DE69433464D1 - Mit zellen beschichtete künstliche nieren betreffende vorrichtungen zum in vivo oder ex vivo gebrauch - Google Patents
Mit zellen beschichtete künstliche nieren betreffende vorrichtungen zum in vivo oder ex vivo gebrauchInfo
- Publication number
- DE69433464D1 DE69433464D1 DE69433464T DE69433464T DE69433464D1 DE 69433464 D1 DE69433464 D1 DE 69433464D1 DE 69433464 T DE69433464 T DE 69433464T DE 69433464 T DE69433464 T DE 69433464T DE 69433464 D1 DE69433464 D1 DE 69433464D1
- Authority
- DE
- Germany
- Prior art keywords
- vivo
- bioreactor
- kidney
- hollow fiber
- related devices
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0687—Renal stem cells; Renal progenitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/022—Artificial gland structures using bioreactors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/06—Tubular
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/02—Membranes; Filters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/16—Hollow fibers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/25—Urinary tract cells, renal cells
- C12N2502/256—Renal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/28—Vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US133436 | 1993-10-08 | ||
US08/133,436 US5549674A (en) | 1992-03-02 | 1993-10-08 | Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo |
PCT/US1994/011384 WO1995011048A2 (en) | 1993-10-08 | 1994-10-11 | METHODS AND COMPOSITIONS OF A BIOARTIFICIAL KIDNEY SUITABLE FOR USE IN VIVO OR $i(EX VIVO) |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69433464D1 true DE69433464D1 (de) | 2004-02-05 |
DE69433464T2 DE69433464T2 (de) | 2004-11-11 |
Family
ID=22458619
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69433464T Expired - Lifetime DE69433464T2 (de) | 1993-10-08 | 1994-10-11 | Mit zellen beschichtete künstliche nieren betreffende vorrichtungen zum in vivo oder ex vivo gebrauch |
Country Status (8)
Country | Link |
---|---|
US (2) | US5549674A (de) |
EP (1) | EP0746343B1 (de) |
JP (2) | JP3614853B2 (de) |
AT (1) | ATE257018T1 (de) |
AU (1) | AU692191B2 (de) |
CA (2) | CA2173594C (de) |
DE (1) | DE69433464T2 (de) |
WO (1) | WO1995011048A2 (de) |
Families Citing this family (114)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6410320B1 (en) | 1992-03-02 | 2002-06-25 | The University Of Michigan | Method and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules |
SE9900043D0 (sv) * | 1999-01-11 | 1999-01-11 | Astra Ab | New use |
JPH09512184A (ja) * | 1994-04-29 | 1997-12-09 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | 内皮下細胞外基質上の内皮を利用する改善された血液接触表面 |
US6152141A (en) * | 1994-07-28 | 2000-11-28 | Heartport, Inc. | Method for delivery of therapeutic agents to the heart |
US6372495B1 (en) * | 1995-10-06 | 2002-04-16 | Seed Capital Investments-2 (Sci-2) B.V. | Bio-artificial organ containing a matrix having hollow fibers for supplying gaseous oxygen |
ATE260076T1 (de) * | 1996-09-05 | 2004-03-15 | Childrens Medical Center | Nierenprothese |
US6673339B1 (en) | 1996-09-05 | 2004-01-06 | Children's Medical Center Corporation | Prosthetic kidney and its use for treating kidney disease |
US6150164A (en) * | 1996-09-30 | 2000-11-21 | The Regents Of The University Of Michigan | Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo |
US5902336A (en) * | 1996-10-15 | 1999-05-11 | Mirimedical, Inc. | Implantable device and method for removing fluids from the blood of a patient method for implanting such a device and method for treating a patient experiencing renal failure |
ATE248615T1 (de) * | 1997-10-31 | 2003-09-15 | Childrens Medical Center | Blasenrekonstruktion |
EP1042019B1 (de) * | 1997-10-31 | 2006-06-07 | Children's Medical Center Corporation | Penis-rekonstruktion |
WO2000061630A1 (en) * | 1999-04-08 | 2000-10-19 | President And Fellows Of Harvard College | Induction of kidney tubule formation |
CA2369576C (en) * | 1999-04-23 | 2005-07-05 | William Frederick Weitzel | Extracorporeal circuit and related methods |
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EP1187909B1 (de) * | 1999-04-30 | 2005-02-02 | Massachusetts General Hospital | Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen |
US7759113B2 (en) * | 1999-04-30 | 2010-07-20 | The General Hospital Corporation | Fabrication of tissue lamina using microfabricated two-dimensional molds |
US20040167634A1 (en) * | 1999-05-26 | 2004-08-26 | Anthony Atala | Prosthetic kidney and its use for treating kidney disease |
JP3229599B2 (ja) * | 1999-06-01 | 2001-11-19 | ホスパル株式会社 | 血液浄化装置とそれを使用した人工腎臓 |
NZ516777A (en) * | 1999-08-10 | 2004-12-24 | Ml Lab Plc | Method for delivery of therapeutic agents, particularly nucleic acids, using a solution of dextrin |
DE19943205C1 (de) * | 1999-09-10 | 2000-11-16 | Geesthacht Gkss Forschung | Verfahren zur Erzeugung, zum Transport und zur Eliminierung von biochemischen Stoffen mittels aktiver biologischer Zellen |
US6479064B1 (en) | 1999-12-29 | 2002-11-12 | Children's Medical Center Corporation | Culturing different cell populations on a decellularized natural biostructure for organ reconstruction |
JP4813734B2 (ja) * | 2000-03-31 | 2011-11-09 | ザ ジェネラル ホスピタル コーポレイション | 毛の成長を調節する方法 |
US7776021B2 (en) * | 2000-04-28 | 2010-08-17 | The Charles Stark Draper Laboratory | Micromachined bilayer unit for filtration of small molecules |
CN101172171B (zh) * | 2000-10-12 | 2012-12-12 | 肾脏治疗公司 | 在体液体外处理中用于体液流动控制的装置和方法 |
US6538010B1 (en) * | 2000-11-08 | 2003-03-25 | Research Triangle Institute | Compounds and methods for promoting smoking cessation |
US6627164B1 (en) * | 2000-11-28 | 2003-09-30 | Renal Solutions, Inc. | Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same |
US7033498B2 (en) * | 2000-11-28 | 2006-04-25 | Renal Solutions, Inc. | Cartridges useful in cleaning dialysis solutions |
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US7476210B2 (en) * | 2001-01-04 | 2009-01-13 | Transvivo Inc. | Apparatus and method for in-vivo plasmapheresis using periodic backflush containing anticoagulant |
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US6582955B2 (en) * | 2001-05-11 | 2003-06-24 | Spectrum Laboratories, Inc. | Bioreactor with application as blood therapy device |
EP1388327B1 (de) * | 2001-05-17 | 2012-02-22 | Kaneka Corporation | Künstliche niere mit proteinmetabolisierungsfunktion und verfahren zu ihrer herstellung |
US6653131B2 (en) | 2001-08-30 | 2003-11-25 | The Regents Of The University Of Michigan | Method of treating systemic inflammatory response syndrome |
US7332330B2 (en) * | 2001-09-11 | 2008-02-19 | Renamed Biologics, Inc. | Device for maintaining vascularization near an implant |
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US8105580B2 (en) | 2001-12-07 | 2012-01-31 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to promote wound healing |
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EP1921133B1 (de) | 2001-12-07 | 2015-05-20 | Cytori Therapeutics, Inc. | System zur Behandlung von Zellen aus Lipoaspirat |
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US7960166B2 (en) | 2003-05-21 | 2011-06-14 | The General Hospital Corporation | Microfabricated compositions and processes for engineering tissues containing multiple cell types |
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US9770180B2 (en) * | 2006-08-17 | 2017-09-26 | Milan Radojicic | System and method for monitoring and delivering therapeutics to the spinal cord |
US10478555B2 (en) | 2006-08-17 | 2019-11-19 | Milan Radojicic | Systems and methods for lumbar cerebrospinal fluid access and treatment |
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WO2008047760A1 (fr) * | 2006-10-17 | 2008-04-24 | Tokai University Educational System | Tubule rénal bioartificiel |
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-
1993
- 1993-10-08 US US08/133,436 patent/US5549674A/en not_active Expired - Lifetime
-
1994
- 1994-10-11 CA CA002173594A patent/CA2173594C/en not_active Expired - Fee Related
- 1994-10-11 EP EP94930647A patent/EP0746343B1/de not_active Expired - Lifetime
- 1994-10-11 AU AU79701/94A patent/AU692191B2/en not_active Ceased
- 1994-10-11 DE DE69433464T patent/DE69433464T2/de not_active Expired - Lifetime
- 1994-10-11 WO PCT/US1994/011384 patent/WO1995011048A2/en active IP Right Grant
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- 1994-10-11 JP JP51191995A patent/JP3614853B2/ja not_active Expired - Fee Related
- 1994-10-11 AT AT94930647T patent/ATE257018T1/de active
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1995
- 1995-06-07 US US08/487,327 patent/US5686289A/en not_active Expired - Lifetime
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US5549674A (en) | 1996-08-27 |
EP0746343A1 (de) | 1996-12-11 |
US5686289A (en) | 1997-11-11 |
WO1995011048A3 (en) | 1995-06-22 |
JP2004267795A (ja) | 2004-09-30 |
JPH09503941A (ja) | 1997-04-22 |
EP0746343A4 (de) | 1997-12-03 |
JP3614853B2 (ja) | 2005-01-26 |
CA2173594A1 (en) | 1995-04-27 |
AU7970194A (en) | 1995-05-08 |
CA2173594C (en) | 2004-09-07 |
JP3795900B2 (ja) | 2006-07-12 |
WO1995011048A2 (en) | 1995-04-27 |
CA2710965A1 (en) | 1995-04-27 |
EP0746343B1 (de) | 2004-01-02 |
AU692191B2 (en) | 1998-06-04 |
CA2710965C (en) | 2012-10-09 |
ATE257018T1 (de) | 2004-01-15 |
DE69433464T2 (de) | 2004-11-11 |
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