DE69420146D1 - Neue sterisch gehinderte nitronylphenole als radikalfänger ("spintraps") - Google Patents

Neue sterisch gehinderte nitronylphenole als radikalfänger ("spintraps")

Info

Publication number
DE69420146D1
DE69420146D1 DE69420146T DE69420146T DE69420146D1 DE 69420146 D1 DE69420146 D1 DE 69420146D1 DE 69420146 T DE69420146 T DE 69420146T DE 69420146 T DE69420146 T DE 69420146T DE 69420146 D1 DE69420146 D1 DE 69420146D1
Authority
DE
Germany
Prior art keywords
spintraps
nitronylphenols
hidden
catchers
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69420146T
Other languages
English (en)
Other versions
DE69420146T2 (de
Inventor
Edward Janzen
Allan L Wilcox
Randall D Hinton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oklahoma Medical Research Foundation
Original Assignee
Oklahoma Medical Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Medical Research Foundation filed Critical Oklahoma Medical Research Foundation
Application granted granted Critical
Publication of DE69420146D1 publication Critical patent/DE69420146D1/de
Publication of DE69420146T2 publication Critical patent/DE69420146T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69420146T 1993-10-22 1994-10-20 Neue sterisch gehinderte nitronylphenole als radikalfänger ("spintraps") Expired - Fee Related DE69420146T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/141,241 US5455272A (en) 1993-10-22 1993-10-22 Spin trap nitronyl hindered phenols
PCT/US1994/012107 WO1995011227A1 (en) 1993-10-22 1994-10-20 Novel spin trap nitronyl hindered phenols

Publications (2)

Publication Number Publication Date
DE69420146D1 true DE69420146D1 (de) 1999-09-23
DE69420146T2 DE69420146T2 (de) 2000-04-20

Family

ID=22494820

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69420146T Expired - Fee Related DE69420146T2 (de) 1993-10-22 1994-10-20 Neue sterisch gehinderte nitronylphenole als radikalfänger ("spintraps")

Country Status (6)

Country Link
US (4) US5455272A (de)
EP (1) EP0724565B1 (de)
AU (1) AU696451B2 (de)
DE (1) DE69420146T2 (de)
ES (1) ES2136209T3 (de)
WO (1) WO1995011227A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723502A (en) * 1985-07-18 1998-03-03 Proctor; Peter H. Topical spin trap composition and method
WO1997010218A1 (en) * 1995-09-11 1997-03-20 Hoechst Marion Roussel, Inc. Cyclic nitrones and pharmaceutical compositions containing them
CA2252494A1 (en) * 1996-04-23 1997-10-30 Kenneth W. Narducy Compositions comprising a nitrone compound for use in treating ocular inflammation
CA2260825A1 (en) * 1996-07-19 1998-01-29 Centaur Pharmaceuticals, Inc. Furan nitrone compounds
TW429241B (en) * 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
US6046232A (en) * 1997-10-17 2000-04-04 Centaur Pharmaceuticals, Inc. α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same
EP1047683A1 (de) * 1998-01-16 2000-11-02 Centaur Pharmaceuticals, Inc. Thioetherfuranyl-nitronderivate
CN1136212C (zh) * 1998-01-16 2004-01-28 桑道药品有限公司 噻吩硝酮化合物
US6194465B1 (en) 1998-05-19 2001-02-27 Centaur Pharmaceuticals, Inc. Benzamide therapeutics for the treatment of inflammatory bowel disease
CA2333190A1 (en) * 1998-05-19 1999-11-25 Beverly Greenwood-Van Meerveld Furan nitrone therapeutics for the treatment of inflammatory bowel disease
PT1077694E (pt) * 1998-05-19 2004-12-31 Renovis Inc Produtos terapeuticos de arilnitrona para o tratamento da doenca inflamatoria dointestino
US6083989A (en) * 1999-05-18 2000-07-04 Centaur Pharmaceuticals, Inc. Aryl nitrone therapeutics for the treatment of inflammatory bowel disease
FR2780404B1 (fr) * 1998-06-26 2001-04-13 Adir Nouveaux derives de nitrone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
NZ509530A (en) 1998-07-17 2003-09-26 Centaur Pharmaceuticals Inc Alpha-(2-hydroxyphenyl) nitrone compounds, pharmaceutical compositions containing the same and their use for treating inflammation
UA66401C2 (en) 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
US6730700B2 (en) 1998-12-02 2004-05-04 Renovis, Inc. 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
IT1312537B1 (it) * 1999-04-16 2002-04-22 Euphar Group Srl Derivati del (-)- verbenone.
WO2002065993A2 (en) * 2001-01-08 2002-08-29 Centaur Pharmaceuticals, Inc. Use of aryl nitrone compounds in methods for treating neuropathic pain
FR2846968B1 (fr) * 2002-11-08 2005-02-04 Salles Jean Pierre Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert- butyl nitrone
US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
US20050215646A1 (en) * 2004-03-09 2005-09-29 Renovis, Inc. Methods for treating multiple sclerosis and pharmaceutical compositions therefor
JP4996575B2 (ja) * 2007-11-15 2012-08-08 ローム アンド ハース カンパニー ニトロンの製造
ES2367330T3 (es) * 2007-11-15 2011-11-02 Rohm And Haas Company Preparación de nitronas.
US9034926B2 (en) 2010-12-30 2015-05-19 Nicholas V. Perricone Topical nitrone spin trap compositions for psoriasis
US8986739B2 (en) 2011-02-28 2015-03-24 Nicholas V. Perricone Treatment of urinary incontinence using nitrone spin traps
BR112014012941B1 (pt) * 2011-11-30 2019-04-09 Dow Global Technologies Llc Composição para cuidado pessoal, método cosmético para tratar pele, e, métodos para inibir a degradação de colágeno na pele e para reduzir os sinais visíveis de envelhecimento
WO2015134688A1 (en) 2014-03-07 2015-09-11 Dow Global Technologies Llc Nitrone compounds and their use in personal care
EP3142752B1 (de) 2014-05-12 2018-06-20 Dow Global Technologies Llc Nitron verbindungen und ihre verwendung in der körperpflege
EP3161025B1 (de) 2014-06-30 2019-11-13 Dow Global Technologies LLC Polymernitrone und deren verwendung bei der körperpflege
EP3270875B1 (de) * 2015-03-20 2019-05-01 Dow Global Technologies LLC Nitronhemmung der oxidation von ungesättigten fetten
CN107427430B (zh) * 2015-03-20 2020-12-04 陶氏环球技术有限责任公司 不饱和脂肪氧化的硝酮抑制

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903049A (en) * 1974-01-30 1975-09-02 Goodyear Tire & Rubber Oxidation resistant sulfur curable rubbery polymers
GB2137619A (en) * 1983-03-30 1984-10-10 Gerald Scott Nitrone compounds and stabilised rubber compositions containing them
US5036097A (en) * 1989-10-17 1991-07-30 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
US5025032A (en) * 1989-10-17 1991-06-18 Oklahoma Medical Research Foundation Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage
JP2797559B2 (ja) * 1989-11-30 1998-09-17 住友化学工業株式会社 ニトロン化合物およびその製造法
EP0590072B1 (de) * 1991-06-18 2001-12-05 Oklahoma Medical Research Foundation Radikalfänger ("spin traps") zur behandlung von mit oxidation von lipiden und proteinen verbundenen erkrankungen

Also Published As

Publication number Publication date
US5532277A (en) 1996-07-02
DE69420146T2 (de) 2000-04-20
EP0724565A1 (de) 1996-08-07
AU696451B2 (en) 1998-09-10
AU8086994A (en) 1995-05-08
US5527828A (en) 1996-06-18
US5455272A (en) 1995-10-03
USRE36594E (en) 2000-02-29
ES2136209T3 (es) 1999-11-16
EP0724565B1 (de) 1999-08-18
WO1995011227A1 (en) 1995-04-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee