DE69519373T2 - Zirkularisierende nukleinsäureprobe, die sich durch ausbildung von catenaten mit der zielsequenz fest verbinden kann - Google Patents

Zirkularisierende nukleinsäureprobe, die sich durch ausbildung von catenaten mit der zielsequenz fest verbinden kann

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Publication number
DE69519373T2
DE69519373T2 DE69519373T DE69519373T DE69519373T2 DE 69519373 T2 DE69519373 T2 DE 69519373T2 DE 69519373 T DE69519373 T DE 69519373T DE 69519373 T DE69519373 T DE 69519373T DE 69519373 T2 DE69519373 T2 DE 69519373T2
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Germany
Prior art keywords
catenates
training
nucleic acid
fixed
target sequence
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Expired - Lifetime
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DE69519373T
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DE69519373D1 (de
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Ulf Landegren
Marek Kwiatkowski
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Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
DE69519373T 1994-02-16 1995-02-16 Zirkularisierende nukleinsäureprobe, die sich durch ausbildung von catenaten mit der zielsequenz fest verbinden kann Expired - Lifetime DE69519373T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9400522A SE9400522D0 (sv) 1994-02-16 1994-02-16 Method and reagent for detecting specific nucleotide sequences
PCT/SE1995/000163 WO1995022623A1 (en) 1994-02-16 1995-02-16 Circularizing nucleic acid probe able to interlock with a target sequence through catenation

Publications (2)

Publication Number Publication Date
DE69519373D1 DE69519373D1 (de) 2000-12-14
DE69519373T2 true DE69519373T2 (de) 2001-06-13

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Application Number Title Priority Date Filing Date
DE69519373T Expired - Lifetime DE69519373T2 (de) 1994-02-16 1995-02-16 Zirkularisierende nukleinsäureprobe, die sich durch ausbildung von catenaten mit der zielsequenz fest verbinden kann

Country Status (6)

Country Link
US (2) US5871921A (de)
EP (1) EP0745140B1 (de)
JP (1) JP3590633B2 (de)
DE (1) DE69519373T2 (de)
SE (1) SE9400522D0 (de)
WO (1) WO1995022623A1 (de)

Families Citing this family (285)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US6261808B1 (en) * 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
SE9400522D0 (sv) * 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
US20070269799A9 (en) * 1994-06-22 2007-11-22 Zhang David Y Nucleic acid amplification methods
US6593086B2 (en) 1996-05-20 2003-07-15 Mount Sinai School Of Medicine Of New York University Nucleic acid amplification methods
US5876924A (en) * 1994-06-22 1999-03-02 Mount Sinai School Of Medicine Nucleic acid amplification method hybridization signal amplification method (HSAM)
US5942391A (en) 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
SE9403805D0 (sv) * 1994-11-07 1994-11-07 Ulf Landegren Method of preparing oligonucleotide probes or primers, vector therefor and use thereof
US5866337A (en) * 1995-03-24 1999-02-02 The Trustees Of Columbia University In The City Of New York Method to detect mutations in a nucleic acid using a hybridization-ligation procedure
SE504798C2 (sv) * 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
JP2809601B2 (ja) * 1995-07-13 1998-10-15 株式会社分子バイオホトニクス研究所 塩基配列増幅方法
US20050026204A1 (en) * 1995-09-08 2005-02-03 Ulf Landegren Methods and compositions for nucleic acid targeting
DE19537952A1 (de) * 1995-10-12 1997-04-17 Boehringer Mannheim Gmbh Verfahren zum Nachweis eines Analyten
JP3974941B2 (ja) 1995-11-21 2007-09-12 イェール ユニバーシティ 単分子セグメントの増幅および検出
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
SE9601676D0 (sv) * 1996-04-30 1996-04-30 Ulf Landegren Improved probing of specific mucleic acids
US5912124A (en) * 1996-06-14 1999-06-15 Sarnoff Corporation Padlock probe detection
US7070925B1 (en) 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
JP2000514307A (ja) * 1996-07-16 2000-10-31 ジェン―プローブ・インコーポレーテッド 増加した標的特異的t▲下m▼を持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法
WO1998011210A1 (fr) * 1996-09-13 1998-03-19 Laboratory Of Molecular Biophotonics Phase solide pour la detection d'acides nucleiques cibles, procede de production de cette phase et procede de detection d'acide nucleique cible
EP1019429A4 (de) * 1997-08-20 2001-08-08 Somagenics Inc Antisense- und antigen-therapeutika mit verbesserten bindungseigenschaften und methoden zu ihrer anwendung
WO2000004193A1 (en) 1998-07-20 2000-01-27 Yale University Method for detecting nucleic acids using target-mediated ligation of bipartite primers
CA2342837A1 (en) 1998-09-15 2000-03-23 Yale University Artificial long terminal repeat vectors
EP1114184A2 (de) 1998-09-15 2001-07-11 Yale University Klonierung mittels "rolling circle" amplifizierung
MXPA01005267A (es) * 1998-11-27 2002-04-24 Synaptics Uk Ltd Sensor de posicion.
NO986133D0 (no) * 1998-12-23 1998-12-23 Preben Lexow FremgangsmÕte for DNA-sekvensering
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US6309836B1 (en) 1999-10-05 2001-10-30 Marek Kwiatkowski Compounds for protecting hydroxyls and methods for their use
US6221603B1 (en) 2000-02-04 2001-04-24 Molecular Dynamics, Inc. Rolling circle amplification assay for nucleic acid analysis
US7306904B2 (en) * 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
US6368801B1 (en) 2000-04-12 2002-04-09 Molecular Staging, Inc. Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase
US6291187B1 (en) 2000-05-12 2001-09-18 Molecular Staging, Inc. Poly-primed amplification of nucleic acid sequences
JP2003535599A (ja) * 2000-06-06 2003-12-02 ティーエム バイオサイエンス コーポレイション 核酸の捕捉部とその使用
US6323009B1 (en) 2000-06-28 2001-11-27 Molecular Staging, Inc. Multiply-primed amplification of nucleic acid sequences
AU2001271722B2 (en) * 2000-06-30 2006-04-13 Qiagen, Gmbh Signal amplification with lollipop probes
US6858412B2 (en) * 2000-10-24 2005-02-22 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic DNA
US6573051B2 (en) 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
US7838270B2 (en) * 2001-05-22 2010-11-23 The University Of Chicago Target-dependent transcription using deletion mutants of N4 RNA polymerase
US7897382B2 (en) 2001-10-22 2011-03-01 Alnylam Pharmaceuticals, Inc. Transfection kinetics and structural promoters
CA2464464A1 (en) * 2001-10-22 2003-05-01 Nucleonics Inc. Transfection kinetics and structural promoters
DE10154318A1 (de) * 2001-10-26 2003-05-15 Epigenomics Ag Verfahren zur Analyse genomischer Methylierungsmuster
GB2382137A (en) 2001-11-20 2003-05-21 Mats Gullberg Nucleic acid enrichment
EP1319718A1 (de) * 2001-12-14 2003-06-18 Keygene N.V. Hochdurchsatzanalyse und Detektion von mehreren Zielsequenzen
US7553619B2 (en) * 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
US20040029142A1 (en) * 2002-02-11 2004-02-12 Schon Eric A. Concatenation-based nucleic acid detection compositions and methods
US20040058314A1 (en) * 2002-05-29 2004-03-25 Ming Liang He Assay for the detection and quantification of HBV cccDNA by real-time PCR
US20050118616A1 (en) * 2002-08-16 2005-06-02 Kawashima Tadashi R. Amplification of target nucleotide sequence without polymerase chain reaction
US20040086892A1 (en) * 2002-11-06 2004-05-06 Crothers Donald M. Universal tag assay
US20050053957A1 (en) * 2002-11-19 2005-03-10 Applera Corporation Polynucleotide sequence detection assays
US20060141475A1 (en) * 2002-11-19 2006-06-29 Applera Corporation Polynucleotide sequence detection assays and analysis
US20040101843A1 (en) * 2002-11-22 2004-05-27 Gerald Zon Detection of methylated DNA sites
US20040121338A1 (en) * 2002-12-19 2004-06-24 Alsmadi Osama A. Real-time detection of rolling circle amplification products
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
CA2930400A1 (en) * 2003-02-26 2004-09-10 Callida Genomics, Inc. Apparatus with pixel alignment system for analyzing nucleic acid
US8043834B2 (en) * 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
EP1623009A4 (de) 2003-04-22 2008-02-13 Nucleonics Inc Transfektionskinetik und strukturelle promotoren
US20040248103A1 (en) * 2003-06-04 2004-12-09 Feaver William John Proximity-mediated rolling circle amplification
WO2004111266A1 (en) 2003-06-17 2004-12-23 Human Genetic Signatures Pty Ltd Methods for genome amplification
SE0301951D0 (sv) * 2003-06-30 2003-06-30 Pyrosequencing Ab New method
ATE419394T1 (de) 2003-09-04 2009-01-15 Human Genetic Signatures Pty Nukleinsäurenachweistest
US20060024681A1 (en) * 2003-10-31 2006-02-02 Agencourt Bioscience Corporation Methods for producing a paired tag from a nucleic acid sequence and methods of use thereof
US8168777B2 (en) 2004-04-29 2012-05-01 Human Genetic Signatures Pty. Ltd. Bisulphite reagent treatment of nucleic acid
WO2005113804A1 (en) * 2004-05-20 2005-12-01 Trillion Genomics Limited Use of mass labelled probes to detect target nucleic acids using mass spectrometry
JP4980219B2 (ja) 2004-09-10 2012-07-18 ヒューマン ジェネティック シグネチャーズ ピーティーワイ リミテッド インターカレート型擬似ヌクレオチド(ipn)を含有するインターカレーティング核酸(ina)を含む増幅ブロッカー
ES2502815T3 (es) 2004-10-27 2014-10-06 Cepheid Reacciones de amplificación de ácido nucleico de múltiples estadios en sistema cerrado
CN101111606B (zh) 2004-12-03 2012-05-16 人类遗传标记控股有限公司 通过化学修饰胞嘧啶而简化微生物核酸的方法
EP1838847B1 (de) * 2005-01-07 2016-06-15 Monsanto Invest B.V. Pflanzenvirus mit der bezeichnung tomato torrado virus
US20060160102A1 (en) 2005-01-18 2006-07-20 Hossein Fakhrai-Rad Identification of rare alleles by enzymatic enrichment of mismatched heteroduplexes
US8309303B2 (en) * 2005-04-01 2012-11-13 Qiagen Gmbh Reverse transcription and amplification of RNA with simultaneous degradation of DNA
US8431347B2 (en) 2005-05-26 2013-04-30 Human Genetic Signatures Pty Ltd Isothermal strand displacement amplification using primers containing a non-regular base
US20090264299A1 (en) * 2006-02-24 2009-10-22 Complete Genomics, Inc. High throughput genome sequencing on DNA arrays
EP3492602A1 (de) 2005-06-15 2019-06-05 Complete Genomics, Inc. Einzelne molekülarrays für genetische und chemische analyse
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
EP1762627A1 (de) 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
US8343738B2 (en) 2005-09-14 2013-01-01 Human Genetic Signatures Pty. Ltd. Assay for screening for potential cervical cancer
CA2624324A1 (en) 2005-10-06 2007-04-19 Lucigen Corporation Thermostable viral polymerases and methods of use
WO2007044245A2 (en) 2005-10-07 2007-04-19 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
US7960104B2 (en) 2005-10-07 2011-06-14 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
WO2007061284A1 (en) 2005-11-22 2007-05-31 Plant Research International B.V. Multiplex nucleic acid detection
US20070168197A1 (en) * 2006-01-18 2007-07-19 Nokia Corporation Audio coding
EP1975254A4 (de) 2006-01-20 2009-12-02 Olympus Corp Verfahren für den nachweis von nukleotidsequenzen mit einer intramolekularen sonde
WO2007092538A2 (en) * 2006-02-07 2007-08-16 President And Fellows Of Harvard College Methods for making nucleotide probes for sequencing and synthesis
EP2495337A1 (de) 2006-02-24 2012-09-05 Callida Genomics, Inc. Genomsequenzierung auf DNA-Arrays mit hohem Durchsatz
US8673567B2 (en) * 2006-03-08 2014-03-18 Atila Biosystems, Inc. Method and kit for nucleic acid sequence detection
DE102006020885A1 (de) * 2006-05-05 2007-11-08 Qiagen Gmbh Einführung von Sequenzelementen in Nukleinsäuren
JP2009536825A (ja) * 2006-05-11 2009-10-22 ジーンオーム サイエンシーズ、インク. 可変ゲノムのための100%配列一致検出方法
US7897747B2 (en) * 2006-05-25 2011-03-01 The Board Of Trustees Of The Leland Stanford Junior University Method to produce single stranded DNA of defined length and sequence and DNA probes produced thereby
US8119352B2 (en) * 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
EP1878803A1 (de) * 2006-07-10 2008-01-16 Wageningen Universiteit Verfahren zur Detektion von Wurzelgallen-Nematoden
US7910354B2 (en) 2006-10-27 2011-03-22 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
US20090105961A1 (en) * 2006-11-09 2009-04-23 Complete Genomics, Inc. Methods of nucleic acid identification in large-scale sequencing
US20090111705A1 (en) * 2006-11-09 2009-04-30 Complete Genomics, Inc. Selection of dna adaptor orientation by hybrid capture
US20080242560A1 (en) * 2006-11-21 2008-10-02 Gunderson Kevin L Methods for generating amplified nucleic acid arrays
EP1939303A1 (de) 2006-12-27 2008-07-02 Wageningen Universiteit Verfahren zur Erkennung von Zystennematoden
US7862999B2 (en) * 2007-01-17 2011-01-04 Affymetrix, Inc. Multiplex targeted amplification using flap nuclease
NL1033431C2 (nl) 2007-02-20 2008-08-21 Expressive Res Bv Bepaling van kwaliteitskenmerken bij land- of tuinbouwproducten.
US20080293589A1 (en) * 2007-05-24 2008-11-27 Affymetrix, Inc. Multiplex locus specific amplification
US7635566B2 (en) 2007-06-29 2009-12-22 Population Genetics Technologies Ltd. Methods and compositions for isolating nucleic acid sequence variants
US8951731B2 (en) * 2007-10-15 2015-02-10 Complete Genomics, Inc. Sequence analysis using decorated nucleic acids
US8415099B2 (en) 2007-11-05 2013-04-09 Complete Genomics, Inc. Efficient base determination in sequencing reactions
US7897344B2 (en) * 2007-11-06 2011-03-01 Complete Genomics, Inc. Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs
US8518640B2 (en) * 2007-10-29 2013-08-27 Complete Genomics, Inc. Nucleic acid sequencing and process
US8617811B2 (en) * 2008-01-28 2013-12-31 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
WO2009059022A1 (en) * 2007-10-30 2009-05-07 Complete Genomics, Inc. Apparatus for high throughput sequencing of nucleic acids
WO2009061840A1 (en) * 2007-11-05 2009-05-14 Complete Genomics, Inc. Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation
CA2706740C (en) 2007-11-27 2017-01-17 Human Genetic Signatures Pty Ltd Enzymes for amplification and copying bisulphite modified nucleic acids
WO2009073629A2 (en) * 2007-11-29 2009-06-11 Complete Genomics, Inc. Efficient shotgun sequencing methods
US9551026B2 (en) 2007-12-03 2017-01-24 Complete Genomincs, Inc. Method for nucleic acid detection using voltage enhancement
US8592150B2 (en) 2007-12-05 2013-11-26 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing
DK2610351T3 (en) 2007-12-05 2015-09-28 Complete Genomics Inc Base efficient provision of sequencing reactions
US20090156412A1 (en) * 2007-12-17 2009-06-18 Helicos Biosciences Corporation Surface-capture of target nucleic acids
JP2011509095A (ja) 2008-01-09 2011-03-24 ライフ テクノロジーズ コーポレーション 核酸配列決定のための対をなすタグのライブラリーを製造する方法
WO2012044847A1 (en) 2010-10-01 2012-04-05 Life Technologies Corporation Nucleic acid adaptors and uses thereof
WO2009094583A1 (en) * 2008-01-23 2009-07-30 Complete Genomics, Inc. Methods and compositions for preventing bias in amplification and sequencing reactions
US20090233809A1 (en) * 2008-03-04 2009-09-17 Affymetrix, Inc. Resequencing methods for identification of sequence variants
AU2009226248B8 (en) 2008-03-17 2014-10-02 Stichting Genetwister Ip Expression-linked gene discovery
WO2009132028A1 (en) * 2008-04-21 2009-10-29 Complete Genomics, Inc. Array structures for nucleic acid detection
JP2009268665A (ja) * 2008-05-07 2009-11-19 Canon Inc 吸入装置
WO2010068102A1 (en) 2008-12-10 2010-06-17 Monsanto Invest N.V. Novel plant virus
CN102325900A (zh) 2008-12-19 2012-01-18 安莎种子控股有限公司 Cysdv抗性黄瓜植物的育种方法
US8790873B2 (en) 2009-01-16 2014-07-29 Affymetrix, Inc. DNA ligation on RNA template
CA2760439A1 (en) 2009-04-30 2010-11-04 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
US20120156728A1 (en) 2010-12-17 2012-06-21 Life Technologies Corporation Clonal amplification of nucleic acid on solid surface with template walking
US20120122161A1 (en) 2009-05-22 2012-05-17 Esther Musgrave-Brown Sorting Asymmetrically Tagged Nucleic Acids by Selective Primer Extension
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
DK2977455T3 (da) 2009-06-15 2020-07-13 Complete Genomics Inc Fremgangsmåde til langfragmentaflæsnings-sekventering
EP3029141A1 (de) 2009-08-20 2016-06-08 Population Genetics Technologies Ltd. Zusammensetzungen und verfahren für intramolekulare neuanordnung von nukleinsäuren
EP2294912A1 (de) 2009-09-04 2011-03-16 Wageningen Universiteit Verfahren zur Erhöhung des Zeaxanthinniveaus in einer Pflanzenlinie, Verfahren zur Auswahl einer Pflanze oder eines Teils davon, einschließlich eines Samens und einer Knolle, sowie Verwendung davon
WO2011049439A1 (en) 2009-10-19 2011-04-28 Universiteit Twente Method for selecting bone forming mesenchymal stem cells
US20120245041A1 (en) 2009-11-04 2012-09-27 Sydney Brenner Base-by-base mutation screening
WO2011066476A1 (en) 2009-11-25 2011-06-03 Quantalife, Inc. Methods and compositions for detecting genetic material
JP5926194B2 (ja) 2010-01-18 2016-05-25 ユニベルシテイト ユトレヒト ホールディング ビー.ブイ. Fecv及びfipvを区別する為の手段及び方法
GB201001088D0 (en) 2010-01-23 2010-03-10 Trillion Genomics Ltd Detection
WO2011101744A2 (en) 2010-02-22 2011-08-25 Population Genetics Technologies Ltd. Region of interest extraction and normalization methods
WO2011107887A2 (en) 2010-03-02 2011-09-09 Population Genetic Technologies Ltd. Methods for replicating polynucleotides with secondary structure
US9371598B2 (en) 2010-04-05 2016-06-21 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
EP2572003A4 (de) 2010-05-18 2016-01-13 Natera Inc Verfahren zur nichtinvasiven pränatalen ploidiezuordnung
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US8828688B2 (en) 2010-05-27 2014-09-09 Affymetrix, Inc. Multiplex amplification methods
WO2011161549A2 (en) 2010-06-24 2011-12-29 Population Genetics Technologies Ltd. Methods and compositions for polynucleotide library production, immortalization and region of interest extraction
WO2011162612A1 (en) 2010-06-25 2011-12-29 Wageningen Universiteit Method for modulating the level of phosphorylation of starch in a plant line, method for selecting a plant or part thereof, including a seed and tuber, and use thereof
CN103168235B (zh) 2010-07-16 2016-01-13 阿姆斯特丹自由大学及阿姆斯特丹自由大学医疗中心基金会 用于分析受试者血样中疾病标记物的存在的方法
EP2603607B1 (de) 2010-08-11 2016-04-06 Celula, Inc. Dns genotypisierung
EP2623613B8 (de) 2010-09-21 2016-09-07 Population Genetics Technologies Ltd. Erhöhung der Verlässlichkeit von Allel-Aufrufen mit Molekülzählung
US8725422B2 (en) 2010-10-13 2014-05-13 Complete Genomics, Inc. Methods for estimating genome-wide copy number variations
WO2012049279A1 (en) 2010-10-14 2012-04-19 Universitaet Des Saarlandes MEANS AND METHODS APPLYING SINGLE NUCLEOTIDE PRIMER EXTENSION WITH ION PAIR-, REVERSED-PHASE HPLC (SIRPH) FOR THE DIAGNOSIS OF SNPs
WO2013082164A1 (en) 2011-11-28 2013-06-06 Life Technologies Corporation Enhanced ligation reactions
BR112013016193B1 (pt) 2010-12-22 2019-10-22 Natera Inc método ex vivo para determinar se um suposto pai é o pai biológico de um feto que está em gestação em uma gestante e relatório
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
ES2645953T3 (es) 2011-01-17 2017-12-11 Life Technologies Corporation Ligamiento enzimático de ácidos nucleicos
EP2665833B1 (de) 2011-01-17 2017-04-19 Life Technologies Corporation Arbeitsablauf zur nachweis von liganden mit nukleinsäuren
US9365897B2 (en) 2011-02-08 2016-06-14 Illumina, Inc. Selective enrichment of nucleic acids
EP3940084A1 (de) 2011-02-09 2022-01-19 Bio-Rad Laboratories, Inc. Analyse von nukleinsäuren
US9556473B2 (en) 2011-02-15 2017-01-31 Leica Biosystems Newcastle Ltd Methods for identifying nucleic acid sequences
CA2827497C (en) 2011-02-15 2014-12-02 Leica Biosystems Newcastle Ltd. Method for localized in situ detection of mrna
NL2006378C2 (en) 2011-03-11 2012-09-12 Univ Wageningen Tyclv resistance.
CN103547920B (zh) 2011-03-18 2016-08-17 高等教育、科学研究及疾病护理协会 分析受试者的血液样品存在疾病标记物的方法
US8759036B2 (en) 2011-03-21 2014-06-24 Affymetrix, Inc. Methods for synthesizing pools of probes
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
WO2012165943A1 (en) 2011-05-27 2012-12-06 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg A method of analysing a blood sample of a subject for the presence of an infectious disease marker
EP2718465B1 (de) 2011-06-09 2022-04-13 Illumina, Inc. Verfahren zur vorbereitung eines analyt-arrays
DK2729580T3 (en) 2011-07-08 2015-12-14 Keygene Nv SEQUENCE BASED genotyping BASED ON OLIGONUKLEOTIDLIGERINGSASSAYS
WO2013022342A1 (en) 2011-08-09 2013-02-14 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg A method of analysing a blood sample of a subject for the presence of a foetal disease or condition marker
PL2748320T3 (pl) * 2011-08-24 2018-11-30 Grifols Therapeutics Llc Kompozycje i sposoby do hybrydyzacji kwasów nukleinowych
EP4219741A3 (de) 2011-09-06 2023-08-23 Gen-Probe Incorporated Geschlossene nukleinsäurestrukturen
ES2613743T3 (es) 2011-09-07 2017-05-25 Human Genetic Signatures Pty Ltd Ensayo de detección molecular
GB201116131D0 (en) * 2011-09-19 2011-11-02 Epistem Ltd Probe
WO2013055995A2 (en) 2011-10-14 2013-04-18 President And Fellows Of Harvard College Sequencing by structure assembly
US9228233B2 (en) 2011-10-17 2016-01-05 Good Start Genetics, Inc. Analysis methods
US8778849B2 (en) 2011-10-28 2014-07-15 Illumina, Inc. Microarray fabrication system and method
US10837879B2 (en) 2011-11-02 2020-11-17 Complete Genomics, Inc. Treatment for stabilizing nucleic acid arrays
EP4108782B1 (de) 2011-12-22 2023-06-07 President and Fellows of Harvard College Zusammensetzungen und verfahren zur analytdetektion
US11021737B2 (en) 2011-12-22 2021-06-01 President And Fellows Of Harvard College Compositions and methods for analyte detection
WO2013123125A1 (en) 2012-02-17 2013-08-22 President And Fellows Of Harvard College Assembly of nucleic acid sequences in emulsions
WO2013124743A1 (en) 2012-02-22 2013-08-29 Population Genetics Technologies Ltd. Compositions and methods for intramolecular nucleic acid rearrangement ii
WO2013128281A1 (en) 2012-02-28 2013-09-06 Population Genetics Technologies Ltd Method for attaching a counter sequence to a nucleic acid sample
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
US9914967B2 (en) 2012-06-05 2018-03-13 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using DNA origami probes
US9628676B2 (en) 2012-06-07 2017-04-18 Complete Genomics, Inc. Imaging systems with movable scan mirrors
US9488823B2 (en) 2012-06-07 2016-11-08 Complete Genomics, Inc. Techniques for scanned illumination
WO2014045254A2 (en) 2012-09-23 2014-03-27 Erasmus University Medical Center Rotterdam Human betacoronavirus lineage c and identification of n-terminal dipeptidyl peptidase as its virus receptor
US10138509B2 (en) 2013-03-12 2018-11-27 President And Fellows Of Harvard College Method for generating a three-dimensional nucleic acid containing matrix
KR20230169418A (ko) 2013-03-13 2023-12-15 메소 스케일 테크놀러지즈, 엘엘시 개선된 분석 방법
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
EP2971159B1 (de) 2013-03-14 2019-05-08 Molecular Loop Biosolutions, LLC Verfahren zur analyse von nukleinsäuren
US9708658B2 (en) 2013-03-19 2017-07-18 New England Biolabs, Inc. Enrichment of target sequences
US8847799B1 (en) 2013-06-03 2014-09-30 Good Start Genetics, Inc. Methods and systems for storing sequence read data
EP3013983B1 (de) 2013-06-25 2023-02-15 Prognosys Biosciences, Inc. Räumlich codierte biologische assays mit einer mikrofluidischen vorrichtung
US20150037787A1 (en) * 2013-07-31 2015-02-05 International Business Machines Corporation Polynucleotide configuration for reliable electrical and optical sensing
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
US11041203B2 (en) 2013-10-18 2021-06-22 Molecular Loop Biosolutions, Inc. Methods for assessing a genomic region of a subject
GB2520765A (en) 2013-12-02 2015-06-03 Vanadis Diagnostics Ab Multiplex detection of nucleic acids
US10112194B2 (en) 2014-04-14 2018-10-30 Q-Linea Ab Detection of microscopic objects
EP3561075A1 (de) 2014-04-21 2019-10-30 Natera, Inc. Nachweis von mutationen in tumorbiopsien und in zellfreie proben
WO2015175530A1 (en) 2014-05-12 2015-11-19 Gore Athurva Methods for detecting aneuploidy
CA2948547A1 (en) 2014-05-15 2015-11-19 Meso Scale Technologies, Llc. Assay methods and kits for detecting an analyte of interest
ES2876432T3 (es) 2014-05-16 2021-11-12 Illumina Inc Técnicas de síntesis de ácidos nucleicos
EP3074539B1 (de) 2014-06-13 2018-01-10 Q-Linea AB Verfahren für den nachweis und die charakterisierung eines mikroorganismus
CA3176503A1 (en) 2014-07-21 2016-01-28 Illumina, Inc Polynucleotide enrichment using crispr-cas systems
US9856521B2 (en) * 2015-01-27 2018-01-02 BioSpyder Technologies, Inc. Ligation assays in liquid phase
US11091810B2 (en) * 2015-01-27 2021-08-17 BioSpyder Technologies, Inc. Focal gene expression profiling of stained FFPE tissues with spatial correlation to morphology
US10683534B2 (en) * 2015-01-27 2020-06-16 BioSpyder Technologies, Inc. Ligation assays in liquid phase
US11408024B2 (en) 2014-09-10 2022-08-09 Molecular Loop Biosciences, Inc. Methods for selectively suppressing non-target sequences
EP3224595A4 (de) 2014-09-24 2018-06-13 Good Start Genetics, Inc. Prozesssteuerung für erhöhte robustheit von genetischen assays
WO2016065207A1 (en) * 2014-10-23 2016-04-28 Ricardo Mancebo Reagents and methods for isothermal chain reaction
EP3218513B1 (de) 2014-11-11 2018-10-31 Illumina, Inc. Polynukleotidamplifikation mit crispr-cas-systemen
JP2017537657A (ja) 2014-12-11 2017-12-21 ニユー・イングランド・バイオレイブス・インコーポレイテツド 標的配列の濃縮
CA3010579A1 (en) 2015-01-06 2016-07-14 Good Start Genetics, Inc. Screening for structural variants
FI3901281T3 (fi) 2015-04-10 2023-01-31 Biologisten näytteiden spatiaalisesti eroteltu moninkertainen nukleiinihappoanalyysi
GB201507026D0 (en) 2015-04-24 2015-06-10 Linea Ab Q Medical sample transportation container
EP3294906A1 (de) 2015-05-11 2018-03-21 Natera, Inc. Verfahren und zusammensetzungen zur bestimmung des ploidiegrades
MX2018005611A (es) 2015-11-03 2018-11-09 Harvard College Metodo y aparato para la formacion de imagenes volumetricas de una matriz tridimensional que contiene acido nucleico.
AU2016352829B2 (en) 2015-11-10 2022-11-10 Vilmorin & Cie Resistance to ToLCNDV in squash
WO2017173279A1 (en) * 2016-03-31 2017-10-05 Arizona Board Of Regents On Behalf Of Arizona State University Probes and methods for measuring tandem repeats
GB2554767A (en) 2016-04-21 2018-04-11 Q Linea Ab Detecting and characterising a microorganism
WO2017189525A1 (en) 2016-04-25 2017-11-02 President And Fellows Of Harvard College Hybridization chain reaction methods for in situ molecular detection
CN116397007A (zh) 2016-05-11 2023-07-07 伊鲁米那股份有限公司 使用argonaute系统的多核苷酸富集和扩增
GB2569252A (en) 2016-08-31 2019-06-12 Harvard College Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
GB2570412A (en) 2016-08-31 2019-07-24 Harvard College Methods of generating libraries of nucleic acid sequences for detection via fluorescent in situ sequencing
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
GB201621514D0 (en) 2016-12-16 2017-02-01 Q-Linea Ab Padlock probe detection method
US10995361B2 (en) 2017-01-23 2021-05-04 Massachusetts Institute Of Technology Multiplexed signal amplified FISH via splinted ligation amplification and sequencing
CA3056650A1 (en) 2017-03-30 2018-10-04 Pioneer Hi-Bred International, Inc. Methods of identifying and characterizing gene editing variations in nucleic acids
EP3639022A4 (de) * 2017-06-15 2021-03-10 Technion - Research & Development Foundation Ltd Zusammensetzungen und verfahren zur erkennung von genomvariationen
US11180804B2 (en) 2017-07-25 2021-11-23 Massachusetts Institute Of Technology In situ ATAC sequencing
US11597965B2 (en) * 2017-10-06 2023-03-07 10X Genomics, Inc. RNA templated ligation
US11298371B2 (en) 2017-10-11 2022-04-12 Nitto Denko Corporation Regulation of nucleic acid molecule expression
EP3995590A1 (de) 2017-10-11 2022-05-11 MGI Tech Co., Ltd. Verfahren zur verbesserung der belastung und stabilität von nukleinsäuren
EP3807420A1 (de) 2018-06-12 2021-04-21 Keygene N.V. Verfahren zur amplifikation von nukleinsäuren
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN112770776A (zh) 2018-07-30 2021-05-07 瑞德库尔有限责任公司 用于样品处理或分析的方法和系统
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
CN113474466A (zh) 2019-02-21 2021-10-01 主基因有限公司 多倍体基因分型
SG11202110571YA (en) 2019-10-25 2021-10-28 Illumina Cambridge Ltd Methods for generating, and sequencing from, asymmetric adaptors on the ends of polynucleotide templates comprising hairpin loops
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
EP4055185A1 (de) 2019-11-08 2022-09-14 10X Genomics, Inc. Räumlich markierte analytfänger für analyt-multiplexing
CN114885610A (zh) 2019-12-23 2022-08-09 10X基因组学有限公司 使用rna模板化连接进行空间分析的方法
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
US20230083623A1 (en) * 2020-02-18 2023-03-16 Agency For Science, Technology And Research Nucleic acid probes
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
EP4242325A3 (de) 2020-04-22 2023-10-04 10X Genomics, Inc. Verfahren zur räumlichen analyse unter verwendung von gezieltem rna-abbau
EP4153775A1 (de) 2020-05-22 2023-03-29 10X Genomics, Inc. Simultane räumlich-zeitliche messung der genexpression und der zellaktivität
WO2021237087A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Spatial analysis to detect sequence variants
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
AU2021283174A1 (en) 2020-06-02 2023-01-05 10X Genomics, Inc. Nucleic acid library methods
CN116249785A (zh) 2020-06-02 2023-06-09 10X基因组学有限公司 用于抗原-受体的空间转录组学
EP4162074A1 (de) 2020-06-08 2023-04-12 10X Genomics, Inc. Verfahren zur bestimmung eines chirurgischen randes und verfahren zur verwendung davon
EP4165207A1 (de) 2020-06-10 2023-04-19 10X Genomics, Inc. Verfahren zur bestimmung einer position eines analyten in einer biologischen probe
EP4172362A1 (de) 2020-06-25 2023-05-03 10X Genomics, Inc. Räumliche analyse der dna-methylierung
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
WO2022140028A1 (en) 2020-12-21 2022-06-30 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
BR112023018152A2 (pt) 2021-03-09 2023-10-31 Illumina Cambridge Ltd Preparação de biblioteca genômica e ensaios epigenéticos direcionados com o uso de ribonucleoproteínas de cas-grna
IL305151A (en) 2021-03-09 2023-10-01 Illumina Inc Expression analysis of protein coding variants in cells
WO2022197589A1 (en) 2021-03-15 2022-09-22 President And Fellows Of Harvard College Methods for in situ sequencing
AU2022238446A1 (en) 2021-03-18 2023-09-07 10X Genomics, Inc. Multiplex capture of gene and protein expression from a biological sample
WO2023034489A1 (en) 2021-09-01 2023-03-09 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
WO2024015766A1 (en) 2022-07-12 2024-01-18 Topogene Inc. Scalable, submicron-resolution replication of dna arrays

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4808519A (en) * 1984-04-06 1989-02-28 Life Technologies, Inc. Method of detecting nucleic acid sequences
US5242794A (en) * 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
DE3732130A1 (de) 1987-09-24 1989-04-06 Gutehoffnungshuette Man Rampenabschnitt fuer zusammenfaltbare schwimmbruecke oder faehre
AU622426B2 (en) * 1987-12-11 1992-04-09 Abbott Laboratories Assay using template-dependent nucleic acid probe reorganization
US5449602A (en) * 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
US4988617A (en) * 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
CA1341584C (en) * 1988-04-06 2008-11-18 Bruce Wallace Method of amplifying and detecting nucleic acid sequences
GB8818150D0 (en) * 1988-07-29 1988-09-01 Crc Technology Gene modification
US5516663A (en) * 1990-01-26 1996-05-14 Abbott Laboratories Ligase chain reaction with endonuclease IV correction and contamination control
CA2049879A1 (en) * 1990-08-30 1992-03-01 Keith C. Backman Controlled initial target-dependent production of templates for ligase chain reaction
JP3080178B2 (ja) * 1991-02-18 2000-08-21 東洋紡績株式会社 核酸配列の増幅方法およびそのための試薬キット
US5426180A (en) * 1991-03-27 1995-06-20 Research Corporation Technologies, Inc. Methods of making single-stranded circular oligonucleotides
JP3085409B2 (ja) * 1991-03-29 2000-09-11 東洋紡績株式会社 標的核酸配列の検出方法およびそのための試薬キット
SE9400522D0 (sv) * 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
SE9403805D0 (sv) * 1994-11-07 1994-11-07 Ulf Landegren Method of preparing oligonucleotide probes or primers, vector therefor and use thereof

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US6235472B1 (en) 2001-05-22
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