DE69418639D1 - Sulfonat- und Carbamatderivate von 3-aroyl-benzo(beta)Thiophenen - Google Patents

Sulfonat- und Carbamatderivate von 3-aroyl-benzo(beta)Thiophenen

Info

Publication number
DE69418639D1
DE69418639D1 DE69418639T DE69418639T DE69418639D1 DE 69418639 D1 DE69418639 D1 DE 69418639D1 DE 69418639 T DE69418639 T DE 69418639T DE 69418639 T DE69418639 T DE 69418639T DE 69418639 D1 DE69418639 D1 DE 69418639D1
Authority
DE
Germany
Prior art keywords
thiophenes
sulfonate
carbamate derivatives
aroyl
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69418639T
Other languages
English (en)
Other versions
DE69418639T2 (de
Inventor
Larry John Black
Henry Uhlman Bryant
George Joseph Cullinan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69418639D1 publication Critical patent/DE69418639D1/de
Application granted granted Critical
Publication of DE69418639T2 publication Critical patent/DE69418639T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
DE69418639T 1993-03-19 1994-03-16 Sulfonat- und Carbamatderivate von 3-aroyl-benzo(beta)Thiophenen Expired - Fee Related DE69418639T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/035,121 US5482949A (en) 1993-03-19 1993-03-19 Sulfonate derivatives of 3-aroylbenzo[b]thiophenes

Publications (2)

Publication Number Publication Date
DE69418639D1 true DE69418639D1 (de) 1999-07-01
DE69418639T2 DE69418639T2 (de) 1999-10-07

Family

ID=21880778

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69418639T Expired - Fee Related DE69418639T2 (de) 1993-03-19 1994-03-16 Sulfonat- und Carbamatderivate von 3-aroyl-benzo(beta)Thiophenen

Country Status (22)

Country Link
US (5) US5482949A (de)
EP (1) EP0617030B1 (de)
JP (1) JPH06321937A (de)
CN (1) CN1097420A (de)
AT (1) ATE180479T1 (de)
AU (1) AU670177B2 (de)
BR (1) BR9401183A (de)
CZ (1) CZ57894A3 (de)
DE (1) DE69418639T2 (de)
DK (1) DK0617030T3 (de)
ES (1) ES2132339T3 (de)
FI (1) FI941262A (de)
GR (1) GR3030317T3 (de)
HU (1) HUT70549A (de)
IL (1) IL108958A0 (de)
NO (1) NO940940L (de)
NZ (1) NZ260085A (de)
PH (1) PH30177A (de)
SI (1) SI0617030T1 (de)
TW (1) TW304953B (de)
YU (1) YU12794A (de)
ZA (1) ZA941786B (de)

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USRE39049E1 (en) 1992-07-28 2006-03-28 Eli Lilly And Company Methods for inhibiting bone loss
US5770609A (en) 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
CA2162586C (en) 1993-05-13 2006-01-03 David J. Grainger Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
WO1996040098A2 (en) 1995-06-07 1996-12-19 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
US5482950A (en) * 1993-10-15 1996-01-09 Eli Lilly And Company Methods for lowering serum cholesterol
US5441964A (en) * 1993-10-15 1995-08-15 Eli Lilly And Company Methods for inhibiting bone loss using substituted benzothiophene
CA2176127A1 (en) * 1993-12-21 1995-06-29 William Henry Walker Lunn Methods for the treatment or prevention of conditions associated with amyloidogenic reptides
US6417198B1 (en) 1993-12-21 2002-07-09 Eli Lilly And Company Methods of inhibiting CNS problems in post-menopausal women
US5478847A (en) 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
IL115022A (en) * 1994-08-22 2000-07-31 Lilly Co Eli Pharmaceutical compositions for inhibiting endometrial cancer
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EP0716854A3 (de) * 1994-10-20 1996-08-28 Lilly Co Eli Zusammensetzungen zur Inhibierung von Neuropeptid Y
US6562862B1 (en) * 1994-10-20 2003-05-13 Eli Lilly And Company Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y
US5552412A (en) * 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
US5571808A (en) * 1995-01-31 1996-11-05 Eli Lilly And Company Method for treating smoking-related bone loss
US20030083733A1 (en) * 1997-10-10 2003-05-01 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5552401A (en) * 1995-02-28 1996-09-03 Eli Lilly And Company 2-benzyl-3-arylbenzothiophenes
US6479517B1 (en) 1995-02-28 2002-11-12 Eli Lilly And Company Phosphorous-containing benzothiophenes
US6384053B1 (en) 1995-03-10 2002-05-07 Eli Lilly And Company α-substituted-1-benzyl-napthyls
US5523309A (en) * 1995-03-10 1996-06-04 Eli Lilly And Company Benzofuran pharmaceutical compounds
US5622974A (en) * 1995-03-10 1997-04-22 Eli Lilly And Company α-substituted-3-benzyl-benzofurans
US5705507A (en) * 1995-03-10 1998-01-06 Eli Lilly And Company Aplha-substituted-3-benzyl-benzofurans
US6653328B1 (en) 1995-03-10 2003-11-25 Eli Lilly And Company 3-benzyl-benzothiophenes
US6395755B1 (en) * 1995-03-10 2002-05-28 Eli Lilly And Company Benzothiophene pharmaceutical compounds
US6391892B1 (en) 1995-03-10 2002-05-21 Eli Lilly And Company Naphthyl pharmaceutical compounds
US6417199B1 (en) 1995-03-10 2002-07-09 Eli Lilly And Company 3-benzyl-benzothiophenes
US6451817B1 (en) 1995-03-10 2002-09-17 Eli Lilly And Company Alpha-substituted-1-benzyl-napthyls
US5532382A (en) * 1995-03-13 1996-07-02 Eli Lilly And Company Benzothiophenes substituted at the 3-carbonyl
US5514703A (en) * 1995-03-13 1996-05-07 Eli Lilly And Company Benzothiophene compounds useful for inhibiting lipoxygenase
US5514704A (en) * 1995-03-13 1996-05-07 Eli Lilly And Company Benzothiophenes to inhibit leukotrienes
US20020091433A1 (en) * 1995-04-19 2002-07-11 Ni Ding Drug release coated stent
US5837313A (en) * 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US6099562A (en) * 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
EP0738725A3 (de) * 1995-04-21 1997-03-05 Lilly Co Eli Benzothiophene mit basischen Seitenketten
US6608090B1 (en) 1995-04-21 2003-08-19 Eli Lilly And Company Benzothiophenes with novel basic side chains
DK0747056T3 (da) * 1995-06-06 2000-05-01 Lilly Co Eli Minimering af knogletab med anti-estrogenkombinationer
EP0747380B1 (de) * 1995-06-07 1998-09-30 Eli Lilly And Company Verbindungen mit N-Acyliertem Piperidin in der Seitenkette und Zusammensetzungen
US5567828A (en) * 1995-06-07 1996-10-22 Eli Lilly And Company Compounds and compositions with nitrogen-containing non-basic side
US6444688B1 (en) 1995-06-07 2002-09-03 Eli Lilly And Company Compounds and compositions with nitrogen-containing non-basic side chains
US5728724A (en) * 1995-08-17 1998-03-17 Eli Lilly And Company Benzothiophene compounds
GB9523999D0 (en) 1995-11-23 1996-01-24 Lilly Co Eli Indolyl neuropeptide y receptor antagonists
US5726168A (en) * 1995-10-12 1998-03-10 Eli Lilly And Company Lipophilic benzothiophenes
EP0773217A1 (de) * 1995-11-07 1997-05-14 Eli Lilly And Company Benzothiophenederivate zur Behandlung von resistenten Tumoren
US6432982B1 (en) * 1996-02-21 2002-08-13 Eli Lilly And Company Benzothiophenes, and formulations and methods using same
DE69706338T2 (de) * 1996-02-22 2002-06-13 Lilly Co Eli Benzothiophene, selbige enthaltende Zusammensetzungen und Verfahren zu deren Herstellung
IL120266A (en) 1996-02-28 2005-05-17 Pfizer Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
US5688796A (en) * 1996-03-12 1997-11-18 Eli Lilly And Company Heterocyclic substituted benzothiophenes, compositions, and methods
PL191148B1 (pl) * 1996-03-26 2006-03-31 Lilly Co Eli Chlorowodorek 6-hydroksy-2-(4-hydroksyfenylo)-3-[4-(2-piperydynoetoksy)benzoilo] benzeno[b] tiofenu i środek farmaceutyczny
US5843984A (en) * 1996-05-09 1998-12-01 Eli Lilly And Company Sulfated benzothiophene derivatives, methods of use and formulations containing same
HUP9904567A3 (en) 1996-06-20 2001-10-29 Univ Texas Use of azo, thioalkyl, thiocarbonyl derivatives substituted by fused heterocycles and/or phenyl group for the preparation of pharmaceutical compositions stimulating bone growth
CA2206752A1 (en) * 1996-07-02 1998-01-02 George Joseph Cullinan Benzothiophene compounds, intermediates, processes, and methods of use
CA2206997A1 (en) * 1996-07-10 1998-01-10 Eli Lilly And Company Benzothiophene compounds and methods of use
EP0826682B1 (de) * 1996-08-28 2003-03-12 Eli Lilly And Company Amorphe Benzothiophen, Verfahren zur Herstellung und Verwendung
CA2214072C (en) * 1996-08-29 2006-11-14 Eli Lilly And Company Benzo [b] thiophene compounds, intermediates, processes, compositions, and methods
CA2213810C (en) * 1996-08-29 2006-06-06 Lewis Dale Pennington Benzo¬b|thiophene compounds, intermediates, processes, compositions and methods
CA2214922A1 (en) * 1996-09-27 1998-03-27 Eli Lilly And Company Benzothiophene compounds, compositions, and methods
US5948796A (en) * 1996-10-10 1999-09-07 Eli Lilly And Company Benzo B!thiophene compounds, intermediates, formulations, and methods
JPH10130258A (ja) * 1996-10-10 1998-05-19 Eli Lilly & Co ベンゾ［ｂ］チオフェン化合物、中間体、製剤、および方法
CA2218756A1 (en) * 1996-10-25 1998-04-25 Kristin Sue Marron Substituted benzo¢b!thiophene compounds having activity as selective estrogen receptor modulators
WO1998046588A2 (en) * 1997-04-11 1998-10-22 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
US6025373A (en) * 1997-04-22 2000-02-15 Eli Lilly And Company Methods for reducing fibrinogen
DE69828522T2 (de) 1997-04-30 2005-12-15 Eli Lilly And Co., Indianapolis Antithrombotische mittel
AU7261598A (en) * 1997-04-30 1998-11-24 Eli Lilly And Company Intermediates and a process for preparing benzo{b}thiophenes
JP2002513415A (ja) 1997-04-30 2002-05-08 イーライ・リリー・アンド・カンパニー 抗血栓剤
CA2231013A1 (en) * 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
CA2287922A1 (en) * 1997-04-30 1998-11-05 Eli Lilly And Company Intermediates and processes for preparing benzo[b]thiophenes
ES2223129T3 (es) 1997-04-30 2005-02-16 Eli Lilly And Company Agentes antitromboticos.
WO1998048792A1 (en) * 1997-04-30 1998-11-05 Eli Lilly And Company A REGIOSELECTIVE ALKYLATION PROCESS FOR PREPARING SUBSTITUTED BENZO[b]THIOPHENES
AU7170898A (en) 1997-04-30 1998-11-24 Eli Lilly And Company Antithrombotic agents
CA2236254A1 (en) * 1997-04-30 1998-10-30 David Warren Hoard Process for preparing benzo¬b|thiophenes
KR20010020378A (ko) * 1997-04-30 2001-03-15 피터 지. 스트링거 벤조티오펜의 제조 방법
US6008232A (en) * 1997-08-20 1999-12-28 Eli Lilly And Company Methods for preventing headaches
US6103740A (en) * 1997-08-21 2000-08-15 Eli Lilly And Company Methods for lowering platelet counts
US6017914A (en) * 1997-09-03 2000-01-25 Eli Lilly And Company Benzo[b]thiophene compounds, intermediates, formulations, and methods
US5990129A (en) * 1997-09-23 1999-11-23 Eli Lilly And Company Methods for regulating trkA expression
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FR2813306B1 (fr) * 2000-08-23 2005-10-21 Sanofi Synthelabo Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
FR2813308B1 (fr) * 2000-08-23 2005-07-01 Sanofi Synthelabo Aminoalkoxybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation ainsi que les compositions les contenant
KR100545430B1 (ko) * 2000-11-02 2006-01-24 에프. 호프만-라 로슈 아게 콜레스테롤 저하성 벤조[ｂ]티오펜 및 벤조[ｄ]이소티아졸
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JPH04312526A (ja) * 1991-04-09 1992-11-04 Fujisawa Pharmaceut Co Ltd 骨疾患治療剤
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TW383306B (en) * 1992-12-22 2000-03-01 Lilly Co Eli New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol
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JP3804824B2 (ja) * 2001-09-19 2006-08-02 ヤマハ株式会社 ディジタルミキサ
JP4665805B2 (ja) * 2006-03-17 2011-04-06 カシオ計算機株式会社 印字装置

Also Published As

Publication number Publication date
CN1097420A (zh) 1995-01-18
FI941262A (fi) 1994-09-20
HU9400774D0 (en) 1994-06-28
US5599833A (en) 1997-02-04
HUT70549A (en) 1995-10-30
TW304953B (de) 1997-05-11
SI0617030T1 (en) 1999-10-31
US5482949A (en) 1996-01-09
GR3030317T3 (en) 1999-09-30
ATE180479T1 (de) 1999-06-15
NO940940L (no) 1994-09-20
PH30177A (en) 1997-01-21
AU5786394A (en) 1994-09-22
JPH06321937A (ja) 1994-11-22
AU670177B2 (en) 1996-07-04
EP0617030B1 (de) 1999-05-26
CZ57894A3 (en) 1994-12-15
NO940940D0 (no) 1994-03-16
EP0617030A1 (de) 1994-09-28
FI941262A0 (fi) 1994-03-17
NZ260085A (en) 1995-12-21
ZA941786B (en) 1995-09-14
IL108958A0 (en) 1994-06-24
US5798351A (en) 1998-08-25
DK0617030T3 (da) 1999-11-08
US5605924A (en) 1997-02-25
US5994371A (en) 1999-11-30
BR9401183A (pt) 1994-11-01
YU12794A (sh) 1997-01-08
DE69418639T2 (de) 1999-10-07
ES2132339T3 (es) 1999-08-16

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