DE69408677D1 - Nickelfreier hämoglobin und verfahren zu seiner herstellung - Google Patents

Nickelfreier hämoglobin und verfahren zu seiner herstellung

Info

Publication number
DE69408677D1
DE69408677D1 DE69408677T DE69408677T DE69408677D1 DE 69408677 D1 DE69408677 D1 DE 69408677D1 DE 69408677 T DE69408677 T DE 69408677T DE 69408677 T DE69408677 T DE 69408677T DE 69408677 D1 DE69408677 D1 DE 69408677D1
Authority
DE
Germany
Prior art keywords
nickel
hemoglobin
production
free hemoglobin
containing hemoglobin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69408677T
Other languages
English (en)
Other versions
DE69408677T2 (de
Inventor
Mark L Chivers
Thomas K Belval
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Biotech Technology SARL
Original Assignee
SOMATOGEN Inc BOULDER US
Somatogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SOMATOGEN Inc BOULDER US, Somatogen Inc filed Critical SOMATOGEN Inc BOULDER US
Publication of DE69408677D1 publication Critical patent/DE69408677D1/de
Application granted granted Critical
Publication of DE69408677T2 publication Critical patent/DE69408677T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69408677T 1993-07-23 1994-07-22 Nickelfreier hämoglobin und verfahren zu seiner herstellung Expired - Fee Related DE69408677T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/097,273 US5578564A (en) 1993-07-23 1993-07-23 Nickel-free hemoglobin and methods for producing such hemoglobin
PCT/IB1994/000225 WO1995003322A1 (en) 1993-07-23 1994-07-22 Nickel-free hemoglobin and methods for producing such hemoglobin

Publications (2)

Publication Number Publication Date
DE69408677D1 true DE69408677D1 (de) 1998-04-02
DE69408677T2 DE69408677T2 (de) 1998-10-01

Family

ID=22262566

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69408677T Expired - Fee Related DE69408677T2 (de) 1993-07-23 1994-07-22 Nickelfreier hämoglobin und verfahren zu seiner herstellung

Country Status (11)

Country Link
US (1) US5578564A (de)
EP (1) EP0711304B1 (de)
JP (1) JPH09500639A (de)
AT (1) ATE163427T1 (de)
AU (1) AU696624B2 (de)
CA (1) CA2166616A1 (de)
DE (1) DE69408677T2 (de)
FI (1) FI960301A (de)
IS (1) IS4192A (de)
NO (1) NO960257L (de)
WO (1) WO1995003322A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150507A (en) * 1995-03-23 2000-11-21 Biopure Corporation Method for producing a purified hemoglobin product
JP2000516455A (ja) 1996-08-02 2000-12-12 バクスター バイオテック テクノロジー エス．アー．エール．エル． ヘモグロビンにおけるβダイマー形成を制御する方法
AU4652797A (en) 1996-09-27 1998-04-17 Board Of Trustees Of The University Of Illinois, The Oxygen-binding heme proteins incorporating circularly-permuted globins
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
US6054427A (en) * 1997-02-28 2000-04-25 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
US6508832B1 (en) * 1999-12-09 2003-01-21 Advanced Cardiovascular Systems, Inc. Implantable nickel-free stainless steel stents and method of making the same
US20030153491A1 (en) * 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20050164915A1 (en) * 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2449885C3 (de) * 1974-10-21 1980-04-30 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat
DE2740053A1 (de) * 1977-09-06 1979-05-03 Klaus Prof Dr Med Gersonde Verwendung von allosterischen effektoren mit hilfe von lipidvesikeln ueber eine irreversible inkorporierung zwecks verbesserter o tief 2 -entladung des haemoglobins in erythrozyten
JPS6023084B2 (ja) * 1979-07-11 1985-06-05 味の素株式会社 代用血液
JPS5716815A (en) * 1980-07-02 1982-01-28 Ajinomoto Co Inc Oxygen transporting agent for artificial blood
JPS57206622A (en) * 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
EP0073888B1 (de) * 1981-06-29 1986-04-23 Clara M. Ambrus Vorrichtung zur Entfernung von Schwermetall-Ionen aus Blut
GB8328917D0 (en) * 1983-10-28 1983-11-30 Fisons Plc Blood substitute
US4831012A (en) * 1984-03-23 1989-05-16 Baxter International Inc. Purified hemoglobin solutions and method for making same
US4600531A (en) * 1984-06-27 1986-07-15 University Of Iowa Research Foundation Production of alpha-alpha cross-linked hemoglobins in high yield
US4598064A (en) * 1984-06-27 1986-07-01 University Of Iowa Research Foundation Alpha-alpha cross-linked hemoglobins
DE3675588D1 (de) * 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
CA1244349A (en) * 1985-06-26 1988-11-08 Jen-Chang Hsia Purification of hemoglobin and modified hemoglobin by affinity chromatography
US5194590A (en) * 1986-06-20 1993-03-16 Northfield Laboratories, Inc. Acellular red blood cell substitute
US5084558A (en) * 1987-10-13 1992-01-28 Biopure Corporation Extra pure semi-synthetic blood substitute
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
GB8710598D0 (en) * 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
US4861867A (en) * 1988-02-03 1989-08-29 Baxter International, Inc. Purified hemoglobin solutions and method for making same
US4952684A (en) * 1988-06-02 1990-08-28 Domtar Inc. Processes for the preparation of amides and amines from a material having carboxyl-containing polysaccharides and products therefrom
US5061688A (en) * 1988-08-19 1991-10-29 Illinois Institute Of Technology Hemoglobin multiple emulsion
SE500110C2 (sv) * 1989-06-27 1994-04-18 Kabi Pharmacia Ab Sätt att rena ett protein från därtill bundna flervärda metalljoner
DE69132763D1 (de) * 1990-12-20 2001-11-15 Univ Alabama Res Foundation Bi Transgenes, vernetztes hämoglobin

Also Published As

Publication number Publication date
WO1995003322A1 (en) 1995-02-02
EP0711304B1 (de) 1998-02-25
AU7131394A (en) 1995-02-20
NO960257D0 (no) 1996-01-22
AU696624B2 (en) 1998-09-17
JPH09500639A (ja) 1997-01-21
NO960257L (no) 1996-01-23
CA2166616A1 (en) 1995-02-02
DE69408677T2 (de) 1998-10-01
ATE163427T1 (de) 1998-03-15
FI960301A (fi) 1996-03-22
IS4192A (is) 1995-01-24
FI960301A0 (fi) 1996-01-22
EP0711304A1 (de) 1996-05-15
US5578564A (en) 1996-11-26

Similar Documents

Publication Publication Date Title
ATE20051T1 (de) Amidinderivate, verfahren zu ihrer herstellung und diese enthaltende antikomplement-mittel.
DE69206386T2 (de) Verfahren zur Herstellung von Kernen für den Feinguss.
DE69814317D1 (de) Verfahren für die Reduzierung von Klärschlamm aus den aeroben Abwasserkläranlagen
DE69931753D1 (de) Azoverbindungen sowie verfahren zur herstellung derselben
ATE268749T1 (de) Verfahren zur herstellung von iopamidol
DE69408677T2 (de) Nickelfreier hämoglobin und verfahren zu seiner herstellung
ATE266030T1 (de) 1,4,7,10-tetraazabicyclo(8.2.2)tetradecan-2-on, verfahren zu ihrer herstellung und ihrer verwendung für die herstellung von tetraazamacrocyclen
DK1301526T3 (da) Fremgangsmåde til oxidation til fremstilling af mellemproduktet 6.alpha.,9alpha.-difluor-11.beta.,17.alpha.-dihydroxy-16.alpha.-methyl-androst-1,4-dien-3-on 17.beta-carboxylsyre
DE69403210T3 (de) Verfahren zur herstellung von n-acetylneuraminsäure
DE60202203D1 (de) Neues verfahren zur herstellung von oxabispidinen
ATE174601T1 (de) Verfahren zur herstellung von bisnoraldehyden aus bisnoralkohol
ATE93863T1 (de) Enzym-hemmende aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung.
DE60308066D1 (de) Verfahren zur herstellung von hyperpolarisiertem 129xe
ATE302749T1 (de) Verfahren zur herstellung von 5-aminosalicylsäure
ATE31928T1 (de) Acylamino-4-aza-1-adamantane, verfahren zu ihrer herstellung und ihre anwendung in der therapeutik.
DE50107440D1 (de) Modifizierter polymerer formkörper, verfahren zu seiner herstellung und seine verwendung
ATE94210T1 (de) Verfahren zur herstellung von glyoxylsaeure durch enzymatische oxydation von glykolsaeure.
DE69926223D1 (de) Verfahren zur herstellung von zwischenprodukten
DE50112449D1 (de) Verfahren zur herstellung von 3,3-diarylpropylaminen
DE69801115T2 (de) Verfahren zur reinigung von wasser mittels einer membranfiltrationseinheit und verwendung einer spüleinheit zum erzeugen von anaerobischen bedingungen
ATE244706T1 (de) Enantiomere von mercaptolactonen und verfahren zu ihrer herstellung
ATE161853T1 (de) Verfahren zur herstellung einer wässrigen aminoxidlösung
DE50000755D1 (de) Verfahren zur herstellung von 4,4- dimethyl -3beta- hydroxypregna -8,14-dien-21- carbonsäureestern und zwischenprodukte im verfahren
ATE317842T1 (de) Verfahren zur herstellung von 2-halo-6- nitrobenzoesäuren
ATE23340T1 (de) 3-alkylthio-2-0-carbamoylpropan-1,2-diol-1-0phosphocholine und verfahren zu ihrer herstellung.

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: BAXTER BIOTECH TECHNOLOGY S.A.R.L., NEUCHATEL, CH

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee