US5298627A
(en)
*
|
1993-03-03 |
1994-03-29 |
Warner-Lambert Company |
Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
|
DE4415331A1
(de)
*
|
1994-05-02 |
1995-11-09 |
Sobrevin |
Fadenspeichervorrichtung mit einstellbarem Fadenabzugswiderstand
|
US5385929A
(en)
*
|
1994-05-04 |
1995-01-31 |
Warner-Lambert Company |
[(Hydroxyphenylamino) carbonyl] pyrroles
|
HRP960312B1
(en)
*
|
1995-07-17 |
2001-10-31 |
Warner Lambert Co |
NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
|
US6087511A
(en)
*
|
1996-07-16 |
2000-07-11 |
Warner-Lambert Company |
Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
|
US20030105154A1
(en)
*
|
2001-10-24 |
2003-06-05 |
Bisgaier Charles Larry |
Statin-carboxyalkylether combinations
|
WO1999032434A1
(en)
*
|
1997-12-19 |
1999-07-01 |
Warner-Lambert Export Limited |
Process for the synthesis of 1,3-diols
|
SI20109A
(sl)
*
|
1998-12-16 |
2000-06-30 |
LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. |
Stabilna farmacevtska formulacija
|
IN191236B
(de)
*
|
1999-05-25 |
2003-10-11 |
Ranbaxy Lab Ltd |
|
US20040063969A1
(en)
*
|
1999-10-18 |
2004-04-01 |
Egis Gyogyszergyar Rt. |
Process for the preparation of amorphous atorvastatin calcium
|
US7411075B1
(en)
*
|
2000-11-16 |
2008-08-12 |
Teva Pharmaceutical Industries Ltd. |
Polymorphic form of atorvastatin calcium
|
EP1237865B1
(de)
|
1999-12-17 |
2005-11-16 |
Pfizer Science and Technology Ireland Limited |
Herstellungsverfahren auf industrieller basis von atorvastatin trihydrat hemi-kalziumsalz in kristalliner form
|
AU780247B2
(en)
|
1999-12-17 |
2005-03-10 |
Pfizer Science And Technology Ireland Limited |
A process for producing crystalline atorvastatin calcium
|
US7608445B1
(en)
|
1999-12-29 |
2009-10-27 |
Verenium Corporation |
Nitrilases, nucleic acids encoding them and methods for making and using them
|
US7300775B2
(en)
|
1999-12-29 |
2007-11-27 |
Verenium Corporation |
Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents
|
US20040014195A1
(en)
*
|
1999-12-29 |
2004-01-22 |
Diversa Corporation |
Nitrilases, nucleic acids encoding them and methods for making and using them
|
US7521216B2
(en)
|
1999-12-29 |
2009-04-21 |
Verenium Corporation |
Nitrilases and methods for making and using them
|
US6777552B2
(en)
*
|
2001-08-16 |
2004-08-17 |
Teva Pharmaceutical Industries, Ltd. |
Processes for preparing calcium salt forms of statins
|
EP1341785B1
(de)
*
|
2000-11-16 |
2008-10-08 |
Teva Pharmaceutical Industries Ltd. |
Hydrolyse von [r(r*,r*)]-2-(4-fluorphenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrol-heptansäureestern mit calciumhydroxid
|
US7501450B2
(en)
*
|
2000-11-30 |
2009-03-10 |
Teva Pharaceutical Industries Ltd. |
Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
|
IL156055A0
(en)
*
|
2000-11-30 |
2003-12-23 |
Teva Pharma |
Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
|
AU2002224952B2
(en)
*
|
2000-12-27 |
2007-04-05 |
Teva Pharmaceutical Industries Ltd. |
Crystalline forms of atorvastatin
|
EP1734034A3
(de)
|
2001-01-09 |
2007-01-03 |
Warner-Lambert Company LLC |
Carbonsäuresalze von beta-Alaninestern oder -Amiden
|
US6476235B2
(en)
*
|
2001-01-09 |
2002-11-05 |
Warner-Lambert Company |
Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
|
WO2002057229A1
(en)
*
|
2001-01-19 |
2002-07-25 |
Biocon India Limited |
FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
|
SI20814A
(sl)
|
2001-01-23 |
2002-08-31 |
LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. |
Priprava amorfnega atorvastatina
|
SI20848A
(sl)
|
2001-03-14 |
2002-10-31 |
Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. |
Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
|
HUP0400381A2
(hu)
|
2001-06-29 |
2004-09-28 |
Warner-Lambert Company Llc |
[R-(R*,R*)]-2-(4fluorfenil)-béta, delta-dihidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)karbonil]-1H-pirrol-1-heptánsav 2:1 arányú kalciumsójának (atorvasztatin) kristályos formái
|
ATE457972T1
(de)
*
|
2001-07-06 |
2010-03-15 |
Basf Se |
Verfahren zur herstellung von 7-amino-syn-3,5- dihydroxyheptansäurederivaten und zwischenverbindungen diesesverfahrens und deren herestellung
|
JP2004533482A
(ja)
*
|
2001-07-06 |
2004-11-04 |
テバ ファーマシューティカル インダストリーズ リミティド |
6−シアノ−syn−3,5−ジヒドロキシ・ヘキサン酸誘導体による7−アミノ−syn−3,5−ジヒドロキシ・ヘプタン酸誘導体の製法
|
US7074818B2
(en)
*
|
2001-07-30 |
2006-07-11 |
Dr. Reddy's Laboratories Limited |
Crystalline forms VI and VII of Atorvastatin calcium
|
EE200400048A
(et)
|
2001-07-30 |
2004-04-15 |
Dr. Reddy's Laboratories Ltd. |
Atorvastatiinkaltsiumi kristalsed vormid VI ja VII
|
EP1572638A4
(de)
*
|
2001-08-31 |
2010-05-05 |
Morepen Lab Ltd |
Verbessertes verfahren zur herstellung von amorphem atorvastatin-calciumsalz (2:1)
|
CA2412012C
(en)
*
|
2001-11-20 |
2011-08-02 |
Ed. Geistlich Soehne Ag Fuer Chemische Industrie |
Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage
|
US20060020137A1
(en)
*
|
2001-11-29 |
2006-01-26 |
Limor Tessler |
Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
|
UA77990C2
(en)
*
|
2001-12-12 |
2007-02-15 |
|
Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
|
CZ296967B6
(cs)
|
2002-02-01 |
2006-08-16 |
Zentiva, A.S. |
Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
|
KR20090045419A
(ko)
*
|
2002-02-19 |
2009-05-07 |
테바 파마슈티컬 인더스트리즈 리미티드 |
아토르바스타틴 헤미-칼슘 용매화합물의 탈용매화
|
DE10212492B4
(de)
*
|
2002-03-21 |
2012-02-02 |
Daimler Ag |
Kolbenpumpe
|
EP1496982A4
(de)
*
|
2002-04-16 |
2006-07-19 |
Merck & Co Inc |
Feste formen von salzen mit tyrosinkinase-wirkung
|
AU2003251523A1
(en)
*
|
2002-06-13 |
2003-12-31 |
Diversa Corporation |
Processes for making (r)-ethyl 4-cyano-3-hydroxybutyric acid
|
US7078430B2
(en)
*
|
2002-07-08 |
2006-07-18 |
Ranbaxy Laboratories Limited |
HMG CoA-reductase inhibitors
|
US20060211761A1
(en)
*
|
2002-07-08 |
2006-09-21 |
Yatendra Kumar |
Hmg-coa-reductase inhibitors
|
CN100357289C
(zh)
*
|
2002-08-06 |
2007-12-26 |
沃尼尔·朗伯有限责任公司 |
制备5-(4-氟苯基)-1-[2-((2r,4r)-4-羟基-6-氧代-四氢-吡喃-2-基)乙基]-2-异丙基-4-苯基-1h-吡咯-3-羧酸苯基酰胺的方法
|
EP1562583A1
(de)
*
|
2002-09-03 |
2005-08-17 |
Morepen Laboratories Ltd. |
Atorvastatin kalzium form vi oder dessen hydrate
|
SI21302A
(sl)
*
|
2002-10-11 |
2004-04-30 |
LEK farmacevtska dru�ba d.d. |
Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino
|
HRP20020885B1
(en)
*
|
2002-11-11 |
2007-05-31 |
GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. |
SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
|
EP1424324A1
(de)
*
|
2002-11-28 |
2004-06-02 |
Teva Pharmaceutical Industries Limited |
Kristalline Form F von Atorvastatin
|
US20040198800A1
(en)
*
|
2002-12-19 |
2004-10-07 |
Geoffrey Allan |
Lipoxygenase inhibitors as hypolipidemic and anti-hypertensive agents
|
BR0317521A
(pt)
|
2002-12-20 |
2005-11-16 |
Pfizer Prod Inc |
Formas de dosagem compreendendo um inibidor da cetp e um inibidor da redutase hmg-coa
|
US20040132771A1
(en)
*
|
2002-12-20 |
2004-07-08 |
Pfizer Inc |
Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
|
HU227041B1
(en)
*
|
2003-03-24 |
2010-05-28 |
Richter Gedeon Nyrt |
Process for the synthesis of amorphous atorvastatin calcium
|
RS20050760A
(sr)
*
|
2003-04-14 |
2008-04-04 |
Warner-Lambert Company Llc., |
Postupak za izradu fenilamida 5-(4- fluorofenil)-1-(2-((2r, 4r)-4-hidroksi- 6-okso-tetrahidro-piran-2-il)etil)-2- izopropil-4-fenil-1h-pirol-3- karboksilne kiseline
|
US20050182125A1
(en)
*
|
2003-05-16 |
2005-08-18 |
Ambit Biosciences Corporation |
Pyrrole compounds and uses thereof
|
EP1626713A2
(de)
*
|
2003-05-16 |
2006-02-22 |
Ambit Biosciences Corporation |
Heterocyclische verbindungen und ihre verwendungen
|
US20040248972A1
(en)
*
|
2003-05-16 |
2004-12-09 |
Ambit Biosciences Corporation |
Compounds and uses thereof
|
US7790197B2
(en)
*
|
2003-06-09 |
2010-09-07 |
Warner-Lambert Company Llc |
Pharmaceutical compositions of atorvastatin
|
US7655692B2
(en)
|
2003-06-12 |
2010-02-02 |
Pfizer Inc. |
Process for forming amorphous atorvastatin
|
US20050271717A1
(en)
*
|
2003-06-12 |
2005-12-08 |
Alfred Berchielli |
Pharmaceutical compositions of atorvastatin
|
US20040253305A1
(en)
*
|
2003-06-12 |
2004-12-16 |
Luner Paul E. |
Pharmaceutical compositions of atorvastatin
|
EP1648866A1
(de)
*
|
2003-07-25 |
2006-04-26 |
Avecia Pharmaceuticals Limited |
Verfahren und zwischenprodukte, die sich für die herstellung von statinen, insbesondere atorvastatin, eignen
|
JP4553899B2
(ja)
|
2003-08-21 |
2010-09-29 |
メルク フロスト カナダ リミテツド |
カテプシンシステインプロテアーゼ阻害剤
|
CA2539158A1
(en)
*
|
2003-09-17 |
2005-03-24 |
Warner-Lambert Company Llc |
Crystalline forms of ['r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid
|
US8227434B1
(en)
|
2003-11-04 |
2012-07-24 |
H. Lee Moffitt Cancer Center & Research Institute, Inc. |
Materials and methods for treating oncological disorders
|
CN1882327A
(zh)
|
2003-11-19 |
2006-12-20 |
症变治疗公司 |
含磷的新的拟甲状腺素药
|
EP1691803A1
(de)
*
|
2003-12-05 |
2006-08-23 |
Warner-Lambert Company LLC |
N-alkyl-pyrrole als hmg-coa-reductase-hemmer
|
US20050152323A1
(en)
*
|
2004-01-12 |
2005-07-14 |
Vincent Bonnassieux |
Plug-in Wi-Fi access point device and system
|
CA2456430A1
(en)
*
|
2004-01-28 |
2005-07-28 |
Brantford Chemicals Inc. |
Improved process for the preparation of amorphous atorvastatin calcium
|
AU2004317570B2
(en)
|
2004-03-17 |
2011-01-06 |
Ranbaxy Laboratories Limited |
Process for the production of atorvastatin calcium in amorphous form
|
KR100829268B1
(ko)
*
|
2004-04-16 |
2008-05-13 |
화이자 프로덕츠 인코포레이티드 |
비정질 아토바스타틴 칼슘의 제조 방법
|
JP2007536373A
(ja)
*
|
2004-05-05 |
2007-12-13 |
ファイザー・プロダクツ・インク |
アトルバスタチンの塩形態
|
EP1771455B1
(de)
*
|
2004-07-16 |
2016-05-11 |
LEK Pharmaceuticals d.d. |
Oxidative abbauprodukte von atorvastatin-calcium
|
WO2006011041A2
(en)
|
2004-07-20 |
2006-02-02 |
Warner-Lambert Company Llc |
Crystalline forms of (r-(r*))-2-(4-fluorophenyl)-beta, gamma-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrole-1-hept anoic acid calcium salt (2:1)
|
CA2578722C
(en)
*
|
2004-08-27 |
2010-02-02 |
Biocon Limited |
Process for atorvastatin calcium amorphous
|
US7939675B2
(en)
|
2004-10-28 |
2011-05-10 |
Pfizer, Inc. |
Process for forming amorphous atorvastatin
|
US20090208539A1
(en)
*
|
2004-11-22 |
2009-08-20 |
Adel Penhasi |
Stable atorvastatin formulations
|
WO2006059224A1
(en)
*
|
2004-12-02 |
2006-06-08 |
Warner-Lambert Company Llc |
Pharmaceutical compositions of amorphous atorvastatin and process for preparing same
|
CA2590860C
(en)
|
2004-12-09 |
2011-05-03 |
Merck & Co., Inc. |
Estrogen receptor modulators
|
CA2498978A1
(en)
*
|
2005-02-28 |
2006-08-28 |
Apotex Pharmachem Inc. |
An improved process for the preparation of atorvastatin and intermediates
|
CA2499047A1
(en)
*
|
2005-03-01 |
2006-09-01 |
Apotex Pharmachem Inc. |
Process for producing atorvastatin hemicalcium
|
JP2008531691A
(ja)
|
2005-03-02 |
2008-08-14 |
メルク エンド カムパニー インコーポレーテッド |
カテプシンk阻害組成物
|
GB2424880A
(en)
*
|
2005-04-06 |
2006-10-11 |
Generics |
Crystalline forms of atorvastatin sodium, processes for their preparation and their use in inhibiting HMG-CoA reductase
|
CZ2007772A3
(cs)
*
|
2005-04-08 |
2008-02-27 |
EGIS GYOGYSZERGYÁR Nyilvánosan Müködö Részvénytársaság |
Nová krystalická polymorfní forma hemivápenaté soli atorvastatinu
|
WO2006123182A2
(en)
|
2005-05-17 |
2006-11-23 |
Merck Sharp & Dohme Limited |
Cyclohexyl sulphones for treatment of cancer
|
PE20070335A1
(es)
*
|
2005-08-30 |
2007-04-21 |
Novartis Ag |
Benzimidazoles sustituidos y metodos para su preparacion
|
US20090221839A1
(en)
*
|
2005-09-09 |
2009-09-03 |
Pfizer Inc. |
Preparation of an Atorvastatin Intermediate
|
JP2009507822A
(ja)
*
|
2005-09-09 |
2009-02-26 |
ファイザー・サイエンス・アンド・テクノロジー・アイルランド・リミテッド |
アトルバスタチン中間体の調製
|
US20090216029A1
(en)
*
|
2005-09-16 |
2009-08-27 |
Yatendra Kumar |
Process for the production of atorvastatin calcium in amorphous form
|
CA2547216A1
(en)
*
|
2005-09-21 |
2007-03-21 |
Renuka D. Reddy |
Process for annealing amorphous atorvastatin
|
ATE466840T1
(de)
|
2005-11-21 |
2010-05-15 |
Warner Lambert Co |
Neue formen von är-(r*,r*)ü-2-(4-fluorphenyl)-b,d-dihydroxy-5-( -methylethyl)-3-phenyl-4- ä(phenylamino)carbonylü-1h-pyrrol-1-heptansäure magnesium
|
BRPI0610344A2
(pt)
*
|
2005-12-13 |
2016-11-29 |
Teva Pharma |
forma cristalizada do atorvastatin hemi-calcium, processo para sua preparação, produto famacêutico derivado e seu uso medicinal
|
EP1810667A1
(de)
|
2006-01-20 |
2007-07-25 |
KRKA, tovarna zdravil, d.d., Novo mesto |
Pharmazeutische Zusammensetzung enthaltend amorphes Atorvastatin
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
CA2640573A1
(en)
*
|
2006-03-01 |
2007-09-13 |
Michael Pinchasov |
Process for preparing a crystalline form of atorvastatin hemi-calcium
|
PL2010528T3
(pl)
|
2006-04-19 |
2018-03-30 |
Novartis Ag |
6-0-podstawione związki benzoksazolowe i benzotiazolowe i sposoby hamowania sygnalizacji csf-1r
|
JP5489333B2
(ja)
|
2006-09-22 |
2014-05-14 |
メルク・シャープ・アンド・ドーム・コーポレーション |
脂肪酸合成阻害剤を用いた治療の方法
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
WO2008053312A2
(en)
*
|
2006-11-02 |
2008-05-08 |
Cadila Pharmaceuticals Limited |
Process for preparing amorphous atorvastatin hemi calcium salt and its intermediate
|
PL2336120T3
(pl)
|
2007-01-10 |
2014-12-31 |
Msd Italia Srl |
Kombinacje zawierające indazole podstawione grupą amidową jako inhibitory polimerazy poli(ADP-rybozy) (PARP)
|
US7834195B2
(en)
*
|
2007-01-24 |
2010-11-16 |
Apotex Pharmachem Inc. |
Atorvastatin calcium propylene glycol solvates
|
EP2115153B1
(de)
|
2007-03-01 |
2013-06-05 |
BP Corporation North America Inc. |
Nitrilasen, dafür kodierende nukleinsäuren sowie verfahren zu ihrer herstellung und verwendung
|
BRPI0808523A2
(pt)
|
2007-03-01 |
2014-08-19 |
Novartis Vaccines & Diagnostic |
Inibidores de pim cinase e métodos de seu uso
|
KR20100017866A
(ko)
|
2007-05-21 |
2010-02-16 |
노파르티스 아게 |
Csf-1r 억제제, 조성물 및 사용 방법
|
CA2690191C
(en)
|
2007-06-27 |
2015-07-28 |
Merck Sharp & Dohme Corp. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
WO2009013633A2
(en)
*
|
2007-07-20 |
2009-01-29 |
Actavis Group Ptc Ehf |
Amorphous coprecipitates of atorvastatin pharmaceutically acceptable salts
|
MX2010006972A
(es)
|
2007-12-21 |
2010-08-26 |
Ligand Pharm Inc |
Moduladores selectivos de receptores de andrógenos (sarm) y usos de los mismos.
|
EP2075246A1
(de)
|
2007-12-27 |
2009-07-01 |
M. J. Institute of Research |
Verfahren zur Herstellung einer amorphen Form von Atorvastatin-Hemicalcium-Salz
|
CN101429195B
(zh)
*
|
2008-11-03 |
2010-12-15 |
华东师范大学 |
一种高纯度阿托伐他汀重要合成中间体的制备方法
|
EP2373609B1
(de)
|
2008-12-19 |
2013-10-16 |
KRKA, D.D., Novo Mesto |
Verwendung amphiphiler verbindungen zur kontrollierten kristallisation von statinen und statinzwischenprodukten
|
EP2327682A1
(de)
|
2009-10-29 |
2011-06-01 |
KRKA, D.D., Novo Mesto |
Verwendung von amphiphilen Verbindungen zur gesteuerten Kristallisation von Statinen und Statin Zwischenprodukte.
|
US8115015B2
(en)
*
|
2009-01-26 |
2012-02-14 |
Cadila Healthcare Limited |
Process for the preparation of amorphous atorvastatin calcium
|
WO2010093601A1
(en)
|
2009-02-10 |
2010-08-19 |
Metabasis Therapeutics, Inc. |
Novel sulfonic acid-containing thyromimetics, and methods for their use
|
WO2010114780A1
(en)
|
2009-04-01 |
2010-10-07 |
Merck Sharp & Dohme Corp. |
Inhibitors of akt activity
|
US8470805B2
(en)
*
|
2009-04-30 |
2013-06-25 |
Kaohsiung Medical University |
Processes for preparing piperazinium salts of KMUP and use thereof
|
UA109417C2
(uk)
|
2009-10-14 |
2015-08-25 |
Мерк Шарп Енд Доме Корп. |
ЗАМІЩЕНІ ПІПЕРИДИНИ, ЯКІ ПІДВИЩУЮТЬ АКТИВНІСТЬ p53, І ЇХ ЗАСТОСУВАННЯ
|
US8999957B2
(en)
|
2010-06-24 |
2015-04-07 |
Merck Sharp & Dohme Corp. |
Heterocyclic compounds as ERK inhibitors
|
KR20120011249A
(ko)
|
2010-07-28 |
2012-02-07 |
주식회사 경보제약 |
아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
|
EP2601293B1
(de)
|
2010-08-02 |
2017-12-06 |
Sirna Therapeutics, Inc. |
Rna-interferenz-vermittelte hemmung der catenin (cadherin-assoziiertes protein)-beta-1 (ctnnb1)- genexpression mittels kurzer interferierender nukleinsäuren (sina)
|
WO2012024170A2
(en)
|
2010-08-17 |
2012-02-23 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US8883801B2
(en)
|
2010-08-23 |
2014-11-11 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
|
EP2613782B1
(de)
|
2010-09-01 |
2016-11-02 |
Merck Sharp & Dohme Corp. |
Indazolderivate als erk-hemmer
|
US9242981B2
(en)
|
2010-09-16 |
2016-01-26 |
Merck Sharp & Dohme Corp. |
Fused pyrazole derivatives as novel ERK inhibitors
|
EP3327125B1
(de)
|
2010-10-29 |
2020-08-05 |
Sirna Therapeutics, Inc. |
Rna-interferenz-vermittelte inhibition von genexpression unter verwendung kurzer interferierender nukleinsäure (sina)
|
TWI462739B
(zh)
|
2010-11-02 |
2014-12-01 |
Univ Kaohsiung Medical |
Sildenafil-同族物四級銨哌嗪鹽類之製備及醫療用途
|
US9351965B2
(en)
|
2010-12-21 |
2016-05-31 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as ERK inhibitors
|
EP2675440B1
(de)
|
2011-02-14 |
2020-03-25 |
Merck Sharp & Dohme Corp. |
Cathepsin-cysteinproteasehemmer
|
US20140045847A1
(en)
|
2011-04-21 |
2014-02-13 |
Piramal Enterprises Limited |
Crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
|
BRPI1101952B1
(pt)
*
|
2011-04-25 |
2022-02-01 |
Universidade Estadual De Campinas - Unicamp |
Processo de obtenção de atorvastatina cálcica utilizando novos intermediários e atorvastatina assim obtida
|
MX2013015272A
(es)
|
2011-07-01 |
2014-04-14 |
Dsm Sinochem Pharm Nl Bv |
Cristales micronizados.
|
US9023865B2
(en)
|
2011-10-27 |
2015-05-05 |
Merck Sharp & Dohme Corp. |
Compounds that are ERK inhibitors
|
DE102011119719A1
(de)
|
2011-11-30 |
2013-06-06 |
GEA CFS Bühl GmbH |
Verfahren zum Aufschneiden eines Lebensmittelriegels unter Verwendung eines Schwingungssensors
|
EP3453762B1
(de)
|
2012-05-02 |
2021-04-21 |
Sirna Therapeutics, Inc. |
Sina-zusammensetzungen
|
CA2882950A1
(en)
|
2012-09-28 |
2014-04-03 |
Merck Sharp & Dohme Corp. |
Novel compounds that are erk inhibitors
|
BR112015012295A8
(pt)
|
2012-11-28 |
2023-03-14 |
Merck Sharp & Dohme |
Uso de um inibidor de wee1, e, kit para identificar um paciente com câncer
|
CN105073746B
(zh)
|
2012-12-20 |
2017-03-22 |
默沙东公司 |
作为hdm2抑制剂的取代的咪唑并吡啶
|
WO2014120748A1
(en)
|
2013-01-30 |
2014-08-07 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as hdm2 inhibitors
|
WO2015034925A1
(en)
|
2013-09-03 |
2015-03-12 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
WO2015051479A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
JP6454335B2
(ja)
|
2013-10-08 |
2019-01-16 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
カテプシンシステインプロテアーゼ阻害剤
|
EP3094323A4
(de)
|
2014-01-17 |
2017-10-11 |
Ligand Pharmaceuticals Incorporated |
Verfahren und zusammensetzungen zur modulierung von hormonspiegeln
|
WO2015120580A1
(en)
|
2014-02-11 |
2015-08-20 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
JO3589B1
(ar)
|
2014-08-06 |
2020-07-05 |
Novartis Ag |
مثبطات كيناز البروتين c وطرق استخداماتها
|
CN105085497B
(zh)
*
|
2015-06-26 |
2017-12-26 |
上海应用技术学院 |
多取代吡咯类他汀含氟衍生物及其用途
|
EP3370703A4
(de)
|
2015-11-06 |
2019-06-19 |
Gemphire Therapeutics Inc. |
Gemcaben-kombinationen zur behandlung von herz-kreislauf-erkrankungen
|
EP3706742B1
(de)
|
2017-11-08 |
2023-03-15 |
Merck Sharp & Dohme LLC |
Prmt5-inhibitoren
|
CN108558726A
(zh)
*
|
2018-03-14 |
2018-09-21 |
湖北广济药业股份有限公司 |
一种高纯度阿托伐他汀钙的制备方法
|
EP3833667B1
(de)
|
2018-08-07 |
2024-03-13 |
Merck Sharp & Dohme LLC |
Prmt5-inhibitoren
|
EP3833668A4
(de)
|
2018-08-07 |
2022-05-11 |
Merck Sharp & Dohme Corp. |
Prmt5-inhibitoren
|
AU2020408148A1
(en)
|
2019-12-17 |
2022-06-16 |
Merck Sharp & Dohme Llc |
PRMT5 inhibitors
|
CN111362856B
(zh)
*
|
2020-04-29 |
2023-08-18 |
福建海西新药创制股份有限公司 |
一种利用微反应装置生产阿托伐他汀钙的方法
|
CN116102482A
(zh)
*
|
2022-08-17 |
2023-05-12 |
重庆普佑生物医药有限公司 |
一种阿托伐他汀钙的制备方法
|