ATE146189T1 (de) 1996-12-15
US5532352A (en) 1996-07-02
DE69401109D1 (de) 1997-01-23
EP0646130B1 (de) 1996-12-11
EP0646130A1 (de) 1995-04-05
AU6179394A (en) 1994-10-11
WO1994021682A1 (en) 1994-09-29
JPH07506123A (ja) 1995-07-06
ES2095751T3 (es) 1997-02-16
CA2131455C (en) 1998-08-18
KR100306000B1 (ko) 2001-12-01
CA2131455A1 (en) 1994-09-29
AU668294B2 (en) 1996-04-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: HEMOSOL INC., MISSISSAUGA, ONTARIO, CA

8339 Ceased/non-payment of the annual fee