DE69429801T2 - Bioresorbierbares Implantat-Vorprodukt - Google Patents

Bioresorbierbares Implantat-Vorprodukt

Info

Publication number
DE69429801T2
DE69429801T2 DE69429801T DE69429801T DE69429801T2 DE 69429801 T2 DE69429801 T2 DE 69429801T2 DE 69429801 T DE69429801 T DE 69429801T DE 69429801 T DE69429801 T DE 69429801T DE 69429801 T2 DE69429801 T2 DE 69429801T2
Authority
DE
Germany
Prior art keywords
precursor
implant
tissue
implant precursor
animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69429801T
Other languages
English (en)
Other versions
DE69429801D1 (de
Inventor
Alan M Polson
Deryl D Swanbom
Richard L Dunn
Charles P Cox
Richard L Norton
Bryan K Lowe
Kenneth S Peterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tolmar Therapeutics Inc
Original Assignee
Atrix Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atrix Laboratories Inc filed Critical Atrix Laboratories Inc
Publication of DE69429801D1 publication Critical patent/DE69429801D1/de
Application granted granted Critical
Publication of DE69429801T2 publication Critical patent/DE69429801T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/07—Stiffening bandages
    • A61L15/12—Stiffening bandages containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C41/08—Coating a former, core or other substrate by spraying or fluidisation, e.g. spraying powder
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C41/12—Spreading-out the material on a substrate, e.g. on the surface of a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C67/00—Shaping techniques not covered by groups B29C39/00 - B29C65/00, B29C70/00 or B29C73/00
    • B29C67/02—Moulding by agglomerating
    • B29C67/06—Coagulating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/43—Hormones, e.g. dexamethasone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037—Other properties
    • B29K2995/0056—Biocompatible, e.g. biopolymers or bioelastomers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037—Other properties
    • B29K2995/0059—Degradable
    • B29K2995/006—Bio-degradable, e.g. bioabsorbable, bioresorbable or bioerodible
DE69429801T 1993-09-28 1994-08-24 Bioresorbierbares Implantat-Vorprodukt Expired - Lifetime DE69429801T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/127,642 US5487897A (en) 1989-07-24 1993-09-28 Biodegradable implant precursor

Publications (2)

Publication Number Publication Date
DE69429801D1 DE69429801D1 (de) 2002-03-21
DE69429801T2 true DE69429801T2 (de) 2002-07-18

Family

ID=22431142

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69429801T Expired - Lifetime DE69429801T2 (de) 1993-09-28 1994-08-24 Bioresorbierbares Implantat-Vorprodukt
DE69433843T Expired - Lifetime DE69433843T2 (de) 1993-09-28 1994-08-24 Biologisch abbaubares Implantat-Vorprodukt

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69433843T Expired - Lifetime DE69433843T2 (de) 1993-09-28 1994-08-24 Biologisch abbaubares Implantat-Vorprodukt

Country Status (12)

Country Link
US (4) US5487897A (de)
EP (2) EP1147781B1 (de)
JP (2) JP3451259B2 (de)
KR (1) KR100248326B1 (de)
AT (2) ATE212866T1 (de)
AU (1) AU6614294A (de)
CA (1) CA2117394A1 (de)
DE (2) DE69429801T2 (de)
DK (2) DK1147781T3 (de)
ES (2) ES2225364T3 (de)
PT (1) PT649662E (de)
SI (1) SI0649662T1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8277828B2 (en) 2004-01-28 2012-10-02 Ultradent Products, Inc. Delivery system for bone growth promoting material

Families Citing this family (318)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5632727A (en) * 1988-10-03 1997-05-27 Atrix Laboratories, Inc. Biodegradable film dressing and method for its formation
US5487897A (en) 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
USRE37950E1 (en) 1990-04-24 2002-12-31 Atrix Laboratories Biogradable in-situ forming implants and methods of producing the same
US5269785A (en) * 1990-06-28 1993-12-14 Bonutti Peter M Apparatus and method for tissue removal
US6503277B2 (en) * 1991-08-12 2003-01-07 Peter M. Bonutti Method of transplanting human body tissue
EP0560014A1 (de) * 1992-03-12 1993-09-15 Atrix Laboratories, Inc. Biologisch abbaubarer Wundverband in Form eines Sprühfilms und Verfahren zu seiner Herstellung
US5681873A (en) * 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
PT754032E (pt) * 1994-04-08 2002-05-31 Atrix Lab Inc Composicoes liquidas para difusao
JPH09511666A (ja) * 1994-04-08 1997-11-25 アトリックス・ラボラトリーズ・インコーポレイテッド 医療装置で使用する付随的ポリマー系
US6306454B1 (en) * 1994-10-17 2001-10-23 Baxter International Inc. Method for producing improved medical devices and devices so produced
US5722950A (en) * 1995-06-07 1998-03-03 Atrix Laboratories, Inc. Method for remote delivery of an aerosolized liquid
US5665731A (en) * 1995-06-07 1997-09-09 Hennessey; Richard K. Method and composition for treating with a vasodilator inflammation, bone loss and detachment of teeth as associated with periodontal
AU6403196A (en) 1995-06-30 1997-02-05 Baylor University Polyester/carboxylic acid composite materials
US5736152A (en) * 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
US6054142A (en) * 1996-08-01 2000-04-25 Cyto Therapeutics, Inc. Biocompatible devices with foam scaffolds
US5786022A (en) * 1996-10-31 1998-07-28 Ethicon, Inc. Coating mixture for surgical articles
DK0959873T3 (da) * 1996-12-20 2006-07-03 Alza Corp Gelsammensætning og fremgangsmåder
US6630168B1 (en) 1997-02-20 2003-10-07 Biomedicines, Inc. Gel delivery vehicles for anticellular proliferative agents
KR100508229B1 (ko) * 1997-03-18 2005-08-17 선스타 가부시키가이샤 고체 입자 형성용 조성물
US7524335B2 (en) * 1997-05-30 2009-04-28 Smith & Nephew, Inc. Fiber-reinforced, porous, biodegradable implant device
AU8530498A (en) 1997-06-05 1998-12-21 Roland Bodmeier Multiphase system
US5962006A (en) * 1997-06-17 1999-10-05 Atrix Laboratories, Inc. Polymer formulation for prevention of surgical adhesions
CA2296056A1 (en) * 1997-07-10 1999-01-21 Keith Baker Methods for universally distributing therapeutic agents to the brain
AUPO907697A0 (en) 1997-09-09 1997-10-02 Day, Robert Edward Chemical supplementation of bone
US6486214B1 (en) * 1997-09-10 2002-11-26 Rutgers, The State University Of New Jersey Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
US6468519B1 (en) * 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
US6193991B1 (en) 1997-10-29 2001-02-27 Atul J. Shukla Biodegradable delivery systems of biologically active substances
ES2359973T3 (es) 1998-03-19 2011-05-30 MERCK SHARP & DOHME CORP. Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas.
EP1071411B1 (de) * 1998-04-20 2007-03-14 Torrey Pines Institute For Molecular Studies Topische immunostimulierung zur induzierung der migration der langerhanszellen
US6132360A (en) * 1998-05-22 2000-10-17 Halpern; Alan A. Magnetic stretching of magnetized neurons for spinal cord or peripheral nerve repair and regeneration
US6245345B1 (en) 1998-07-07 2001-06-12 Atrix Laboratories, Inc. Filamentous porous films and methods for producing the same
US6261583B1 (en) 1998-07-28 2001-07-17 Atrix Laboratories, Inc. Moldable solid delivery system
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US7790192B2 (en) * 1998-08-14 2010-09-07 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US7229621B2 (en) * 1998-10-20 2007-06-12 Torrey Pines Institute For Molecular Studies Method to enhance the immunogenicity of an antigen
US6565874B1 (en) * 1998-10-28 2003-05-20 Atrix Laboratories Polymeric delivery formulations of leuprolide with improved efficacy
US6143314A (en) * 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
US6200550B1 (en) 1998-12-11 2001-03-13 Q-Pharma, Inc. Oral care compositions comprising coenzyme Q10
US7371408B1 (en) * 1999-06-07 2008-05-13 Wright Medical Technology, Inc. Bone graft substitute composition
US6179840B1 (en) 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
US20020095157A1 (en) * 1999-07-23 2002-07-18 Bowman Steven M. Graft fixation device combination
US8226598B2 (en) * 1999-09-24 2012-07-24 Tolmar Therapeutics, Inc. Coupling syringe system and methods for obtaining a mixed composition
US20020055708A1 (en) * 1999-09-24 2002-05-09 Peterson Kenneth R. Coupling syringe system and methods for obtaining a mixed composition
US6461631B1 (en) 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
US6685928B2 (en) 1999-12-07 2004-02-03 Rutgers, The State University Of New Jersey Therapeutic compositions and methods
US20040038948A1 (en) 1999-12-07 2004-02-26 Uhrich Kathryn E. Therapeutic compositions and methods
UA78486C2 (uk) * 1999-12-10 2007-04-10 Хемджен Корпорейшн Композиція для перорального введення птахам та тваринам для лікування або зниження ризику інфекції травного тракту (варіанти), її застосування (варіанти) та спосіб лікування або зниження ризику інфекцій травного тракту (варіанти)
US20010037091A1 (en) * 1999-12-29 2001-11-01 Wironen John F. System for reconstituting pastes and methods of using same
EP1248596B1 (de) 2000-01-11 2007-03-07 Roland Bodmeier Kit zur implantation enthaltend eine trägerphase und ein lösungsmittel
WO2001051089A1 (de) * 2000-01-13 2001-07-19 Merck Patent Gmbh Pharmazeutische zubereitungen enthaltend 2-pyrrolidon als lösungsvermittler
US7373197B2 (en) * 2000-03-03 2008-05-13 Intramedical Imaging, Llc Methods and devices to expand applications of intraoperative radiation probes
US20030211974A1 (en) * 2000-03-21 2003-11-13 Brodbeck Kevin J. Gel composition and methods
US6566144B1 (en) 2000-03-27 2003-05-20 Atrix Laboratories Cover plate for use in lyophilization
US6626870B1 (en) 2000-03-27 2003-09-30 Artix Laboratories, Inc. Stoppering method to maintain sterility
AU5911101A (en) 2000-04-19 2001-10-30 Genentech Inc Sustained release formulations
US7771482B1 (en) 2000-05-09 2010-08-10 Ben-Zion Karmon Method for tissue expansion and regeneration using bioresorbable inflatable devices
AU2001245346A1 (en) * 2000-06-28 2002-01-08 Atul J. Shukla Biodegradable vehicles and delivery systems of biologically active substances
US6719970B1 (en) 2000-07-10 2004-04-13 Alkermes Controlled Therapeutics, Inc. Method of generating cartilage
WO2002009768A2 (en) * 2000-07-27 2002-02-07 Rutgers, The State University Therapeutic polyesters and polyamides
US6602915B2 (en) 2000-07-27 2003-08-05 Rutgers, The State University Of New Jersey Therapeutic azo-compounds for drug delivery
EP1315777B1 (de) * 2000-09-06 2007-10-31 AP Pharma, Inc. Abbaubare polyacetal-polymere
US6296607B1 (en) * 2000-10-20 2001-10-02 Praxis, Llc. In situ bulking device
US8470359B2 (en) 2000-11-13 2013-06-25 Qlt Usa, Inc. Sustained release polymer
DE10061297C2 (de) * 2000-12-08 2003-05-28 Siemens Ag Verfahren zur Sturkturierung eines OFETs
US20020127265A1 (en) * 2000-12-21 2002-09-12 Bowman Steven M. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
CA2365376C (en) 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US9080146B2 (en) * 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
US7700819B2 (en) 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
US7763769B2 (en) * 2001-02-16 2010-07-27 Kci Licensing, Inc. Biocompatible wound dressing
WO2002067991A1 (en) * 2001-02-23 2002-09-06 Genentech, Inc. Erodible polymers for injection
WO2002083194A1 (en) * 2001-04-12 2002-10-24 Therics, Inc. Method and apparatus for engineered regenerative biostructures
WO2002083188A2 (en) * 2001-04-16 2002-10-24 Cassidy James J Dense/porous structures for use as bone substitutes
US20030152630A1 (en) * 2001-05-11 2003-08-14 Ng Steven Y. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6590059B2 (en) * 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
IL159048A0 (en) * 2001-06-21 2004-05-12 Genentech Inc Sustained release formulation
US6949154B2 (en) * 2001-07-28 2005-09-27 Boehringer Ingelheim Pharma Kg Method and apparatus for sealing medicinal capsules
AU2002316314B8 (en) * 2001-07-31 2008-04-03 Covidien Lp Bioabsorbable adhesive compounds and compositions
US7371409B2 (en) 2001-09-06 2008-05-13 Wright Medical Technology, Inc. Bone graft substitute composition
US7303817B2 (en) 2001-10-24 2007-12-04 Weitao Jia Dental filling material
US7750063B2 (en) 2001-10-24 2010-07-06 Pentron Clinical Technologies, Llc Dental filling material
US7204875B2 (en) * 2001-10-24 2007-04-17 Pentron Clinical Technologies, Llc Dental filling material
US7204874B2 (en) 2001-10-24 2007-04-17 Pentron Clinical Technologies, Llc Root canal filling material
KR100436307B1 (ko) * 2001-11-02 2004-06-19 이진호 생분해성 고분자 다공성 지지체의 친수화, 유연화 처리방법
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
KR20040058100A (ko) * 2001-11-14 2004-07-03 알자 코포레이션 주입가능한 데포 조성물 및 그의 용도
DE60239556D1 (de) * 2001-11-14 2011-05-05 Durect Corp Katheterinjizierbare depotzusammensetzungen und deren verwendung
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
US20030105530A1 (en) * 2001-12-04 2003-06-05 Inion Ltd. Biodegradable implant and method for manufacturing one
US6758673B2 (en) 2001-12-05 2004-07-06 Ofir Fromovich Periosteal distraction
US8501165B2 (en) 2001-12-12 2013-08-06 Promethean Surgical Devices Llc In situ bonds
US20030118651A1 (en) * 2001-12-21 2003-06-26 Jampani Hanuman B. Bio-compatible means for controlled drug delivery to tissue and method of use
WO2003080629A2 (en) 2002-02-25 2003-10-02 Guilford Pharmaceuticals, Inc. Phosphorus-containing compounds with polymeric chains, and methods of making and using the same
EP1344538A1 (de) * 2002-03-14 2003-09-17 Degradable Solutions AG Poröses und bioabbaubares Implantatmaterial und Verfahren zu seiner Herstellung
JP2005526079A (ja) * 2002-03-15 2005-09-02 サイプレス バイオサイエンス， インコーポレイテッド 内蔵痛症候群を処置するためのｎｅおよび５−ｈｔ再取り込み阻害剤
ATE490745T1 (de) 2002-03-29 2010-12-15 Wright Medical Tech Inc Knochentransplantat-ersatzzusammensetzung
CA2488059C (en) * 2002-06-06 2014-05-06 Arnulf Pascher Non-polymeric hematopoietic cell clots for delivery of active agents
US7291179B2 (en) 2002-06-24 2007-11-06 Wright Medical Technology, Inc. Bone graft substitute composition
US6652887B1 (en) 2002-06-24 2003-11-25 Wright Medical Technology, Inc. Bone graft substitute composition
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US20080226723A1 (en) * 2002-07-05 2008-09-18 Celonova Biosciences, Inc. Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
US7049348B2 (en) * 2002-07-06 2006-05-23 Kensey Nash Corporation Resorbable structure for treating and healing of tissue defects
AU2003251992A1 (en) * 2002-07-17 2004-02-02 Rutgers, The State University Therapeutic devices for patterned cell growth
CA2494342A1 (en) * 2002-07-31 2004-02-12 Alza Corporation Injectable depot compositions and uses thereof
DE60325742D1 (de) * 2002-07-31 2009-02-26 Alza Corp Injizierbare multimodale polymere depotzusammensetzungen und ihre verwendungen
US7824701B2 (en) * 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US20040132826A1 (en) * 2002-10-25 2004-07-08 Collegium Pharmaceutical, Inc. Modified release compositions of milnacipran
US20060003004A1 (en) * 2002-10-25 2006-01-05 Collegium Pharmaceutical, Inc. Pulsatile release compositions of milnacipran
ES2327918T3 (es) * 2002-10-28 2009-11-05 Tyco Healthcare Group Lp Compuestos adhesivos bioabsorbibles.
MXPA05008033A (es) * 2003-01-28 2006-04-28 Collegium Pharmaceutical Inc Composiciones de milnacipran en forma de multiparticulas para administracion oral.
US7507257B2 (en) * 2003-02-04 2009-03-24 Wright Medical Technology, Inc. Injectable resorbable bone graft material, powder for forming same and methods relating thereto for treating bone defects
ES2695401T3 (es) * 2003-02-12 2019-01-04 Syncera Inc Composiciones de aleación de polímeros de óxido de alquileno aleatorios y no aleatorios
US8197837B2 (en) 2003-03-07 2012-06-12 Depuy Mitek, Inc. Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
WO2004081196A2 (en) * 2003-03-11 2004-09-23 Qlt Usa Inc. Formulations for cell- schedule dependent anticancer agents
EP1608292A4 (de) * 2003-03-13 2007-10-31 Univ Rice William M Injizierbares und vorgefertigtes verbundmaterial als knochenersatz und verfahren zur herstellung eines derartigen knochenersatzmaterials
GB0307011D0 (en) 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
US9289195B2 (en) * 2003-06-04 2016-03-22 Access Closure, Inc. Auto-retraction apparatus and methods for sealing a vascular puncture
US7331979B2 (en) * 2003-06-04 2008-02-19 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US8226715B2 (en) * 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US10583220B2 (en) 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
US8541051B2 (en) * 2003-08-14 2013-09-24 Halliburton Energy Services, Inc. On-the fly coating of acid-releasing degradable material onto a particulate
US7674753B2 (en) * 2003-09-17 2010-03-09 Halliburton Energy Services, Inc. Treatment fluids and methods of forming degradable filter cakes comprising aliphatic polyester and their use in subterranean formations
US7833944B2 (en) * 2003-09-17 2010-11-16 Halliburton Energy Services, Inc. Methods and compositions using crosslinked aliphatic polyesters in well bore applications
US7829507B2 (en) 2003-09-17 2010-11-09 Halliburton Energy Services Inc. Subterranean treatment fluids comprising a degradable bridging agent and methods of treating subterranean formations
US20050085922A1 (en) * 2003-10-17 2005-04-21 Shappley Ben R. Shaped filler for implantation into a bone void and methods of manufacture and use thereof
PL1680089T3 (pl) * 2003-10-22 2014-03-31 Lidds Ab Kompozycja zawierająca biodegradowalną ceramikę hydratującą do kontrolowanego dostarczania leków
US20070224278A1 (en) 2003-11-12 2007-09-27 Lyons Robert T Low immunogenicity corticosteroid compositions
US20050101582A1 (en) 2003-11-12 2005-05-12 Allergan, Inc. Compositions and methods for treating a posterior segment of an eye
US20060141049A1 (en) * 2003-11-12 2006-06-29 Allergan, Inc. Triamcinolone compositions for intravitreal administration to treat ocular conditions
US20050250737A1 (en) * 2003-11-12 2005-11-10 Allergan, Inc. Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7979150B2 (en) * 2003-12-05 2011-07-12 The Regents Of The University Of Michigan Biodegradable/bioresorbable tissue augmentation/reconstruction device
US7901461B2 (en) * 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
US20050129733A1 (en) * 2003-12-09 2005-06-16 Milbocker Michael T. Surgical adhesive and uses therefore
US7195068B2 (en) * 2003-12-15 2007-03-27 Halliburton Energy Services, Inc. Filter cake degradation compositions and methods of use in subterranean operations
US20050149117A1 (en) * 2003-12-24 2005-07-07 Farhad Khosravi Apparatus and methods for delivering sealing materials during a percutaneous procedure to facilitate hemostasis
US20070060950A1 (en) * 2003-12-24 2007-03-15 Farhad Khosravi Apparatus and methods for delivering sealing materials during a percutaneous procedure to facilitate hemostasis
AU2005209201B2 (en) 2004-01-20 2010-06-03 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US8048101B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US9238127B2 (en) 2004-02-25 2016-01-19 Femasys Inc. Methods and devices for delivering to conduit
US8052669B2 (en) 2004-02-25 2011-11-08 Femasys Inc. Methods and devices for delivery of compositions to conduits
US8048086B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US8221780B2 (en) * 2004-04-20 2012-07-17 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8137686B2 (en) 2004-04-20 2012-03-20 Depuy Mitek, Inc. Nonwoven tissue scaffold
US20070078063A1 (en) * 2004-04-26 2007-04-05 Halliburton Energy Services, Inc. Subterranean treatment fluids and methods of treating subterranean formations
US8147865B2 (en) * 2004-04-30 2012-04-03 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US8119154B2 (en) 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US8163030B2 (en) * 2004-05-06 2012-04-24 Degradable Solutions Ag Biocompatible bone implant compositions and methods for repairing a bone defect
US20050249791A1 (en) * 2004-05-07 2005-11-10 3M Innovative Properties Company Antimicrobial articles
EP1604693A1 (de) 2004-06-09 2005-12-14 Scil Technology GmbH In-situ hergestelltes Gerüst, dessen Herstellungsverfahren und dessen Verwendung
JP2008505978A (ja) * 2004-07-12 2008-02-28 アラーガン、インコーポレイテッド 眼病用組成物および眼病治療法
US7547665B2 (en) * 2005-04-29 2009-06-16 Halliburton Energy Services, Inc. Acidic treatment fluids comprising scleroglucan and/or diutan and associated methods
US7621334B2 (en) * 2005-04-29 2009-11-24 Halliburton Energy Services, Inc. Acidic treatment fluids comprising scleroglucan and/or diutan and associated methods
US7475728B2 (en) * 2004-07-23 2009-01-13 Halliburton Energy Services, Inc. Treatment fluids and methods of use in subterranean formations
US8980300B2 (en) 2004-08-05 2015-03-17 Advanced Cardiovascular Systems, Inc. Plasticizers for coating compositions
US20060035039A1 (en) * 2004-08-12 2006-02-16 3M Innovative Properties Company Silver-releasing articles and methods of manufacture
US20060034899A1 (en) * 2004-08-12 2006-02-16 Ylitalo Caroline M Biologically-active adhesive articles and methods of manufacture
US8348971B2 (en) * 2004-08-27 2013-01-08 Accessclosure, Inc. Apparatus and methods for facilitating hemostasis within a vascular puncture
US20060046938A1 (en) * 2004-09-02 2006-03-02 Harris Philip C Methods and compositions for delinking crosslinked fluids
US7641688B2 (en) 2004-09-16 2010-01-05 Evera Medical, Inc. Tissue augmentation device
US7244270B2 (en) 2004-09-16 2007-07-17 Evera Medical Systems and devices for soft tissue augmentation
US7413017B2 (en) * 2004-09-24 2008-08-19 Halliburton Energy Services, Inc. Methods and compositions for inducing tip screenouts in frac-packing operations
US8313763B2 (en) * 2004-10-04 2012-11-20 Tolmar Therapeutics, Inc. Sustained delivery formulations of rapamycin compounds
CA2582374A1 (en) * 2004-10-04 2006-04-20 Qlt Usa, Inc. Ocular delivery of polymeric delivery formulations
US7250550B2 (en) * 2004-10-22 2007-07-31 Wright Medical Technology, Inc. Synthetic bone substitute material
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
KR101153785B1 (ko) * 2004-10-25 2012-07-09 셀로노바 바이오사이언시스 저머니 게엠베하 치료 및/또는 진단용으로 부가할 수 있는 중합체 입자 및이의 제조 및 사용 방법
US9107850B2 (en) * 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US9114162B2 (en) * 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US7862835B2 (en) * 2004-10-27 2011-01-04 Boston Scientific Scimed, Inc. Method of manufacturing a medical device having a porous coating thereon
WO2006050493A2 (en) 2004-11-03 2006-05-11 The Regents Of The University Of Michigan Biodegradable implant for intertransverse process fusion
US8262693B2 (en) 2004-11-05 2012-09-11 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
JP5244394B2 (ja) 2004-11-10 2013-07-24 トルマー セラピューティクス， インコーポレイテッド． 安定化されたポリマー送達系
US7553800B2 (en) * 2004-11-17 2009-06-30 Halliburton Energy Services, Inc. In-situ filter cake degradation compositions and methods of use in subterranean formations
US7648946B2 (en) * 2004-11-17 2010-01-19 Halliburton Energy Services, Inc. Methods of degrading filter cakes in subterranean formations
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
US20080009423A1 (en) * 2005-01-31 2008-01-10 Halliburton Energy Services, Inc. Self-degrading fibers and associated methods of use and manufacture
US20060169448A1 (en) * 2005-02-01 2006-08-03 Halliburton Energy Services, Inc. Self-degrading cement compositions and methods of using self-degrading cement compositions in subterranean formations
US7353876B2 (en) * 2005-02-01 2008-04-08 Halliburton Energy Services, Inc. Self-degrading cement compositions and methods of using self-degrading cement compositions in subterranean formations
US7497258B2 (en) * 2005-02-01 2009-03-03 Halliburton Energy Services, Inc. Methods of isolating zones in subterranean formations using self-degrading cement compositions
US20060169450A1 (en) * 2005-02-02 2006-08-03 Halliburton Energy Services, Inc. Degradable particulate generation and associated methods
US20070298977A1 (en) * 2005-02-02 2007-12-27 Halliburton Energy Services, Inc. Degradable particulate generation and associated methods
US20060172894A1 (en) * 2005-02-02 2006-08-03 Halliburton Energy Services, Inc. Degradable particulate generation and associated methods
US20060172895A1 (en) * 2005-02-02 2006-08-03 Halliburton Energy Services, Inc. Degradable particulate generation and associated methods
US8598092B2 (en) * 2005-02-02 2013-12-03 Halliburton Energy Services, Inc. Methods of preparing degradable materials and methods of use in subterranean formations
EP1846505B1 (de) 2005-02-09 2015-11-11 Covidien LP Synthetische dichtungsmittel
US7506689B2 (en) * 2005-02-22 2009-03-24 Halliburton Energy Services, Inc. Fracturing fluids comprising degradable diverting agents and methods of use in subterranean formations
US8221504B2 (en) * 2005-02-23 2012-07-17 Wright Medical Technology, Inc. Coating an implant for increased bone in-growth
WO2006104901A2 (en) * 2005-03-28 2006-10-05 University Of Florida Research Foundation, Inc. Materials and methods for improved tissue engineering
US20060222596A1 (en) 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
US20060242562A1 (en) * 2005-04-22 2006-10-26 Microsoft Corporation Embedded method for embedded interaction code array
US20100100124A1 (en) * 2005-05-05 2010-04-22 Tyco Healthcare Group Lp Bioabsorbable surgical composition
US20090177226A1 (en) * 2005-05-05 2009-07-09 Jon Reinprecht Bioabsorbable Surgical Compositions
US20100016888A1 (en) * 2005-05-05 2010-01-21 Allison Calabrese Surgical Gasket
US8044234B2 (en) * 2005-05-05 2011-10-25 Tyco Healthcare Group Lp Bioabsorbable surgical composition
US7662753B2 (en) * 2005-05-12 2010-02-16 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US7608567B2 (en) * 2005-05-12 2009-10-27 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US20060276345A1 (en) * 2005-06-07 2006-12-07 Halliburton Energy Servicers, Inc. Methods controlling the degradation rate of hydrolytically degradable materials
US7595280B2 (en) * 2005-08-16 2009-09-29 Halliburton Energy Services, Inc. Delayed tackifying compositions and associated methods involving controlling particulate migration
US7484564B2 (en) * 2005-08-16 2009-02-03 Halliburton Energy Services, Inc. Delayed tackifying compositions and associated methods involving controlling particulate migration
US20070100199A1 (en) * 2005-11-03 2007-05-03 Lilip Lau Apparatus and method of delivering biomaterial to the heart
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
US20070049501A1 (en) * 2005-09-01 2007-03-01 Halliburton Energy Services, Inc. Fluid-loss control pills comprising breakers that comprise orthoesters and/or poly(orthoesters) and methods of use
US8025903B2 (en) 2005-09-09 2011-09-27 Wright Medical Technology, Inc. Composite bone graft substitute cement and articles produced therefrom
CN103349793B (zh) 2005-09-09 2016-02-10 阿格诺沃斯健康关爱公司 复合骨移植替代物水泥以及由其制得的制品
US7713916B2 (en) * 2005-09-22 2010-05-11 Halliburton Energy Services, Inc. Orthoester-based surfactants and associated methods
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
WO2007142667A2 (en) 2005-10-13 2007-12-13 Human Genome Sciences, Inc. Treatment of patients with autoantibody positive disease
US7461697B2 (en) * 2005-11-21 2008-12-09 Halliburton Energy Services, Inc. Methods of modifying particulate surfaces to affect acidic sites thereon
JP2009518129A (ja) 2005-12-06 2009-05-07 タイコ ヘルスケア グループ リミテッド パートナーシップ 生体吸収性外科用組成物
EP1968617A4 (de) * 2005-12-06 2012-05-02 Tyco Healthcare Biokompatible gewebeabdichtungsmittel und klebstoffe
JP5333911B2 (ja) * 2005-12-06 2013-11-06 コヴィディエン リミテッド パートナーシップ 生体適合性外科用組成物
AU2006321914B2 (en) * 2005-12-06 2012-01-19 Covidien Lp Bioabsorbable compounds and compositions containing them
JP2009518519A (ja) * 2005-12-06 2009-05-07 タイコ ヘルスケア グループ リミテッド パートナーシップ 官能化ポリエチレングリコールのカルボジイミド架橋
CA2629932C (en) * 2005-12-08 2014-07-08 Tyco Healthcare Group Lp Viscosity-reduced sprayable compositions
WO2007067806A2 (en) * 2005-12-08 2007-06-14 Tyco Healthcare Group Lp Biocompatible surgical compositons
AU2006321856B2 (en) * 2005-12-08 2013-01-31 Covidien Lp Biocompatible surgical compositions
EP1984009B1 (de) 2006-01-18 2012-10-24 Qps, Llc Pharmazeutische zusammensetzungen mit verbesserter stabilität
US7431088B2 (en) * 2006-01-20 2008-10-07 Halliburton Energy Services, Inc. Methods of controlled acidization in a wellbore
CA2573472A1 (en) * 2006-01-23 2007-07-23 Tyco Healthcare Group Lp Biodegradable hemostatic compositions
US20070178159A1 (en) * 2006-01-30 2007-08-02 Alza Corporation In-Situ Forming Porous Scaffold
US20070184087A1 (en) * 2006-02-06 2007-08-09 Bioform Medical, Inc. Polysaccharide compositions for use in tissue augmentation
CA2637220C (en) 2006-02-22 2015-04-21 Tyco Healthcare Group Lp Biodegradable phosphoester polyamines
US7608566B2 (en) * 2006-03-30 2009-10-27 Halliburton Energy Services, Inc. Degradable particulates as friction reducers for the flow of solid particulates and associated methods of use
US20090311328A1 (en) * 2006-03-31 2009-12-17 Csir Bulking of Soft Tissue
US7872068B2 (en) * 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
DK2054073T3 (da) * 2006-07-11 2015-03-02 Foresee Pharmaceuticals Inc Farmaceutiske præparater til fremføring med langvarig frigivelse af peptider
US20080026959A1 (en) * 2006-07-25 2008-01-31 Halliburton Energy Services, Inc. Degradable particulates and associated methods
US20080026960A1 (en) * 2006-07-25 2008-01-31 Halliburton Energy Services, Inc. Degradable particulates and associated methods
US20080026955A1 (en) * 2006-07-25 2008-01-31 Halliburton Energy Services, Inc. Degradable particulates and associated methods
US8329621B2 (en) * 2006-07-25 2012-12-11 Halliburton Energy Services, Inc. Degradable particulates and associated methods
US9192418B2 (en) * 2006-08-22 2015-11-24 National University Corporation Hokkaido University Laser processing apparatus, osseointegration method, implant material, and implant-material fabrication method
EP2102144A4 (de) 2006-09-13 2011-03-23 Univ Rutgers Wirkstoffe und ihre oligomere und polymere
US7455112B2 (en) * 2006-09-29 2008-11-25 Halliburton Energy Services, Inc. Methods and compositions relating to the control of the rates of acid-generating compounds in acidizing operations
US9289279B2 (en) * 2006-10-06 2016-03-22 Promethean Surgical Devices, Llc Apparatus and method for limiting surgical adhesions
US8076448B2 (en) * 2006-10-11 2011-12-13 Tolmar Therapeutics, Inc. Preparation of biodegradable polyesters with low-burst properties by supercritical fluid extraction
US7686080B2 (en) * 2006-11-09 2010-03-30 Halliburton Energy Services, Inc. Acid-generating fluid loss control additives and associated methods
US8220548B2 (en) 2007-01-12 2012-07-17 Halliburton Energy Services Inc. Surfactant wash treatment fluids and associated methods
AU2008214359B2 (en) 2007-02-05 2014-01-16 Apellis Pharmaceuticals, Inc. Local complement inhibition for treatment of complement-mediated disorders
DK2115029T3 (en) * 2007-02-15 2015-10-05 Tolmar Therapeutics Inc LAVSPRÆNGNING poly (lactide / glycolide) and methods to produce polymers
US20110123476A1 (en) * 2007-05-24 2011-05-26 Mbiya Kapiamba Adhesive Formulations
CN101801415B (zh) 2007-05-25 2015-09-23 Rb医药品有限公司 利培酮化合物的持续递送制剂
US7858835B2 (en) * 2007-06-27 2010-12-28 Tyco Healthcare Group Lp Foam control for synthetic adhesive/sealant
US20090004243A1 (en) 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
US9125807B2 (en) * 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
WO2009020607A2 (en) * 2007-08-07 2009-02-12 Arsenal Medical, Inc. Method and apparatus for composite drug delivery medical devices
US20090062157A1 (en) * 2007-08-30 2009-03-05 Halliburton Energy Services, Inc. Methods and compositions related to the degradation of degradable polymers involving dehydrated salts and other associated methods
US8470360B2 (en) * 2008-04-18 2013-06-25 Warsaw Orthopedic, Inc. Drug depots having different release profiles for reducing, preventing or treating pain and inflammation
US20090110738A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110730A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
EP2209426A4 (de) * 2007-11-02 2015-04-22 Incept Llc Gerät und verfahren zur abdichtung einer gefässpunktion
US8500947B2 (en) 2007-11-15 2013-08-06 Covidien Lp Speeding cure rate of bioadhesives
US20090181068A1 (en) * 2008-01-14 2009-07-16 Dunn Richard L Low Viscosity Liquid Polymeric Delivery System
US20090198329A1 (en) 2008-02-01 2009-08-06 Kesten Randy J Breast implant with internal flow dampening
US20090197780A1 (en) * 2008-02-01 2009-08-06 Weaver Jimmie D Ultrafine Grinding of Soft Materials
US8029533B2 (en) 2008-04-04 2011-10-04 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US9364206B2 (en) 2008-04-04 2016-06-14 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US8006760B2 (en) 2008-04-10 2011-08-30 Halliburton Energy Services, Inc. Clean fluid systems for partial monolayer fracturing
US7906464B2 (en) 2008-05-13 2011-03-15 Halliburton Energy Services, Inc. Compositions and methods for the removal of oil-based filtercakes
US8877225B2 (en) * 2008-06-03 2014-11-04 Tolmar Therapeutics, Inc. Controlled release copolymer formulation with improved release kinetics
WO2009148579A2 (en) 2008-06-03 2009-12-10 Qlt Usa, Inc. Dehydrated hydrogel inclusion complex of a bioactive agent with flowable drug delivery system
WO2010009291A1 (en) * 2008-07-16 2010-01-21 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles containing bioactive peptides
AU2009270695A1 (en) 2008-07-17 2010-01-21 Ap Pharma Methods for enhancing the stability of polyorthoesters and their formulations
US7833943B2 (en) * 2008-09-26 2010-11-16 Halliburton Energy Services Inc. Microemulsifiers and methods of making and using same
US9554826B2 (en) 2008-10-03 2017-01-31 Femasys, Inc. Contrast agent injection system for sonographic imaging
US10070888B2 (en) * 2008-10-03 2018-09-11 Femasys, Inc. Methods and devices for sonographic imaging
WO2010093873A2 (en) 2009-02-12 2010-08-19 Incept, Llc Drug delivery through hydrogel plugs
WO2010093993A2 (en) 2009-02-12 2010-08-19 Human Genome Sciences, Inc. Use of b lymphocyte stimulator protein antagonists to promote transplantation tolerance
US20100212906A1 (en) * 2009-02-20 2010-08-26 Halliburton Energy Services, Inc. Method for diversion of hydraulic fracture treatments
US8574612B2 (en) * 2009-03-04 2013-11-05 Boston Scientific Scimed, Inc. Medical devices having a coating of biologic macromolecules
US8377316B2 (en) * 2009-04-30 2013-02-19 Xerox Corporation Structure and method for creating surface texture of compliant coatings on piezo ink jet imaging drums
CA2760704C (en) * 2009-05-04 2017-10-03 Incept, Llc Biomaterials for track and puncture closure
JP5847706B2 (ja) * 2009-06-01 2016-01-27 タイレックス・インコーポレイテッドＴｙｒｘ Ｉｎｃ． 胸骨創感染症を予防するための組成物および方法
US8082992B2 (en) 2009-07-13 2011-12-27 Halliburton Energy Services, Inc. Methods of fluid-controlled geometry stimulation
EP2477617B1 (de) 2009-09-18 2018-01-31 Bioinspire Technologies Inc. Autonomes bioabbaubares pflaster
US9271925B2 (en) 2013-03-11 2016-03-01 Bioinspire Technologies, Inc. Multi-layer biodegradable device having adjustable drug release profile
DE102010020940B4 (de) * 2010-05-19 2014-09-25 Heraeus Medical Gmbh Antibiotische Beschichtung
GB2481017B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
JP5963208B2 (ja) * 2010-08-10 2016-08-03 ライフセル コーポレーションＬｉｆｅＣｅｌｌ Ｃｏｒｐｏｒａｔｉｏｎ 再生組織足場
US8741317B2 (en) 2010-08-19 2014-06-03 Rutgers, The State University Of New Jersey Slow-degrading polymers comprising salicylic acid for undelayed and sustained drug delivery
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
GB201016433D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Apparatus and method for making solid beads
GB201016436D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Method of making solid beads
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
EP3821820A1 (de) 2011-01-19 2021-05-19 Access Closure, Inc. Vorrichtung und verfahren zur herstellung einer versiegelung einer gefässpunktion
US9820728B2 (en) 2011-01-19 2017-11-21 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
JP6189827B2 (ja) * 2011-04-13 2017-08-30 ニュー ジャージー インスティテューツ オブ テクノロジー 骨修復のためのエレクトロスピニングによる生分解性の足場のためのシステムと方法
US9265830B2 (en) 2011-04-20 2016-02-23 Warsaw Orthopedic, Inc. Implantable compositions and methods for preparing the same
US9386968B2 (en) 2011-05-11 2016-07-12 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US9216181B2 (en) 2011-06-08 2015-12-22 Southwest Research Institute BMP-2 upregulating compounds for healing bone tissue and screening methods for selecting such compounds
WO2013074099A1 (en) * 2011-11-16 2013-05-23 Empire Technology Development Llc Three-dimensional porous biodegradable cell scaffold
US9205150B2 (en) 2011-12-05 2015-12-08 Incept, Llc Medical organogel processes and compositions
US20150031772A1 (en) * 2012-02-17 2015-01-29 Bacterin International, Inc. Adjustable bioactive agent dispersion within a polymeric coating
US9144579B2 (en) 2012-08-17 2015-09-29 Rutgers, The State University Of New Jersey Polyesters and methods of use thereof
US20140120057A1 (en) 2012-10-25 2014-05-01 Rutgers, The State University Of New Jersey Polymers and methods thereof for wound healing
US9387250B2 (en) 2013-03-15 2016-07-12 Rutgers, The State University Of New Jersey Therapeutic compositions for bone repair
KR101395712B1 (ko) 2013-03-18 2014-05-19 주식회사 엘앤씨바이오 진피조직체의 동결건조용 지그
US9862672B2 (en) 2013-05-29 2018-01-09 Rutgers, The State University Of New Jersey Antioxidant-based poly(anhydride-esters)
CA2931547A1 (en) 2013-12-09 2015-06-18 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
GB201404139D0 (en) 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
AU2015231595A1 (en) * 2014-03-17 2016-09-22 The Penn State Research Foundation Methods of promoting bone growth and healing
US10023521B2 (en) 2014-06-13 2018-07-17 Rutgers, The State University Of New Jersey Process and intermediates for preparing poly(anhydride-esters)
US20160106804A1 (en) 2014-10-15 2016-04-21 Yuhua Li Pharmaceutical composition with improved stability
GB2554218A (en) * 2015-03-17 2018-03-28 Harvard College Automated membrane fabrication system
US10543162B2 (en) 2015-04-10 2020-01-28 Rutgers, The State University Of New Jersey Kojic acid polymers
IL243401A (en) 2015-12-29 2017-12-31 Zion Karmon Ben Instruments and methods for lifting Schneider membrane
IL248472A0 (en) 2016-10-13 2017-01-31 Zion Karmon Ben Devices for tissue growth
SG11202004525TA (en) 2017-12-18 2020-06-29 Foresee Pharmaceuticals Co Ltd Pharmaceutical compositions having a selected release duration
US10926005B2 (en) * 2018-12-21 2021-02-23 BioSapien Inc. Drug-eluting surgical articles with a plurality of geometric elements
WO2021146215A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
CN114159103B (zh) * 2021-11-23 2022-09-13 深圳市华晨阳科技有限公司 一种可降解的一次性采样口腔拭子

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2155658A (en) * 1936-01-08 1939-04-25 Chemische Forschungs Gmbh Surgical and medical preparations
NL109113C (de) * 1957-03-27
US3328246A (en) * 1957-08-20 1967-06-27 Bicrex Lab Ltd Dental compositions and methods of making same
US3218283A (en) * 1962-07-26 1965-11-16 Monsanto Co Novel solutions of poly-(acrylic anhydride) and poly-(methacrylic anhydride) polymers
US3219527A (en) * 1963-06-17 1965-11-23 Loyola University Peridontal pack or dressing composition
US3463158A (en) * 1963-10-31 1969-08-26 American Cyanamid Co Polyglycolic acid prosthetic devices
US3520949A (en) * 1966-07-26 1970-07-21 Nat Patent Dev Corp Hydrophilic polymers,articles and methods of making same
US3458622A (en) * 1967-04-07 1969-07-29 Squibb & Sons Inc Controlled release tablet
US3887699A (en) * 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3767784A (en) * 1970-12-01 1973-10-23 S Gluck Composition for the protection and treatment of injured body tissue and method of utilizing the same
US3760034A (en) * 1971-01-26 1973-09-18 Union Carbide Corp Graft copolymers of lactone polyesters
US3755558A (en) * 1971-02-23 1973-08-28 Du Pont Polylactide drug mixtures for topical application atelet aggregation
US3696811A (en) * 1971-06-17 1972-10-10 Squibb & Sons Inc Periodontal bandage and backing therefor
US3975350A (en) * 1972-08-02 1976-08-17 Princeton Polymer Laboratories, Incorporated Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles
US4450150A (en) * 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
US3919773A (en) * 1973-12-20 1975-11-18 Sybron Corp Direct moldable implant material
US3939111A (en) * 1974-07-01 1976-02-17 The B. F. Goodrich Company Stable polyurethane solutions
US3935308A (en) * 1974-08-08 1976-01-27 The United States Of America As Represented By The Secretary Of The Navy Wound covering and method of application
US3931678A (en) * 1974-09-24 1976-01-13 Loctite (Ireland) Limited Dental filling method and composition formed thereby
US3949073A (en) * 1974-11-18 1976-04-06 The Board Of Trustees Of Leland Stanford Junior University Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution
US4088798A (en) * 1975-11-11 1978-05-09 Sandoz, Inc. Methods for the preparation of controlled gastric residence time medicament formulations
CH625702A5 (de) * 1977-01-18 1981-10-15 Delalande Sa
US4127127A (en) * 1977-05-23 1978-11-28 Alza Corporation Therapeutic systems made from certain segmented copolyesters
US4148871A (en) * 1977-10-11 1979-04-10 Pitt Colin G Sustained subdermal delivery ofdrugs using poly(ε-caprolactone) and its copolymers
DE2917037C2 (de) 1979-04-27 1980-12-11 Josef Dipl.-Chem. Dr. 8000 Muenchen Gaensheimer Parenteral arzneimittelhaltige partiell resorbierbare Mehrkomponentenmasse auf Basis von polymeren Stoffen
US4789732A (en) * 1980-08-04 1988-12-06 Regents Of The University Of California Bone morphogenetic protein composition
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4619989A (en) * 1981-05-05 1986-10-28 The Regents Of The University Of Cal. Bone morphogenetic protein composition
US4761471A (en) * 1980-08-04 1988-08-02 The Regents Of The University Of California Bone morphogenetic protein composition
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4408023A (en) * 1980-11-12 1983-10-04 Tyndale Plains-Hunter, Ltd. Polyurethane diacrylate compositions useful for contact lenses and the like
DE3045135A1 (de) * 1980-11-29 1982-06-09 Sandoz-Patent-GmbH, 7850 Lörrach Pharmazeutische kompositionen enthaltende bioabbaubare polymere
JPS57110254A (en) * 1980-12-29 1982-07-09 Teijin Ltd Coating agent of injured membrane part of oral cavity
US4793336A (en) * 1981-03-25 1988-12-27 Wang Paul Y Wound coverings and processes for their preparation
US4447562A (en) * 1981-07-15 1984-05-08 Ivani Edward J Amino-polysaccharides and copolymers thereof for contact lenses and ophthalmic compositions
FR2515955B1 (fr) * 1981-11-11 1987-11-20 South African Inventions Implant chirurgical
US4582640A (en) * 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
US4570629A (en) * 1982-03-17 1986-02-18 University Of Illinois Foundation Hydrophilic biopolymeric copolyelectrolytes, and biodegradable wound dressing comprising same
EP0092329B1 (de) * 1982-04-07 1988-07-27 Bernard Paul Philippe Feinmann Material und Methode für die Zahnmedizin
ATE37983T1 (de) * 1982-04-22 1988-11-15 Ici Plc Mittel mit verzoegerter freigabe.
CA1211266A (en) * 1982-11-12 1986-09-16 Alfred E. Lauchenauer Shaped semi-solid articles
US4443430A (en) * 1982-11-16 1984-04-17 Ethicon, Inc. Synthetic absorbable hemostatic agent
US4439420A (en) * 1982-11-16 1984-03-27 Ethicon, Inc. Absorbable hemostatic composition
US5286763A (en) * 1983-03-22 1994-02-15 Massachusetts Institute Of Technology Bioerodible polymers for drug delivery in bone
US4904478A (en) * 1983-08-11 1990-02-27 Mission Pharmacal Company Slow-release sodium fluoride tablet and method for treatment of osteoporosis
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4631188A (en) * 1983-08-31 1986-12-23 S.K.Y. Polymers, Ltd. (Kingston Technologies) Injectable physiologically-acceptable polymeric composition
US4932973A (en) * 1983-09-30 1990-06-12 El Gendler Cartilage and bone induction by artificially perforated organic bone matrix
GR80494B (en) * 1983-10-07 1985-02-04 Forsyth Dental Infirmary Intra-pocket drug delivery devices for treatment of periodontal diseases
US4526909A (en) * 1984-01-09 1985-07-02 Regents Of The University Of California Polymethylmethacrylate delivery system for bone morphogenetic protein
SE452404B (sv) * 1984-02-03 1987-11-30 Medinvent Sa Flerskiktat protesmaterial samt forfarande for dess framstellning
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4596574A (en) * 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
US4663077A (en) * 1984-06-11 1987-05-05 Morton Thiokol Inc. Microbiocidal compositions comprising an aryl alkanol and a microbiocidal compound dissolved therein
GB8416234D0 (en) * 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
IN164495B (de) * 1984-07-06 1989-03-25 Gore & Ass
EP0169016B2 (de) * 1984-07-16 2004-04-28 Celtrix Pharmaceuticals, Inc. Knorpel-induzierende Polypeptid-Faktoren aus Knochen
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
US4614787A (en) * 1984-11-13 1986-09-30 Thermedics, Inc. Drug dispensing wound dressing
US4687768A (en) * 1984-12-21 1987-08-18 The Procter & Gamble Company Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism
US4595713A (en) * 1985-01-22 1986-06-17 Hexcel Corporation Medical putty for tissue augmentation
US4568536A (en) * 1985-02-08 1986-02-04 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4650665A (en) * 1985-02-08 1987-03-17 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
EP0200508B1 (de) * 1985-04-27 1991-10-02 Nitto Denko Corporation Klebepflaster und Arzneimittel für die Mundhöhle
US4857456A (en) * 1985-04-30 1989-08-15 The Regents Of The University Of California Assay of Bone morphogenetic protein (BMP) and anti-BMP antibody for the diagnosis of bone disorders
US4767627A (en) * 1985-05-29 1988-08-30 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
DE3519361A1 (de) * 1985-05-30 1986-12-04 Boehringer Ingelheim International GmbH, 6507 Ingelheim (gamma)-ifn als wirkstoff zur hemmung (verhinderung) von abbauprozessen im knochen
US4702917A (en) * 1985-11-18 1987-10-27 Research Triangle Institute Porous bioabsorbable polyesters
CH667874A5 (fr) * 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.
US4767861A (en) * 1986-01-28 1988-08-30 Vipont Laboratories Recovery of benzo-c-phenanthridine alkaloids
US4774227A (en) * 1986-02-14 1988-09-27 Collagen Corporation Collagen compositions for bone repair containing autogeneic marrow
JPS62223112A (ja) * 1986-03-25 1987-10-01 Rooto Seiyaku Kk 歯周病治療剤
US4919939A (en) * 1986-04-29 1990-04-24 Pharmetrix Corporation Periodontal disease treatment system
US4780320A (en) * 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
US4946870A (en) * 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4857602A (en) * 1986-09-05 1989-08-15 American Cyanamid Company Bioabsorbable surgical suture coating
FI81010C (fi) * 1986-09-05 1990-09-10 Biocon Oy Stoedstruktur foer bentransplantat.
US4905680A (en) * 1986-10-27 1990-03-06 Johnson & Johnson Orthopaedics, Inc. Absorbable bone plate
US4902296A (en) * 1986-10-29 1990-02-20 The University Of Virginia Alumni Patents Foundation Use of demineralized bone matrix in the repair of segmental defects
GB8626623D0 (en) * 1986-11-07 1986-12-10 Shirley Inst Vascular prosthesis
US4846165A (en) * 1986-11-26 1989-07-11 Dentsply Research & Development Corp. Wound dressing membrane
US4800219A (en) * 1986-12-22 1989-01-24 E. I. Du Pont De Nemours And Company Polylactide compositions
US4981696A (en) * 1986-12-22 1991-01-01 E. I. Du Pont De Nemours And Company Polylactide compositions
US4983689A (en) * 1987-05-07 1991-01-08 Yu Simon H Process for making macromolecular monomers of polylactones with terminal acryloyl unsaturation and block copolymers thereof
US5013553A (en) * 1987-06-30 1991-05-07 Vipont Pharmaceutical, Inc. Drug delivery devices
IL86802A0 (en) * 1987-06-30 1988-11-30 Vipont Pharma Drug delivery devices
SE8802414D0 (sv) * 1988-06-27 1988-06-28 Astra Meditec Ab Nytt kirurgiskt material
US4912141A (en) * 1987-07-28 1990-03-27 Kronman Joseph H Fibrous and cartilaginous tissue replacement
US5019379A (en) * 1987-07-31 1991-05-28 Massachusetts Institute Of Technology Unsaturated polyanhydrides
US4911931A (en) * 1987-08-03 1990-03-27 Baylink David J Pharmaceutical combination for treatment of bone-wasting diseases
US4804691A (en) * 1987-08-28 1989-02-14 Richards Medical Company Method for making a biodegradable adhesive for soft living tissue
DE3734223A1 (de) * 1987-10-09 1989-04-20 Boehringer Ingelheim Kg Implantierbares, biologisch abbaubares wirkstofffreigabesystem
US5149052A (en) * 1987-11-16 1992-09-22 Kingston Technologies, Inc. Precision molding of polymers
US4920203A (en) * 1987-12-17 1990-04-24 Allied-Signal Inc. Medical devices fabricated from homopolymers and copolymers having recurring carbonate units
US4961707A (en) * 1987-12-22 1990-10-09 University Of Florida Guided periodontal tissue regeneration
US4916241A (en) * 1988-06-06 1990-04-10 American Home Products Corporation Inhibition of bone loss by 4-substituted-5-hydroxy-2(5H)-furanones
US5250584A (en) * 1988-08-31 1993-10-05 G-C Dental Industrial Corp. Periodontium-regenerative materials
JP2709349B2 (ja) * 1988-08-31 1998-02-04 株式会社 ジーシー 歯周組織再生用素材
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5702716A (en) * 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US5324520A (en) * 1988-12-19 1994-06-28 Vipont Pharmaceutical, Inc. Intragingival delivery systems for treatment of periodontal disease
SE8804641D0 (sv) * 1988-12-23 1988-12-23 Procordia Oratech Ab Surgical barrier
US5007940A (en) * 1989-06-09 1991-04-16 American Medical Systems, Inc. Injectable polymeric bodies
US5487897A (en) 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
US5077049A (en) * 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5198220A (en) * 1989-11-17 1993-03-30 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
AU2605592A (en) * 1991-10-15 1993-04-22 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
EP0560014A1 (de) 1992-03-12 1993-09-15 Atrix Laboratories, Inc. Biologisch abbaubarer Wundverband in Form eines Sprühfilms und Verfahren zu seiner Herstellung

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8277828B2 (en) 2004-01-28 2012-10-02 Ultradent Products, Inc. Delivery system for bone growth promoting material
US8323339B2 (en) 2004-01-28 2012-12-04 Ultradent Products, Inc. Methods of manufacturing a delivery system for promoting bone growth

Also Published As

Publication number Publication date
JP3451259B2 (ja) 2003-09-29
JPH07163654A (ja) 1995-06-27
SI0649662T1 (en) 2002-06-30
AU6614294A (en) 1995-04-13
DK1147781T3 (da) 2004-10-18
ATE268611T1 (de) 2004-06-15
CA2117394A1 (en) 1995-03-29
US5487897A (en) 1996-01-30
US20020001608A1 (en) 2002-01-03
DE69433843D1 (de) 2004-07-15
EP1147781B1 (de) 2004-06-09
ATE212866T1 (de) 2002-02-15
ES2225364T3 (es) 2005-03-16
JP2003093498A (ja) 2003-04-02
ES2173102T3 (es) 2002-10-16
EP0649662A1 (de) 1995-04-26
US5660849A (en) 1997-08-26
PT649662E (pt) 2002-07-31
DK0649662T3 (da) 2002-05-13
DE69429801D1 (de) 2002-03-21
KR950007878A (ko) 1995-04-15
US6395293B2 (en) 2002-05-28
US6071530A (en) 2000-06-06
EP1147781A1 (de) 2001-10-24
KR100248326B1 (ko) 2000-06-01
DE69433843T2 (de) 2005-06-23
EP0649662B1 (de) 2002-02-06

Similar Documents

Publication Publication Date Title
DE69429801D1 (de) Bioresorbierbares Implantat-Vorprodukt
DE60108258T2 (de) Selbstklebende, hydratierbare matrix für therapeutische anwendungen
CA2307567A1 (en) Polymer matrix/cell construct for bladder reconstruction
DE69224456T2 (de) Biologisch abbaubare Polymerzusammensetzung
RU94028108A (ru) Трансплантант, способ восстановления функционирования нерва, способ замены кровеносного сосуда
SE9602226D0 (sv) Biocompatible glue
CN1440818A (zh) 胶原材料及其制造方法
IS2351B (is) Aðferð og búnaður sem auðveldar ígræðslu á lífrænu efni
AU609108B2 (en) Injectable soft tissue augmentation materials from the placenta and their method of manufacture
DE69534780D1 (de) Flüssige Zusammensetzungen zur Arzneistoffabgabe
DE69833375D1 (de) Implantate zur gesteuerten freisetzung von pharmazeutischen wirkstoffen und verfahren zur herstellung
ATE257396T1 (de) Verfahren zur herstellung von stabilem alginatmaterial
DE68923423D1 (de) Antithromotisches medizinisches Material, künstliches inneres Organ und Verfahren zur Herstellung eines antithrombotischen medizinischen Materials.
CA2218333A1 (en) Surgical method for rejuvenating or reshaping body members by bone grafting _______________________________________________________
RU1768146C (ru) Устройство дл восстановлени утраченных участков трубчатых костей
DE69727691D1 (de) Verwendung von keratinocyten-wachstumsfaktor-2
US20170071604A1 (en) Device for Spinal Cord Nerve Regeneration
Calderhead Review of the Biostimulation Session of the 11th Meeting of the American Society for laser medicine and Surgery (ASLMS)
RU2034464C1 (ru) Способ формирования эндопротезов
Power The future of nerve repair and regeneration
Dawbarn SURGERY BY AID OF ANODAL DIFFUSION
Hämmerle et al. Healing‐in of root analogue titanium implants placed in extraction sockets. An experimental study in the beagle dog.
DE10317578A1 (de) Chitosanfolie als Periost-Ersatz

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: QLT USA INC., FORT COLLINS, COL., US