DE69418639D1 - Sulfonat- und Carbamatderivate von 3-aroyl-benzo(beta)Thiophenen - Google Patents

Sulfonat- und Carbamatderivate von 3-aroyl-benzo(beta)Thiophenen

Info

Publication number
DE69418639D1
DE69418639D1 DE69418639T DE69418639T DE69418639D1 DE 69418639 D1 DE69418639 D1 DE 69418639D1 DE 69418639 T DE69418639 T DE 69418639T DE 69418639 T DE69418639 T DE 69418639T DE 69418639 D1 DE69418639 D1 DE 69418639D1
Authority
DE
Germany
Prior art keywords
thiophenes
sulfonate
carbamate derivatives
aroyl
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69418639T
Other languages
English (en)
Other versions
DE69418639T2 (de
Inventor
Larry John Black
Henry Uhlman Bryant
George Joseph Cullinan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69418639D1 publication Critical patent/DE69418639D1/de
Application granted granted Critical
Publication of DE69418639T2 publication Critical patent/DE69418639T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
DE69418639T 1993-03-19 1994-03-16 Sulfonat- und Carbamatderivate von 3-aroyl-benzo(beta)Thiophenen Expired - Fee Related DE69418639T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/035,121 US5482949A (en) 1993-03-19 1993-03-19 Sulfonate derivatives of 3-aroylbenzo[b]thiophenes

Publications (2)

Publication Number Publication Date
DE69418639D1 true DE69418639D1 (de) 1999-07-01
DE69418639T2 DE69418639T2 (de) 1999-10-07

Family

ID=21880778

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69418639T Expired - Fee Related DE69418639T2 (de) 1993-03-19 1994-03-16 Sulfonat- und Carbamatderivate von 3-aroyl-benzo(beta)Thiophenen

Country Status (22)

Country Link
US (5) US5482949A (de)
EP (1) EP0617030B1 (de)
JP (1) JPH06321937A (de)
CN (1) CN1097420A (de)
AT (1) ATE180479T1 (de)
AU (1) AU670177B2 (de)
BR (1) BR9401183A (de)
CZ (1) CZ57894A3 (de)
DE (1) DE69418639T2 (de)
DK (1) DK0617030T3 (de)
ES (1) ES2132339T3 (de)
FI (1) FI941262A (de)
GR (1) GR3030317T3 (de)
HU (1) HUT70549A (de)
IL (1) IL108958A0 (de)
NO (1) NO940940L (de)
NZ (1) NZ260085A (de)
PH (1) PH30177A (de)
SI (1) SI0617030T1 (de)
TW (1) TW304953B (de)
YU (1) YU12794A (de)
ZA (1) ZA941786B (de)

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USRE39049E1 (en) 1992-07-28 2006-03-28 Eli Lilly And Company Methods for inhibiting bone loss
US5770609A (en) 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
ATE406909T1 (de) * 1993-05-13 2008-09-15 Poniard Pharmaceuticals Inc Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
WO1996040098A2 (en) * 1995-06-07 1996-12-19 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
US5441964A (en) * 1993-10-15 1995-08-15 Eli Lilly And Company Methods for inhibiting bone loss using substituted benzothiophene
US5482950A (en) * 1993-10-15 1996-01-09 Eli Lilly And Company Methods for lowering serum cholesterol
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EP0716854A3 (de) * 1994-10-20 1996-08-28 Lilly Co Eli Zusammensetzungen zur Inhibierung von Neuropeptid Y
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US5571808A (en) * 1995-01-31 1996-11-05 Eli Lilly And Company Method for treating smoking-related bone loss
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US5552401A (en) * 1995-02-28 1996-09-03 Eli Lilly And Company 2-benzyl-3-arylbenzothiophenes
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US5523309A (en) * 1995-03-10 1996-06-04 Eli Lilly And Company Benzofuran pharmaceutical compounds
US6391892B1 (en) 1995-03-10 2002-05-21 Eli Lilly And Company Naphthyl pharmaceutical compounds
US6395755B1 (en) * 1995-03-10 2002-05-28 Eli Lilly And Company Benzothiophene pharmaceutical compounds
US6653328B1 (en) 1995-03-10 2003-11-25 Eli Lilly And Company 3-benzyl-benzothiophenes
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US5705507A (en) * 1995-03-10 1998-01-06 Eli Lilly And Company Aplha-substituted-3-benzyl-benzofurans
US5514703A (en) * 1995-03-13 1996-05-07 Eli Lilly And Company Benzothiophene compounds useful for inhibiting lipoxygenase
US5514704A (en) * 1995-03-13 1996-05-07 Eli Lilly And Company Benzothiophenes to inhibit leukotrienes
US5532382A (en) * 1995-03-13 1996-07-02 Eli Lilly And Company Benzothiophenes substituted at the 3-carbonyl
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US5728724A (en) * 1995-08-17 1998-03-17 Eli Lilly And Company Benzothiophene compounds
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US5726168A (en) * 1995-10-12 1998-03-10 Eli Lilly And Company Lipophilic benzothiophenes
EP0773217A1 (de) * 1995-11-07 1997-05-14 Eli Lilly And Company Benzothiophenederivate zur Behandlung von resistenten Tumoren
US6432982B1 (en) 1996-02-21 2002-08-13 Eli Lilly And Company Benzothiophenes, and formulations and methods using same
IL125863A (en) * 1996-02-22 2000-10-31 Lilly Co Eli Benzothiophenes and formulations containing same
IL120266A (en) * 1996-02-28 2005-05-17 Pfizer Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
US5688796A (en) * 1996-03-12 1997-11-18 Eli Lilly And Company Heterocyclic substituted benzothiophenes, compositions, and methods
DE69739855D1 (de) * 1996-03-26 2010-06-02 Lilly Co Eli Benzothiophene und denen enthaltende zusammensetzungen
US5843984A (en) * 1996-05-09 1998-12-01 Eli Lilly And Company Sulfated benzothiophene derivatives, methods of use and formulations containing same
AU727708B2 (en) 1996-06-20 2000-12-21 Board Of Regents, The University Of Texas System Compounds and methods for providing pharmacologically active preparations and uses thereof
CA2206752A1 (en) * 1996-07-02 1998-01-02 George Joseph Cullinan Benzothiophene compounds, intermediates, processes, and methods of use
CA2206997A1 (en) * 1996-07-10 1998-01-10 Eli Lilly And Company Benzothiophene compounds and methods of use
BR9713176A (pt) * 1996-08-28 2000-02-08 Lilly Co Eli Benzotiofenos amorfos,métodos de preparação e métodos de uso
CA2213810C (en) * 1996-08-29 2006-06-06 Lewis Dale Pennington Benzo¬b|thiophene compounds, intermediates, processes, compositions and methods
CA2214072C (en) * 1996-08-29 2006-11-14 Eli Lilly And Company Benzo [b] thiophene compounds, intermediates, processes, compositions, and methods
CA2214922A1 (en) * 1996-09-27 1998-03-27 Eli Lilly And Company Benzothiophene compounds, compositions, and methods
US5948796A (en) * 1996-10-10 1999-09-07 Eli Lilly And Company Benzo B!thiophene compounds, intermediates, formulations, and methods
CA2217373A1 (en) * 1996-10-10 1998-04-10 Michael John Martin Benzo¬b|thiophene compounds, intermediates, formulations, and methods
CA2218756A1 (en) * 1996-10-25 1998-04-25 Kristin Sue Marron Substituted benzo¢b!thiophene compounds having activity as selective estrogen receptor modulators
AU6959898A (en) * 1997-04-11 1998-11-11 David J. Grainger Compounds and therapies for the prevention of vascular and non-vascular pathol ogies
US6025373A (en) * 1997-04-22 2000-02-15 Eli Lilly And Company Methods for reducing fibrinogen
CA2236254A1 (en) * 1997-04-30 1998-10-30 David Warren Hoard Process for preparing benzo¬b|thiophenes
WO1998048793A1 (en) * 1997-04-30 1998-11-05 Eli Lilly And Company INTERMEDIATES AND PROCESSES FOR PREPARING BENZO[b]THIOPHENES
AU7170898A (en) 1997-04-30 1998-11-24 Eli Lilly And Company Antithrombotic agents
US6271227B1 (en) 1997-04-30 2001-08-07 Eli Lilly And Company Antithrombotic Agents
CA2231013A1 (en) * 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
KR20010020379A (ko) * 1997-04-30 2001-03-15 피터 지. 스트링거 치환된 벤조[ｂ]티오펜을 제조하기 위한 레지오선택적 알킬화 방법
KR20010020380A (ko) * 1997-04-30 2001-03-15 피터 지. 스트링거 벤조[ｂ]티오펜의 제조 방법 및 중간체
EP0980367A4 (de) 1997-04-30 2003-03-19 Lilly Co Eli Antithrombosemittel
ATE286395T1 (de) 1997-04-30 2005-01-15 Lilly Co Eli Antithrombotische mittel
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US6008232A (en) * 1997-08-20 1999-12-28 Eli Lilly And Company Methods for preventing headaches
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US5990129A (en) * 1997-09-23 1999-11-23 Eli Lilly And Company Methods for regulating trkA expression
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FR2813308B1 (fr) 2000-08-23 2005-07-01 Sanofi Synthelabo Aminoalkoxybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation ainsi que les compositions les contenant
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JP3804824B2 (ja) * 2001-09-19 2006-08-02 ヤマハ株式会社 ディジタルミキサ
JP4665805B2 (ja) * 2006-03-17 2011-04-06 カシオ計算機株式会社 印字装置

Also Published As

Publication number Publication date
ZA941786B (en) 1995-09-14
US5798351A (en) 1998-08-25
AU670177B2 (en) 1996-07-04
US5482949A (en) 1996-01-09
DK0617030T3 (da) 1999-11-08
US5605924A (en) 1997-02-25
JPH06321937A (ja) 1994-11-22
TW304953B (de) 1997-05-11
EP0617030A1 (de) 1994-09-28
AU5786394A (en) 1994-09-22
BR9401183A (pt) 1994-11-01
GR3030317T3 (en) 1999-09-30
CN1097420A (zh) 1995-01-18
DE69418639T2 (de) 1999-10-07
ES2132339T3 (es) 1999-08-16
NZ260085A (en) 1995-12-21
SI0617030T1 (en) 1999-10-31
PH30177A (en) 1997-01-21
CZ57894A3 (en) 1994-12-15
IL108958A0 (en) 1994-06-24
FI941262A (fi) 1994-09-20
YU12794A (sh) 1997-01-08
US5599833A (en) 1997-02-04
NO940940D0 (no) 1994-03-16
FI941262A0 (fi) 1994-03-17
HUT70549A (en) 1995-10-30
HU9400774D0 (en) 1994-06-28
US5994371A (en) 1999-11-30
EP0617030B1 (de) 1999-05-26
NO940940L (no) 1994-09-20
ATE180479T1 (de) 1999-06-15

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