DE69432815D1 - Wachstumsfaktor-8 - Google Patents

Wachstumsfaktor-8

Info

Publication number
DE69432815D1
DE69432815D1 DE69432815T DE69432815T DE69432815D1 DE 69432815 D1 DE69432815 D1 DE 69432815D1 DE 69432815 T DE69432815 T DE 69432815T DE 69432815 T DE69432815 T DE 69432815T DE 69432815 D1 DE69432815 D1 DE 69432815D1
Authority
DE
Germany
Prior art keywords
growth factor
growth
factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69432815T
Other languages
English (en)
Other versions
DE69432815T2 (de
Inventor
Se-Jin Lee
Alexandra C Mcpherron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
School of Medicine of Johns Hopkins University
Original Assignee
Johns Hopkins University
School of Medicine of Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University, School of Medicine of Johns Hopkins University filed Critical Johns Hopkins University
Application granted granted Critical
Publication of DE69432815D1 publication Critical patent/DE69432815D1/de
Publication of DE69432815T2 publication Critical patent/DE69432815T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/495Transforming growth factor [TGF]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
DE69432815T 1993-03-19 1994-03-18 Wachstumsfaktor-8 Expired - Lifetime DE69432815T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3392393A 1993-03-19 1993-03-19
PCT/US1994/003019 WO1994021681A1 (en) 1993-03-19 1994-03-18 Growth differentiation factor-8

Publications (2)

Publication Number Publication Date
DE69432815D1 true DE69432815D1 (de) 2003-07-17
DE69432815T2 DE69432815T2 (de) 2003-12-11

Family

ID=21873232

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69432815T Expired - Lifetime DE69432815T2 (de) 1993-03-19 1994-03-18 Wachstumsfaktor-8

Country Status (8)

Country Link
US (5) US5827733A (de)
EP (2) EP1333035A3 (de)
JP (4) JPH09507829A (de)
CA (1) CA2157577C (de)
DE (1) DE69432815T2 (de)
DK (1) DK0690873T3 (de)
ES (1) ES2201076T3 (de)
WO (1) WO1994021681A1 (de)

Families Citing this family (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE238417T1 (de) 1991-11-04 2003-05-15 Inst Genetics Llc Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
US20030074680A1 (en) * 1993-03-19 2003-04-17 Johns Hopkins University School Of Medicine Growth differentiation factor-8
US5994618A (en) 1997-02-05 1999-11-30 Johns Hopkins University School Of Medicine Growth differentiation factor-8 transgenic mice
US6607884B1 (en) 1993-03-19 2003-08-19 The Johns Hopkins University School Of Medicine Methods of detecting growth differentiation factor-8
US7393682B1 (en) * 1993-03-19 2008-07-01 The Johns Hopkins University School Of Medicine Polynucleotides encoding promyostatin polypeptides
JPH09507829A (ja) 1993-03-19 1997-08-12 ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 増殖分化因子−8
US7566768B1 (en) 1995-10-26 2009-07-28 The Johns Hopkins University School Of Medicine Promyostatin peptides and methods of using same
US6465239B1 (en) 1993-03-19 2002-10-15 The John Hopkins University School Of Medicine Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species
EP2272959A1 (de) * 1993-05-12 2011-01-12 Genetics Institute, LLC BMP-11 Zusammenstellungen
US6713302B1 (en) * 1993-07-09 2004-03-30 The Johns Hopkins University School Of Medicine Growth differentiation factor-6
US7332575B2 (en) 1994-03-18 2008-02-19 The Johns Hopkins University School Of Medicine Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species
US6008434A (en) 1994-07-08 1999-12-28 Johns Hopkins University School Of Medicine Growth differentiation factor-11 transgenic mice
CA2194660C (en) * 1994-07-08 2009-09-29 Se-Jin Lee Growth differentiation factor-11
US20030167492A1 (en) 1994-07-08 2003-09-04 Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same
US5846770A (en) * 1994-11-22 1998-12-08 Genetics Institute, Inc. DNA molecules encoding human chordin
US5635372A (en) * 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
CA2220555C (en) 1995-06-05 2011-07-19 John M. Wozney Methods and compositions for healing and repair of connective tissue attachment
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
US5965403A (en) * 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
EP0985149A1 (de) 1997-05-30 2000-03-15 Creative Biomolecules, Inc. Verfahren zur bestimmung der gewebemorphogenese und morphogenesische tätigkeit
US20070067859A1 (en) * 1997-07-14 2007-03-22 Michel Georges Double-muscling in mammals
PT2045322E (pt) * 1997-07-14 2015-10-16 Université de Liège Musculatura dupla em mamíferos
US6103466A (en) * 1997-07-14 2000-08-15 University Of Liege Double-muscling in mammals
US6656475B1 (en) 1997-08-01 2003-12-02 The Johns Hopkins University School Of Medicine Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
US6891082B2 (en) * 1997-08-01 2005-05-10 The Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a truncated activintype II receptor
US6696260B1 (en) * 1997-08-01 2004-02-24 The Johns Hopkins University School Of Medicine Methods to identify growth differentiation factor (GDF) binding proteins
US20020052026A1 (en) 1997-10-08 2002-05-02 Steven M. Vicik Methods of refolding proteins
US6027917A (en) * 1997-12-10 2000-02-22 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-17 and BMP-18 compositions
CA2319703C (en) * 1998-02-05 2005-09-20 The Johns Hopkins University School Of Medicine Growth differentiation factor-8
US6369201B1 (en) * 1998-02-19 2002-04-09 Metamorphix International, Inc. Myostatin multimers
US6004937A (en) * 1998-03-09 1999-12-21 Genetics Institute, Inc. Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11]
AU765214B2 (en) * 1998-05-06 2003-09-11 Metamorphix International, Inc. Methods for treating diabetes by inhibiting gdf-8
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
WO2000004051A2 (en) * 1998-07-15 2000-01-27 Metamorphix, Inc. Growth differentiation factor promoter and uses therefor
WO2000043781A2 (en) * 1999-01-21 2000-07-27 Metamorphix, Inc. Growth differentiation factor inhibitors and uses therefor
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
US6284882B1 (en) * 1999-06-10 2001-09-04 Abbott Laboratories Myostatin gene promoter and inhibition of activation thereof
AU4889100A (en) 1999-07-30 2001-02-01 Pfizer Products Inc. Myostatin regulatory region, nucleotide sequence determination and methods for its use
US6756215B1 (en) * 2000-10-20 2004-06-29 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Functionalized TGF-β fusion proteins
US7037501B2 (en) * 2001-01-04 2006-05-02 Regents Of The University Of Minnesota Myostatin immnoconjugate
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
KR100420798B1 (ko) * 2001-02-10 2004-03-02 (주)알에이싸이언스 펩타이드 벡터
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US7320789B2 (en) * 2001-09-26 2008-01-22 Wyeth Antibody inhibitors of GDF-8 and uses thereof
US6798160B2 (en) * 2001-11-02 2004-09-28 Honda Giken Kogyo Kabushiki Kaisha Electric working machine
EP1572934A4 (de) * 2002-02-21 2007-12-19 Wyeth Corp Proteine mit follistatindomäne
EP1572909A4 (de) 2002-02-21 2007-06-06 Wyeth Corp Protein mit follistatindomäne
EP2192129A1 (de) * 2002-09-16 2010-06-02 Johns Hopkins University Metalloproteaseaktivierung von Myostatin sowie Verfahren zur Modulation der Myostatinaktivität
US7261893B2 (en) 2002-10-22 2007-08-28 Wyeth Neutralizing antibodies against GDF-8 and uses therefor
US20040223966A1 (en) * 2002-10-25 2004-11-11 Wolfman Neil M. ActRIIB fusion polypeptides and uses therefor
EP2272864A3 (de) 2002-12-20 2011-02-16 Amgen Inc. Bindende Wirkstoffe zum Hemmen von Myostatin
CA2526669A1 (en) 2003-06-02 2004-12-16 Wyeth Use of myostatin (gdf8) inhibitors in conjunction with corticosteroids for treating neuromuscular disorders
EP1675608B1 (de) 2003-09-12 2007-03-21 Wyeth Injizierbare feste calciumphosphat-stäbe zur abgabe von osteogenen proteinen
JP2007535912A (ja) * 2003-12-31 2007-12-13 シェーリング−プラウ・リミテッド 中和エピトープベースの増殖増強性ワクチン
CA2558395C (en) 2004-03-10 2011-11-29 Scil Technology Gmbh Coated implants, their manufacturing and use thereof
MXPA06010929A (es) * 2004-03-23 2007-01-16 Lilly Co Eli Anticuerpos anti-miostatina.
JP4688483B2 (ja) * 2004-04-15 2011-05-25 株式会社テクノネットワーク四国 フォリスタチン変異体ポリペプチド
US7575751B2 (en) 2004-04-27 2009-08-18 Research Development Foundation Activin-A mutants
WO2005115438A1 (en) 2004-05-25 2005-12-08 Stryker Corporation Use of morphogenic proteins for treating cartilage defects
US20060034831A1 (en) * 2004-08-12 2006-02-16 Wyeth Combination therapy for diabetes, obesity and cardiovascular diseases using GDF-8 inhibitors
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
AR051853A1 (es) * 2004-12-30 2007-02-14 Schering Plough Ltd Vacuna para aumentar el crecimiento basada en epitopes neutralizantes
US20060166251A1 (en) * 2005-01-26 2006-07-27 Archambault Joanne M Use of sFRPs as markers of BMP activity
CA2596506C (en) 2005-02-09 2021-04-06 Avi Biopharma, Inc. Antisense composition and method for treating muscle atrophy
CN101137906A (zh) * 2005-03-23 2008-03-05 惠氏公司 对gdf-8调节剂的免疫应答的检测
EP1863518A2 (de) * 2005-03-30 2007-12-12 Wyeth VERFAHREN ZUR STIMULATION DES WAARWACHSTUMS MITTELS VERABREICHUNG VON BMPs
DK1915397T3 (en) 2005-08-19 2015-04-20 Wyeth Llc Antagonist AGAINST GDF-8 AND USES IN TREATMENT OF ALS AND OTHER GDF-8-ASSOCIATED DISEASES
ES2533464T3 (es) * 2005-10-06 2015-04-10 Eli Lilly And Company Anticuerpos anti-miostatina
UA92504C2 (en) 2005-10-12 2010-11-10 Эли Лилли Энд Компани Anti-myostatin monoclonal antibody
US8067562B2 (en) 2005-11-01 2011-11-29 Amgen Inc. Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
MX2008007324A (es) * 2005-12-06 2009-03-04 Amgen Inc Usos de antagonistas de miostatina.
EP2311505B1 (de) 2006-02-09 2013-11-06 BioMimetic Therapeutics, LLC Zusammensetzungen und Verfahren zur Behandlung von Knochen
WO2007114319A1 (ja) 2006-03-31 2007-10-11 Chugai Seiyaku Kabushiki Kaisha 抗体の血中動態を制御する方法
EP2035030A2 (de) 2006-05-17 2009-03-18 Stryker Corporation Verwendung löslicher morphogener proteinkomplexe zur behandlung von knorpeldefekten
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US9642891B2 (en) 2006-06-30 2017-05-09 Biomimetic Therapeutics, Llc Compositions and methods for treating rotator cuff injuries
US8524265B2 (en) 2006-08-17 2013-09-03 Warsaw Orthopedic, Inc. Medical implant sheets useful for tissue regeneration
PL2066695T3 (pl) 2006-09-05 2013-08-30 Lilly Co Eli Przeciwciała przeciwko miostatynie
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
AU2007339280B2 (en) 2006-12-21 2013-12-05 Stryker Corporation Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents
US8501678B2 (en) 2007-03-06 2013-08-06 Atara Biotherapeutics, Inc. Variant activin receptor polypeptides and uses thereof
US7947646B2 (en) 2007-03-06 2011-05-24 Amgen Inc. Variant activin receptor polypeptides
US8236751B2 (en) * 2007-03-07 2012-08-07 The Johns Hopkins University Methods of increasing muscle mass using follistatin-like related gene (FLRG)
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
GB0715087D0 (en) 2007-08-03 2007-09-12 Summit Corp Plc Drug combinations for the treatment of duchenne muscular dystrophy
EP3251694A1 (de) 2007-08-03 2017-12-06 Summit (Oxford) Limited Wirkstoffkombinationen zur behandlung der duchenne-muskeldystrophie
EP2187932B1 (de) 2007-08-07 2015-01-28 DePuy Synthes Products, LLC Proteinformulierungen mit gdf-5 in wässriger saurer lösung
EP2202245B1 (de) 2007-09-26 2016-08-24 Chugai Seiyaku Kabushiki Kaisha Verfahren zum modifizieren des isoelektrischen punkts eines antikörpers durch aminosäuresubstitution in der cdr
US8741840B2 (en) 2008-02-13 2014-06-03 Washington University BMP-7 for use in treating neointimal hyperplasia
WO2009111793A2 (en) 2008-03-07 2009-09-11 Myoscience, Inc. Subdermal tissue remodeling using myostatin, methods and related systems
SI2275443T1 (sl) 2008-04-11 2016-03-31 Chugai Seiyaku Kabushiki Kaisha Antigen-vezavna molekula, ki se je sposobna ponovljivo vezati na dve ali več antigenskih molekul
WO2009129101A1 (en) 2008-04-14 2009-10-22 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered gdf-5 formulations
BR122020000059B8 (pt) 2008-09-09 2021-06-22 Biomimetic Therapeutics Inc composição que compreende uma matriz biocompatível e um fator de crescimento derivado de plaqueta e kit
EA201100832A1 (ru) 2008-11-26 2011-12-30 Амген Инк. Варианты полипептидов рецептора iib активина и их применение
TW201029662A (en) 2008-12-19 2010-08-16 Glaxo Group Ltd Novel antigen binding proteins
WO2010093925A2 (en) 2009-02-12 2010-08-19 Stryker Corporation PERIPHERAL ADMINISTRATION OF PROTEINS INCLUDING TGF-β SUPERFAMILY MEMBERS FOR TREATMENT OF SYSTEMIC DISORDERS AND DISEASE
EP2396026A2 (de) 2009-02-12 2011-12-21 Stryker Corporation Zusammensetzungen und verfahren für die minimal invasive systemische abgabe von proteinen einschliesslich mitglieder der tgf-superfamilie
US20120148539A1 (en) 2009-03-24 2012-06-14 Moulay Hicham Alaoui-Ismaili Methods and Compositions for Tissue Engineering
US8609127B2 (en) 2009-04-03 2013-12-17 Warsaw Orthopedic, Inc. Medical implant with bioactive material and method of making the medical implant
US20110002897A1 (en) 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells
WO2011031856A1 (en) 2009-09-09 2011-03-17 Stryker Corporation Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint
ES2387379T3 (es) 2009-09-17 2012-09-21 Stryker Corporation Tampones para controlar el pH de las proteínas morfogenéticas óseas
JP2013514811A (ja) 2009-12-22 2013-05-02 ストライカー コーポレイション 免疫原性が抑制されたbmp−7変異体
JP6144049B2 (ja) 2010-02-22 2017-06-07 バイオミメティック セラピューティクス,リミテッド ライアビリティ カンパニー 腱障害を処置するための血小板由来成長因子組成物及び方法
JO3340B1 (ar) 2010-05-26 2019-03-13 Regeneron Pharma مضادات حيوية لـعامل تمايز النمو 8 البشري
AR081556A1 (es) 2010-06-03 2012-10-03 Glaxo Group Ltd Proteinas de union al antigeno humanizadas
MX2013001845A (es) 2010-08-16 2013-08-27 Amgen Inc Polipetidos que enlazan miostatina, composiciones y metodos.
JP5985480B2 (ja) 2010-08-20 2016-09-06 ワイス・エルエルシー デザイナー骨形成タンパク質
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
TWI654204B (zh) 2010-11-30 2019-03-21 中外製藥股份有限公司 具有鈣依存性的抗原結合能力之抗體
US20130085139A1 (en) 2011-10-04 2013-04-04 Royal Holloway And Bedford New College Oligomers
US8871209B2 (en) 2011-11-14 2014-10-28 Regeneron Pharmaceuticals, Inc. Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing GDF8 and or Activin A
EA201491231A8 (ru) 2011-12-19 2015-01-30 Амген Инк. Варианты полипептидов рецептора активина и их применение
WO2013186719A1 (en) 2012-06-15 2013-12-19 Pfizer Inc. Improved antagonist antibodies against gdf-8 and uses therefor
US10034945B2 (en) 2012-07-13 2018-07-31 Trustees Of Tufts College Silk powder compaction for production of constructs with high mechanical strength and stiffness
WO2014039189A1 (en) 2012-08-01 2014-03-13 Mcnally Elizabeth Mitigating tissue damage and fibrosis via latent transforming growth factor beta binding protein (ltbp4)
JP6774164B2 (ja) 2012-08-24 2020-10-21 中外製薬株式会社 マウスFcγRII特異的Fc抗体
NZ705370A (en) 2012-08-24 2018-06-29 Chugai Pharmaceutical Co Ltd Fcγriib-specific fc region variant
MY189682A (en) 2012-09-13 2022-02-25 Bristol Myers Squibb Co Fibronectin based scaffold domain proteins that bind to myostatin
EA201591423A1 (ru) 2013-02-01 2016-01-29 Санта Мария Биотерапевтикс, Инк. Введение антитела к активину-а пациентам
EP3783017A1 (de) 2013-04-02 2021-02-24 Chugai Seiyaku Kabushiki Kaisha Varianten der fc-region
HUE052232T2 (hu) 2013-05-06 2021-04-28 Scholar Rock Inc Készítmények és eljárások növekedési faktor modulálására
TW201920262A (zh) 2013-07-30 2019-06-01 美商再生元醫藥公司 抗活化素a之抗體及其用途
CA3005158A1 (en) 2014-11-06 2016-05-12 Scholar Rock, Inc. Anti-pro/latent-myostatin antibodies and uses thereof
WO2016073879A2 (en) * 2014-11-06 2016-05-12 Scholar Rock, Inc. Transforming growth factor-related antibodies and uses thereof
KR101860280B1 (ko) 2014-12-19 2018-05-21 추가이 세이야쿠 가부시키가이샤 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법
KR20170110129A (ko) 2015-02-05 2017-10-10 추가이 세이야쿠 가부시키가이샤 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용
MA41795A (fr) 2015-03-18 2018-01-23 Sarepta Therapeutics Inc Exclusion d'un exon induite par des composés antisens dans la myostatine
EP3283519A1 (de) 2015-04-15 2018-02-21 Regeneron Pharmaceuticals, Inc. Verfahren zur erhöhung der stärke und funktionalität mit gdf8-inhibitoren
KR20230155021A (ko) 2015-09-15 2023-11-09 스칼러 락, 인크. 항-프로/잠재성-미오스타틴 항체 및 그의 용도
MA45819A (fr) 2015-10-09 2018-08-15 Sarepta Therapeutics Inc Compositions et méthodes pour traiter la dystrophie musculaire de duchenne et troubles associés
JP7025021B2 (ja) 2015-10-26 2022-02-24 プレジデント アンド フェローズ オブ ハーバード カレッジ 還元多糖および酸化多糖ならびにそれらの使用の方法
EP3394098A4 (de) 2015-12-25 2019-11-13 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin-antikörper und verfahren zur verwendung
CN115814077A (zh) * 2016-01-08 2023-03-21 供石公司 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其使用方法
US10946036B2 (en) 2016-06-13 2021-03-16 Scholar Rock, Inc. Use of myostatin inhibitors and combination therapies
KR102306744B1 (ko) 2016-06-17 2021-09-28 추가이 세이야쿠 가부시키가이샤 항-마이오스타틴 항체 및 사용 방법
WO2018025982A1 (ja) 2016-08-05 2018-02-08 中外製薬株式会社 Il-8関連疾患の治療用又は予防用組成物
ES2944357T3 (es) 2017-01-06 2023-06-20 Scholar Rock Inc Tratamiento de enfermedades metabólicas inhibiendo la activación de miostatina
CN111787981A (zh) 2018-03-01 2020-10-16 瑞泽恩制药公司 改变身体组成的方法
US20220220213A1 (en) 2018-12-18 2022-07-14 Regeneron Pharmaceuticals, Inc. Compositions and Methods for Enhancing Body Weight and Lean Muscle Mass Using Antagonists Against Leptin Receptor, GDF8 and Activin A
CA3124415A1 (en) 2018-12-21 2020-06-25 Northwestern University Use of annexins in preventing and treating muscle membrane injury
WO2020139977A1 (en) 2018-12-26 2020-07-02 Northwestern University Use of glucocorticoid steroids in preventing and treating conditions of muscle wasting, aging and metabolic disorder
JP7375525B2 (ja) * 2019-12-23 2023-11-08 株式会社島津製作所 患者認証システムおよび患者認証方法
JP7397822B2 (ja) 2021-05-14 2023-12-13 花王株式会社 口腔用貼付シート
WO2024064842A1 (en) 2022-09-21 2024-03-28 Regeneron Pharmaceuticals, Inc. Methods of treating obesity, diabetes, and liver dysfunction

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766073A (en) * 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
EP0502036B1 (de) 1989-11-22 1995-12-20 Genentech, Inc. Latenz assoziierte peptide und deren verwendung
AU7312891A (en) * 1990-02-12 1991-09-03 Board Of Regents, The University Of Texas System Satellite cell proliferation in adult skeletal muscle
JP3415643B2 (ja) * 1992-12-04 2003-06-09 株式会社ミノファーゲン製薬 筋ジストロフィー症治療薬
US5994618A (en) * 1997-02-05 1999-11-30 Johns Hopkins University School Of Medicine Growth differentiation factor-8 transgenic mice
JPH09507829A (ja) * 1993-03-19 1997-08-12 ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 増殖分化因子−8
CA2194660C (en) 1994-07-08 2009-09-29 Se-Jin Lee Growth differentiation factor-11
US5616561A (en) 1995-03-31 1997-04-01 Regents Of The University Of California TGF-β antagonists as mitigators of radiation-induced tissue damage
WO1998033887A1 (en) 1997-02-05 1998-08-06 The Johns Hopkins University School Of Medicine Growth differentiation factor-8
PT2045322E (pt) 1997-07-14 2015-10-16 Université de Liège Musculatura dupla em mamíferos
US6656475B1 (en) * 1997-08-01 2003-12-02 The Johns Hopkins University School Of Medicine Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
CA2319703C (en) 1998-02-05 2005-09-20 The Johns Hopkins University School Of Medicine Growth differentiation factor-8
US6369201B1 (en) 1998-02-19 2002-04-09 Metamorphix International, Inc. Myostatin multimers

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CA2157577C (en) 2009-11-17
US7534432B2 (en) 2009-05-19
ES2201076T3 (es) 2004-03-16
DK0690873T3 (da) 2003-09-29
US6096506A (en) 2000-08-01
JP2006117682A (ja) 2006-05-11
JPH09507829A (ja) 1997-08-12
WO1994021681A1 (en) 1994-09-29
US5827733A (en) 1998-10-27
US20070185321A1 (en) 2007-08-09
DE69432815T2 (de) 2003-12-11
CA2157577A1 (en) 1994-09-29
EP0690873A1 (de) 1996-01-10
JP2007306920A (ja) 2007-11-29
US6500664B1 (en) 2002-12-31
EP0690873A4 (de) 2000-11-22
US20030120058A1 (en) 2003-06-26
JP2004121265A (ja) 2004-04-22
EP1333035A3 (de) 2004-07-07
US7179884B2 (en) 2007-02-20
EP1333035A2 (de) 2003-08-06
EP0690873B1 (de) 2003-06-11

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