DE69412610T2 - Emulsionen als kontrastmittel und deren verwendung - Google Patents

Emulsionen als kontrastmittel und deren verwendung

Info

Publication number
DE69412610T2
DE69412610T2 DE69412610T DE69412610T DE69412610T2 DE 69412610 T2 DE69412610 T2 DE 69412610T2 DE 69412610 T DE69412610 T DE 69412610T DE 69412610 T DE69412610 T DE 69412610T DE 69412610 T2 DE69412610 T2 DE 69412610T2
Authority
DE
Germany
Prior art keywords
emulsions
contrast agents
image
application
ultrasonic energy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69412610T
Other languages
English (en)
Other versions
DE69412610D1 (de
Inventor
Rolf Lohrmann
Kenneth Widder
Ashwin Krishnan
Dung Hong
Jialun Meng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Biosystems Inc
Original Assignee
Molecular Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22108224&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69412610(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Molecular Biosystems Inc filed Critical Molecular Biosystems Inc
Application granted granted Critical
Publication of DE69412610D1 publication Critical patent/DE69412610D1/de
Publication of DE69412610T2 publication Critical patent/DE69412610T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/226Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924Significant dispersive or manipulative operation or step in making or stabilizing colloid system
    • Y10S516/929Specified combination of agitation steps, e.g. mixing to make subcombination composition followed by homogenization
DE69412610T 1993-06-04 1994-05-26 Emulsionen als kontrastmittel und deren verwendung Expired - Fee Related DE69412610T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/072,535 US5716597A (en) 1993-06-04 1993-06-04 Emulsions as contrast agents and method of use
PCT/US1994/005965 WO1994028939A1 (en) 1993-06-04 1994-05-26 Emulsions as contrast agents and method of use

Publications (2)

Publication Number Publication Date
DE69412610D1 DE69412610D1 (de) 1998-09-24
DE69412610T2 true DE69412610T2 (de) 1999-01-14

Family

ID=22108224

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69412610T Expired - Fee Related DE69412610T2 (de) 1993-06-04 1994-05-26 Emulsionen als kontrastmittel und deren verwendung

Country Status (10)

Country Link
US (3) US5716597A (de)
EP (2) EP0701451B1 (de)
JP (2) JP3016592B2 (de)
AT (1) ATE169828T1 (de)
CA (1) CA2164410C (de)
DE (1) DE69412610T2 (de)
DK (1) DK0701451T3 (de)
ES (1) ES2120053T3 (de)
GR (1) GR3027727T3 (de)
WO (1) WO1994028939A1 (de)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5773024A (en) 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5705187A (en) 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US20020150539A1 (en) * 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5305757A (en) 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IN172208B (de) * 1990-04-02 1993-05-01 Sint Sa
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
US6875420B1 (en) 1991-09-17 2005-04-05 Amersham Health As Method of ultrasound imaging
MX9205298A (es) 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
HUT72323A (en) * 1993-01-25 1996-04-29 Sonus Pharma Inc Phase shift colloids as ultrasound contrast agents
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
DE69434119T3 (de) * 1993-07-30 2011-05-05 Imcor Pharmaceutical Co., San Diego Stabilisierte mikrogasbläschen-zusammensetzungen für echographie
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
AU679295B2 (en) * 1993-12-15 1997-06-26 Bracco Suisse S.A. Gas mixtures useful as ultrasound contrast media
US5736121A (en) 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
WO1998053855A1 (en) 1997-05-30 1998-12-03 Alliance Pharmaceutical Corp. Methods and apparatus for monitoring and quantifying the movement of fluid
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6521211B1 (en) * 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5897851A (en) * 1995-06-07 1999-04-27 Sonus Pharmaceuticals, Inc. Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
US6821506B2 (en) 1995-06-08 2004-11-23 Barnes-Jewish Hospital Site specific binding system, imaging compositions and methods
US6548046B1 (en) * 1995-06-08 2003-04-15 Barnes-Jewish Hospital Site specific binding system, imaging compositions and methods
JPH0924269A (ja) * 1995-07-10 1997-01-28 M Technic Kk リン脂質を使ったマイクロカプセルの製造方法
US5840276A (en) * 1996-01-11 1998-11-24 Apfel Enterprises, Inc. Activatable infusable dispersions containing drops of a superheated liquid for methods of therapy and diagnosis
WO1997040679A1 (en) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
CA2263568C (en) 1996-09-11 2008-12-02 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a contrast agent and a renal vasodilator
JP2001502349A (ja) * 1996-10-21 2001-02-20 ニユコメド・イメージング・アクシエセルカペト 造影剤におけるまたはこれに関する改良
GB9622711D0 (en) 1996-10-31 1997-01-08 British Tech Group Instrument having enhanced ultrasound visibility
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US20050019266A1 (en) * 1997-05-06 2005-01-27 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US20030032879A1 (en) * 1997-07-07 2003-02-13 Steven Quay Microbubble formation using ultrasound
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
GB9726773D0 (en) 1997-12-18 1998-02-18 Nycomed Imaging As Improvements in or relating to ultrasonagraphy
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US6171245B1 (en) * 1998-03-12 2001-01-09 Siemens Medical Systems, Inc. Method of imaging scatterers based on acoustically stimulated changes of their acoustic properties
US20040131547A1 (en) * 1998-04-22 2004-07-08 Balin Balinov Contrast agents
GB9808599D0 (en) * 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or realting to contrast agents
US7686763B2 (en) * 1998-09-18 2010-03-30 University Of Washington Use of contrast agents to increase the effectiveness of high intensity focused ultrasound therapy
US6444192B1 (en) 1999-02-05 2002-09-03 The Regents Of The University Of California Diagnostic imaging of lymph structures
FR2795633A1 (fr) * 1999-06-30 2001-01-05 Oreal Utilisation dans une composition cosmetique demaquillante ou nettoyante d'au moins un compose fluore volatil
US7510536B2 (en) * 1999-09-17 2009-03-31 University Of Washington Ultrasound guided high intensity focused ultrasound treatment of nerves
US7520856B2 (en) * 1999-09-17 2009-04-21 University Of Washington Image guided high intensity focused ultrasound device for therapy in obstetrics and gynecology
US7220401B2 (en) * 1999-09-24 2007-05-22 Barnes-Jewish Hospital Blood clot-targeted nanoparticles
CA2387127A1 (en) 1999-10-25 2001-05-17 Therus Corporation Use of focused ultrasound for vascular sealing
US6626855B1 (en) 1999-11-26 2003-09-30 Therus Corpoation Controlled high efficiency lesion formation using high intensity ultrasound
US7179449B2 (en) 2001-01-30 2007-02-20 Barnes-Jewish Hospital Enhanced ultrasound detection with temperature-dependent contrast agents
DE10119522A1 (de) * 2001-04-20 2002-12-05 Innovacell Biotechnologie Gmbh Herstellung und Anwendung einer Suspensionszusammensetzung mit einem Ultraschall-Kontrastmittel
JP2006505498A (ja) * 2002-04-03 2006-02-16 シー,ジャッキー アール. 病変組織の超音波イメージング及び処置方法
US7357937B2 (en) * 2002-09-24 2008-04-15 Therox, Inc. Perfluorocarbon emulsions with non-fluorinated surfactants
US20060046975A1 (en) * 2002-12-10 2006-03-02 Ola Carlsson Method for preparing a medical solution for the manufacture of a medicament for peritoneal dialysis
US20110040171A1 (en) * 2003-12-16 2011-02-17 University Of Washington Image guided high intensity focused ultrasound treatment of nerves
US20060033072A1 (en) * 2004-04-16 2006-02-16 Honeywell International Inc. Stabilized trifluoroiodomethane compositions
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US9066679B2 (en) 2004-08-31 2015-06-30 University Of Washington Ultrasonic technique for assessing wall vibrations in stenosed blood vessels
CA2575687A1 (en) * 2004-09-16 2006-03-23 University Of Washington Acoustic coupler using an independent water pillow with circulation for cooling a transducer
US8323620B2 (en) * 2004-10-22 2012-12-04 Hitachi Medical Corporation Ultrasound contrast agent
CN100574809C (zh) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用氟碳乳剂类助剂及其应用
CN100574811C (zh) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用微粒类助剂及其应用
JP4630127B2 (ja) * 2005-05-17 2011-02-09 株式会社日立製作所 超音波診断治療装置
EP1921976A2 (de) * 2005-08-12 2008-05-21 University of Washington Verfahren und gerät zur vorbereitung von organen und geweben für eine laparoskopische operation
US8414494B2 (en) * 2005-09-16 2013-04-09 University Of Washington Thin-profile therapeutic ultrasound applicators
US8016757B2 (en) * 2005-09-30 2011-09-13 University Of Washington Non-invasive temperature estimation technique for HIFU therapy monitoring using backscattered ultrasound
US20070233185A1 (en) 2005-10-20 2007-10-04 Thomas Anderson Systems and methods for sealing a vascular opening
AU2007244705A1 (en) * 2006-04-27 2007-11-08 Barnes-Jewish Hospital Detection and imaging of target tissue
JP5162923B2 (ja) * 2007-02-27 2013-03-13 株式会社日立製作所 超音波撮像装置
JP5124185B2 (ja) * 2007-07-02 2013-01-23 株式会社日立製作所 診断又は治療用薬剤の調製方法及び装置
US9000053B2 (en) * 2008-06-17 2015-04-07 The Regents Of The University Of California Process and system for reducing sizes of emulsion droplets and emulsions having reduced droplet sizes
US20100160781A1 (en) * 2008-12-09 2010-06-24 University Of Washington Doppler and image guided device for negative feedback phased array hifu treatment of vascularized lesions
US8469904B2 (en) 2009-10-12 2013-06-25 Kona Medical, Inc. Energetic modulation of nerves
US20110092880A1 (en) 2009-10-12 2011-04-21 Michael Gertner Energetic modulation of nerves
US20110118600A1 (en) 2009-11-16 2011-05-19 Michael Gertner External Autonomic Modulation
US8295912B2 (en) 2009-10-12 2012-10-23 Kona Medical, Inc. Method and system to inhibit a function of a nerve traveling with an artery
US8986231B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US20160059044A1 (en) 2009-10-12 2016-03-03 Kona Medical, Inc. Energy delivery to intraparenchymal regions of the kidney to treat hypertension
US8517962B2 (en) 2009-10-12 2013-08-27 Kona Medical, Inc. Energetic modulation of nerves
US9174065B2 (en) 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
US8986211B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US9119951B2 (en) 2009-10-12 2015-09-01 Kona Medical, Inc. Energetic modulation of nerves
US9427410B2 (en) 2010-10-08 2016-08-30 The University Of North Carolina At Chapel Hill Formulation of acoustically activatable particles having low vaporization energy and methods for using same
US20140046181A1 (en) * 2011-01-05 2014-02-13 The Regents Of The University Of California Acoustically responsive particles with decreased cavitation threshold
EP2744771B1 (de) * 2011-08-19 2020-10-21 The Trustees of Princeton University Herstellung einer c-halogen-bindung
WO2014055832A1 (en) 2012-10-04 2014-04-10 The University Of North Carolina At Chapel Hill Methods and systems for using encapsulated microbubbles to process biological samples
US10925579B2 (en) 2014-11-05 2021-02-23 Otsuka Medical Devices Co., Ltd. Systems and methods for real-time tracking of a target tissue using imaging before and during therapy delivery
CN109983111B (zh) * 2016-11-24 2021-01-19 松下知识产权经营株式会社 微细气泡生成促进剂、含微细气泡的液体、含微细气泡的液体的制造方法及制造装置
CN116650678A (zh) * 2017-07-07 2023-08-29 德雷克塞尔大学 电压活化的治疗、诊断和/或诊疗构建体
WO2019183637A1 (en) * 2018-03-23 2019-09-26 University Of Washington Immunosuppressive materials and related methods
US20220080243A1 (en) * 2020-09-11 2022-03-17 Honeywell International Inc. Azeotrope or azeotrope-like compositions of trifluoroiodomethane (cf3i) and water
JP2022064317A (ja) * 2020-10-13 2022-04-25 トスレック株式会社 Ufb水溶液生成装置、ufb水溶液生成方法および水溶液

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3778381A (en) * 1972-04-24 1973-12-11 Allied Chem Fluorocarbon microemulsions
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4622219A (en) * 1983-06-17 1986-11-11 Haynes Duncan H Method of inducing local anesthesia using microdroplets of a general anesthetic
US4725442A (en) * 1983-06-17 1988-02-16 Haynes Duncan H Microdroplets of water-insoluble drugs and injectable formulations containing same
US4900540A (en) * 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
US5219538A (en) * 1987-03-13 1993-06-15 Micro-Pak, Inc. Gas and oxygen carrying lipid vesicles
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
IE66912B1 (en) * 1988-02-05 1996-02-07 Schering Ag Ultrasonic contrast agents process for their preparation and their use as diagnostic and therapeutic agents
US4996041A (en) * 1988-08-19 1991-02-26 Toshiyuki Arai Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system
US4993415A (en) * 1988-08-19 1991-02-19 Alliance Pharmaceutical Corp. Magnetic resonance imaging with perfluorocarbon hydrides
DE3828905A1 (de) * 1988-08-23 1990-03-15 Schering Ag Mittel bestehend aus cavitate oder clathrate bildenden wirt/gast-komplexen als kontrastmittel
US4957656A (en) * 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
US5234680A (en) * 1989-07-31 1993-08-10 Johns Hopkins Univ. Perfluoro-t-butyl-containing compounds for use in fluorine-19 NMR and/or MRI
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
IN172208B (de) * 1990-04-02 1993-05-01 Sint Sa
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
EP0504340B1 (de) * 1990-10-05 1995-06-21 BRACCO International B.V. Verfahren zur herstellung von stabilen suspensionen von hohlen mit gasgefüllten mikrosphären zur verwendung in ultraschallechographie
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
ES2145011T5 (es) * 1991-09-17 2008-02-01 Ge Healthcare As Medios de contraste gaseoso para ecografias.
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
DK0660724T3 (da) * 1992-09-16 1998-11-02 Nycomed Imaging As Forberinger vedrørende kontrastmidler
HUT72323A (en) * 1993-01-25 1996-04-29 Sonus Pharma Inc Phase shift colloids as ultrasound contrast agents
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
GB9305349D0 (en) * 1993-03-16 1993-05-05 Nycomed Imaging As Improvements in or relating to contrast agents

Also Published As

Publication number Publication date
EP0852145A3 (de) 2000-07-05
ATE169828T1 (de) 1998-09-15
EP0701451A1 (de) 1996-03-20
WO1994028939A1 (en) 1994-12-22
US6030603A (en) 2000-02-29
DK0701451T3 (da) 1998-12-14
JPH11193247A (ja) 1999-07-21
EP0701451B1 (de) 1998-08-19
GR3027727T3 (en) 1998-11-30
JPH08509984A (ja) 1996-10-22
US5716597A (en) 1998-02-10
JP3016592B2 (ja) 2000-03-06
EP0852145A2 (de) 1998-07-08
US5536489A (en) 1996-07-16
CA2164410C (en) 2000-02-22
ES2120053T3 (es) 1998-10-16
DE69412610D1 (de) 1998-09-24

Similar Documents

Publication Publication Date Title
DE69412610T2 (de) Emulsionen als kontrastmittel und deren verwendung
MY112403A (en) Viscous surfactant emulsion compositions.
DK0630286T3 (da) Farmaceutiske eller kosmetiske olie-i-vand-emulsioner af positivt ladede partikler
DE59914308D1 (de) Emulgatorfreie feindisperse Systeme vom Type Öl-in-Wasser und Wasser-in-Öl
ES2106472T3 (es) Procedimiento para la preparacion de esferulas.
DE59611239D1 (de) Kosmetische und dermatologische Lichtschutzformulierungen in Form von Emulsionen
DE60001345T2 (de) Mindestens ein unlösliches organisches UV-Filter und ein assoziatives Polymer enthaltende Emulsionen
ZA862250B (en) Method for the control of dust using methacrylate containing emulsions and compositions
WO2003082356A3 (en) Fragrance containing emulsions
DE69615153T2 (de) Absorbierendes schaummaterial hergestellt in wasser in öl emulsion brauchbar zurgewinnung und abgabe von wässrigen flüssigkeiten
DE68900185D1 (de) Verfahren und vorrichtung zum vernichten von chemisch stabilen abfaellen.
MY114828A (en) High spf perpiration-resistant sunscreen
ES2025064B3 (es) Mezclas preservadoras.
EP1367456A3 (de) Bilderzeugungsgerät
PL320655A1 (en) Method of producng water-in-oil emulsions
ATE388168T1 (de) Antikörper gegen den il-8 rezeptor und deren therapeutische verwendungen
FR2786691B1 (fr) Composition sous forme d'emulsion e/h a forte teneur en cire et ses utilisations dans les domaines cosmetiques et dermatologique
ATE352279T1 (de) Sonnenschutzmilch
DE69625847T2 (de) Kolloidale Dispersionen von flüssigem Persäure-Ausgangsmaterial: Öl-Kern-Vesikel
ATE257508T1 (de) Emulsion von heterogene fettabfallstoffe enthaltende brennstoffzusammensetzung und verfajren zu deren herstellung
PL339905A1 (en) Method of smoke-curing small solid particles or drops of liquid dispersed, emulsified or suspended in a liquid medium
Peremans et al. A biologically inspired sonarhead
NZ510481A (en) Explosive composition comprising a discontinuous oxidiser phase dispersed throughout a continuous fuel phase
Welch et al. Ecological Assessment
Warner Municipal Solid Waste Landfills

Legal Events

Date Code Title Description
8363 Opposition against the patent
8339 Ceased/non-payment of the annual fee