DE69525643D1 - Sulfur-substituierte azetdinone als hypocholesterolmischmittel - Google Patents

Sulfur-substituierte azetdinone als hypocholesterolmischmittel

Info

Publication number
DE69525643D1
DE69525643D1 DE69525643T DE69525643T DE69525643D1 DE 69525643 D1 DE69525643 D1 DE 69525643D1 DE 69525643 T DE69525643 T DE 69525643T DE 69525643 T DE69525643 T DE 69525643T DE 69525643 D1 DE69525643 D1 DE 69525643D1
Authority
DE
Germany
Prior art keywords
aryl
coor6
lower alkyl
nr6r7
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69525643T
Other languages
English (en)
Other versions
DE69525643T2 (de
Inventor
A Mckittrick
Sundeep Dugar
A Burnett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/342,197 external-priority patent/US5624920A/en
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE69525643D1 publication Critical patent/DE69525643D1/de
Publication of DE69525643T2 publication Critical patent/DE69525643T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
DE69525643T 1994-11-18 1995-11-15 Sulfur-substituierte azetdinone als hypocholesterolmischmittel Expired - Lifetime DE69525643T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/342,197 US5624920A (en) 1994-11-18 1994-11-18 Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US08/463,619 US5633246A (en) 1994-11-18 1995-06-05 Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
PCT/US1995/014134 WO1996016037A1 (en) 1994-11-18 1995-11-15 Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents

Publications (2)

Publication Number Publication Date
DE69525643D1 true DE69525643D1 (de) 2002-04-04
DE69525643T2 DE69525643T2 (de) 2002-09-26

Family

ID=26992866

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69525643T Expired - Lifetime DE69525643T2 (de) 1994-11-18 1995-11-15 Sulfur-substituierte azetdinone als hypocholesterolmischmittel

Country Status (25)

Country Link
US (2) US5633246A (de)
EP (1) EP0792264B1 (de)
JP (1) JP2908031B2 (de)
KR (1) KR100235806B1 (de)
CN (1) CN1083833C (de)
AT (1) ATE213726T1 (de)
AU (1) AU698750B2 (de)
BR (1) BR9509669A (de)
CA (1) CA2205202C (de)
CZ (1) CZ289033B6 (de)
DE (1) DE69525643T2 (de)
DK (1) DK0792264T3 (de)
ES (1) ES2169162T3 (de)
FI (1) FI116220B (de)
HK (1) HK1002558A1 (de)
HU (1) HU227672B1 (de)
MX (1) MX9703577A (de)
NO (1) NO308468B1 (de)
NZ (1) NZ296720A (de)
PL (1) PL184310B1 (de)
PT (1) PT792264E (de)
RU (1) RU2159243C2 (de)
SK (1) SK283860B6 (de)
UA (1) UA54381C2 (de)
WO (1) WO1996016037A1 (de)

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US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
EP1510521A1 (de) * 2000-12-20 2005-03-02 Schering Corporation Zuckersubstituierte 2-Azetidinone Verwendbar als Hypocholesterdenische Arzneimittel
TR200402758T4 (tr) * 2000-12-20 2004-11-22 Schering Corporation Hipokolesterolemik ajanlar olarak faydalı şekerle ikame edilen 2-azetidinonlar.
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
RS51449B (sr) * 2001-01-26 2011-04-30 Schering Corporation Kombinacija aktivatora peroksizom proliferator-aktiviranog receptora (ppar) i inhibitora apsorpcije sterola i lečenje vaskularnih indikacija
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
EP1911462A3 (de) 2001-01-26 2011-11-30 Schering Corporation Zusammensetzungen enthaltend einen Sterolabsorptionshemmer
RS50406B (sr) * 2001-01-26 2009-12-31 Schering Corporation, Upotreba supstituisanih jedinjenja azetidinona za lečenje sitosterolemije
ATE305459T1 (de) 2001-03-28 2005-10-15 Schering Corp Verfahren für die enantioselektive synthese von azetidinon-zwischenprodukten
EP1859796A3 (de) * 2001-09-21 2008-07-02 Schering Corporation Behandlung von xanthom mit azetidinon-derivaten als hemmer der sterol absorption
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
ATE345793T1 (de) * 2001-09-21 2006-12-15 Schering Corp Behandlung von xanthom mittels azetidinon- derivate als hemmer der sterol absorption
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AR040588A1 (es) * 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
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US7235543B2 (en) * 2003-03-07 2007-06-26 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
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UY29607A1 (es) * 2005-06-20 2007-01-31 Astrazeneca Ab Compuestos quimicos
AR057072A1 (es) * 2005-06-22 2007-11-14 Astrazeneca Ab Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto
AR056866A1 (es) * 2005-06-22 2007-10-31 Astrazeneca Ab Compuestos quimicos derivados de 2-azetidinona, una formulacion farmaceutica y un proceso de preparacion del compuesto
AR057380A1 (es) * 2005-06-22 2007-11-28 Astrazeneca Ab Compuestos quimicos derivados de 2-azetidinona y uso terapeutico de los mismos
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US20070161578A1 (en) * 2005-12-21 2007-07-12 Hwa Joyce J Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and/or H3 receptor antagonist/inverse agonist
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US7910698B2 (en) * 2006-02-24 2011-03-22 Schering Corporation NPC1L1 orthologues
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MX2009002398A (es) * 2006-09-05 2009-03-16 Schering Corp Combinaciones farmaceuticas para manejo de lipidos y en el tratamiento de aterosclerosis y estatosis hepatica.
MX2009002922A (es) 2006-09-15 2009-04-01 Schering Corp Derivados de azetidina y azetidona utiles en el tratamiento del dolor y de trastornos del metabolismo lipidico.
WO2008033431A1 (en) * 2006-09-15 2008-03-20 Schering Corporation Spirocyclic azetidinone derivatives for the treatment of disorders of lipid metabolism, pain, diabetes and other disorders
MX2009002921A (es) * 2006-09-15 2009-04-01 Schering Corp Derivados de azetidinona para el tratamiento de trastornos del metabolismo lipidico.
CN101541795A (zh) * 2006-09-15 2009-09-23 先灵公司 用于治疗疼痛、糖尿病和脂类代谢紊乱的螺-稠合氮杂环丁烷衍生物
MX2009002918A (es) * 2006-09-15 2009-03-31 Schering Corp Derivados azetidinona y sus metodos de uso.
EP2133347A4 (de) 2007-03-06 2010-03-17 Teijin Pharma Ltd 1-biarylazetidinonderivate
US20100197564A1 (en) * 2007-04-19 2010-08-05 Schering Corporation Diaryl morpholines as cb1 modulators
NZ582249A (en) * 2007-06-28 2012-06-29 Intervet Int Bv Substituted piperazines as cb1 antagonists
CN101790521A (zh) * 2007-06-28 2010-07-28 英特维特国际股份有限公司 作为cb1拮抗剂的取代哌嗪
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Also Published As

Publication number Publication date
BR9509669A (pt) 1997-10-28
MX9703577A (es) 1997-08-30
NO308468B1 (no) 2000-09-18
FI972099A (fi) 1997-05-16
FI972099A0 (fi) 1997-05-16
PT792264E (pt) 2002-07-31
AU698750B2 (en) 1998-11-05
UA54381C2 (uk) 2003-03-17
NO972272L (no) 1997-05-16
HU227672B1 (en) 2011-11-28
ATE213726T1 (de) 2002-03-15
US5633246A (en) 1997-05-27
JPH09512833A (ja) 1997-12-22
DE69525643T2 (de) 2002-09-26
ES2169162T3 (es) 2002-07-01
EP0792264B1 (de) 2002-02-27
CN1083833C (zh) 2002-05-01
FI116220B (fi) 2005-10-14
PL184310B1 (pl) 2002-09-30
CN1174548A (zh) 1998-02-25
DK0792264T3 (da) 2002-04-22
KR100235806B1 (ko) 2000-02-01
AU4140196A (en) 1996-06-17
CZ289033B6 (cs) 2001-10-17
HUT77088A (hu) 1998-03-02
SK283860B6 (sk) 2004-03-02
NO972272D0 (no) 1997-05-16
CZ148697A3 (en) 1997-11-12
CA2205202A1 (en) 1996-05-30
JP2908031B2 (ja) 1999-06-21
HK1002558A1 (en) 1998-09-04
CA2205202C (en) 2002-01-08
NZ296720A (en) 1999-03-29
KR970707092A (ko) 1997-12-01
EP0792264A1 (de) 1997-09-03
SK61697A3 (en) 1997-12-10
RU2159243C2 (ru) 2000-11-20
US5744467A (en) 1998-04-28
PL320092A1 (en) 1997-09-15
WO1996016037A1 (en) 1996-05-30

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