DE69533942D1 - Behandlung von lösungen roter blutkörperchen mit antiviralen wirkstoffen - Google Patents

Behandlung von lösungen roter blutkörperchen mit antiviralen wirkstoffen

Info

Publication number
DE69533942D1
DE69533942D1 DE69533942T DE69533942T DE69533942D1 DE 69533942 D1 DE69533942 D1 DE 69533942D1 DE 69533942 T DE69533942 T DE 69533942T DE 69533942 T DE69533942 T DE 69533942T DE 69533942 D1 DE69533942 D1 DE 69533942D1
Authority
DE
Germany
Prior art keywords
solutions
treatment
red blood
active substances
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69533942T
Other languages
English (en)
Other versions
DE69533942T2 (de
Inventor
David Cook
Susan Wollowitz
Aileen Niero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cerus Corp
Original Assignee
Cerus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerus Corp filed Critical Cerus Corp
Application granted granted Critical
Publication of DE69533942D1 publication Critical patent/DE69533942D1/de
Publication of DE69533942T2 publication Critical patent/DE69533942T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C07D219/12—Amino-alkylamino radicals attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10161—Methods of inactivation or attenuation
    • C12N2730/10163—Methods of inactivation or attenuation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16061—Methods of inactivation or attenuation
    • C12N2740/16063—Methods of inactivation or attenuation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18111—Leviviridae
    • C12N2795/18161—Methods of inactivation or attenuation
    • C12N2795/18163—Methods of inactivation or attenuation by chemical treatment
DE69533942T 1994-11-14 1995-11-08 Behandlung von lösungen roter blutkörperchen mit antiviralen wirkstoffen Expired - Lifetime DE69533942T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/338,040 US5691132A (en) 1994-11-14 1994-11-14 Method for inactivating pathogens in red cell compositions using quinacrine mustard
US338040 1994-11-14
PCT/US1995/014550 WO1996014737A1 (en) 1994-11-14 1995-11-08 Treating red blood cell solutions with anti-viral agents

Publications (2)

Publication Number Publication Date
DE69533942D1 true DE69533942D1 (de) 2005-02-24
DE69533942T2 DE69533942T2 (de) 2005-12-29

Family

ID=23323153

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69533942T Expired - Lifetime DE69533942T2 (de) 1994-11-14 1995-11-08 Behandlung von lösungen roter blutkörperchen mit antiviralen wirkstoffen

Country Status (8)

Country Link
US (6) US5691132A (de)
EP (1) EP0804074B1 (de)
JP (1) JP3145124B2 (de)
AT (1) ATE287210T1 (de)
AU (1) AU712034B2 (de)
CA (1) CA2203885C (de)
DE (1) DE69533942T2 (de)
WO (1) WO1996014737A1 (de)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4107396A (en) 1992-03-02 1996-06-06 Cerus Corporation Synthetic media for blood components
US5691132A (en) * 1994-11-14 1997-11-25 Cerus Corporation Method for inactivating pathogens in red cell compositions using quinacrine mustard
DE4444045C2 (de) * 1994-12-10 1997-04-17 Behringwerke Ag Verfahren zur Inaktivierung von Viren mit Hilfe von Acridin oder Acridinderivaten
US6544727B1 (en) 1995-06-07 2003-04-08 Cerus Corporation Methods and devices for the removal of psoralens from blood products
US20040048235A1 (en) * 1995-08-29 2004-03-11 V.I. Technologies, Inc. Methods and compositions for the selective modification of nucleic acids
US6136586A (en) * 1995-08-29 2000-10-24 Vi Technologies, Inc. Methods for the selective modification of viral nucleic acids
US20040053208A1 (en) * 1995-08-29 2004-03-18 V. I. TECHNOLOGIES, Inc. Methods to selectively inactivate parasites in biological compositions
FR2753536B1 (fr) * 1996-09-16 1998-11-20 Aetsrn Procede d'evaluation de la phagocytose de cellules cibles par des macrophages in vitro ; applications diagnostiques et application au controle de qualite de stocks de cellules
US6190609B1 (en) 1996-11-19 2001-02-20 Baxter International Inc. Methods and apparatus for inactivating contaminants in biological fluid
US5922278A (en) * 1996-11-19 1999-07-13 Baxter International Inc. Method and apparatus for inactivating contaminants in biological fluid
WO1998030545A1 (en) * 1997-01-06 1998-07-16 Cerus Corporation Frangible compounds for pathogen inactivation
US6514987B1 (en) * 1997-01-06 2003-02-04 Cerus Corporation Frangible compounds for pathogen inactivation
US6093725A (en) * 1997-01-06 2000-07-25 Cerus Corporation Frangible compounds for pathogen inactivation
EP1364944A1 (de) * 1997-01-06 2003-11-26 Cerus Corporation Verbindungen mit leicht spaltbaren Bindungen zur Inaktivierung von Pathogenen
US20010018179A1 (en) 1998-01-06 2001-08-30 Derek J. Hei Batch devices for the reduction of compounds from biological compositions containing cells and methods of use
US20010009756A1 (en) 1998-01-06 2001-07-26 Derek Hei Flow devices for the reduction of compounds from biological compositions and methods of use
US6093564A (en) * 1997-10-03 2000-07-25 V.I. Technologies, Inc. Methods and compositions for the selective modification of nucleic acids
US6352695B1 (en) 1997-10-03 2002-03-05 V.I. Technologies, Inc. Methods and compositions for the selective modification of nucleic acids
EP1032265B1 (de) * 1997-11-20 2003-10-29 Cerus Corporation Neue psoralene zur inaktivierung von pathogenen
AU745209B2 (en) * 1998-01-06 2002-03-14 Cerus Corporation Methods for quenching pathogen inactivators in biological materials
US7611831B2 (en) * 1998-01-06 2009-11-03 Cerus Corporation Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
US6369048B1 (en) 1998-01-12 2002-04-09 V.I. Technologies, Inc. Methods and compositions for inactivating viruses
CA2332314A1 (en) 1998-06-11 1999-12-16 Cerus Corporation Use of alkylating compounds for inhibiting proliferation of arterial smooth muscle cells
US6908553B1 (en) 1998-07-08 2005-06-21 Baxter International Inc. Composite membrane with particulate matter substantially immobilized therein
US6099734A (en) * 1998-07-08 2000-08-08 Baxter International Inc. Apparatus, membranes and methods for removing organic compounds from a biological fluid
US6277337B1 (en) 1998-07-21 2001-08-21 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using photosensitizers
US20070099170A1 (en) * 1998-07-21 2007-05-03 Navigant Biotechnologies, Inc. Method for treatment and storage of blood and blood products using endogenous alloxazines and acetate
US6258577B1 (en) 1998-07-21 2001-07-10 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers
US6617100B2 (en) 1998-09-25 2003-09-09 V.I. Technologies, Inc. Solid phase quenching systems
US6403359B1 (en) 1998-09-25 2002-06-11 V. I. TECHNOLOGIES, Inc. Solid phase quenching systems
US6150109A (en) 1999-01-25 2000-11-21 V. I. TECHNOLOGIES, Inc. Lipophilic quenching of viral inactivating agents
US7025877B1 (en) 1999-06-03 2006-04-11 Baxter International Inc. Processing set for processing and treating a biological fluid
US7445756B2 (en) 1999-06-03 2008-11-04 Fenwal, Inc. Fluid processing sets and organizers for the same
US7068361B2 (en) 1999-06-03 2006-06-27 Baxter International Apparatus, systems and methods for processing and treating a biological fluid with light
US6565802B1 (en) 1999-06-03 2003-05-20 Baxter International Inc. Apparatus, systems and methods for processing and treating a biological fluid with light
US6268120B1 (en) 1999-10-19 2001-07-31 Gambro, Inc. Isoalloxazine derivatives to neutralize biological contaminants
TW590780B (en) 2000-06-02 2004-06-11 Gambro Inc Additive solutions containing riboflavin
US7648699B2 (en) 2000-06-02 2010-01-19 Caridianbct Biotechnologies, Llc Preventing transfusion related complications in a recipient of a blood transfusion
US7985588B2 (en) 2000-06-02 2011-07-26 Caridianbct Biotechnologies, Llc Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
US9044523B2 (en) 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
AU2002211795C1 (en) * 2000-10-17 2008-04-17 Zeptometrix Corporation Nucleic acid amplification controls
DE10051628B4 (de) * 2000-10-18 2007-06-06 Fresenius Hemocare Beteiligungs Gmbh Einzelsträngiges Oligonukleotid und dessen Verwendung
US6548241B1 (en) * 2000-11-28 2003-04-15 Gambro, Inc. Storage solution containing photosensitizer for inactivation of biological contaminants
CA2434256A1 (en) * 2000-12-21 2003-07-31 David Cook Methods for inactivation of pathogens in biological materials
US20020131958A1 (en) * 2001-01-22 2002-09-19 John Chapman Method for purifying a biological composition
US7381976B2 (en) 2001-03-13 2008-06-03 Triton Thalassic Technologies, Inc. Monochromatic fluid treatment systems
US20030031584A1 (en) * 2001-08-10 2003-02-13 Wilson Burgess Methods for sterilizing biological materials using dipeptide stabilizers
US7235392B2 (en) * 2001-12-07 2007-06-26 The Ohio State University Research Foundation Apoptotic EBV-transformed lymphocytes, a therapeutic agent for post-transplant lymphoproliferative disorder
US7745180B2 (en) * 2002-04-24 2010-06-29 Hitachi Chemical Co., Ltd. Device and method for high-throughput quantification of mRNA from whole blood
EP1531823A4 (de) 2002-05-10 2007-07-18 Univ Ohio State Flavin n-oxide: neue krebsmittel und mittel zur beseitigung von erregern
US20090110702A1 (en) * 2002-07-12 2009-04-30 The Johns Hopkins University Mesothelin Vaccines and Model Systems and Control of Tumors
US9200036B2 (en) 2002-07-12 2015-12-01 The Johns Hopkins University Mesothelin vaccines and model systems
CA2492160A1 (en) * 2002-07-12 2004-01-22 The Johns Hopkins University Mesothelin vaccines and model systems
AU2003272491B2 (en) * 2002-09-18 2008-10-02 The Trustees Of The University Of Pennsylvania Compositions, methods and kits for detection of an antigen on a cell and in a biological mixture
CA2515298C (en) * 2003-02-06 2014-04-08 Cerus Corporation Modified free-living microbes, vaccine compositions and methods of use thereof
US7695725B2 (en) 2003-02-06 2010-04-13 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
EP1592441B1 (de) * 2003-02-06 2012-04-11 Aduro Biotech Listerien deren eindringen in nicht-phagozytische zellen abgeschwächt ist, impfstoffe, die diese listerien enthalten und deren verwendungen
US7534348B2 (en) * 2003-09-12 2009-05-19 Fenwal, Inc. Flow-through removal device and system using such device
US20050137517A1 (en) 2003-12-19 2005-06-23 Baxter International Inc. Processing systems and methods for providing leukocyte-reduced blood components conditioned for pathogen inactivation
US7842289B2 (en) * 2003-12-24 2010-11-30 Aduro Biotech Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
US20120225044A9 (en) * 2004-09-07 2012-09-06 Zymequest, Inc. Compositions and methods for prolonging survival of platelets
CA2621250A1 (en) * 2004-09-07 2006-03-16 Zymequest, Inc. Apparatus for prolonging survival of platelets
BRPI0518198B8 (pt) * 2004-10-29 2021-06-22 Cerus Corp método ex vivo para tratar uma composição de células hemácias para inativar um patógeno, se presente, bem como composição e kit
DE102007038513A1 (de) 2007-08-16 2009-02-19 Robert Bosch Gmbh Monostatischer Mehrstrahlradarsensor für Kraftfahrzeuge
US9318248B2 (en) 2007-10-25 2016-04-19 Iii Holdings 2, Llc Spin valve element and method of manufacturing same
KR101742533B1 (ko) 2008-04-09 2017-06-01 세루스 코포레이션 적혈구 병원체 불활성화를 위한 개선된 퀀칭 방법
JP2011523553A (ja) 2008-05-19 2011-08-18 アデュロ バイオテック ＰｒｆＡ＊変異株リステリアを含む組成物およびその使用法
WO2010107789A1 (en) * 2009-03-17 2010-09-23 Marv Enterprises Llc Sequential extracorporeal treatment of bodily fluids
EP3834851A1 (de) * 2010-12-30 2021-06-16 Laboratoire Français du Fractionnement et des Biotechnologies Glykole als pathogeninaktivierungsstoffe
WO2013148405A2 (en) * 2012-03-27 2013-10-03 Felder Mitchell S Treatment for atherosclerosis
JP6268167B2 (ja) 2012-05-31 2018-01-24 エイジェンシー フォー サイエンス，テクノロジー アンド リサーチ タンパク質製剤中の凝集物含量を低減するために混合型多官能表面を使用する方法
JP6297029B2 (ja) 2012-05-31 2018-03-20 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 多様な官能基を有する粒子による免疫グロブリンｇ調製物のクロマトグラフィー精製
SG11201407812SA (en) 2012-05-31 2014-12-30 Agency Science Tech & Res Methods for reducing levels of protein-contaminant complexes and aggregates in protein preparations by treatment with electropositive organic additives
WO2014123484A1 (en) 2013-02-06 2014-08-14 Agency For Science, Technology And Research Methods For Reducing Aggregate Content In Protein Preparations
EP3194576B1 (de) 2014-07-23 2020-11-18 Cerus Corporation Verfahren zur herstellung von thrombozyten-produkten
DE202015100806U1 (de) 2015-02-19 2015-04-15 Paul Schaffrath Vorrichtung zur Inaktivierung von Krankheitserregern in Flüssigkeiten
CN108135936A (zh) 2015-06-26 2018-06-08 塞鲁斯公司 冷沉淀物组合物及其制备方法
US10799533B2 (en) 2015-10-23 2020-10-13 Cerus Corporation Plasma compositions and methods of use thereof
EA201991506A1 (ru) 2016-12-23 2020-01-23 Сирус Корпорейшн Системы и способы для тестирования и скрининга с использованием связанных с соединениями субстратов
EP3562493A1 (de) 2016-12-31 2019-11-06 Cerus Corporation Zusammensetzungen und verfahren zur herstellung von erythrozyten
US11235090B2 (en) 2017-03-03 2022-02-01 Cerus Corporation Kits and methods for preparing pathogen-inactivated platelet compositions
AU2018395525B2 (en) 2017-12-29 2023-09-14 Cerus Corporation Systems and methods for treating biological fluids
MX2021003180A (es) 2018-09-20 2021-05-14 Cerus Corp Métodos y kits para preparar sangre entera con inactivación de patógenos.
WO2020264421A1 (en) 2019-06-28 2020-12-30 Cerus Corporation System and methods for implementing a biological fluid treatment device

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE444045C (de) 1925-10-20 1927-05-13 Ernst Kaempfer Verfahren zur Herstellung von Schweissdraht
US3819270A (en) * 1972-10-02 1974-06-25 Block Engineering Blood cell analyzer
US4196281A (en) * 1976-10-20 1980-04-01 Regents Of The University Of California Psoralens
US4124598A (en) * 1976-10-20 1978-11-07 Hoffmann-La Roche Inc. Psoralens
US4182750A (en) * 1977-04-21 1980-01-08 Sullivan Thomas E Bloodcompatible functional polymers
US4107182A (en) * 1977-07-29 1978-08-15 Hoffmann-La Roche Inc. 7-Oxo-9-methoxy-7H-furo[3,2-g][1]benzopyran-6-carboxylic acid
US4252653A (en) * 1978-08-25 1981-02-24 Stolle Research And Development Corporation Hemoperfusion device for specific modification or removal of components of whole blood
US4269851A (en) * 1979-09-10 1981-05-26 Thomas C. Elder, Inc. 8-Aminoalkyl-4-alkylpsoralens
US4269852A (en) 1979-09-10 1981-05-26 Thomas C. Elder, Inc. 4'-Substituted-4,5',8-trialkylpsoralens
US4370344A (en) * 1979-09-10 1983-01-25 Elder Pharmaceuticals, Inc. 5'-Aminoalkyl-4'-alkylpsoralens
US4298614A (en) 1979-09-10 1981-11-03 Thomas C. Elder, Inc. 5'-Aminoalkyl-4',4-dialkylpsoralens
US4294822A (en) 1980-07-29 1981-10-13 Thomas C. Elder, Inc. 5-Aminoalkyl-4,4,8-trialkylpsoralens
US4613322A (en) * 1982-12-08 1986-09-23 Edelson Richard Leslie Method and system for externally treating the blood
US4748120A (en) * 1983-05-02 1988-05-31 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
US4727027A (en) * 1983-05-02 1988-02-23 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
IT1169415B (it) * 1983-05-09 1987-05-27 Jean Jacques Goupil Prodotti medicinali contenenti un derivato del psoralene
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4704352A (en) 1985-06-25 1987-11-03 Baxter Travenol Laboratories, Inc. L-ascorbate-2-phosphate salts in blood cell storage
US5055485A (en) 1988-12-02 1991-10-08 New York Blood Center, Inc. Inactivation of viruses in cell- and protein-containing compositions using aryl diol epoxides
US5356929A (en) * 1989-01-23 1994-10-18 Lehigh University Reduced and quaternized psoralens as photo-activated therapeutics
US5342752A (en) 1990-04-16 1994-08-30 Cryopharm Corporation Method of inactivation of viral blood contaminants using acridine deriatives
US5691371A (en) 1993-05-25 1997-11-25 Auckland Uniservices Limited Nitrobenzyl mustard quaternary salts and their use as hypoxia-selective cytotoxic agents
US5399719A (en) * 1993-06-28 1995-03-21 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood
AU1565895A (en) 1994-01-10 1995-08-01 Hemasure, Inc. Inactivation of viruses present in blood components using chemically-activated compounds
US5691132A (en) * 1994-11-14 1997-11-25 Cerus Corporation Method for inactivating pathogens in red cell compositions using quinacrine mustard
DE4444045C2 (de) 1994-12-10 1997-04-17 Behringwerke Ag Verfahren zur Inaktivierung von Viren mit Hilfe von Acridin oder Acridinderivaten
US6177441B1 (en) * 1995-06-05 2001-01-23 Cerus Corporation Treating red blood cell solutions with anti-viral agents
EP0773716A4 (de) * 1995-06-07 1999-08-04 Cerus Corp Behandlung von lösungen roter blutkörperchen mit antivralen wirkstoffen
AU7717396A (en) 1995-06-29 1997-02-05 Hemasure, Inc. Inactivation of pathogens using hydroxymethylamines
US6114108A (en) * 1995-08-29 2000-09-05 V.I. Technologies, Inc. Methods and compositions for the selective modification of viral nucleic acids
US6136586A (en) 1995-08-29 2000-10-24 Vi Technologies, Inc. Methods for the selective modification of viral nucleic acids
US6093725A (en) * 1997-01-06 2000-07-25 Cerus Corporation Frangible compounds for pathogen inactivation
US5891705A (en) 1997-04-08 1999-04-06 Pentose Pharmaceuticals, Inc. Method for inactivating a virus
US6093564A (en) 1997-10-03 2000-07-25 V.I. Technologies, Inc. Methods and compositions for the selective modification of nucleic acids
US6150109A (en) 1999-01-25 2000-11-21 V. I. TECHNOLOGIES, Inc. Lipophilic quenching of viral inactivating agents

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JPH10507367A (ja) 1998-07-21
EP0804074B1 (de) 2005-01-19
US5559250A (en) 1996-09-24
AU4151396A (en) 1996-06-06
JP3145124B2 (ja) 2001-03-12
ATE287210T1 (de) 2005-02-15
US5691132A (en) 1997-11-25
CA2203885A1 (en) 1996-05-23
WO1996014737A1 (en) 1996-05-23
DE69533942T2 (de) 2005-12-29
CA2203885C (en) 2007-01-09
US20020182581A1 (en) 2002-12-05
EP0804074A4 (de) 1999-12-08
US6171777B1 (en) 2001-01-09
US6410219B1 (en) 2002-06-25
EP0804074A1 (de) 1997-11-05
US6143490A (en) 2000-11-07
AU712034B2 (en) 1999-10-28

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