DE69434119D1 - Stabilisierte mikrogasblaeschen-zusammensetzungen für echografie - Google Patents

Stabilisierte mikrogasblaeschen-zusammensetzungen für echografie

Info

Publication number
DE69434119D1
DE69434119D1 DE69434119T DE69434119T DE69434119D1 DE 69434119 D1 DE69434119 D1 DE 69434119D1 DE 69434119 T DE69434119 T DE 69434119T DE 69434119 T DE69434119 T DE 69434119T DE 69434119 D1 DE69434119 D1 DE 69434119D1
Authority
DE
Germany
Prior art keywords
gas
stabilized
average diameter
microgas
echography
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69434119T
Other languages
English (en)
Other versions
DE69434119T2 (de
DE69434119T3 (de
Inventor
Ernest G Schutt
David P Evitts
Rene Alta Kinner
Jeffry G Weers
Charles David Anderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imcor Pharmaceutical Co
Original Assignee
Alliance Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22277383&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69434119(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alliance Pharmaceutical Corp filed Critical Alliance Pharmaceutical Corp
Application granted granted Critical
Publication of DE69434119D1 publication Critical patent/DE69434119D1/de
Publication of DE69434119T2 publication Critical patent/DE69434119T2/de
Publication of DE69434119T3 publication Critical patent/DE69434119T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/0001—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems
    • G02B6/0005—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being of the fibre type
    • G02B6/0006—Coupling light into the fibre
DE69434119T 1993-07-30 1994-08-01 Stabilisierte mikrogasbläschen-zusammensetzungen für echographie Expired - Lifetime DE69434119T3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9995193A 1993-07-30 1993-07-30
US99951 1993-07-30
PCT/US1994/008671 WO1995003835A1 (en) 1993-07-30 1994-08-01 Stabilized microbubble compositions for ultrasound

Publications (3)

Publication Number Publication Date
DE69434119D1 true DE69434119D1 (de) 2004-12-09
DE69434119T2 DE69434119T2 (de) 2005-11-03
DE69434119T3 DE69434119T3 (de) 2011-05-05

Family

ID=22277383

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69434119T Expired - Lifetime DE69434119T3 (de) 1993-07-30 1994-08-01 Stabilisierte mikrogasbläschen-zusammensetzungen für echographie

Country Status (12)

Country Link
US (17) US5605673A (de)
EP (2) EP0711179B2 (de)
JP (1) JP3559849B2 (de)
AT (1) ATE281183T1 (de)
AU (1) AU694135B2 (de)
CA (1) CA2164813C (de)
DE (1) DE69434119T3 (de)
DK (1) DK0711179T3 (de)
ES (1) ES2231775T5 (de)
HK (1) HK1013403A1 (de)
PT (1) PT711179E (de)
WO (1) WO1995003835A1 (de)

Families Citing this family (251)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US20020150539A1 (en) * 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (de) 1990-04-02 1993-05-01 Sint Sa
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
US6875420B1 (en) 1991-09-17 2005-04-05 Amersham Health As Method of ultrasound imaging
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
GB9221329D0 (en) * 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
US20050053552A1 (en) * 1993-01-25 2005-03-10 Quay Steven C. Phase shift colloids as ultrasound contrast agents
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
CA2154590C (en) * 1993-01-25 2001-06-12 Steven C. Quay Phase shift colloids as ultrasound contrast agents
DE69434119T3 (de) * 1993-07-30 2011-05-05 Imcor Pharmaceutical Co., San Diego Stabilisierte mikrogasbläschen-zusammensetzungen für echographie
GB9318288D0 (en) * 1993-09-03 1993-10-20 Nycomed Imaging As Improvements in or relating to contrast agents
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
PT682530E (pt) * 1993-12-15 2003-06-30 Bracco Research Sa Misturas de gases uteis como meios de contraste para ultrassons
GB9402867D0 (en) * 1994-02-15 1994-04-06 Nycomed Imaging As Improvements in or relating to contrast agents
DE4406474A1 (de) * 1994-02-23 1995-08-24 Schering Ag Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel
US5736121A (en) * 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
GB9423419D0 (en) * 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US5606973A (en) * 1995-06-07 1997-03-04 Molecular Biosystems, Inc. Liquid core microdroplets for ultrasound imaging
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5897851A (en) * 1995-06-07 1999-04-27 Sonus Pharmaceuticals, Inc. Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
DE19602930A1 (de) * 1996-01-18 1997-07-24 Schering Ag Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung
EP0935415B1 (de) 1996-05-01 2006-11-22 Imarx Pharmaceutical Corp. In vitro verfahren zum einbringen von nukleinsäuren in eine zelle
DE19626530A1 (de) * 1996-07-02 1998-01-15 Byk Gulden Lomberg Chem Fab MR-Kontrastmittelzubereitungen
GB9617811D0 (en) 1996-08-27 1996-10-09 Nycomed Imaging As Improvements in or relating to contrast agents
US6414139B1 (en) * 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US6017310A (en) * 1996-09-07 2000-01-25 Andaris Limited Use of hollow microcapsules
ATE366588T1 (de) 1996-09-11 2007-08-15 Imarx Pharmaceutical Corp Verfahren zur diagnostischen bilderzeugung der nierenregion unter verwendung eines kontrastmittels und eines vasodilators
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
TR199901544T2 (xx) * 1996-10-21 1999-09-21 Nycomed Imaging As Kontrast ajanlar�ndaki veya kontrast ajanlar�yla ilgili geli�meler.
US6068600A (en) * 1996-12-06 2000-05-30 Quadrant Healthcare (Uk) Limited Use of hollow microcapsules
CZ294766B6 (cs) * 1996-12-24 2005-03-16 Rhone-Poulenc Agro 1-Arylpyrazolové sloučeniny, pesticidní prostředky obsahující tyto sloučeniny jako účinné látky a způsob hubení škůdců
GB9701237D0 (en) * 1997-01-22 1997-03-12 Nycomed Imaging As Improvements in or relating to contrast agents
US5881826A (en) 1997-02-13 1999-03-16 Actisystems, Inc. Aphron-containing well drilling and servicing fluids
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6537246B1 (en) * 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
GB9708240D0 (en) * 1997-04-23 1997-06-11 Nycomed Imaging As Improvements in or relating to contrast agents
US20050019266A1 (en) * 1997-05-06 2005-01-27 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
AU7702798A (en) * 1997-05-30 1998-12-30 Alliance Pharmaceutical Corporation Methods and apparatus for monitoring and quantifying the movement of fluid
GB9717588D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
DK1019022T4 (da) * 1997-09-29 2010-11-08 Novartis Ag Perforerede mikropartikler og fremgangsmåde til anvendelse deraf
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US6433040B1 (en) * 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US20020017295A1 (en) * 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
AU9550498A (en) * 1997-10-21 1999-05-10 Nycomed Imaging As Ultrasound imaging with contrast agent targeted to microvasculature and a vasodilator drug
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US6054319A (en) * 1998-02-03 2000-04-25 Board Of Trustees Operating Michigan State University Method and apparatus for growing cells using gas or liquid aphrons
GB9808599D0 (en) * 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or realting to contrast agents
ES2243270T3 (es) * 1999-05-21 2005-12-01 Mallinckrodt Inc. Dispositivo de resuspension de un agente de contraste.
ATE555773T1 (de) * 1999-06-09 2012-05-15 Sievers Robert E Überkritische fluidgestützte verneblung und blasen trochnen
AU7743200A (en) * 1999-10-06 2001-05-10 Imarx Therapeutics, Inc. Improved methods for delivering bioactive agents
US7028267B1 (en) * 1999-12-07 2006-04-11 Microsoft Corporation Method and apparatus for capturing and rendering text annotations for non-modifiable electronic content
US6649571B1 (en) 2000-04-04 2003-11-18 Masi Technologies, L.L.C. Method of generating gas bubbles in oleaginous liquids
US8574146B2 (en) 2000-04-14 2013-11-05 Attenuex Technologies, Inc. Implant with high vapor pressure medium
US6682473B1 (en) 2000-04-14 2004-01-27 Solace Therapeutics, Inc. Devices and methods for attenuation of pressure waves in the body
US10327880B2 (en) 2000-04-14 2019-06-25 Attenuex Technologies, Inc. Attenuation device for use in an anatomical structure
WO2001085136A2 (en) 2000-05-10 2001-11-15 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US8404217B2 (en) * 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) * 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US20020106368A1 (en) * 2000-07-28 2002-08-08 Adrian Bot Novel methods and compositions to upregulate, redirect or limit immune responses to peptides, proteins and other bioactive compounds and vectors expressing the same
US8036731B2 (en) 2001-01-22 2011-10-11 Spectrum Dynamics Llc Ingestible pill for diagnosing a gastrointestinal tract
US8909325B2 (en) 2000-08-21 2014-12-09 Biosensors International Group, Ltd. Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US8565860B2 (en) 2000-08-21 2013-10-22 Biosensors International Group, Ltd. Radioactive emission detector equipped with a position tracking system
US7826889B2 (en) * 2000-08-21 2010-11-02 Spectrum Dynamics Llc Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US8489176B1 (en) 2000-08-21 2013-07-16 Spectrum Dynamics Llc Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US7776310B2 (en) 2000-11-16 2010-08-17 Microspherix Llc Flexible and/or elastic brachytherapy seed or strand
NO20010234D0 (no) * 2001-01-12 2001-01-12 Nycomed Imaging As Perfusjon avbildningsbilde
CN1310617C (zh) 2001-01-22 2007-04-18 V-目标技术有限公司 可咽下装置
DE10119522A1 (de) * 2001-04-20 2002-12-05 Innovacell Biotechnologie Gmbh Herstellung und Anwendung einer Suspensionszusammensetzung mit einem Ultraschall-Kontrastmittel
ITSV20010020A1 (it) * 2001-06-08 2002-12-08 Esaote Spa Macchina per l'acquisizione di immagini della zona interna di un corpo in particolare per l'acquisizione di immagini diagnostiche
DE60142311D1 (de) * 2001-08-08 2010-07-15 Dominguez Maria Antonia Garcia-Olmedo Injizierbarer schaum und neue pharmazeutische anwendungen dafür
US8512680B2 (en) * 2001-08-08 2013-08-20 Btg International Ltd. Injectables in foam, new pharmaceutical applications
DE10146264A1 (de) 2001-09-20 2003-04-17 Ecolab Gmbh & Co Ohg Verwendung von O/W-Emulsionen zur Kettenschmierung
US20070255169A1 (en) * 2001-11-19 2007-11-01 Dune Medical Devices Ltd. Clean margin assessment tool
US7505811B2 (en) 2001-11-19 2009-03-17 Dune Medical Devices Ltd. Method and apparatus for examining tissue for predefined target cells, particularly cancerous cells, and a probe useful in such method and apparatus
TWI324518B (en) 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
US8032211B2 (en) * 2002-01-04 2011-10-04 Dune Medical Devices Ltd. Probes, systems, and methods for examining tissue according to the dielectric properties thereof
US8721565B2 (en) * 2005-08-04 2014-05-13 Dune Medical Devices Ltd. Device for forming an effective sensor-to-tissue contact
US8116845B2 (en) 2005-08-04 2012-02-14 Dune Medical Devices Ltd. Tissue-characterization probe with effective sensor-to-tissue contact
US7720532B2 (en) * 2004-03-23 2010-05-18 Dune Medical Ltd. Clean margin assessment tool
US7809425B2 (en) * 2003-07-24 2010-10-05 Dune Medical Devices Ltd. Method and apparatus for examining a substance, particularly tissue, to characterize its type
US8019411B2 (en) * 2002-01-04 2011-09-13 Dune Medical Devices Ltd. Probes, systems, and methods for examining tissue according to the dielectric properties thereof
WO2004069153A2 (en) * 2003-01-27 2004-08-19 Medrad, Inc. Apparatus, system and method for generating bubbles on demand
CA2418229A1 (en) * 2002-05-16 2003-11-16 Rohan Dharmakumar Microbubble construct for sensitivity enhanced mr manometry
WO2004006964A1 (en) * 2002-07-11 2004-01-22 Targeson, Llc Microbubble compositions, and methods for preparing and using same
AU2003279070A1 (en) * 2002-09-30 2004-04-23 Acusphere Inc Sustained release porous microparticles for inhalation
US20040116807A1 (en) * 2002-10-17 2004-06-17 Roni Amrami Blood vessels wall imaging catheter
AU2003276658A1 (en) 2002-11-04 2004-06-07 V-Target Technologies Ltd. Apparatus and methods for imaging and attenuation correction
US6962006B2 (en) * 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US7623908B2 (en) 2003-01-24 2009-11-24 The Board Of Trustees Of The University Of Illinois Nonlinear interferometric vibrational imaging
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
EP1590006B1 (de) * 2003-02-04 2010-09-08 Bracco Suisse SA Ultraschall kontrastmittel und verfahren zur erstellung
US7198777B2 (en) * 2003-06-17 2007-04-03 The Board Of Trustees Of The University Of Illinois Optical contrast agents for optically modifying incident radiation
US7217410B2 (en) * 2003-06-17 2007-05-15 The Board Of Trustees Of The Universtiy Of Illinois Surface modified protein microparticles
US20050069591A1 (en) * 2003-09-30 2005-03-31 Howard Bernstein Injectable, oral, or topical sustained release pharmaceutical formulations
CA2546076A1 (en) 2003-11-17 2005-06-02 Btg International Limited Therapeutic foam
US20070081946A1 (en) * 2003-12-22 2007-04-12 Bracco Research S.A. Assembly of gas-filled microvesicle with active component for contrast imaging
CA2547024C (en) * 2003-12-22 2013-12-17 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
US7610074B2 (en) * 2004-01-08 2009-10-27 The Board Of Trustees Of The University Of Illinois Multi-functional plasmon-resonant contrast agents for optical coherence tomography
US9470801B2 (en) 2004-01-13 2016-10-18 Spectrum Dynamics Llc Gating with anatomically varying durations
US8586932B2 (en) 2004-11-09 2013-11-19 Spectrum Dynamics Llc System and method for radioactive emission measurement
WO2005067383A2 (en) 2004-01-13 2005-07-28 Spectrum Dynamics Llc Multi-dimensional image reconstruction
WO2008010227A2 (en) 2006-07-19 2008-01-24 Spectrum Dynamics Llc Imaging protocols
WO2007010537A2 (en) 2005-07-19 2007-01-25 Spectrum Dynamics Llc Reconstruction stabilizer and active vision
US8571881B2 (en) 2004-11-09 2013-10-29 Spectrum Dynamics, Llc Radiopharmaceutical dispensing, administration, and imaging
US7968851B2 (en) 2004-01-13 2011-06-28 Spectrum Dynamics Llc Dynamic spect camera
US9750425B2 (en) 2004-03-23 2017-09-05 Dune Medical Devices Ltd. Graphical user interfaces (GUI), methods and apparatus for data presentation
US7904145B2 (en) 2004-03-23 2011-03-08 Dune Medical Devices Ltd. Clean margin assessment tool
WO2005112895A2 (en) * 2004-05-20 2005-12-01 Spectrum Dynamics Llc Ingestible device platform for the colon
EP1778957A4 (de) 2004-06-01 2015-12-23 Biosensors Int Group Ltd Optimierung der messung radioaktiver strahlung an besonderen körperstrukturen
US8280124B2 (en) 2004-06-01 2012-10-02 Spectrum Dynamics Llc Methods of view selection for radioactive emission measurements
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
JP4837663B2 (ja) 2004-08-18 2011-12-14 ブラッコ・シュイス・ソシエテ・アノニム 造影画像化のためのガス充填微小胞組成物
US8658453B2 (en) * 2004-09-15 2014-02-25 Sonetics Ultrasound, Inc. Capacitive micromachined ultrasonic transducer
US7888709B2 (en) * 2004-09-15 2011-02-15 Sonetics Ultrasound, Inc. Capacitive micromachined ultrasonic transducer and manufacturing method
US8309428B2 (en) * 2004-09-15 2012-11-13 Sonetics Ultrasound, Inc. Capacitive micromachined ultrasonic transducer
US8615405B2 (en) 2004-11-09 2013-12-24 Biosensors International Group, Ltd. Imaging system customization using data from radiopharmaceutical-associated data carrier
US8423125B2 (en) 2004-11-09 2013-04-16 Spectrum Dynamics Llc Radioimaging
EP1827505A4 (de) 2004-11-09 2017-07-12 Biosensors International Group, Ltd. Radiodarstellung
US9943274B2 (en) 2004-11-09 2018-04-17 Spectrum Dynamics Medical Limited Radioimaging using low dose isotope
US9316743B2 (en) 2004-11-09 2016-04-19 Biosensors International Group, Ltd. System and method for radioactive emission measurement
US20090011972A1 (en) * 2004-12-28 2009-01-08 Sanyo Chemical Industries, Ltd. Surfactant for Fine-Bubble Formation
US7872235B2 (en) 2005-01-13 2011-01-18 Spectrum Dynamics Llc Multi-dimensional image reconstruction and analysis for expert-system diagnosis
US7586618B2 (en) * 2005-02-28 2009-09-08 The Board Of Trustees Of The University Of Illinois Distinguishing non-resonant four-wave-mixing noise in coherent stokes and anti-stokes Raman scattering
CA2603025C (en) * 2005-03-29 2014-05-20 Dune Medical Devices Ltd. Electromagnetic sensors for tissue characterization
US7725169B2 (en) * 2005-04-15 2010-05-25 The Board Of Trustees Of The University Of Illinois Contrast enhanced spectroscopic optical coherence tomography
US20070031342A1 (en) * 2005-06-22 2007-02-08 Nektar Therapeutics Sustained release microparticles for pulmonary delivery
US8644910B2 (en) 2005-07-19 2014-02-04 Biosensors International Group, Ltd. Imaging protocols
US8837793B2 (en) 2005-07-19 2014-09-16 Biosensors International Group, Ltd. Reconstruction stabilizer and active vision
US20070038088A1 (en) * 2005-08-04 2007-02-15 Rich Collin A Medical imaging user interface and control scheme
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US7967763B2 (en) * 2005-09-07 2011-06-28 Cabochon Aesthetics, Inc. Method for treating subcutaneous tissues
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
WO2007038476A2 (en) 2005-09-26 2007-04-05 Atteneux Technologies, Inc. Pressure attenuation device
US8257338B2 (en) 2006-10-27 2012-09-04 Artenga, Inc. Medical microbubble generation
US7705316B2 (en) 2005-11-09 2010-04-27 Spectrum Dynamics Llc Dynamic SPECT camera
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
US7913223B2 (en) * 2005-12-16 2011-03-22 Dialogic Corporation Method and system for development and use of a user-interface for operations, administration, maintenance and provisioning of a telecommunications system
US8204500B2 (en) 2005-12-28 2012-06-19 Starhome Gmbh Optimal voicemail deposit for roaming cellular telephony
JP2007197403A (ja) * 2006-01-30 2007-08-09 Hitachi Ltd 薬物キャリアー及び超音波装置
AU2007211061B2 (en) 2006-01-31 2013-04-18 The Board Of Trustees Of The University Of Illinois Method and apparatus for measurement of optical properties in tissue
US20070255659A1 (en) * 2006-05-01 2007-11-01 Wei Yen System and method for DRM translation
US8894974B2 (en) 2006-05-11 2014-11-25 Spectrum Dynamics Llc Radiopharmaceuticals for diagnosis and therapy
ITBO20060593A1 (it) * 2006-08-04 2008-02-05 Francesca Cavalieri Microbolle realizzate in alcol polivinilico e relativo caricamento delle stesse con ossido di azoto
CN100551440C (zh) * 2006-08-30 2009-10-21 中国人民解放军第三军医大学第二附属医院 一种用于肿瘤超声治疗的治疗型超声微泡及其制备方法
WO2008028917A1 (en) 2006-09-05 2008-03-13 Bracco Research Sa Gas-filled microvesicles with polymer-modified lipids
US20080071149A1 (en) * 2006-09-20 2008-03-20 Collin Rich Method and system of representing a medical event
US20080071292A1 (en) * 2006-09-20 2008-03-20 Rich Collin A System and method for displaying the trajectory of an instrument and the position of a body within a volume
US8610075B2 (en) 2006-11-13 2013-12-17 Biosensors International Group Ltd. Radioimaging applications of and novel formulations of teboroxime
US8200961B2 (en) * 2006-11-19 2012-06-12 Igware, Inc. Securing a flash memory block in a secure device system and method
JP2007126467A (ja) * 2006-12-15 2007-05-24 Bracco Research Sa 超音波造影媒体、この媒体を含む造影剤及び方法
WO2008075192A2 (en) * 2006-12-19 2008-06-26 Bracco International Bv Targeting and therapeutic compounds and gas-filled microvesicles comprising said com ounds
WO2008075362A2 (en) 2006-12-20 2008-06-26 Spectrum Dynamics Llc A method, a system, and an apparatus for using and processing multidimensional data
US8147423B2 (en) * 2007-03-01 2012-04-03 Dune Medical Devices, Ltd. Tissue-characterization system and method
US20090088393A1 (en) 2007-09-28 2009-04-02 Zomanex, Llc Methods and formulations for converting intravenous and injectable drugs into oral dosage forms
US20090093723A1 (en) * 2007-10-05 2009-04-09 Cabochon Aesthetics, Inc. Ultrasound device including dispenser
US20090093738A1 (en) * 2007-10-09 2009-04-09 Cabochon Aesthetics, Inc. Device and method for monitoring a treatment area
EP2209424A1 (de) * 2007-10-09 2010-07-28 Cabochon Aesthetics, Inc. Ultraschallgerät mit behandlungslinse
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
US8521253B2 (en) 2007-10-29 2013-08-27 Spectrum Dynamics Llc Prostate imaging
US7751057B2 (en) 2008-01-18 2010-07-06 The Board Of Trustees Of The University Of Illinois Magnetomotive optical coherence tomography
US8983580B2 (en) * 2008-01-18 2015-03-17 The Board Of Trustees Of The University Of Illinois Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors
US8115934B2 (en) 2008-01-18 2012-02-14 The Board Of Trustees Of The University Of Illinois Device and method for imaging the ear using optical coherence tomography
EP2090322A1 (de) 2008-02-18 2009-08-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Verwendung von FSH-Rezeptorliganden zur Diagnose und Behandlung von Krebs
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
EP2350999A4 (de) 2008-09-25 2017-04-05 CAE Healthcare Canada Inc. Simulation der medizinischen bildgebung
WO2010040772A2 (en) * 2008-10-07 2010-04-15 Bracco Research Sa Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same
US20100106063A1 (en) * 2008-10-29 2010-04-29 Cabochon Aesthetics, Inc. Ultrasound Enhancing Target for Treating Subcutaneous Tissue
US9060916B2 (en) 2009-01-12 2015-06-23 Jason International, Inc. Microbubble therapy method and generating apparatus
US8201811B2 (en) 2009-01-12 2012-06-19 Jason International, Inc. Microbubble therapy method and generating apparatus
US8322634B2 (en) * 2009-01-12 2012-12-04 Jason International, Inc. Microbubble therapy method and generating apparatus
US8579266B2 (en) * 2009-01-12 2013-11-12 Jason International, Inc. Microbubble therapy method and generating apparatus
US8720867B2 (en) * 2009-01-12 2014-05-13 Jason International, Inc. Microbubble therapy method and generating apparatus
US8729440B2 (en) * 2009-03-02 2014-05-20 Harris Corporation Applicator and method for RF heating of material
US8315125B2 (en) * 2009-03-18 2012-11-20 Sonetics Ultrasound, Inc. System and method for biasing CMUT elements
US8167280B2 (en) * 2009-03-23 2012-05-01 Cabochon Aesthetics, Inc. Bubble generator having disposable bubble cartridges
US20100256596A1 (en) * 2009-04-07 2010-10-07 Cabochon Aesthetics, Inc. Fiber growth promoting implants for reducing the appearance of cellulite
US8338788B2 (en) 2009-07-29 2012-12-25 Spectrum Dynamics Llc Method and system of optimized volumetric imaging
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
EP2470287A4 (de) * 2009-08-28 2015-01-21 Univ Columbia Systeme, verfahren und vorrichtungen zur herstellung gasgefüllter mikroblasen
EP2477550A4 (de) * 2009-09-15 2013-12-04 Univ Columbia Systeme, verfahren und vorrichtungen für mikrobläschen
EP2312303A1 (de) * 2009-10-12 2011-04-20 Koninklijke Philips Electronics N.V. Magnetresonanztomographiesystem und Verfahren zur Detektion von Gasbläschen
DK2603242T3 (en) 2010-08-09 2018-06-18 Bracco Suisse Sa TARGETED GAS FILLED MICROVESICLES
WO2012085072A1 (en) 2010-12-24 2012-06-28 Bracco Suisse Sa Gas-filled microvesicles for use as vaccine
US10279053B2 (en) 2011-07-19 2019-05-07 Nuvox Pharma Llc Microbubble compositions, method of making same, and method using same
JP6045181B2 (ja) * 2011-11-29 2016-12-14 ダンロップスポーツ株式会社 ゴルフボール用樹脂組成物及びゴルフボール
US8894563B2 (en) 2012-08-10 2014-11-25 Attenuex Technologies, Inc. Methods and systems for performing a medical procedure
CN107206065A (zh) 2014-12-22 2017-09-26 博莱科瑞士股份有限公司 用作疫苗的气体填充的微囊
CA2972423A1 (en) 2014-12-31 2016-07-07 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
US11147531B2 (en) 2015-08-12 2021-10-19 Sonetics Ultrasound, Inc. Method and system for measuring blood pressure using ultrasound by emitting push pulse to a blood vessel
WO2017083753A1 (en) * 2015-11-12 2017-05-18 Herr John C Compositions and methods for vas-occlusive contraception and reversal thereof
US20190117800A1 (en) * 2016-04-19 2019-04-25 Microvascuar Therapeutics Llc Systems and methods for filling vials with gases
TWI740937B (zh) 2016-05-04 2021-10-01 美商藍瑟斯醫學影像公司 用於製備超音波顯影劑之裝置及方法
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
CN109983111B (zh) * 2016-11-24 2021-01-19 松下知识产权经营株式会社 微细气泡生成促进剂、含微细气泡的液体、含微细气泡的液体的制造方法及制造装置
CN110381854A (zh) 2017-01-05 2019-10-25 考恩特兰有限公司 用于植入和逆转刺激响应性植入物的方法
KR102103810B1 (ko) * 2018-05-24 2020-04-24 한국원자력의학원 과불화탄소 나노입자, 이를 포함하는 약물 전달용 초음파 조영제 및 그의 제조방법
EP3880273A4 (de) 2018-11-13 2022-08-24 Contraline, Inc. Systeme und verfahren zur abgabe von biomaterialien
EP3880081A1 (de) * 2018-11-14 2021-09-22 Robeaute System und verfahren zur echtzeitlokalisierung
CN113677256A (zh) 2019-02-07 2021-11-19 索雷斯医疗公司 压力衰减装置
WO2021222520A1 (en) * 2020-04-29 2021-11-04 Integrity Bio-Chemicals, Llc Fatty acid reaction products of dextrins or dextran formulated with a surfactant
US11191888B1 (en) 2020-05-18 2021-12-07 Agitated Solutions Inc. Syringe-based microbubble generator

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US552133A (en) * 1895-12-31 Condensation of vapors
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4276685A (en) 1979-12-12 1981-07-07 Callahan David K Portable in-line press
US4657756A (en) † 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
US4681119A (en) * 1980-11-17 1987-07-21 Schering Aktiengesellschaft Method of production and use of microbubble precursors
JPS5787216A (en) 1980-11-19 1982-05-31 Nippon Gakki Seizo Kk Amplifying circuit
DE3141641A1 (de) † 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
JPS58110522A (ja) * 1981-12-25 1983-07-01 Green Cross Corp:The 血管造影剤
JPS5967229A (ja) 1982-10-08 1984-04-16 Green Cross Corp:The 超音波診断造影剤
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4718433A (en) 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
DE3313947A1 (de) 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
DE3324754A1 (de) * 1983-07-06 1985-01-17 Schering AG, 1000 Berlin und 4709 Bergkamen Ultraschallkontrastmittel sowie dessen herstellung
IT1198860B (it) 1984-06-08 1988-12-21 Mario Gonzi Dispositivo intecettore di microtrafilamenti,per evitare e/o segnalare perdite d'olio in impianti idraulici e per impieghi equivalenti
US5186922A (en) * 1985-03-15 1993-02-16 See/Shell Biotechnology, Inc. Use of biodegradable microspheres labeled with imaging energy constrast materials
US4613326A (en) * 1985-07-12 1986-09-23 Becton, Dickinson And Company Two-component medication syringe assembly
DE3529195A1 (de) * 1985-08-14 1987-02-26 Max Planck Gesellschaft Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung
US4684479A (en) 1985-08-14 1987-08-04 Arrigo Joseph S D Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
WO1987002893A1 (en) * 1985-11-18 1987-05-21 Board Of Regents, The University Of Texas System Polychelating agents for image and spectral enhancement (and spectral shift)
US4898735A (en) 1985-12-06 1990-02-06 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Liposome/doxorubicin composition and method
US4640246A (en) 1986-01-03 1987-02-03 Sturdy Truck Equipment, Incorporated Road and engine speed governor with power demand control
US4927623A (en) * 1986-01-14 1990-05-22 Alliance Pharmaceutical Corp. Dissolution of gas in a fluorocarbon liquid
GB8601100D0 (en) * 1986-01-17 1986-02-19 Cosmas Damian Ltd Drug delivery system
US5536753A (en) * 1986-01-24 1996-07-16 Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center And Hemagen/Pfc Stable perfluorocarbon and oil emulsions
US5684050A (en) * 1986-01-24 1997-11-04 Hemagen/Pfc Stable emulsions of highly fluorinated organic compounds
DE3785054T2 (de) * 1986-01-24 1993-07-08 Childrens Hosp Medical Center Stabile emulsionen von stark fluorierten, organischen verbindungen.
DE3637926C1 (de) 1986-11-05 1987-11-26 Schering Ag Ultraschall-Manometrieverfahren in einer Fluessigkeit mittels Mikroblaeschen
US4925678A (en) * 1987-04-01 1990-05-15 Ranney David F Endothelial envelopment drug carriers
US4781676A (en) * 1987-02-20 1988-11-01 Air Products And Chemicals, Inc. Interstitial administration of perfluorochemical emulsions for reoxygenation of hypoxic tumor cells
US5108759A (en) * 1987-04-01 1992-04-28 Ranney David F Endothelial envelopment drug carriers
DE3741199A1 (de) * 1987-12-02 1989-08-17 Schering Ag Verwendung von ultraschallkontrastmitteln fuer die ultraschall-lithotripsie
DE3741201A1 (de) * 1987-12-02 1989-06-15 Schering Ag Ultraschallarbeitsverfahren und mittel zu dessen durchfuehrung
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
JP2907911B2 (ja) * 1988-02-05 1999-06-21 シエーリング アクチエンゲゼルシヤフト 超音波造影剤、その製造方法及び該超音波造影剤からなる診断又は治療用製剤
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
DE3828905A1 (de) * 1988-08-23 1990-03-15 Schering Ag Mittel bestehend aus cavitate oder clathrate bildenden wirt/gast-komplexen als kontrastmittel
US5410516A (en) 1988-09-01 1995-04-25 Schering Aktiengesellschaft Ultrasonic processes and circuits for performing them
DE3829999A1 (de) 1988-09-01 1990-03-15 Schering Ag Ultraschallverfahren und schaltungen zu deren durchfuehrung
US4957656A (en) 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
US5705187A (en) 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US5228446A (en) * 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5305757A (en) * 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US6088613A (en) * 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5088499A (en) 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5123414A (en) 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5334381A (en) * 1989-12-22 1994-08-02 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
GB9003821D0 (en) * 1990-02-20 1990-04-18 Danbiosyst Uk Diagnostic aid
IN172208B (de) * 1990-04-02 1993-05-01 Sint Sa
US5556610A (en) * 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5190982A (en) 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
GB9009423D0 (en) * 1990-04-26 1990-06-20 Williams Alun R Assessment of vascular perfusion by the display of harmonic echoes from ultrasonically excited gas bubbles
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5420176A (en) * 1990-06-01 1995-05-30 Imarx Pharmaceutical Corp. Contrast media for ultrasonic imaging
US5315997A (en) † 1990-06-19 1994-05-31 Molecular Biosystems, Inc. Method of magnetic resonance imaging using diamagnetic contrast
JP2599492B2 (ja) * 1990-08-21 1997-04-09 第一製薬株式会社 リポソーム製剤の製造法
AU635449B2 (en) * 1990-10-05 1993-03-18 Bracco International B.V. Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
CA2063529A1 (en) * 1991-03-22 1992-09-23 Katsuro Tachibana Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same
US5205290A (en) * 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
GB9107628D0 (en) † 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
DK0586524T3 (de) * 1991-06-03 1997-05-20 Nycomed Imaging As
CA2112109A1 (en) * 1991-07-05 1993-01-21 Arne Berg Improvements in or relating to contrast agents
GB9115324D0 (en) 1991-07-16 1991-08-28 Ici Plc Rodenticide bait package
US5837273A (en) 1991-07-16 1998-11-17 The United States Of America As Represented By The Secretary Of Agriculture Methods and compositions of adherent starch granules for encapsulating pest control agents
GB9116610D0 (en) * 1991-08-01 1991-09-18 Danbiosyst Uk Preparation of microparticles
WO1993003671A1 (en) * 1991-08-13 1993-03-04 Molecular Biosystem, Inc. Method of mri imaging using diamagnetic contrast agents
NZ244147A (en) 1991-09-03 1994-09-27 Hoechst Ag Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents
JP3231768B2 (ja) * 1991-09-17 2001-11-26 ソーナス ファーマシューティカルス，インコーポレイテッド 気体状超音波造影剤及び超音波造影剤として使用する気体の選定方法
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
US5409688A (en) 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
WO1993006869A1 (en) * 1991-10-04 1993-04-15 Mallinckrodt Medical, Inc. Gaseous ultrasound contrast agents
US5196183A (en) * 1991-12-04 1993-03-23 Sterling Winthrop Inc. Contrast agents for ultrasound imaging
US5255683A (en) * 1991-12-30 1993-10-26 Sound Science Limited Partnership Methods of and systems for examining tissue perfusion using ultrasonic contrast agents
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) † 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
DE4219723A1 (de) * 1992-06-13 1993-12-16 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik
WO1994001140A1 (de) * 1992-07-03 1994-01-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Echokontrastmittelzubereitung
WO1994006477A1 (en) * 1992-09-16 1994-03-31 Holmes, Michael, John Improvements in or relating to contrast agents
US5314644A (en) * 1992-10-19 1994-05-24 Virginia Polytechnic Institute And State University Microbubble generator
CA2148372A1 (en) * 1992-11-02 1994-05-11 Margaret A. Wheatley Surfactant-stabilized microbubble mixtures, process for preparing and methods of using the same
US5393527A (en) * 1993-01-04 1995-02-28 Becton, Dickinson And Company Stabilized microspheres and methods of preparation
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
CA2154590C (en) * 1993-01-25 2001-06-12 Steven C. Quay Phase shift colloids as ultrasound contrast agents
IL108367A0 (en) 1993-01-27 1994-04-12 Hektoen Inst For Medical Resea Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells
US5333613A (en) * 1993-03-23 1994-08-02 Delineate Microparticles as ultrasonic contrast media
US5716597A (en) 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
JP2905598B2 (ja) * 1993-07-02 1999-06-14 モレキュラー バイオシステムズ，インコーポレイテッド 熱変性されたタンパク質からカプセル化されたマイクロスフェアを製造する方法
DE69434119T3 (de) * 1993-07-30 2011-05-05 Imcor Pharmaceutical Co., San Diego Stabilisierte mikrogasbläschen-zusammensetzungen für echographie
PT682530E (pt) 1993-12-15 2003-06-30 Bracco Research Sa Misturas de gases uteis como meios de contraste para ultrassons
US5562893A (en) * 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients

Also Published As

Publication number Publication date
ATE281183T1 (de) 2004-11-15
US5605673A (en) 1997-02-25
US5695741A (en) 1997-12-09
DK0711179T3 (da) 2005-02-14
EP0711179A1 (de) 1996-05-15
ES2231775T5 (es) 2011-02-02
US5639443A (en) 1997-06-17
US5720938A (en) 1998-02-24
US6706253B2 (en) 2004-03-16
WO1995003835A1 (en) 1995-02-09
AU694135B2 (en) 1998-07-16
EP0711179B2 (de) 2010-09-01
US6287539B1 (en) 2001-09-11
EP0711179B1 (de) 2004-11-03
ES2231775T3 (es) 2005-05-16
US20040033199A1 (en) 2004-02-19
US6372195B1 (en) 2002-04-16
DE69434119T2 (de) 2005-11-03
JPH09501164A (ja) 1997-02-04
US6280704B1 (en) 2001-08-28
US20020054854A1 (en) 2002-05-09
US20050281747A1 (en) 2005-12-22
US5626833A (en) 1997-05-06
US7005120B2 (en) 2006-02-28
US20020098151A1 (en) 2002-07-25
CA2164813A1 (en) 1995-02-09
JP3559849B2 (ja) 2004-09-02
US6939531B2 (en) 2005-09-06
DE69434119T3 (de) 2011-05-05
US6258339B1 (en) 2001-07-10
US20020051750A1 (en) 2002-05-02
US20040228801A1 (en) 2004-11-18
US20020028179A1 (en) 2002-03-07
AU7478294A (en) 1995-02-28
HK1013403A1 (en) 1999-08-27
CA2164813C (en) 2009-11-24
US20050244338A1 (en) 2005-11-03
US6953569B2 (en) 2005-10-11
PT711179E (pt) 2005-03-31
EP1550464A1 (de) 2005-07-06

Similar Documents

Publication Publication Date Title
DE69434119D1 (de) Stabilisierte mikrogasblaeschen-zusammensetzungen für echografie
BR9916228A (pt) Processos de produção de uma espuma aquosa, para a preparação de uma composição espumante compreendendo água, tensoativo, e espessante não hidratado, e para melhorar a estabilidade de uma espuma, e, composição aquosa
ES2192572T3 (es) Medios de contraste de ultrasonidos, agentes de contraste que contienen los medios, y metodo.
EP0732142A3 (de) Einstellung der Menge an gelösten Gasen in Flüssigkeiten
AU7692700A (en) Membrane and use thereof
CA2059288A1 (en) Fluorine and phosphorous-containing amphiphilic molecules with surfactant properties
CA2277960A1 (en) Emulsified comb polymer and defoaming agent composition and method of making same
AU7400791A (en) Enzyme stabilizing composition and stabilized enzyme containing built detergent compositions
EP1616933A3 (de) Wasser in Öl Emulsion verwendbar als umweltfreundlicher Brennstoff und Verfahren zu dessen Herstellung
GB9928820D0 (en) Stable high glycerol liquids comprising sulfosuccinic acid monoesters
AP1467A (en) Chemical agent for stabilizing soil.
CA2316245A1 (en) Invert emulsion drilling fluid containing mixtures of secondary esters obtained by conversion of olefins, and preparation thereof
MX9800458A (es) Composicion de espuma empacada.
CA2305341A1 (en) Stabilization of envelope glycoprotein trimers by disulfide bonds introduced into a gp41 glycoprotein ectodomain
HUP0203694A2 (hu) Bizonyos nemionos felületaktív anyagot tartalmazó új peszticid és/vagy növekedésszabályozó készítmények
GR862455B (en) Nematicide substances
ATE196060T1 (de) Trockene mischung fuer farbstabile,fluessige zubereitungen
ID24279A (id) Komposisi kering yang terlarut dalam air
CA2416954A1 (en) Method of preparing a compound concentrate and processing such a concentrate
WO2001074474A1 (fr) Procede de production d'agent de traitement de gaz de combustion
MX9307650A (es) Polieteresteroles, proceso para su preparacion y su uso para la preparacion de poliuretanos.
WO1999049716A3 (de) Verfahren zur herstellung von liposomalen wirkstoffformulierungen mit hochdruckhomogemisation
DE69405135D1 (de) Verfahren zur Herstellung einer aktiven Zusammensetzung und damit hergestellte Zusammensetzung
ATE277051T1 (de) Verfahren zur herstellung von debromohymenialdisin und deren analogen
SU1113366A1 (ru) Состав ванны дл упрочнени изделий из стекла

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: IMCOR PHARMACEUTICAL CO., SAN DIEGO, CALIF., US

8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings