DE69418613T2 - Hydroxy-substituierte azetidinonderivate als hypocholesterolemische mittel - Google Patents
Hydroxy-substituierte azetidinonderivate als hypocholesterolemische mittelInfo
- Publication number
- DE69418613T2 DE69418613T2 DE69418613T DE69418613T DE69418613T2 DE 69418613 T2 DE69418613 T2 DE 69418613T2 DE 69418613 T DE69418613 T DE 69418613T DE 69418613 T DE69418613 T DE 69418613T DE 69418613 T2 DE69418613 T2 DE 69418613T2
- Authority
- DE
- Germany
- Prior art keywords
- aryl
- alkyl
- substd
- hydroxy
- coor6
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10244093A | 1993-09-21 | 1993-09-21 | |
US08/257,593 US5631365A (en) | 1993-09-21 | 1994-06-09 | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
PCT/US1994/010099 WO1995008532A1 (en) | 1993-09-21 | 1994-09-14 | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69418613D1 DE69418613D1 (de) | 1999-06-24 |
DE69418613T2 true DE69418613T2 (de) | 1999-09-30 |
Family
ID=26799377
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69418613T Expired - Lifetime DE69418613T2 (de) | 1993-09-21 | 1994-09-14 | Hydroxy-substituierte azetidinonderivate als hypocholesterolemische mittel |
DE2003199001 Active DE10399001I2 (de) | 1993-09-21 | 1994-09-14 | Hydroxy-substituierte azetidinonderivate als hypocholesterolemische Mittel |
DE200412000026 Active DE122004000026I2 (de) | 1993-09-21 | 1994-09-14 | Hydroxy-substituierte Azetidinonderivate als hypocholesterolemische Mittel. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2003199001 Active DE10399001I2 (de) | 1993-09-21 | 1994-09-14 | Hydroxy-substituierte azetidinonderivate als hypocholesterolemische Mittel |
DE200412000026 Active DE122004000026I2 (de) | 1993-09-21 | 1994-09-14 | Hydroxy-substituierte Azetidinonderivate als hypocholesterolemische Mittel. |
Country Status (35)
Country | Link |
---|---|
US (5) | US5631365A (de) |
EP (1) | EP0720599B1 (de) |
JP (1) | JP2803908B2 (de) |
KR (1) | KR100186853B1 (de) |
CN (1) | CN1050830C (de) |
AT (1) | ATE180249T1 (de) |
AU (1) | AU681445C (de) |
BE (1) | BE2014C056I2 (de) |
BR (1) | BR1100159A (de) |
CA (1) | CA2172149C (de) |
CZ (2) | CZ288861B6 (de) |
DE (3) | DE69418613T2 (de) |
DK (1) | DK0720599T3 (de) |
ES (1) | ES2132432T3 (de) |
FI (1) | FI110321B (de) |
FR (1) | FR05C0040I2 (de) |
GE (1) | GEP20043149B (de) |
GR (1) | GR3030312T3 (de) |
HU (1) | HU221185B1 (de) |
IL (1) | IL110956A (de) |
LU (4) | LU91050I2 (de) |
MA (1) | MA23332A1 (de) |
MY (1) | MY111314A (de) |
NL (2) | NL300132I2 (de) |
NO (6) | NO305902B1 (de) |
NZ (1) | NZ274041A (de) |
PL (1) | PL182617B1 (de) |
RU (1) | RU2138480C1 (de) |
SG (1) | SG46208A1 (de) |
SK (1) | SK281067B6 (de) |
TN (1) | TNSN94094A1 (de) |
TW (1) | TW427974B (de) |
UA (1) | UA41948C2 (de) |
WO (1) | WO1995008532A1 (de) |
ZA (1) | ZA947086B (de) |
Families Citing this family (243)
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WO1995035277A1 (en) * | 1994-06-20 | 1995-12-28 | Schering Corporation | Substituted azetidinone compounds useful as hypocholesterolemic agents |
US6262277B1 (en) * | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
US5633246A (en) * | 1994-11-18 | 1997-05-27 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5624920A (en) * | 1994-11-18 | 1997-04-29 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
AU7361796A (en) * | 1995-09-27 | 1997-04-17 | Schering Corporation | Stereoselective microbial reduction process |
EP0766962A3 (de) * | 1995-10-03 | 2000-05-10 | Beiersdorf-Lilly GmbH | Behandlung der Atherosclerose |
US5843938A (en) * | 1995-10-03 | 1998-12-01 | Beiersdorf-Lilly Gmbh | Treatment of atherosclerosis |
AR004701A1 (es) * | 1995-10-31 | 1999-03-10 | Schering Corp | 2-azetidinonas substituidas con azucares utiles como agentes hipocolesterolemicos, composicion farmaceutica, proceso para la preparacion dedicha composicion, uso de dichos compuestos para fabricar medicamentos y un equipo. |
WO1997016424A1 (en) * | 1995-11-02 | 1997-05-09 | Schering Corporation | Process for preparing 1-(4-fluorophenyl)-3(r)-(3(s)-hydroxy-3-([phenyl or 4-fluorophenyl])-propyl)-4(s)-(4-hydroxyphenyl)-2-azetidinone |
AU1977997A (en) | 1996-02-23 | 1997-09-10 | Eli Lilly And Company | Non-peptidyl vasopressin v1a antagonists |
US5739321A (en) * | 1996-05-31 | 1998-04-14 | Schering Corporation | 3-hydroxy γ-lactone based enantionselective synthesis of azetidinones |
US5886171A (en) * | 1996-05-31 | 1999-03-23 | Schering Corporation | 3-hydroxy gamma-lactone based enantioselective synthesis of azetidinones |
US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
FR2762336B1 (fr) * | 1997-04-21 | 1999-06-11 | Francois Trantoul | Procede de fabrication d'un film a motif non reproductible par lecture optique pour la protection de documents |
US6133001A (en) * | 1998-02-23 | 2000-10-17 | Schering Corporation | Stereoselective microbial reduction for the preparation of 1-(4-fluorophenyl)-3(R)-[3(S)-Hydroxy-3-(4-fluorophenyl)propyl)]-4(S)-(4 -hydroxyphenyl)-2-azetidinone |
US5919672A (en) * | 1998-10-02 | 1999-07-06 | Schering Corporation | Resolution of trans-2-(alkoxycarbonylethyl)-lactams useful in the synthesis of 1-(4-fluoro-phenyl)-3(R)- (S)-hydroxy-3-(4-fluorophenyl)-propyl!-4(S)-(4-hydroxyphenyl)-2-azetidinone |
US6207822B1 (en) | 1998-12-07 | 2001-03-27 | Schering Corporation | Process for the synthesis of azetidinones |
WO2000034240A1 (en) * | 1998-12-07 | 2000-06-15 | Schering Corporation | Process for the synthesis of azetidinones |
EA009466B1 (ru) | 1998-12-23 | 2007-12-28 | Джи.Ди. Сирл Ллс | Ингибитор белка, переносящего эфир холестерила |
JP2002533411A (ja) * | 1998-12-23 | 2002-10-08 | ジー.ディー.サール エルエルシー | 心臓血管に適用するための組み合わせ |
EP1140184B1 (de) * | 1998-12-23 | 2003-06-04 | G.D. Searle LLC. | Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen |
DE69907960T2 (de) | 1998-12-23 | 2004-02-26 | G.D. Searle Llc, Chicago | Kombinationen von ileumgallensäuretransports inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen |
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