DE69427017D1 - Herstellung von 3,4,4-trisubstituiertem Piperidinyl-n-alkylcarboxylaten und Zwischenverbindungen, verwendbar als opioid Antagonisten - Google Patents

Herstellung von 3,4,4-trisubstituiertem Piperidinyl-n-alkylcarboxylaten und Zwischenverbindungen, verwendbar als opioid Antagonisten

Info

Publication number
DE69427017D1
DE69427017D1 DE69427017T DE69427017T DE69427017D1 DE 69427017 D1 DE69427017 D1 DE 69427017D1 DE 69427017 T DE69427017 T DE 69427017T DE 69427017 T DE69427017 T DE 69427017T DE 69427017 D1 DE69427017 D1 DE 69427017D1
Authority
DE
Germany
Prior art keywords
intermediates
usable
preparation
opioid antagonists
trisubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69427017T
Other languages
English (en)
Other versions
DE69427017T2 (de
Inventor
Scott Alan Frank
Douglas Edward Prather
Jeffrey Alan Ward
John Arnold Werner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69427017D1 publication Critical patent/DE69427017D1/de
Application granted granted Critical
Publication of DE69427017T2 publication Critical patent/DE69427017T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
DE69427017T 1993-12-08 1994-12-02 Herstellung von 3,4,4-trisubstituiertem Piperidinyl-n-alkylcarboxylaten und Zwischenverbindungen, verwendbar als opioid Antagonisten Expired - Lifetime DE69427017T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/164,074 US5434171A (en) 1993-12-08 1993-12-08 Preparation of 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates and intermediates

Publications (2)

Publication Number Publication Date
DE69427017D1 true DE69427017D1 (de) 2001-05-10
DE69427017T2 DE69427017T2 (de) 2001-09-06

Family

ID=22592858

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69427017T Expired - Lifetime DE69427017T2 (de) 1993-12-08 1994-12-02 Herstellung von 3,4,4-trisubstituiertem Piperidinyl-n-alkylcarboxylaten und Zwischenverbindungen, verwendbar als opioid Antagonisten

Country Status (31)

Country Link
US (1) US5434171A (de)
EP (3) EP1607387A3 (de)
JP (2) JP3834075B2 (de)
KR (1) KR100356239B1 (de)
CN (2) CN1057294C (de)
AT (1) ATE200279T1 (de)
AU (1) AU681198B2 (de)
BR (1) BR9404842A (de)
CA (1) CA2137221C (de)
CO (1) CO4290427A1 (de)
CZ (1) CZ290559B6 (de)
DE (1) DE69427017T2 (de)
DK (1) DK0657428T3 (de)
ES (1) ES2155844T3 (de)
FI (2) FI106455B (de)
GR (1) GR3036136T3 (de)
HK (1) HK1013826A1 (de)
HU (1) HUT71489A (de)
IL (1) IL111843A (de)
MY (1) MY121543A (de)
NO (1) NO302884B1 (de)
NZ (1) NZ270039A (de)
PE (1) PE41495A1 (de)
PL (1) PL181734B1 (de)
PT (1) PT657428E (de)
RU (1) RU2145958C1 (de)
SI (1) SI0657428T1 (de)
TW (1) TW290540B (de)
UA (1) UA52577C2 (de)
YU (2) YU49312B (de)
ZA (1) ZA949584B (de)

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GB9912413D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912410D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912416D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912415D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912411D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
US6451806B2 (en) 1999-09-29 2002-09-17 Adolor Corporation Methods and compositions involving opioids and antagonists thereof
US6469030B2 (en) 1999-11-29 2002-10-22 Adolor Corporation Methods for the treatment and prevention of ileus
DE60234183D1 (de) * 2001-06-05 2009-12-10 Univ Chicago Verwendung von methylnaltrexon zur behandlung von immunsuppression
US20030068829A1 (en) * 2001-06-25 2003-04-10 Symyx Technologies, Inc. High throughput crystallographic screening of materials
PT1436012T (pt) * 2001-10-18 2018-03-27 Nektar Therapeutics Conjugados poliméricos de antagonistas de opióides
US6794510B2 (en) * 2002-08-08 2004-09-21 Adolor Corporation Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto
US7381721B2 (en) * 2003-03-17 2008-06-03 Adolor Corporation Substituted piperidine compounds
RU2373936C2 (ru) * 2003-04-08 2009-11-27 Проджиникс Фармасьютикалз, Инк. Применение метилналтрексона для лечения синдрома раздраженного кишечника
MXPA05010817A (es) 2003-04-08 2006-03-30 Progenics Pharm Inc Formulaciones farmaceuticas que contienen metilnaltrexona.
US6992090B2 (en) * 2003-06-16 2006-01-31 Adolor Corporation Substituted piperidine compounds and methods of their use
FR2861304B1 (fr) * 2003-10-23 2008-07-18 Univ Grenoble 1 Modulateurs des canaux cftr
US20050148630A1 (en) * 2003-12-02 2005-07-07 Carpenter Randall L. Methods of preventing and treating non-opioid induced gastrointestinal dysfunction
US8946262B2 (en) * 2003-12-04 2015-02-03 Adolor Corporation Methods of preventing and treating gastrointestinal dysfunction
WO2005058367A2 (en) * 2003-12-16 2005-06-30 Nektar Therapeutics Al, Corporation Pegylated small molecules
US20060182692A1 (en) * 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
US7087749B2 (en) * 2004-03-11 2006-08-08 Adolor Corporation Substituted piperidine compounds and methods of their use
US20050240177A1 (en) * 2004-04-26 2005-10-27 Packaging Service Corporation Of Kentucky Electrosurgical forceps
US7700626B2 (en) 2004-06-04 2010-04-20 Adolor Corporation Compositions containing opioid antagonists
PT1789067E (pt) * 2004-08-12 2012-08-06 Helsinn Healthcare Sa Utilização de hormona do crescimento secretagogo para a estimulação da motilidade do sistema gastrointestinal
US8039456B2 (en) 2004-08-12 2011-10-18 Helsinn Therapeutics (U.S.), Inc. Method of stimulating the motility of the gastrointestinal system using ipamorelin
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
US20060211733A1 (en) * 2005-03-04 2006-09-21 Adolor Corporation Methods of preventing and treating opioid bowel dysfunction
ES2714198T3 (es) * 2005-03-07 2019-05-27 Univ Chicago Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
EP1906952A4 (de) * 2005-07-01 2010-04-14 Jenrin Discovery Mao-b-hemmer zur behandlung von adipositas
US7914776B2 (en) * 2005-10-07 2011-03-29 Adolor Corporation Solid dispersions of opioid antagonists
US20070092576A1 (en) * 2005-10-20 2007-04-26 Adolor Corporation Compositions containing opioid antagonists
US7538110B2 (en) * 2005-10-27 2009-05-26 Adolor Corporation Opioid antagonists
CN100383121C (zh) * 2006-03-07 2008-04-23 天津泰普药品科技发展有限公司 阿韦苄酯化合物及其制备方法和以该化合物制备阿韦莫哌的工艺
ATE516021T1 (de) 2006-04-21 2011-07-15 Dsm Ip Assets Bv Verwendung von opioid-rezeptor-antagonisten
EP2101773A2 (de) * 2006-11-22 2009-09-23 Progenics Pharmaceuticals, Inc. (r)-n-stereoisomere von 7,8-gesättigten-4,5-epoxy-morphinanium-analoga
PT2139890E (pt) 2007-03-29 2014-09-03 Wyeth Llc Antagonistas do receptor opióide periférico e respectivas utilizações
JP5461386B2 (ja) 2007-03-29 2014-04-02 プロジェニックス ファーマシューティカルズ，インコーポレーテッド 末梢オピオイド受容体アンタゴニストおよびその使用
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Also Published As

Publication number Publication date
EP1607387A3 (de) 2007-01-03
CZ290559B6 (cs) 2002-08-14
MY121543A (en) 2006-02-28
HUT71489A (en) 1995-11-28
FI945703A0 (fi) 1994-12-02
GR3036136T3 (en) 2001-09-28
PT657428E (pt) 2001-07-31
EP0657428B1 (de) 2001-04-04
PL306068A1 (en) 1995-06-12
AU681198B2 (en) 1997-08-21
EP1607387A2 (de) 2005-12-21
FI945703A (fi) 1995-06-09
ZA949584B (en) 1996-06-03
CN1121387C (zh) 2003-09-17
CO4290427A1 (es) 1996-04-17
FI20000353A (fi) 2000-02-17
CA2137221C (en) 2011-02-22
NO944644D0 (no) 1994-12-02
IL111843A (en) 2000-02-29
BR9404842A (pt) 1995-08-08
ATE200279T1 (de) 2001-04-15
FI106455B (fi) 2001-02-15
US5434171A (en) 1995-07-18
FI106860B (fi) 2001-04-30
HU9403466D0 (en) 1995-02-28
HK1013826A1 (en) 1999-09-10
PL181734B1 (pl) 2001-09-28
JP3834075B2 (ja) 2006-10-18
CN1057294C (zh) 2000-10-11
EP0984004A2 (de) 2000-03-08
YU70294A (sh) 1997-07-31
CN1223257A (zh) 1999-07-21
DK0657428T3 (da) 2001-05-07
YU49312B (sh) 2005-06-10
CA2137221A1 (en) 1995-06-09
KR100356239B1 (ko) 2002-12-26
RU2145958C1 (ru) 2000-02-27
TW290540B (de) 1996-11-11
EP0984004A3 (de) 2003-10-15
CN1111239A (zh) 1995-11-08
AU7917094A (en) 1995-06-15
SI0657428T1 (en) 2001-08-31
JP2006070042A (ja) 2006-03-16
KR950017957A (ko) 1995-07-22
ES2155844T3 (es) 2001-06-01
PE41495A1 (es) 1995-11-28
NZ270039A (en) 1996-08-27
JPH07215937A (ja) 1995-08-15
DE69427017T2 (de) 2001-09-06
CZ299294A3 (en) 1995-10-18
NO302884B1 (no) 1998-05-04
IL111843A0 (en) 1995-03-15
YU82304A (sh) 2006-03-03
NO944644L (no) 1995-06-09
UA52577C2 (uk) 2003-01-15
RU94042903A (ru) 1996-10-27
EP0657428A1 (de) 1995-06-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN