DE69430823T2 - Verfahren zur behandlung von gram-negativen bakterien infektion durch verabreichung von bakterientötendem/durchlässigkeiterhöhendem (bpi) proteinprodukt und antibiotikum - Google Patents
Verfahren zur behandlung von gram-negativen bakterien infektion durch verabreichung von bakterientötendem/durchlässigkeiterhöhendem (bpi) proteinprodukt und antibiotikumInfo
- Publication number
- DE69430823T2 DE69430823T2 DE69430823T DE69430823T DE69430823T2 DE 69430823 T2 DE69430823 T2 DE 69430823T2 DE 69430823 T DE69430823 T DE 69430823T DE 69430823 T DE69430823 T DE 69430823T DE 69430823 T2 DE69430823 T2 DE 69430823T2
- Authority
- DE
- Germany
- Prior art keywords
- antibiotic
- bacteria
- bpi
- protein product
- pleasureability
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1751—Bactericidal/permeability-increasing protein [BPI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12565193A | 1993-09-22 | 1993-09-22 | |
US27340194A | 1994-07-11 | 1994-07-11 | |
PCT/US1994/011225 WO1995008344A1 (en) | 1993-09-22 | 1994-09-22 | Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (bpi) protein product and antibiotic |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69430823D1 DE69430823D1 (de) | 2002-07-18 |
DE69430823T2 true DE69430823T2 (de) | 2003-02-20 |
Family
ID=26823793
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69430823T Expired - Fee Related DE69430823T2 (de) | 1993-09-22 | 1994-09-22 | Verfahren zur behandlung von gram-negativen bakterien infektion durch verabreichung von bakterientötendem/durchlässigkeiterhöhendem (bpi) proteinprodukt und antibiotikum |
Country Status (13)
Country | Link |
---|---|
US (2) | US5523288A (de) |
EP (1) | EP0759774B1 (de) |
JP (1) | JPH09502987A (de) |
AT (1) | ATE218880T1 (de) |
AU (1) | AU695814B2 (de) |
CA (1) | CA2172245C (de) |
DE (1) | DE69430823T2 (de) |
DK (1) | DK0759774T3 (de) |
ES (1) | ES2178656T3 (de) |
HK (1) | HK1014155A1 (de) |
NZ (1) | NZ275205A (de) |
PT (1) | PT759774E (de) |
WO (1) | WO1995008344A1 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5652332A (en) * | 1993-03-12 | 1997-07-29 | Xoma | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
DE69430823T2 (de) * | 1993-09-22 | 2003-02-20 | Xoma Technology Ltd | Verfahren zur behandlung von gram-negativen bakterien infektion durch verabreichung von bakterientötendem/durchlässigkeiterhöhendem (bpi) proteinprodukt und antibiotikum |
US5447913A (en) | 1994-03-11 | 1995-09-05 | Xoma Corporation | Therapeutic uses of bactericidal/permeability-increasing protein dimer products |
JP2001520631A (ja) * | 1995-07-20 | 2001-10-30 | ゾーマ コーポレイション | 抗真菌性ペプチド |
AUPN771596A0 (en) | 1996-01-25 | 1996-02-15 | Mclean, Allan Joseph | Methods of and compositions for potentiating the action of agents active on cell-wall sites of susceptible bacteria |
DE69703689T2 (de) * | 1996-05-10 | 2001-05-10 | Xoma Technology Ltd | Therapeutische anwendungen von bpi-protein-produkten zur behandlung von humaner meningococcämia |
US5741779A (en) | 1996-05-10 | 1998-04-21 | Xoma Corporation | Antithrombotic materials and methods |
AU736096B2 (en) * | 1996-05-23 | 2001-07-26 | Xoma Corporation | Therapeutic uses of BPI protein products in humans with hemorrhage due to trauma |
US5888973A (en) * | 1996-08-09 | 1999-03-30 | Xoma Corporation | Anti-chlamydial uses of BPI protein products |
US6180604B1 (en) | 1996-08-21 | 2001-01-30 | Micrologix Biotech Inc. | Compositions and methods for treating infections using analogues of indolicidin |
US6503881B2 (en) * | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
US6482796B2 (en) * | 1996-11-01 | 2002-11-19 | Xoma Corporation | Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients |
US6406880B1 (en) | 1997-05-02 | 2002-06-18 | Integrated Research Technology, Llc | Betaines as adjuvants to susceptibility testing and antimicrobial therapy |
US7067500B2 (en) * | 1997-05-02 | 2006-06-27 | Integrated Research Technology, Llc | Betaines as adjuvants to susceptibility testing and antimicrobial therapy |
AU7365298A (en) * | 1997-05-02 | 1998-11-27 | Integrated Research Technology, Llc | Betaines as adjudvants to susceptibility testing and antimicrobial thera py |
US6093573A (en) * | 1997-06-20 | 2000-07-25 | Xoma | Three-dimensional structure of bactericidal/permeability-increasing protein (BPI) |
AU3642199A (en) * | 1998-04-14 | 1999-11-01 | Ribogene, Inc. | Assays for inhibitors of bacterial translation initiation factor |
US6013631A (en) * | 1998-06-19 | 2000-01-11 | Xoma Corporation | Bactericidal/permeability-increasing protein (BPI) deletion analogs |
US5977091A (en) * | 1998-09-21 | 1999-11-02 | The Research Foundation Of State University Of New York | Method of preventing acute lung injury |
US6790661B1 (en) * | 1999-07-16 | 2004-09-14 | Verax Biomedical, Inc. | System for detecting bacteria in blood, blood products, and fluids of tissues |
US6696239B1 (en) * | 2000-04-20 | 2004-02-24 | Biolog, Inc. | Comparative phenotype analysis for assessment of biological active compounds such as antimicrobials |
JP2004517865A (ja) * | 2000-12-01 | 2004-06-17 | ゾーマ テクノロジー リミテッド | Bpiタンパク質産物またはbpiインヒビターを使用する、周皮細胞増殖の調節 |
DE60139964D1 (de) | 2000-12-15 | 2009-10-29 | Vertex Pharma | Bakterielle Gyrase-Hemmer sowie deren Verwendung |
US6835536B2 (en) | 2001-08-21 | 2004-12-28 | Micrologix Biotech Inc. | Antimicrobial cationic peptides and formulations thereof |
JP4511173B2 (ja) | 2001-08-24 | 2010-07-28 | マイジェニックス インコーポレイテッド | 抗菌性および抗炎症性ペプチド |
US20030232401A1 (en) * | 2002-06-12 | 2003-12-18 | Pugia Michael J. | Bacterial test method by glycated label binding |
US20040037895A1 (en) * | 2002-08-23 | 2004-02-26 | Alex Zhu | Methods of treating involuntary facial spasms and facial wrinkles |
US7655646B2 (en) * | 2003-01-21 | 2010-02-02 | Thallion Pharmaceuticals, Inc. | Dibenzodiazepinone analogues, processes for their production and their use as pharmaceuticals |
US7101872B2 (en) * | 2003-01-21 | 2006-09-05 | Ecopia Biosciences, Inc. | Farnesyl dibenzodiazepinone, and processes for its production |
WO2005024025A1 (en) * | 2003-09-11 | 2005-03-17 | Ecopia Biosciences Inc. | Polyene polyketides and methods of production |
US20060106028A1 (en) * | 2004-11-08 | 2006-05-18 | Ecopia Biosciences, Inc. | Polycyclic aromatics and derivatives thereof and processes for their preparation |
EP1741440A1 (de) | 2005-07-08 | 2007-01-10 | Mellitus S.L. | Verwendung von BPI-proteine zur Behandlung von stoffwechselbedingten Erkrankungen und Herzkreislaufstörungen |
US20080114054A1 (en) * | 2006-11-14 | 2008-05-15 | Rath Microbes | Compositions and methods for reducing antimicrobial resistance of microbes |
EP2601194B1 (de) | 2010-08-03 | 2016-05-25 | Merck Sharp & Dohme Corp. | Als antimikrobielle wirkstoffe geeignete fusionierte imidazoylverbindungen |
AU2012205415B2 (en) * | 2011-01-14 | 2017-02-02 | Spero Therapeutics, Inc. | Pyrimidine gyrase and topoisomerase IV inhibitors |
WO2012112438A2 (en) * | 2011-02-16 | 2012-08-23 | The Penn State Research Foundation | Anti-microbial agents and compositions and methods of production and use thereof |
CN103702994B (zh) | 2011-06-20 | 2016-03-23 | 沃泰克斯药物股份有限公司 | 旋转酶和拓扑异构酶抑制剂的磷酸酯 |
WO2014015105A1 (en) | 2012-07-18 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Solid forms of (r)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1h-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof |
WO2014026143A1 (en) * | 2012-08-09 | 2014-02-13 | Pono Corporation | Conjugated anti-microbial compounds and conjugated anti-cancer compounds and uses thereof |
WO2014160814A1 (en) * | 2013-03-26 | 2014-10-02 | Rutgers, The State University Of New Jersey | Synthetic and enhanced bacterial killing involving bicyclomycin |
KR101811437B1 (ko) * | 2015-09-17 | 2018-01-25 | 서울대학교산학협력단 | 그람 음성균에 대한 항균 활성을 나타내는 끊어진 또는 꺾어진 나선 펩타이드 또는 펩타이드 유사체 및 이의 용도 |
US11185555B2 (en) | 2016-04-11 | 2021-11-30 | Noah James Harrison | Method to kill pathogenic microbes in a patient |
US20210023101A1 (en) * | 2017-07-19 | 2021-01-28 | The University Of North Carolina At Chapel Hill | Potentiation of antibiotic effect |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5028251A (de) * | 1973-07-12 | 1975-03-22 | ||
JPS55134471A (en) * | 1979-04-04 | 1980-10-20 | Toshiba Corp | Sales management system in small-scale computer constitution |
CA1237671A (en) * | 1983-08-01 | 1988-06-07 | Michael W. Fountain | Enhancement of pharmaceutical activity |
JPS60128596A (ja) * | 1983-12-15 | 1985-07-09 | 東芝テック株式会社 | 電子キヤツシユレジスタ |
JPS619790A (ja) * | 1984-06-25 | 1986-01-17 | オムロン株式会社 | 電子式キヤツシユレジスタ |
US4863727A (en) * | 1986-04-09 | 1989-09-05 | Cetus Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
EP1659132A1 (de) * | 1987-08-11 | 2006-05-24 | New York University | BPI Fragmente |
US5198541A (en) * | 1987-08-11 | 1993-03-30 | New York University | Dna encoding bactericidal/permeability-increasing proteins |
EP0379549B1 (de) * | 1988-06-23 | 1995-12-27 | Associates Of Cape Cod, Inc. | Endotoxin-bindeprotein und dessen verwendung |
US5334584A (en) * | 1989-02-14 | 1994-08-02 | Incyte Pharamaceuticals, Inc. | Recombinant, non-glycosylated bpi protein and uses thereof |
US5308834A (en) * | 1989-02-14 | 1994-05-03 | Incyte Pharmaceuticals, Inc. | Treatment of endotoxin-associated shock and prevention thereof using a BPI protein |
US5234912A (en) * | 1989-02-14 | 1993-08-10 | Incyte Pharmaceuticals, Inc. | Pharmaceutical compositions comprising recombinant BPI proteins and a lipid carrier and uses thereof |
US5089274A (en) * | 1989-02-14 | 1992-02-18 | Incyte Pharmaceuticals, Inc. | Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat endotoxin-related disorders |
US5171739A (en) * | 1989-02-14 | 1992-12-15 | Incyte Pharmaceuticals, Inc. | Treatment of endotoxin-associated shock and preventation thereof using a BPI protein |
EP0563222B1 (de) * | 1990-12-03 | 1998-02-25 | New York University | Biologisch aktive bakterizide/permeabilitätserhöhende proteinbruchstücke |
US5156665A (en) * | 1991-01-03 | 1992-10-20 | Rohm And Haas Company | Antimicrobial compositions comprising iodopropargyl compounds and isothiazolones and methods of controlling microbes |
EP0605653A4 (de) * | 1991-09-26 | 1995-03-15 | Incyte Pharma Inc | Neue art eines liposaccharid bindendes protein (lbp). |
WO1993023540A2 (en) * | 1992-05-19 | 1993-11-25 | Xoma Corporation | Improved methods for the preparation of endotoxin-binding proteins |
US5643570A (en) * | 1992-05-19 | 1997-07-01 | Xoma Corporation | BPI-immunoglobulin fusion proteins |
EP0682524B1 (de) * | 1993-02-02 | 2001-10-04 | XOMA Technology Ltd. | Arzneizusammensetzungen enthaltend ein bakterizides permeabilität erhöhendes protein und ein tensid |
US5420019A (en) * | 1993-02-02 | 1995-05-30 | Xoma Corporation | Stable bactericidal/permeability-increasing protein muteins |
AU694108B2 (en) * | 1993-03-12 | 1998-07-16 | Xoma Corporation | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
MX9401807A (es) * | 1993-03-12 | 1995-01-31 | Xoma Corp | Usos terapeuticos de productos de proteina que incrementan lapermeabilidad/bactericidas. |
ATE165976T1 (de) * | 1993-03-12 | 1998-05-15 | Xoma Corp | Behandlung von mycobakteriellen erkrankungen durch verabreichung von bakrerientötende, durchlässigkeitserhöhende proteinfragmente |
US5348942A (en) * | 1993-03-12 | 1994-09-20 | Xoma Corporation | Therapeutic uses of bactericidal/permeability increasing protein products |
DE69430823T2 (de) * | 1993-09-22 | 2003-02-20 | Xoma Technology Ltd | Verfahren zur behandlung von gram-negativen bakterien infektion durch verabreichung von bakterientötendem/durchlässigkeiterhöhendem (bpi) proteinprodukt und antibiotikum |
-
1994
- 1994-09-22 DE DE69430823T patent/DE69430823T2/de not_active Expired - Fee Related
- 1994-09-22 NZ NZ275205A patent/NZ275205A/en not_active IP Right Cessation
- 1994-09-22 CA CA002172245A patent/CA2172245C/en not_active Expired - Fee Related
- 1994-09-22 WO PCT/US1994/011225 patent/WO1995008344A1/en active IP Right Grant
- 1994-09-22 US US08/311,611 patent/US5523288A/en not_active Expired - Lifetime
- 1994-09-22 PT PT94931793T patent/PT759774E/pt unknown
- 1994-09-22 JP JP7509977A patent/JPH09502987A/ja not_active Expired - Lifetime
- 1994-09-22 ES ES94931793T patent/ES2178656T3/es not_active Expired - Lifetime
- 1994-09-22 AU AU80740/94A patent/AU695814B2/en not_active Ceased
- 1994-09-22 EP EP94931793A patent/EP0759774B1/de not_active Expired - Lifetime
- 1994-09-22 DK DK94931793T patent/DK0759774T3/da active
- 1994-09-22 AT AT94931793T patent/ATE218880T1/de not_active IP Right Cessation
-
1996
- 1996-06-03 US US08/657,162 patent/US6140306A/en not_active Expired - Fee Related
-
1998
- 1998-12-24 HK HK98115454A patent/HK1014155A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5523288A (en) | 1996-06-04 |
ES2178656T3 (es) | 2003-01-01 |
PT759774E (pt) | 2002-11-29 |
EP0759774B1 (de) | 2002-06-12 |
US6140306A (en) | 2000-10-31 |
NZ275205A (en) | 1998-03-25 |
WO1995008344A1 (en) | 1995-03-30 |
HK1014155A1 (en) | 1999-09-24 |
AU695814B2 (en) | 1998-08-20 |
CA2172245A1 (en) | 1995-03-30 |
JPH09502987A (ja) | 1997-03-25 |
DE69430823D1 (de) | 2002-07-18 |
CA2172245C (en) | 2003-04-08 |
EP0759774A1 (de) | 1997-03-05 |
AU8074094A (en) | 1995-04-10 |
DK0759774T3 (da) | 2002-10-07 |
ATE218880T1 (de) | 2002-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |