DE69431568T2 - Inhibierung der migration und proliferation glatter muskeln mit hydroxycarbazolverbindungen - Google Patents
Inhibierung der migration und proliferation glatter muskeln mit hydroxycarbazolverbindungenInfo
- Publication number
- DE69431568T2 DE69431568T2 DE69431568T DE69431568T DE69431568T2 DE 69431568 T2 DE69431568 T2 DE 69431568T2 DE 69431568 T DE69431568 T DE 69431568T DE 69431568 T DE69431568 T DE 69431568T DE 69431568 T2 DE69431568 T2 DE 69431568T2
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- proliferation
- migration
- hydroxycarbazol
- inhibition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/157,588 US5393772A (en) | 1993-11-24 | 1993-11-24 | Use of, and method of treatment using, hydroxycarbazole compounds for inhibition of smooth muscle migration and proliferation |
PCT/US1994/013561 WO1995014384A1 (en) | 1993-11-24 | 1994-11-22 | Inhibition of smooth muscle migration and proliferation with hydroxy carbazole compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69431568D1 DE69431568D1 (de) | 2002-11-21 |
DE69431568T2 true DE69431568T2 (de) | 2003-06-26 |
Family
ID=22564393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69431568T Expired - Fee Related DE69431568T2 (de) | 1993-11-24 | 1994-11-22 | Inhibierung der migration und proliferation glatter muskeln mit hydroxycarbazolverbindungen |
Country Status (12)
Country | Link |
---|---|
US (1) | US5393772A (de) |
EP (1) | EP0741567B1 (de) |
JP (1) | JPH09505809A (de) |
KR (1) | KR100386229B1 (de) |
CN (1) | CN1102388C (de) |
AT (1) | ATE226072T1 (de) |
AU (1) | AU686706B2 (de) |
CA (1) | CA2176377A1 (de) |
DE (1) | DE69431568T2 (de) |
ES (1) | ES2185691T3 (de) |
WO (1) | WO1995014384A1 (de) |
ZA (1) | ZA949246B (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5811447A (en) * | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5770609A (en) | 1993-01-28 | 1998-06-23 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
US6395494B1 (en) | 1993-05-13 | 2002-05-28 | Neorx Corporation | Method to determine TGF-β |
US6251920B1 (en) | 1993-05-13 | 2001-06-26 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
US6306421B1 (en) | 1992-09-25 | 2001-10-23 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6663881B2 (en) | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5595722A (en) * | 1993-01-28 | 1997-01-21 | Neorx Corporation | Method for identifying an agent which increases TGF-beta levels |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
JPH08510451A (ja) * | 1993-05-13 | 1996-11-05 | ネオルックス コーポレイション | 異常増殖性平滑筋細胞に関連した病因の予防及び治療 |
WO1996040098A2 (en) * | 1995-06-07 | 1996-12-19 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies with tamoxifen analogues |
US20030083733A1 (en) * | 1997-10-10 | 2003-05-01 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6099562A (en) * | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
US20020091433A1 (en) * | 1995-04-19 | 2002-07-11 | Ni Ding | Drug release coated stent |
US5837313A (en) * | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
US7611533B2 (en) * | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
ZA967892B (en) * | 1995-09-21 | 1998-03-18 | Lilly Co Eli | Selective β3 adrenergic agonists. |
AU4083097A (en) * | 1996-08-23 | 1998-03-06 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership No. 1 | Method for inhibiting the expression of fas |
US5808080A (en) * | 1996-09-05 | 1998-09-15 | Eli Lilly And Company | Selective β3 adrenergic agonists |
ATE215369T1 (de) | 1996-09-05 | 2002-04-15 | Lilly Co Eli | Carbazolanaloge als selektive beta3-adrenergische agonisten |
PL332638A1 (en) * | 1996-10-09 | 1999-09-27 | Boehringer Mannheim Pharm Corp | Method of inhibiting stress-activated proteinous kinases |
AU765934B2 (en) * | 1996-10-09 | 2003-10-02 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership No. 1 | Method for inhibiting stress-activated protein kinases |
CO5011072A1 (es) | 1997-12-05 | 2001-02-28 | Lilly Co Eli | Etanolaminas pirazinil substituidas como agfonistas de los receptores |
DE19830472B4 (de) * | 1998-07-08 | 2013-06-27 | Robert Bosch Gmbh | Externe Komponente für ein Mikroprozessorsystem und Betriebsverfahren |
US6776796B2 (en) | 2000-05-12 | 2004-08-17 | Cordis Corportation | Antiinflammatory drug and delivery device |
US20040243097A1 (en) * | 2000-05-12 | 2004-12-02 | Robert Falotico | Antiproliferative drug and delivery device |
US8236048B2 (en) * | 2000-05-12 | 2012-08-07 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US20050002986A1 (en) * | 2000-05-12 | 2005-01-06 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US20020111590A1 (en) * | 2000-09-29 | 2002-08-15 | Davila Luis A. | Medical devices, drug coatings and methods for maintaining the drug coatings thereon |
US7261735B2 (en) * | 2001-05-07 | 2007-08-28 | Cordis Corporation | Local drug delivery devices and methods for maintaining the drug coatings thereon |
CA2424029C (en) * | 2000-09-29 | 2008-01-29 | Cordis Corporation | Coated medical devices |
US20020051730A1 (en) * | 2000-09-29 | 2002-05-02 | Stanko Bodnar | Coated medical devices and sterilization thereof |
US6613083B2 (en) * | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
US7195640B2 (en) * | 2001-09-25 | 2007-03-27 | Cordis Corporation | Coated medical devices for the treatment of vulnerable plaque |
US7108701B2 (en) * | 2001-09-28 | 2006-09-19 | Ethicon, Inc. | Drug releasing anastomosis devices and methods for treating anastomotic sites |
US20030065345A1 (en) * | 2001-09-28 | 2003-04-03 | Kevin Weadock | Anastomosis devices and methods for treating anastomotic sites |
US20030065377A1 (en) * | 2001-09-28 | 2003-04-03 | Davila Luis A. | Coated medical devices |
KR100752549B1 (ko) * | 2001-09-28 | 2007-08-30 | 에프. 호프만-라 로슈 아게 | 카르베딜올의 유사다형태 |
US8101209B2 (en) * | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
AU2003231283A1 (en) * | 2002-04-30 | 2003-11-17 | Sb Pharmco Puerto Rico Inc. | Carvedilol monocitrate monohydrate |
WO2004002419A2 (en) * | 2002-06-27 | 2004-01-08 | Sb Pharmco Puerto Rico Inc. | Carvedilol phosphate salts and/or solvates thereof, correspondinq compositions, and/or methods of treatment |
WO2004002472A1 (en) * | 2002-06-27 | 2004-01-08 | Sb Pharmco Puerto Rico Inc. | Carvedilol hydrobromide |
ES2662903T3 (es) * | 2003-11-25 | 2018-04-10 | Smithkline Beecham (Cork) Limited | Base libre de carvedilol, sales, formas anhidras o solvato de la misma, composiciones farmacéuticas correspondientes, formulaciones de liberación controlada, y procedimientos de tratamiento o administración |
EP1686986A4 (de) * | 2003-11-25 | 2009-05-27 | Sb Pharmco Inc | Carvedilol-salze, entsprechende zusammensetzungen, verfahren zur abgabe und/oder behandlung |
US20050169994A1 (en) * | 2003-11-25 | 2005-08-04 | Burke Matthew D. | Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods |
US10281374B2 (en) * | 2015-11-04 | 2019-05-07 | Diagnostic Biosystems | Method of pretreatment of biological samples for an analyte-staining assay method |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2815926A1 (de) * | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US5308862A (en) * | 1993-03-05 | 1994-05-03 | Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beecham Corp., Ltd. Partnership No. 1 | Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation |
-
1993
- 1993-11-24 US US08/157,588 patent/US5393772A/en not_active Expired - Lifetime
-
1994
- 1994-11-22 EP EP95902689A patent/EP0741567B1/de not_active Expired - Lifetime
- 1994-11-22 KR KR1019960702460A patent/KR100386229B1/ko not_active IP Right Cessation
- 1994-11-22 JP JP7515231A patent/JPH09505809A/ja active Pending
- 1994-11-22 AT AT95902689T patent/ATE226072T1/de not_active IP Right Cessation
- 1994-11-22 CA CA002176377A patent/CA2176377A1/en not_active Abandoned
- 1994-11-22 ES ES95902689T patent/ES2185691T3/es not_active Expired - Lifetime
- 1994-11-22 WO PCT/US1994/013561 patent/WO1995014384A1/en active IP Right Grant
- 1994-11-22 DE DE69431568T patent/DE69431568T2/de not_active Expired - Fee Related
- 1994-11-22 ZA ZA949246A patent/ZA949246B/xx unknown
- 1994-11-22 AU AU11867/95A patent/AU686706B2/en not_active Ceased
- 1994-11-22 CN CN94194188A patent/CN1102388C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU1186795A (en) | 1995-06-13 |
US5393772A (en) | 1995-02-28 |
DE69431568D1 (de) | 2002-11-21 |
AU686706B2 (en) | 1998-02-12 |
EP0741567A4 (de) | 1996-12-04 |
ES2185691T3 (es) | 2003-05-01 |
ATE226072T1 (de) | 2002-11-15 |
KR100386229B1 (ko) | 2003-08-21 |
CN1135161A (zh) | 1996-11-06 |
ZA949246B (en) | 1995-07-04 |
EP0741567A1 (de) | 1996-11-13 |
WO1995014384A1 (en) | 1995-06-01 |
CA2176377A1 (en) | 1995-06-01 |
CN1102388C (zh) | 2003-03-05 |
JPH09505809A (ja) | 1997-06-10 |
EP0741567B1 (de) | 2002-10-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |