DE69514530T2 - Verfahren und gerät zur freisetzung fester arzneimittelzusammensetzungen - Google Patents

Verfahren und gerät zur freisetzung fester arzneimittelzusammensetzungen

Info

Publication number
DE69514530T2
DE69514530T2 DE1995614530 DE69514530T DE69514530T2 DE 69514530 T2 DE69514530 T2 DE 69514530T2 DE 1995614530 DE1995614530 DE 1995614530 DE 69514530 T DE69514530 T DE 69514530T DE 69514530 T2 DE69514530 T2 DE 69514530T2
Authority
DE
Germany
Prior art keywords
solid composition
housing
drug
actuator
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE1995614530
Other languages
English (en)
Other versions
DE69514530D1 (de
Inventor
Roland Cherif-Cheikh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Delab
Original Assignee
Delab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delab filed Critical Delab
Publication of DE69514530D1 publication Critical patent/DE69514530D1/de
Application granted granted Critical
Publication of DE69514530T2 publication Critical patent/DE69514530T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
DE1995614530 1994-09-02 1995-08-31 Verfahren und gerät zur freisetzung fester arzneimittelzusammensetzungen Expired - Fee Related DE69514530T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/300,138 US5837276A (en) 1994-09-02 1994-09-02 Apparatus for the delivery of elongate solid drug compositions
US30412994A 1994-09-12 1994-09-12
PCT/IB1995/000779 WO1996007440A2 (en) 1994-09-02 1995-08-31 Methods and apparatus for the delivery of solid drug compositions

Publications (2)

Publication Number Publication Date
DE69514530D1 DE69514530D1 (de) 2000-02-17
DE69514530T2 true DE69514530T2 (de) 2000-07-27

Family

ID=26971612

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1995614530 Expired - Fee Related DE69514530T2 (de) 1994-09-02 1995-08-31 Verfahren und gerät zur freisetzung fester arzneimittelzusammensetzungen

Country Status (11)

Country Link
US (4) US5837276A (de)
EP (2) EP0953362A3 (de)
AT (1) ATE188615T1 (de)
AU (1) AU3398295A (de)
DE (1) DE69514530T2 (de)
DK (1) DK0778785T3 (de)
ES (1) ES2141956T3 (de)
GR (1) GR3032947T3 (de)
PT (1) PT778785E (de)
WO (1) WO1996007440A2 (de)
ZA (1) ZA957355B (de)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837276A (en) * 1994-09-02 1998-11-17 Delab Apparatus for the delivery of elongate solid drug compositions
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
JP2002542183A (ja) 1999-04-16 2002-12-10 ノボ ノルディスク アクティーゼルスカブ 成形可能な乾燥した医薬製剤
US6468264B1 (en) 1999-10-12 2002-10-22 Durect Corporation Closed exchange system
ATE323470T1 (de) * 1999-12-10 2006-05-15 Massachusetts Inst Technology Mikrochip-arzneistoffverabreichungssysteme und herstellungsverfahren
US6454759B2 (en) * 2000-02-28 2002-09-24 The Regents Of The University Of California Microfabricated injectable drug delivery system
ATE499988T1 (de) * 2000-03-02 2011-03-15 Microchips Inc Mikromechanische geräte und verfahren zur speicherung und zur selektiven exposition von chemikalien
DE60127139T2 (de) * 2000-07-14 2007-12-13 Novo Nordisk A/S Verfahren zum formen einer pharmazeutischen zusammensetzung in einem verpackungsmaterial
US6719739B2 (en) 2000-08-30 2004-04-13 Medtronic, Inc. System and method for attaching upper and lower outer cases in an implantable drug pump
EP1339312B1 (de) * 2000-10-10 2006-01-04 Microchips, Inc. Mikrochip-reservoir-vorrichtungen mit drahtloser übertragung von energie und daten
EP1353649A2 (de) * 2000-12-21 2003-10-22 Oscar M. Bassinson Karte zur abgabe von personengebundenen medikamenten
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
CA2432438C (en) * 2001-01-09 2011-04-26 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US7041468B2 (en) 2001-04-02 2006-05-09 Therasense, Inc. Blood glucose tracking apparatus and methods
WO2002089767A1 (en) 2001-05-03 2002-11-14 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
ATE285756T1 (de) 2001-06-28 2005-01-15 Microchips Inc Verfahren zum hermetischen versiegeln von mikrochip-reservoir-vorrichtungen
GB0116341D0 (en) 2001-07-04 2001-08-29 Smith & Nephew Biodegradable polymer systems
US8454997B2 (en) 2001-12-18 2013-06-04 Novo Nordisk A/S Solid dose micro implant
GB0202233D0 (en) 2002-01-31 2002-03-20 Smith & Nephew Bioresorbable polymers
TWI314464B (en) * 2002-06-24 2009-09-11 Alza Corp Reusable, spring driven autoinjector
WO2004022033A1 (en) * 2002-09-04 2004-03-18 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
CA2496687A1 (en) * 2002-09-18 2004-04-01 Centre Hospitalier De L'universite De Montreal (Chum) Ghrh analogues
US7468065B2 (en) 2002-09-18 2008-12-23 Allergan, Inc. Apparatus for delivery of ocular implants
TWI282271B (en) * 2002-09-18 2007-06-11 Allergan Inc Apparatus for delivery of ocular implants
US6899717B2 (en) * 2002-09-18 2005-05-31 Allergan, Inc. Methods and apparatus for delivery of ocular implants
WO2004026281A2 (en) * 2002-09-23 2004-04-01 Microchips, Inc. Micro-reservoir osmotic release systems and microtube array device
ES2737835T3 (es) 2003-04-23 2020-01-16 Valeritas Inc Bomba accionada hidráulicamente para la administración de medicamentos de larga duración
EP2092956B1 (de) * 2003-06-06 2015-01-07 Telea Electronic Engineering S.R.L. Kosmetikvorrichtung zur Behandlung von Hautalterung
IL157981A (en) 2003-09-17 2014-01-30 Elcam Medical Agricultural Cooperative Ass Ltd Auto injector
US7141354B2 (en) * 2003-09-30 2006-11-28 Dai Nippon Printing Co., Ltd. Photo radical generator, photo sensitive resin composition and article
WO2005041767A2 (en) 2003-11-03 2005-05-12 Microchips, Inc. Medical device for sensing glucose
GB0329654D0 (en) 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
IL160891A0 (en) 2004-03-16 2004-08-31 Auto-mix needle
US9089636B2 (en) 2004-07-02 2015-07-28 Valeritas, Inc. Methods and devices for delivering GLP-1 and uses thereof
WO2006015299A2 (en) * 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
WO2006026768A1 (en) * 2004-09-01 2006-03-09 Microchips, Inc. Multi-cap reservoir devices for controlled release or exposure of reservoir contents
US7335155B2 (en) * 2004-09-14 2008-02-26 Boston Scientific Scimed, Inc. Unitary formulation delivery device
US20080076975A1 (en) * 2005-01-25 2008-03-27 Microchips, Inc. Method and implantable device with reservoir array for pre-clinical in vivo testing
US7488316B2 (en) * 2005-01-25 2009-02-10 Microchips, Inc. Control of drug release by transient modification of local microenvironments
JP2006210507A (ja) * 2005-01-26 2006-08-10 Renesas Technology Corp 半導体装置の製造方法および半導体製造装置
WO2006080508A1 (ja) * 2005-01-31 2006-08-03 Bioserentach Co., Ltd. 経皮吸収製剤、経皮吸収製剤保持シート、及び経皮吸収製剤保持用具
US7972295B2 (en) * 2005-03-11 2011-07-05 Boston Scientific Scimed, Inc. Apparatus and methods for delivering a bolus of therapeutic material
US8591457B2 (en) 2005-08-10 2013-11-26 Alza Corporation Method for making a needle-free jet injection drug delivery device
JP4355722B2 (ja) * 2005-11-17 2009-11-04 セイコーエプソン株式会社 流体輸送装置
WO2007103276A2 (en) 2006-03-03 2007-09-13 Smith & Nephew, Inc. Systems and methods for delivering a medicament
SG173319A1 (en) 2006-03-30 2011-08-29 Valeritas Inc Multi-cartridge fluid delivery device
WO2007143225A2 (en) 2006-06-07 2007-12-13 Abbott Diabetes Care, Inc. Analyte monitoring system and method
US8668676B2 (en) * 2006-06-19 2014-03-11 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
WO2008000634A1 (en) * 2006-06-30 2008-01-03 Novo Nordisk A/S Perfusion device with compensation of medical infusion during wear-time
US20080097335A1 (en) * 2006-08-04 2008-04-24 Allergan, Inc. Ocular implant delivery assemblies
US8722783B2 (en) 2006-11-30 2014-05-13 Smith & Nephew, Inc. Fiber reinforced composite material
US20080228056A1 (en) 2007-03-13 2008-09-18 Michael Blomquist Basal rate testing using frequent blood glucose input
CN101678038A (zh) * 2007-03-14 2010-03-24 华盛顿大学 用于眼内药物递送的装置和方法
AU2008240418B2 (en) * 2007-04-18 2013-08-15 Smith & Nephew Plc Expansion moulding of shape memory polymers
EP2142227B1 (de) * 2007-04-19 2012-02-29 Smith & Nephew, Inc. Multimodale formgedächtnis-polymere
US9770534B2 (en) * 2007-04-19 2017-09-26 Smith & Nephew, Inc. Graft fixation
US7751907B2 (en) 2007-05-24 2010-07-06 Smiths Medical Asd, Inc. Expert system for insulin pump therapy
US8221345B2 (en) 2007-05-30 2012-07-17 Smiths Medical Asd, Inc. Insulin pump based expert system
WO2009061988A1 (en) 2007-11-08 2009-05-14 Alimera Sciences, Inc. Ocular implantation device
US20090177147A1 (en) 2008-01-07 2009-07-09 Michael Blomquist Insulin pump with insulin therapy coaching
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US8202090B2 (en) * 2008-02-29 2012-06-19 Pharmaco-Kinesis Corporation Artificial tooth medicating apparatus for controlling, regulating, sensing, and releasing medical agents into the body
WO2009147641A2 (en) * 2008-06-06 2009-12-10 Wockhardt Research Centre A device and a system for delivery of biological material
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
EP2334234A4 (de) 2008-09-19 2013-03-20 Tandem Diabetes Care Inc Vorrichtung zur messung der konzentration eines gelösten stoffs und entsprechende verfahren
US8545554B2 (en) 2009-01-16 2013-10-01 Allergan, Inc. Intraocular injector
US8573027B2 (en) 2009-02-27 2013-11-05 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
US9250106B2 (en) 2009-02-27 2016-02-02 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
JP2012520731A (ja) 2009-03-20 2012-09-10 インキューブ ラブズ， エルエルシー 固形薬物送達装置、処方物および使用法
WO2010109004A1 (en) * 2009-03-27 2010-09-30 Novo Nordisk A/S Solid dose delivery device
CA2921304C (en) 2009-07-30 2018-06-05 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8882701B2 (en) 2009-12-04 2014-11-11 Smiths Medical Asd, Inc. Advanced step therapy delivery for an ambulatory infusion pump and system
US20110306820A1 (en) * 2010-06-14 2011-12-15 Coloplast A/S Method of treating incontinence
WO2012118687A1 (en) * 2011-02-28 2012-09-07 Merck Sharp & Dohme Corp. Manually operated injector with restricted injection sequence
WO2012125999A2 (en) * 2011-03-17 2012-09-20 Emory University Delivery devices and methods for delivering therapeutic agents
EP2763716B1 (de) * 2011-10-04 2017-12-06 Incube Labs, Llc Feststoffverabreichungsvorrichtung
US20150032088A1 (en) 2012-01-24 2015-01-29 The Methodist Hospital Research Institute Sustained drug delivery from solid state compositions with nanochannel membranes
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9238100B2 (en) 2012-06-07 2016-01-19 Tandem Diabetes Care, Inc. Device and method for training users of ambulatory medical devices
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US9492608B2 (en) 2013-03-15 2016-11-15 Tandem Diabetes Care, Inc. Method and device utilizing insulin delivery protocols
US10369340B2 (en) 2013-08-12 2019-08-06 Nanomedical Systems, Inc. Device and method for sustained release of low water solubility therapeutic agent in solubilizer
WO2016019133A1 (en) 2014-07-30 2016-02-04 Tandem Diabetes Care, Inc. Temporary suspension for closed-loop medicament therapy
EP3364946A4 (de) 2015-10-23 2019-06-26 Lyndra, Inc. Magenverweilsysteme zur verzögerten freisetzung von therapeutischen wirkstoffen und verfahren zu deren verwendung
US10569016B2 (en) 2015-12-29 2020-02-25 Tandem Diabetes Care, Inc. System and method for switching between closed loop and open loop control of an ambulatory infusion pump
WO2017186562A1 (de) 2016-04-26 2017-11-02 Lts Lohmann Therapie-Systeme Ag Vorrichtung und verfahren zum spenden wirkstoffhaltiger oder wirkstofftragender streifen
AU2017336154B2 (en) 2016-09-30 2023-11-09 Lyndra Therapeutics, Inc. Gastric residence systems for sustained delivery of adamantane-class drugs
US20180250238A1 (en) * 2017-02-23 2018-09-06 Incube Labs, Llc Solid drug dispensing apparatus, formulations, and methods of use
US11585042B2 (en) 2020-09-30 2023-02-21 Haier Us Appliance Solutions, Inc. Dryer appliance with additive dispenser
EP3978065A1 (de) * 2020-10-02 2022-04-06 Heraeus Medical GmbH Implantat zur lokalen wirkstofffreisetzung

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2513014A (en) * 1946-11-18 1950-06-27 Abbott Lab Apparatus for implanting medicinal pellets subcutaneously
US3995631A (en) * 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US3760806A (en) * 1971-01-13 1973-09-25 Alza Corp Helical osmotic dispenser with non-planar membrane
US3692027A (en) * 1971-04-23 1972-09-19 Everett H Ellinwood Jr Implanted medication dispensing device and method
US3774607A (en) * 1971-11-22 1973-11-27 Commercial Solvents Corp Pellet implant gun
US4177256A (en) * 1973-04-25 1979-12-04 Alza Corporation Osmotic bursting drug delivery device
US3995632A (en) * 1973-05-04 1976-12-07 Alza Corporation Osmotic dispenser
FR2239989A1 (en) * 1973-08-08 1975-03-07 Aries Robert Pellets for subcutaneous treatment of animals - pref. implanted from a cartridge contg. several, by means of an injection force
US3942539A (en) * 1974-04-08 1976-03-09 Corliss Joseph J Antiseptic cleansing dental floss
US4142526A (en) * 1974-12-23 1979-03-06 Alza Corporation Osmotic releasing system with means for changing release therefrom
US4086914A (en) * 1977-02-11 1978-05-02 Edwin Bailey Moore Implant injector
US4263910A (en) * 1978-09-27 1981-04-28 Eli Lilly And Company Implantate package, system and method
US4360019A (en) * 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4344743A (en) * 1979-12-04 1982-08-17 Bessman Samuel P Piezoelectric driven diaphragm micro-pump
CA1174284A (en) * 1980-09-02 1984-09-11 Medtronic, Inc. Body implantable lead
US4315516A (en) * 1980-09-19 1982-02-16 Joseph Zappel Continuous chain formed from a multiplicity of loops formed from dental floss material and apparatus for producing the same
US4326524A (en) * 1980-09-30 1982-04-27 Minnesota Mining And Manufacturing Company Solid dose ballistic projectile
US4327725A (en) * 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4451253A (en) * 1980-12-18 1984-05-29 Harman Sherman M Means and method for administering medicinals
US4340054A (en) * 1980-12-29 1982-07-20 Alza Corporation Dispenser for delivering fluids and solids
US4581018A (en) * 1983-02-08 1986-04-08 Novacor Medical Corporation Implantable infusion device
DE3317536A1 (de) * 1983-05-13 1984-11-15 Siemens AG, 1000 Berlin und 8000 München Dosiervorrichtung fuer ein medikament
CA1196864A (en) * 1983-06-10 1985-11-19 Mattheus F.A. Goosen Controlled release of injectable and implantable insulin compositions
US4753636A (en) * 1983-08-02 1988-06-28 Endocon, Inc. Subcutaneous implant kit
IL69431A (en) * 1983-08-04 1987-12-31 Omikron Scient Ltd Liquid delivery system particularly useful as an implantable micro-pump for delivering insulin or other drugs
EP0139286B1 (de) * 1983-10-14 1991-08-21 Sumitomo Pharmaceuticals Company, Limited Verlängerte Präparate mit verzögerter Abgabe
US4595583A (en) * 1984-03-19 1986-06-17 Alza Corporation Delivery system controlled administration of beneficial agent to ruminants
US4886514A (en) * 1985-05-02 1989-12-12 Ivac Corporation Electrochemically driven drug dispenser
US4720384A (en) * 1985-05-03 1988-01-19 E. I. Du Pont De Nemours And Company Manufacture of hollow fine tubular drug delivery systems
US4712460A (en) * 1985-11-18 1987-12-15 Biotrack, Inc. Integrated drug dosage form and metering system
ATE87469T1 (de) * 1985-12-27 1993-04-15 Sumitomo Pharma Verfahren zur herstellung einer formulierung mit verzoegerter freisetzung.
US4772263A (en) * 1986-02-03 1988-09-20 Regents Of The University Of Minnesota Spring driven infusion pump
US4661103A (en) * 1986-03-03 1987-04-28 Engineering Development Associates, Ltd. Multiple implant injector
US4723958A (en) * 1986-05-23 1988-02-09 Merck & Co., Inc. Pulsatile drug delivery system
EP0255123A3 (de) * 1986-07-30 1988-04-20 Sumitomo Pharmaceuticals Company, Limited Instrument zur Verabreichung von pillenförmigen Präparaten
GB8701731D0 (en) * 1987-01-27 1987-03-04 Patcentre Benelux Nv Sa Pumps
US4863736A (en) * 1987-03-16 1989-09-05 Monsanto Company Somatotropin prolonged release
US4994028A (en) * 1987-03-18 1991-02-19 Endocon, Inc. Injector for inplanting multiple pellet medicaments
DE3855054T2 (de) * 1987-05-26 1996-07-18 Sumitomo Pharma Vorrichtung zur Verabreichung von festen Präparaten
FR2618329B1 (fr) * 1987-07-22 1997-03-28 Dow Corning Sa Procede de fabrication d'un anneau capable d'assurer la liberation d'un agent therapeutique, et anneau fabrique par ce procede
DE3802158A1 (de) * 1987-08-11 1989-02-23 Hoechst Ag Vorrichtung zur applikation von implantaten
US4936827A (en) * 1988-04-11 1990-06-26 Ivy Laboratories, Inc. Implanter applicator
US4834704A (en) * 1988-04-13 1989-05-30 Eaton Corporation Injectable infusion pump apparatus for implanting long-term dispensing module and medication in an animal and method therefor
US5350741A (en) * 1988-07-30 1994-09-27 Kanji Takada Enteric formulations of physiologically active peptides and proteins
US4976966A (en) * 1988-12-29 1990-12-11 Alza Corporation Delayed release osmotically driven fluid dispenser
US5054674A (en) * 1989-02-27 1991-10-08 Fortman Eugene J Disposable dental floss cassette dispenser system
US5226895A (en) * 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
US5112614A (en) * 1989-09-14 1992-05-12 Alza Corporation Implantable delivery dispenser
US5110008A (en) * 1989-09-29 1992-05-05 Moulding Jr Thomas S Dispenser adapted to isolate the dispensed objects by compression between two moveable structures
US5086787A (en) * 1989-12-06 1992-02-11 Medtronic, Inc. Steroid eluting intramuscular lead
US5030216A (en) * 1989-12-15 1991-07-09 Alza Corporation Osmotically driven syringe
US5049141A (en) * 1990-04-25 1991-09-17 Infusaid, Inc. Programmable valve pump
KR930001079B1 (ko) * 1990-07-18 1993-02-15 한국과학기술연구원 자가 방출 조절형 인슐린 제형
IL105553A (en) * 1992-05-06 1998-01-04 Janssen Pharmaceutica Inc Solid dosage forms consisting of a porous network of matrix that releases a substance that dissipates rapidly in water
ATE155681T1 (de) 1992-05-18 1997-08-15 Minnesota Mining & Mfg Einrichtung zur transmucosalen wirkstoffabgabe
DK42093D0 (da) * 1993-04-07 1993-04-07 Bukh Meditec Administrationsmetode
WO1995022314A1 (en) * 1994-02-18 1995-08-24 Innovac Co. Inoculation of animals with dried, pelleted biological materials
US5837276A (en) * 1994-09-02 1998-11-17 Delab Apparatus for the delivery of elongate solid drug compositions
US5582591A (en) * 1994-09-02 1996-12-10 Delab Delivery of solid drug compositions

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PT778785E (pt) 2000-04-28
US6306420B1 (en) 2001-10-23
ZA957355B (en) 1996-06-25
EP0953362A2 (de) 1999-11-03
EP0953362A3 (de) 2000-03-08
DE69514530D1 (de) 2000-02-17
EP0778785B1 (de) 2000-01-12
ATE188615T1 (de) 2000-01-15
US5837276A (en) 1998-11-17
ES2141956T3 (es) 2000-04-01
EP0778785A2 (de) 1997-06-18
WO1996007440A3 (en) 1996-05-23
GR3032947T3 (en) 2000-07-31
US6142972A (en) 2000-11-07
US5660846A (en) 1997-08-26
WO1996007440A2 (en) 1996-03-14
DK0778785T3 (da) 2000-05-29
AU3398295A (en) 1996-03-27

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