DE69512083D1 - Vorrichtung zur erhöhung der wirkstoffsverabreichung durch elektrotransport - Google Patents

Vorrichtung zur erhöhung der wirkstoffsverabreichung durch elektrotransport

Info

Publication number
DE69512083D1
DE69512083D1 DE69512083T DE69512083T DE69512083D1 DE 69512083 D1 DE69512083 D1 DE 69512083D1 DE 69512083 T DE69512083 T DE 69512083T DE 69512083 T DE69512083 T DE 69512083T DE 69512083 D1 DE69512083 D1 DE 69512083D1
Authority
DE
Germany
Prior art keywords
agent
electrotransport
increasing
ionic
hydrophobic site
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69512083T
Other languages
English (en)
Other versions
DE69512083T2 (de
Inventor
Leslie Holladay
Lynda Treat-Clemons
Patricia Bassett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of DE69512083D1 publication Critical patent/DE69512083D1/de
Publication of DE69512083T2 publication Critical patent/DE69512083T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/0436—Material of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir
DE69512083T 1994-11-17 1995-11-03 Vorrichtung zur erhöhung der wirkstoffsverabreichung durch elektrotransport Expired - Lifetime DE69512083T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34124694A 1994-11-17 1994-11-17
PCT/US1995/012948 WO1996015826A1 (en) 1994-11-17 1995-11-03 Composition and method for enhancing electrotransport agent delivery

Publications (2)

Publication Number Publication Date
DE69512083D1 true DE69512083D1 (de) 1999-10-14
DE69512083T2 DE69512083T2 (de) 2000-03-30

Family

ID=23336811

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69512083T Expired - Lifetime DE69512083T2 (de) 1994-11-17 1995-11-03 Vorrichtung zur erhöhung der wirkstoffsverabreichung durch elektrotransport

Country Status (8)

Country Link
US (1) US6328728B1 (de)
EP (1) EP0793517B1 (de)
JP (1) JPH10509072A (de)
AT (1) ATE184206T1 (de)
AU (1) AU4129696A (de)
DE (1) DE69512083T2 (de)
ES (1) ES2137551T3 (de)
WO (1) WO1996015826A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2755372B1 (fr) * 1996-11-07 1998-12-24 Elf Aquitaine Dispositif d'ionophorese comportant au moins un ensemble electrode a membrane, pour l'administration transcutanee de principes actifs a un sujet
EP1183068A4 (de) * 1999-05-10 2008-12-17 Gentronics Inc Verfahren zur durch elektroporation erleichterte verabreichung aktiver substanzen
US7171264B1 (en) * 1999-05-10 2007-01-30 Genetronics, Inc. Intradermal delivery of active agents by needle-free injection and electroporation
US6591133B1 (en) * 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
US7244703B2 (en) 2001-06-22 2007-07-17 Bentley Pharmaceuticals, Inc. Pharmaceutical compositions and methods for peptide treatment
US7141544B2 (en) * 2003-10-10 2006-11-28 Baxter International, Inc. Stabilization of pharmaceutical protein formulations with small peptides
AU2004287411A1 (en) * 2003-10-31 2005-05-19 Alza Corporation System and method for transdermal vaccine delivery
BRPI0418589A (pt) * 2003-12-08 2008-01-29 Bentley Pharmaceuticals Inc composições farmacêuticas e métodos para tratamento por insulina
US7706873B2 (en) 2004-05-05 2010-04-27 Mario Ammirati System and method for controlled delivery of a therapeutic agent to a target location within an internal body tissue
US7527749B2 (en) 2004-10-18 2009-05-05 Georgia Tech Research Corporation Electrically conductive adhesives and methods of making
JP4646669B2 (ja) * 2005-03-30 2011-03-09 キヤノン株式会社 吐出用液体、吐出方法、液滴化方法、カートリッジ及び吐出装置
US20070025869A1 (en) * 2005-07-15 2007-02-01 Gordon John H Fluid Delivery Device
US20080147186A1 (en) * 2006-12-14 2008-06-19 Joshi Ashok V Electrochemical Implant For Delivering Beneficial Agents
US8389582B2 (en) * 2007-08-06 2013-03-05 Samir Mitragotri Composition for solubilizing tissue comprising 3-(decyl dimethyl ammonio) propane sulfonate and tetraethylene glycol dodecyl ether
US8609041B2 (en) 2007-08-06 2013-12-17 Samir Mitragotri Apparatus for solubilizing tissue
US9814422B2 (en) 2007-08-06 2017-11-14 The Regents Of The University Of California Compositions for solubilizing cells and/or tissue
WO2009048681A2 (en) * 2007-08-06 2009-04-16 The Regents Of The University Of California Methods of tissue-based diagnosis
US8642664B2 (en) 2007-08-06 2014-02-04 Samir Mitragotri Composition for solubilizing tissue and cells comprising N-tetradecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate and polyoxyethylene (10) cetyl ether
DE102008034098A1 (de) * 2008-07-21 2010-02-04 Lts Lohmann Therapie-Systeme Ag Zubereitung und lontophoretische Vorrichtung für die transdermale Anwendung von Wirkstoffen
JP5632459B2 (ja) 2009-05-15 2014-11-26 バーゼル・ポリオレフィン・イタリア・ソチエタ・ア・レスポンサビリタ・リミタータ ポリマーペレットの非付着処理方法及びこの方法に用いる遠心脱水機
KR20140022783A (ko) * 2010-12-22 2014-02-25 데이고꾸세이약꾸가부시끼가이샤 이온 도입 치료법에 사용되는 전극 패드
ES2755801R1 (es) * 2018-06-29 2020-04-29 Teixidor Marta Tomas Metodo de fijacion de compresas desechables y protegeslips

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4153689A (en) 1975-06-13 1979-05-08 Takeda Chemical Industries, Ltd. Stable insulin preparation for nasal administration
US4141359A (en) 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4250878A (en) 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4383529A (en) 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
JPS5810066A (ja) 1981-07-10 1983-01-20 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体
GB2127689B (en) 1982-10-05 1986-07-09 Sandoz Ltd Calcitonin inhalation compositions
US4588580B2 (en) 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4568343A (en) 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
US4722726A (en) 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
US5250022A (en) * 1990-09-25 1993-10-05 Rutgers, The State University Of New Jersey Iontotherapeutic devices, reservoir electrode devices therefore, process and unit dose
WO1988006041A1 (en) 1987-02-23 1988-08-25 Shiseido Company Ltd. Percutaneous absorption promoter and dermatologic preparation for external use
US4994439A (en) 1989-01-19 1991-02-19 California Biotechnology Inc. Transmembrane formulations for drug administration
US5374241A (en) * 1989-07-21 1994-12-20 Iomed, Inc. Electrodes for iontophoresis
JPH0616538A (ja) * 1992-07-03 1994-01-25 Japan Tobacco Inc イオントフォレーゼのための薬物吸収用液組成物
ATE197396T1 (de) * 1994-07-13 2000-11-11 Alza Corp Zusammensetzung und verfahren zur förderung von transdermaler elektrotransport-darreichung

Also Published As

Publication number Publication date
ATE184206T1 (de) 1999-09-15
ES2137551T3 (es) 1999-12-16
JPH10509072A (ja) 1998-09-08
US6328728B1 (en) 2001-12-11
WO1996015826A1 (en) 1996-05-30
EP0793517B1 (de) 1999-09-08
DE69512083T2 (de) 2000-03-30
AU4129696A (en) 1996-06-17
EP0793517A1 (de) 1997-09-10

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