DE69404632D1 - Verfahren zur herstellung von trans-6-[2-(substituierte-pyrrol-1-yl)alkyl]pyran-2-one verwendbar als inhibitoren der cholesterol-synthese - Google Patents

Verfahren zur herstellung von trans-6-[2-(substituierte-pyrrol-1-yl)alkyl]pyran-2-one verwendbar als inhibitoren der cholesterol-synthese

Info

Publication number
DE69404632D1
DE69404632D1 DE69404632T DE69404632T DE69404632D1 DE 69404632 D1 DE69404632 D1 DE 69404632D1 DE 69404632 T DE69404632 T DE 69404632T DE 69404632 T DE69404632 T DE 69404632T DE 69404632 D1 DE69404632 D1 DE 69404632D1
Authority
DE
Germany
Prior art keywords
pyran
substituted
alkyl
pyrrol
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69404632T
Other languages
English (en)
Other versions
DE69404632T2 (de
Inventor
Donald BUTLER
Tung Van Le
Thomas Nanninga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of DE69404632D1 publication Critical patent/DE69404632D1/de
Publication of DE69404632T2 publication Critical patent/DE69404632T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
DE69404632T 1993-03-03 1994-02-24 Verfahren zur herstellung von trans-6-[2-(substituierte-pyrrol-1-yl)alkyl]pyran-2-one verwendbar als inhibitoren der cholesterol-synthese Expired - Fee Related DE69404632T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/025,701 US5298627A (en) 1993-03-03 1993-03-03 Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
PCT/US1994/002180 WO1994020492A1 (en) 1993-03-03 1994-02-24 Novel process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis

Publications (2)

Publication Number Publication Date
DE69404632D1 true DE69404632D1 (de) 1997-09-04
DE69404632T2 DE69404632T2 (de) 1998-01-29

Family

ID=21827596

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69404632T Expired - Fee Related DE69404632T2 (de) 1993-03-03 1994-02-24 Verfahren zur herstellung von trans-6-[2-(substituierte-pyrrol-1-yl)alkyl]pyran-2-one verwendbar als inhibitoren der cholesterol-synthese

Country Status (19)

Country Link
US (8) US5298627A (de)
EP (1) EP0687263B1 (de)
JP (1) JP3510253B2 (de)
KR (1) KR100302431B1 (de)
AT (1) ATE156127T1 (de)
AU (1) AU677047B2 (de)
CA (1) CA2155952C (de)
CZ (4) CZ285554B6 (de)
DE (1) DE69404632T2 (de)
DK (1) DK0687263T3 (de)
ES (1) ES2108435T3 (de)
FI (3) FI109999B (de)
GR (1) GR3024784T3 (de)
HU (1) HU222177B1 (de)
NO (3) NO308529B1 (de)
NZ (1) NZ262830A (de)
RU (1) RU2138497C1 (de)
SK (4) SK281983B6 (de)
WO (1) WO1994020492A1 (de)

Families Citing this family (151)

* Cited by examiner, † Cited by third party
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