DE69534245D1 - Vorrichtung zur lokalen verabreichung einer arznei - Google Patents

Vorrichtung zur lokalen verabreichung einer arznei

Info

Publication number
DE69534245D1
DE69534245D1 DE69534245T DE69534245T DE69534245D1 DE 69534245 D1 DE69534245 D1 DE 69534245D1 DE 69534245 T DE69534245 T DE 69534245T DE 69534245 T DE69534245 T DE 69534245T DE 69534245 D1 DE69534245 D1 DE 69534245D1
Authority
DE
Germany
Prior art keywords
substance
conduit
locally
medicine
delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69534245T
Other languages
English (en)
Other versions
DE69534245T2 (de
Inventor
R Hanson
A Scott
B King
A Harker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
Original Assignee
Emory University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University filed Critical Emory University
Application granted granted Critical
Publication of DE69534245D1 publication Critical patent/DE69534245D1/de
Publication of DE69534245T2 publication Critical patent/DE69534245T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/064—Blood vessels with special features to facilitate anastomotic coupling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0102—Insertion or introduction using an inner stiffening member, e.g. stylet or push-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0063—Catheters; Hollow probes characterised by structural features having means, e.g. stylets, mandrils, rods or wires to reinforce or adjust temporarily the stiffness, column strength or pushability of catheters which are already inserted into the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0041—Catheters; Hollow probes characterised by the form of the tubing pre-formed, e.g. specially adapted to fit with the anatomy of body channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M25/007—Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
DE69534245T 1994-01-28 1995-01-27 Vorrichtung zur lokalen verabreichung einer arznei Expired - Fee Related DE69534245T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/188,248 US5523092A (en) 1993-04-14 1994-01-28 Device for local drug delivery and methods for using the same
US188248 1994-01-28
PCT/US1995/001080 WO1995020416A1 (en) 1994-01-28 1995-01-27 A device for local drug delivery and methods for using the same

Publications (2)

Publication Number Publication Date
DE69534245D1 true DE69534245D1 (de) 2005-07-07
DE69534245T2 DE69534245T2 (de) 2006-01-26

Family

ID=22692364

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69534245T Expired - Fee Related DE69534245T2 (de) 1994-01-28 1995-01-27 Vorrichtung zur lokalen verabreichung einer arznei

Country Status (11)

Country Link
US (2) US5523092A (de)
EP (1) EP0754072B1 (de)
JP (1) JPH10500028A (de)
AT (1) ATE296660T1 (de)
AU (1) AU682582B2 (de)
CA (1) CA2182201A1 (de)
DE (1) DE69534245T2 (de)
DK (1) DK0754072T3 (de)
ES (1) ES2243934T3 (de)
PT (1) PT754072E (de)
WO (1) WO1995020416A1 (de)

Families Citing this family (523)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5985307A (en) 1993-04-14 1999-11-16 Emory University Device and method for non-occlusive localized drug delivery
US5891108A (en) * 1994-09-12 1999-04-06 Cordis Corporation Drug delivery stent
US6558798B2 (en) 1995-02-22 2003-05-06 Scimed Life Systems, Inc. Hydrophilic coating and substrates coated therewith having enhanced durability and lubricity
US6231600B1 (en) 1995-02-22 2001-05-15 Scimed Life Systems, Inc. Stents with hybrid coating for medical devices
US6451047B2 (en) 1995-03-10 2002-09-17 Impra, Inc. Encapsulated intraluminal stent-graft and methods of making same
US6264684B1 (en) 1995-03-10 2001-07-24 Impra, Inc., A Subsidiary Of C.R. Bard, Inc. Helically supported graft
US6579314B1 (en) * 1995-03-10 2003-06-17 C.R. Bard, Inc. Covered stent with encapsulated ends
US6743198B1 (en) * 1995-03-20 2004-06-01 Conticare Medical, Inc. Self-cleansing bladder drainage device
US6099562A (en) * 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US6322548B1 (en) 1995-05-10 2001-11-27 Eclipse Surgical Technologies Delivery catheter system for heart chamber
US5779673A (en) * 1995-06-26 1998-07-14 Focal, Inc. Devices and methods for application of intraluminal photopolymerized gels
US6283951B1 (en) 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
US6302875B1 (en) 1996-10-11 2001-10-16 Transvascular, Inc. Catheters and related devices for forming passageways between blood vessels or other anatomical structures
US5603694A (en) * 1995-10-17 1997-02-18 Brown; Joe E. Infusion coil apparatus and method for delivering fluid-based agents intravascularly
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US6402736B1 (en) * 1996-02-16 2002-06-11 Joe E. Brown Apparatus and method for filtering intravascular fluids and for delivering diagnostic and therapeutic agents
SG64340A1 (en) * 1996-02-27 1999-04-27 Inst Of Systems Science Nation Curved surgical instruments and methods of mapping a curved path for stereotactic surgery
US6783543B2 (en) * 2000-06-05 2004-08-31 Scimed Life Systems, Inc. Intravascular stent with increasing coating retaining capacity
DK0914102T3 (da) 1996-05-24 2006-01-09 Angiotech Pharm Inc Præparater og fremgangsmåder til behandling eller forebyggelse af syddomme i legemskanaler
US6190402B1 (en) * 1996-06-21 2001-02-20 Musc Foundation For Research Development Insitu formable and self-forming intravascular flow modifier (IFM) and IFM assembly for deployment of same
US5797887A (en) * 1996-08-27 1998-08-25 Novovasc Llc Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation
WO1998014232A1 (en) * 1996-10-03 1998-04-09 Dubrul William R Self coiling catheter
US7341598B2 (en) * 1999-01-13 2008-03-11 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US6379334B1 (en) * 1997-02-10 2002-04-30 Essex Technology, Inc. Rotate advance catheterization system
AU6162498A (en) * 1997-02-14 1998-09-08 Joe E. Brown Coil apparatus and method for delivering diagnostic and therapeutic agents intravascularly
JP3274384B2 (ja) * 1997-03-31 2002-04-15 株式会社パイオラックス 留置カテーテル及びその挿入装置
US5865815A (en) * 1997-04-25 1999-02-02 Contimed, Inc. Prostatic obstruction relief catheter
IT1293973B1 (it) 1997-08-13 1999-03-15 Sorin Biomedica Cardio Spa Elemento per l'ancoraggio in situ di dispositivi di impianto.
US6012034A (en) * 1997-08-18 2000-01-04 Becton, Dickinson And Company System and method for selecting an intravenous device
US20020055717A1 (en) * 1997-10-20 2002-05-09 Philippe Poncet Fluid-based agent delivery device with self-expanding delivery element
US6241691B1 (en) 1997-12-05 2001-06-05 Micrus Corporation Coated superelastic stent
US6159165A (en) 1997-12-05 2000-12-12 Micrus Corporation Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand
US6168570B1 (en) 1997-12-05 2001-01-02 Micrus Corporation Micro-strand cable with enhanced radiopacity
US6358229B1 (en) * 1998-02-17 2002-03-19 Conticare Medical, Inc. Urinary drain
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7208011B2 (en) 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6478773B1 (en) 1998-12-21 2002-11-12 Micrus Corporation Apparatus for deployment of micro-coil using a catheter
US6296622B1 (en) 1998-12-21 2001-10-02 Micrus Corporation Endoluminal device delivery system using axially recovering shape memory material
US6500149B2 (en) 1998-08-31 2002-12-31 Deepak Gandhi Apparatus for deployment of micro-coil using a catheter
US6358276B1 (en) * 1998-09-30 2002-03-19 Impra, Inc. Fluid containing endoluminal stent
US6375648B1 (en) * 1998-10-02 2002-04-23 Misonix Incorporated Infiltration cannula with teflon coated outer surface
US6048332A (en) * 1998-10-09 2000-04-11 Ave Connaught Dimpled porous infusion balloon
US6293967B1 (en) 1998-10-29 2001-09-25 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US6214042B1 (en) * 1998-11-10 2001-04-10 Precision Vascular Systems, Inc. Micro-machined stent for vessels, body ducts and the like
US6413273B1 (en) * 1998-11-25 2002-07-02 Israel Aircraft Industries Ltd. Method and system for temporarily supporting a tubular organ
US6348067B1 (en) * 1998-11-25 2002-02-19 Israel Aircraft Industries Ltd. Method and system with shape memory heating apparatus for temporarily supporting a tubular organ
US6258118B1 (en) 1998-11-25 2001-07-10 Israel Aircraft Industries Ltd. Removable support device
US6835185B2 (en) 1998-12-21 2004-12-28 Micrus Corporation Intravascular device deployment mechanism incorporating mechanical detachment
JP3524788B2 (ja) 1998-12-24 2004-05-10 株式会社パイオラックス 制癌剤投与用体内留置カテーテル
US6398803B1 (en) 1999-02-02 2002-06-04 Impra, Inc., A Subsidiary Of C.R. Bard, Inc. Partial encapsulation of stents
US6419692B1 (en) 1999-02-03 2002-07-16 Scimed Life Systems, Inc. Surface protection method for stents and balloon catheters for drug delivery
US6398758B1 (en) 1999-02-16 2002-06-04 Stephen C. Jacobsen Medicament delivery system
US20010041870A1 (en) * 1999-03-09 2001-11-15 Edward M. Gillis Implantable device for access to a treatment site
US6702811B2 (en) 1999-04-05 2004-03-09 Medtronic, Inc. Ablation catheter assembly with radially decreasing helix and method of use
US6595959B1 (en) 1999-04-23 2003-07-22 Alexander A. Stratienko Cardiovascular sheath/catheter
US6245045B1 (en) 1999-04-23 2001-06-12 Alexander Andrew Stratienko Combination sheath and catheter for cardiovascular use
US6514236B1 (en) 1999-04-23 2003-02-04 Alexander A. Stratienko Method for treating a cardiovascular condition
US6156373A (en) * 1999-05-03 2000-12-05 Scimed Life Systems, Inc. Medical device coating methods and devices
US6290673B1 (en) * 1999-05-20 2001-09-18 Conor Medsystems, Inc. Expandable medical device delivery system and method
US6478778B1 (en) * 1999-05-28 2002-11-12 Precision Vascular Systems, Inc. Apparatus for delivering fluids to blood vessels, body cavities, and the like
DE60044131D1 (de) * 1999-06-16 2010-05-20 Medi Tech Co Ltd Katheter
US6368315B1 (en) 1999-06-23 2002-04-09 Durect Corporation Composite drug delivery catheter
US6258121B1 (en) 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US6283947B1 (en) 1999-07-13 2001-09-04 Advanced Cardiovascular Systems, Inc. Local drug delivery injection catheter
US6494862B1 (en) * 1999-07-13 2002-12-17 Advanced Cardiovascular Systems, Inc. Substance delivery apparatus and a method of delivering a therapeutic substance to an anatomical passageway
US7547302B2 (en) * 1999-07-19 2009-06-16 I-Flow Corporation Anti-microbial catheter
US7452353B2 (en) * 1999-07-19 2008-11-18 I-Flow Corporation Catheter for uniform delivery of medication
US7510550B2 (en) * 1999-07-19 2009-03-31 I-Flow Corporation Catheter for uniform delivery of medication
US7004923B2 (en) * 1999-07-19 2006-02-28 I-Flow Corporation Catheter for uniform delivery of medication
US6350253B1 (en) 1999-07-19 2002-02-26 I-Flow Corporation Catheter for uniform delivery of medication
WO2001013986A1 (en) * 1999-08-25 2001-03-01 Georgetown University Delivery system for therapy comprising hollow seeds, preferably metal, and use thereof
US7048717B1 (en) 1999-09-27 2006-05-23 Essex Technology, Inc. Rotate-to-advance catheterization system
AU7839900A (en) 1999-09-29 2001-04-30 Sterling Medivations, Inc. Reusable medication delivery device
US6596235B2 (en) 1999-09-30 2003-07-22 Therox, Inc. Method for blood oxygenation
US7544500B2 (en) 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
WO2001037723A2 (en) 1999-11-22 2001-05-31 Boston Scientific Limited Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US7897140B2 (en) * 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
US7670327B2 (en) * 2000-01-20 2010-03-02 Regents Of The University Of Minnesota Catheter systems for delivery of agents and related method thereof
US6929633B2 (en) 2000-01-25 2005-08-16 Bacchus Vascular, Inc. Apparatus and methods for clot dissolution
US6663613B1 (en) 2000-01-25 2003-12-16 Bacchus Vascular, Inc. System and methods for clot dissolution
US7740637B2 (en) * 2000-02-09 2010-06-22 Micrus Endovascular Corporation Apparatus and method for deployment of a therapeutic device using a catheter
US6379382B1 (en) 2000-03-13 2002-04-30 Jun Yang Stent having cover with drug delivery capability
US6613082B2 (en) 2000-03-13 2003-09-02 Jun Yang Stent having cover with drug delivery capability
WO2001070322A1 (en) 2000-03-24 2001-09-27 Stephen Brushey Anesthesia conduction catheter
US7805188B2 (en) * 2000-03-24 2010-09-28 Micor, Inc. Anesthesia conduction catheter for delivery of electrical stimulus
AU2001253479A1 (en) * 2000-04-13 2001-10-30 Sts Biopolymers, Inc. Targeted therapeutic agent release devices and methods of making and using the same
US6776796B2 (en) 2000-05-12 2004-08-17 Cordis Corportation Antiinflammatory drug and delivery device
US20050002986A1 (en) * 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US8236048B2 (en) 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
US20040243097A1 (en) * 2000-05-12 2004-12-02 Robert Falotico Antiproliferative drug and delivery device
AU6539101A (en) * 2000-06-05 2001-12-17 G David Jang Intravascular stent with increasing coating retaining capacity
US6685672B1 (en) 2000-07-13 2004-02-03 Edwards Lifesciences Corporation Multi-balloon drug delivery catheter for angiogenesis
US7261735B2 (en) * 2001-05-07 2007-08-28 Cordis Corporation Local drug delivery devices and methods for maintaining the drug coatings thereon
ATE343969T1 (de) 2000-09-29 2006-11-15 Cordis Corp Beschichtete medizinische geräte
US20020051730A1 (en) * 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof
US20020111590A1 (en) * 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
DE20122506U1 (de) 2000-10-16 2005-12-08 Conor Medsystems, Inc., Menlo Park Ausdehnbare medizinische Vorrichtung zur Abgabe eines nützlichen Agens
US6764507B2 (en) 2000-10-16 2004-07-20 Conor Medsystems, Inc. Expandable medical device with improved spatial distribution
US6692458B2 (en) 2000-12-19 2004-02-17 Edwards Lifesciences Corporation Intra-pericardial drug delivery device with multiple balloons and method for angiogenesis
US20040073294A1 (en) 2002-09-20 2004-04-15 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US6964680B2 (en) * 2001-02-05 2005-11-15 Conor Medsystems, Inc. Expandable medical device with tapered hinge
US7771468B2 (en) * 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
US6719804B2 (en) * 2001-04-02 2004-04-13 Scimed Life Systems, Inc. Medical stent and related methods
DE10131152B4 (de) * 2001-04-30 2004-05-27 Nutricia Healthcare S.A. Medizinisches Ballon-Button-System
DE60202677T2 (de) * 2001-05-25 2005-12-29 Medtronic, Inc., Minneapolis Implantierbare medizinische vorrichtung mit kontrollierter freigabe von gasförmigen mitteln
US8252040B2 (en) 2001-07-20 2012-08-28 Microvention, Inc. Aneurysm treatment device and method of use
US6629969B2 (en) * 2001-07-26 2003-10-07 Durect Corporation Catheter for modification of agent formulation
US7364565B2 (en) 2001-07-27 2008-04-29 Ramot At Tel Aviv University Ltd. Controlled enzymatic removal and retrieval of cells
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
US7056338B2 (en) 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US7195640B2 (en) * 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US20030065345A1 (en) * 2001-09-28 2003-04-03 Kevin Weadock Anastomosis devices and methods for treating anastomotic sites
US7108701B2 (en) * 2001-09-28 2006-09-19 Ethicon, Inc. Drug releasing anastomosis devices and methods for treating anastomotic sites
US20030065377A1 (en) * 2001-09-28 2003-04-03 Davila Luis A. Coated medical devices
US6620202B2 (en) * 2001-10-16 2003-09-16 Scimed Life Systems, Inc. Medical stent with variable coil and related methods
CA2463724A1 (en) * 2001-10-16 2003-04-24 Structural Bioinformatics Inc. Organosulfur inhibitors of tyrosine phosphatases
US6936040B2 (en) * 2001-10-29 2005-08-30 Medtronic, Inc. Method and apparatus for endovenous pacing lead
US7438710B2 (en) * 2001-11-07 2008-10-21 Anderson Kent D Distal protection device with local drug infusion by physician to maintain patency
US7041139B2 (en) 2001-12-11 2006-05-09 Boston Scientific Scimed, Inc. Ureteral stents and related methods
WO2003072024A2 (en) * 2002-02-13 2003-09-04 Beth Israel Deaconess Medical Center, Inc. Methods of treating vascular disease
US8506647B2 (en) * 2002-02-14 2013-08-13 Boston Scientific Scimed, Inc. System for maintaining body canal patency
US8328877B2 (en) 2002-03-19 2012-12-11 Boston Scientific Scimed, Inc. Stent retention element and related methods
US20030191453A1 (en) * 2002-04-03 2003-10-09 Velez Omar E. Catheter assembly
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US8097585B2 (en) 2002-04-15 2012-01-17 Beth Israel Deaconess Medical Center, Inc. Methods of treating inflammation by administration of heme oxygenase-1 and products of heme degradation
US7122048B2 (en) * 2002-05-03 2006-10-17 Scimed Life Systems, Inc. Hypotube endoluminal device
US8829198B2 (en) * 2007-10-31 2014-09-09 Proteotech Inc Compounds, compositions and methods for the treatment of beta-amyloid diseases and synucleinopathies
RS110504A (en) * 2002-06-21 2007-02-05 University Of Pittsburgh Of The Commonwealth System Of Higher Education, Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
WO2004002476A2 (en) 2002-06-27 2004-01-08 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
AU2003249742A1 (en) * 2002-07-02 2004-01-23 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
EP1521603B1 (de) 2002-07-12 2011-01-19 Cook Incorporated Beschichtete medizinische vorrichtung
JP3887588B2 (ja) * 2002-08-30 2007-02-28 株式会社リガク Ｘ線回折による応力測定法
US20040127976A1 (en) * 2002-09-20 2004-07-01 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US20040059228A1 (en) * 2002-09-23 2004-03-25 Scimed Life Systems, Inc. Systems and methods for flushing catheters
WO2004045672A2 (en) * 2002-11-15 2004-06-03 The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services Variable curve catheter
EP1610823B1 (de) 2003-03-28 2011-09-28 Innovational Holdings, LLC Implantierbares medizinprodukt mit kontinuierlichem mittel-konzentrationsgefälle
US20040242886A1 (en) * 2003-04-30 2004-12-02 Sandeep Gupta Monocyclic diazodioxide based Bcl-2 protein antagonists related applications
WO2004099162A1 (en) * 2003-04-30 2004-11-18 Ricerca Biosciences, Llc. Polycyclic diazodioxide-based bcl-2 protein antagonist
EP1633320A2 (de) * 2003-05-02 2006-03-15 SurModics, Inc. Implantierbares system zur kontrollierten freisetzung eines bioaktiven wirkstoffs
JP4847868B2 (ja) * 2003-05-14 2011-12-28 ニューロジェネティック ファーマシューティカルズ、 インコーポレイテッド 化合物、及び、アミロイドベータの調節におけるその使用
US20090227647A1 (en) * 2008-03-05 2009-09-10 Thomas Lake Compounds, Compositions and Methods for the Treatment of Islet Amyloid Polypeptide (IAPP) Accumulation in Diabetes
US8916598B2 (en) 2003-05-30 2014-12-23 Proteotech Inc Compounds, compositions, and methods for the treatment of β-amyloid diseases and synucleinopathies
US20040249364A1 (en) * 2003-06-03 2004-12-09 Ilya Kaploun Device and method for dispensing medication to tissue lining a body cavity
US7169179B2 (en) * 2003-06-05 2007-01-30 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
US20040260271A1 (en) * 2003-06-18 2004-12-23 Huyser Richard F. Extended fenestration catheter with internal coil and method of making the same
US7057100B2 (en) * 2003-06-26 2006-06-06 The J.C. Robinson Seed Co. Inbred corn line W23129
US7785653B2 (en) 2003-09-22 2010-08-31 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
US20050101938A1 (en) * 2003-11-06 2005-05-12 Leiboff Arnold R. Guidewire for use in colonic irrigation
WO2005090370A1 (en) * 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
US20050261365A1 (en) 2004-05-20 2005-11-24 The Scripps Research Institute Transthyretin stabilization
EP1753369B1 (de) 2004-06-08 2013-05-29 Advanced Stent Technologies, Inc. Stent mit herausragendem astteil für verzweigte gefässe
JP2008503490A (ja) * 2004-06-17 2008-02-07 センジェント・セラピューティクス・インコーポレイテッド チロシンホスファターゼの三置換窒素調節物質
EP1786421A2 (de) * 2004-07-09 2007-05-23 Cengent Therapeutics, Inc. Sauerstoff/stickstoff-heterozyklus-hemmer von tyrosinphosphatasen
FR2873016B1 (fr) * 2004-07-15 2006-09-29 Pierre Marcel Bourgogne Protheses vasculaires artificielles delivrant en permanence des produits actifs empechant toute stenose, thrombose, proliferation cellulaire, etc.. d'acces aise permanent pour toute intervention
US20060063930A1 (en) * 2004-08-20 2006-03-23 Agoston Gregory E Compositions and methods comprising proteinase activated receptor antagonists
WO2006028970A1 (en) 2004-09-02 2006-03-16 Cengent Therapeutics, Inc. Derivatives of thiazole and thiadiazole inhibitors of tyrosine phosphatases
WO2006034003A2 (en) 2004-09-17 2006-03-30 Whitehead Institute For Biomedical Research Compounds, compositions and methods of inhibiting a-synuclein toxicity
US20060067889A1 (en) * 2004-09-27 2006-03-30 Light Sciences Corporation Singlet oxygen photosensitizers activated by target binding enhancing the selectivity of targeted PDT agents
US20080140187A1 (en) * 2004-10-15 2008-06-12 Krause Arthur A Anti-clotting, anti-microbial, anti-inflammatory medical stent
WO2006063199A2 (en) 2004-12-09 2006-06-15 The Foundry, Inc. Aortic valve repair
US8983582B2 (en) * 2004-12-20 2015-03-17 Advanced Cardiovascular Systems, Inc. Methods and apparatuses for positioning within an internal channel
WO2006093976A1 (en) 2005-02-28 2006-09-08 Spirus Medical Inc. Rotate-to-advance catheterization system
WO2006130217A2 (en) * 2005-04-01 2006-12-07 The Regents Of The University Of California Substituted phosphate esters of nucleoside phosphonates
WO2006137953A1 (en) 2005-04-01 2006-12-28 The Regents Of The Univerisity Of California Phosphono-pent-2-en-1-yl nucleosides and analogs
US20060229573A1 (en) * 2005-04-08 2006-10-12 Mckinley Medical L.L.L.P. Adjustable infusion catheter
US8414477B2 (en) 2005-05-04 2013-04-09 Olympus Endo Technology America Inc. Rotate-to-advance catheterization system
US8343040B2 (en) 2005-05-04 2013-01-01 Olympus Endo Technology America Inc. Rotate-to-advance catheterization system
US7780650B2 (en) 2005-05-04 2010-08-24 Spirus Medical, Inc. Rotate-to-advance catheterization system
US8235942B2 (en) 2005-05-04 2012-08-07 Olympus Endo Technology America Inc. Rotate-to-advance catheterization system
US8317678B2 (en) 2005-05-04 2012-11-27 Olympus Endo Technology America Inc. Rotate-to-advance catheterization system
US7396366B2 (en) 2005-05-11 2008-07-08 Boston Scientific Scimed, Inc. Ureteral stent with conforming retention structure
US20100098640A1 (en) * 2005-06-20 2010-04-22 Cohen Seth M Multidentate Pyrone-Derived Chelators for Medicinal Imaging and Chelation
WO2007000159A1 (en) * 2005-06-27 2007-01-04 William Cook Europe Aps A dilator for performing a percutaneous medical procedure
US9101949B2 (en) * 2005-08-04 2015-08-11 Eilaz Babaev Ultrasonic atomization and/or seperation system
US20070031611A1 (en) * 2005-08-04 2007-02-08 Babaev Eilaz P Ultrasound medical stent coating method and device
DK1933810T3 (da) * 2005-08-11 2013-01-28 Childrens Medical Center Intravesikal lægemiddelafgivelsesindretning og fremgangsmåde
US7896539B2 (en) * 2005-08-16 2011-03-01 Bacoustics, Llc Ultrasound apparatus and methods for mixing liquids and coating stents
US8492428B2 (en) * 2005-09-20 2013-07-23 Mayo Foundation For Medical Education And Research Small-molecule botulinum toxin inhibitors
US7540881B2 (en) * 2005-12-22 2009-06-02 Boston Scientific Scimed, Inc. Bifurcation stent pattern
US8138361B2 (en) * 2005-12-28 2012-03-20 The Trustees Of The University Of Pennsylvania C-10 carbamates of taxanes
US8435229B2 (en) 2006-02-28 2013-05-07 Olympus Endo Technology America Inc. Rotate-to-advance catheterization system
US8574220B2 (en) 2006-02-28 2013-11-05 Olympus Endo Technology America Inc. Rotate-to-advance catheterization system
JP5424480B2 (ja) * 2006-03-13 2014-02-26 杏林製薬株式会社 Ｇｓｋ−３インヒビターとしてのアミノキノロン
BRPI0709699A2 (pt) * 2006-03-29 2011-07-26 Foldrx Pharmaceuticals Inc inibiÇço da toxidez da alfa-sinucleina
US20090318886A1 (en) * 2006-04-27 2009-12-24 Anna Norlin Medical device
SG170032A1 (en) 2006-08-28 2011-04-29 Kyowa Hakko Kirin Co Ltd Antagonistic human light-specific human monoclonal antibodies
US7547323B2 (en) * 2006-08-29 2009-06-16 Sinexus, Inc. Stent for irrigation and delivery of medication
AU2007297597B2 (en) 2006-09-21 2013-02-21 Kyorin Pharmaceuticals Co., Ltd. Serine hydrolase inhibitors
WO2008042311A1 (en) * 2006-09-28 2008-04-10 Nmt Medical. Inc. Perforated expandable implant recovery sheath
US7951191B2 (en) * 2006-10-10 2011-05-31 Boston Scientific Scimed, Inc. Bifurcated stent with entire circumferential petal
US20080140176A1 (en) * 2006-10-18 2008-06-12 Krause Arthur A Medical stent and devices for localized treatment of disease
EP2081893B1 (de) 2006-10-19 2011-03-23 Auspex Pharmaceuticals, Inc. Substituierte indole
US8287519B2 (en) * 2006-10-27 2012-10-16 Smith Tech Innovations, Llc Self-cleansing bladder drainage catheter
US20100137421A1 (en) * 2006-11-08 2010-06-03 Emmanuel Theodorakis Small molecule therapeutics, synthesis of analogues and derivatives and methods of use
US7842082B2 (en) * 2006-11-16 2010-11-30 Boston Scientific Scimed, Inc. Bifurcated stent
US8419710B2 (en) * 2006-12-06 2013-04-16 Medtronic, Inc. Methods for infusing fluids via an implantable infusion system
US20080142616A1 (en) * 2006-12-15 2008-06-19 Bacoustics Llc Method of Producing a Directed Spray
AU2007333667A1 (en) 2006-12-19 2008-06-26 Auspex Pharmaceuticals, Inc. Preperation and utility of CCR5 inhibitors
EP2125739A1 (de) * 2006-12-22 2009-12-02 Encysive Pharmaceuticals, Inc. Modulatoren des c3a-rezeptors und verfahren zu deren anwendung
CA2696053A1 (en) * 2007-02-28 2008-09-04 Conatus Pharmaceuticals, Inc. Methods for the treatment of liver diseases
WO2008106167A1 (en) * 2007-02-28 2008-09-04 Conatus Pharmaceuticals, Inc. Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases
SI2125698T1 (sl) 2007-03-15 2016-12-30 Auspex Pharmaceuticals, Inc. Devterirani d9-venlafaksin
AU2008227875B2 (en) 2007-03-19 2014-06-12 Insuline Medical Ltd. Drug delivery device
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
WO2008122048A2 (en) 2007-04-02 2008-10-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Removal of contrast agents from blood
US7892776B2 (en) 2007-05-04 2011-02-22 The Regents Of The University Of California Screening assay to identify modulators of protein kinase A
US20080281291A1 (en) * 2007-05-07 2008-11-13 Claude Tihon Drainage/irrigation urethral catheter
US20120149985A1 (en) * 2007-05-18 2012-06-14 Frassica James J Rotate-to-advance catheterization system
US8870755B2 (en) 2007-05-18 2014-10-28 Olympus Endo Technology America Inc. Rotate-to-advance catheterization system
US8721711B2 (en) * 2007-06-20 2014-05-13 Oregon Health & Science University Graft having microporous membrane for uniform fluid infusion
JP5734650B2 (ja) 2007-06-25 2015-06-17 マイクロベンション インコーポレイテッド 自己拡張プロテーゼ
WO2009009367A2 (en) 2007-07-06 2009-01-15 Allievion Medical, Inc. Constrained fluid delivery device
BRPI0814542A2 (pt) * 2007-07-12 2014-09-30 Tragara Pharmaceuticals Inc Métodos e composições para o tratamento de câncer, tumores e desordens relacionadas a tumores
US7753285B2 (en) 2007-07-13 2010-07-13 Bacoustics, Llc Echoing ultrasound atomization and/or mixing system
US7780095B2 (en) 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
ES2371800T3 (es) * 2007-09-11 2012-01-10 Kyorin Pharmaceutical Co.,Ltd. Cianoaminoquinolonas como inhibidores de gsk-3.
MX2010002662A (es) 2007-09-12 2010-04-09 Activx Biosciences Inc Aminoquinolonas espirociclicas como inhibidores de gsk-3.
US7959669B2 (en) * 2007-09-12 2011-06-14 Boston Scientific Scimed, Inc. Bifurcated stent with open ended side branch support
US8100855B2 (en) 2007-09-17 2012-01-24 Abbott Cardiovascular Systems, Inc. Methods and devices for eluting agents to a vessel
US20090076591A1 (en) * 2007-09-19 2009-03-19 Boston Scientific Scimed, Inc. Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface
US20090264421A1 (en) * 2007-10-05 2009-10-22 Bible Keith C Methods and Compositions for Treating Cancer
US9867971B2 (en) * 2007-10-09 2018-01-16 Assistance Publique—Hopitaux de Paris Device for administering cells and cell-therapy methods using said device
CA2706465A1 (en) * 2007-11-21 2009-05-28 Pharmaxis Ltd. Haloallylamine inhibitors of ssao/vap-1 and uses therefor
US7833266B2 (en) 2007-11-28 2010-11-16 Boston Scientific Scimed, Inc. Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
CN101896221B (zh) 2007-12-11 2013-06-05 麻省理工学院 用于治疗膀胱和其它体囊或体腔的可植入式药物递送设备和方法
WO2009079388A2 (en) * 2007-12-14 2009-06-25 Oregon Health & Science University Drug delivery cuff
EP2231229A1 (de) 2007-12-18 2010-09-29 Insuline Medical Ltd. Wirkstofffreisetzungsvorrichtung mit sensor für geschlossenen kreislauf
US8277501B2 (en) * 2007-12-21 2012-10-02 Boston Scientific Scimed, Inc. Bi-stable bifurcated stent petal geometry
US8221494B2 (en) 2008-02-22 2012-07-17 Endologix, Inc. Apparatus and method of placement of a graft or graft system
US8196279B2 (en) 2008-02-27 2012-06-12 C. R. Bard, Inc. Stent-graft covering process
US8618289B2 (en) 2008-03-17 2013-12-31 Ambit Biosciences Corporation RAF kinase modulator compounds and methods of use thereof
US20090240318A1 (en) * 2008-03-19 2009-09-24 Boston Scientific Scimed, Inc. Stent expansion column, strut and connector slit design
US20090275918A1 (en) * 2008-05-01 2009-11-05 Stemcor Systems, Inc. Pancreatic delivery catheter
US8932340B2 (en) * 2008-05-29 2015-01-13 Boston Scientific Scimed, Inc. Bifurcated stent and delivery system
CN102057044B (zh) 2008-06-04 2013-05-01 泰勒克里斯生物治疗学公司 用于制备纤溶酶的组合物，方法以及试剂盒
BRPI0917135A2 (pt) * 2008-08-09 2015-11-10 Massachusetts Inst Technology dispositivo médico para extensão e retenção em uma vesícula seminal, duto ejaculatório, próstata ou vaso deferente de um paciente, uso de um elastômero reabsorvível, e, dispositivo de bomba osmótica.
US20120034156A1 (en) * 2010-08-03 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Artificial cells
CN101658533A (zh) * 2008-08-29 2010-03-03 首都医科大学宣武医院 抗肿瘤药物的干细胞递送
US8187222B2 (en) * 2008-09-12 2012-05-29 Boston Scientific Scimed, Inc. Devices and systems for delivery of therapeutic agents to body lumens
WO2010036541A1 (en) * 2008-09-24 2010-04-01 Cook Incorporated Catheter system having variable stiffness
DK2346559T3 (da) * 2008-10-09 2013-12-16 Nyxx Technologies Ltd Medicinsk anordning
WO2010059364A2 (en) * 2008-10-30 2010-05-27 Epitek, Inc. Method and apparatus for sub-xiphoid delivery of therapeutic agents
EP2355758A2 (de) 2008-11-07 2011-08-17 Insuline Medical Ltd. Arzneimittelabgabevorrichtung und -verfahren
WO2010088450A2 (en) 2009-01-30 2010-08-05 Celladon Corporation Methods for treating diseases associated with the modulation of serca
US8568793B2 (en) 2009-02-11 2013-10-29 Hope Medical Enterprises, Inc. Sodium nitrite-containing pharmaceutical compositions
MY159327A (en) 2009-02-27 2016-12-25 Ambit Biosciences Corp Jak kinase modulating quinazoline derivatives and methods of use thereof
ES2552337T3 (es) 2009-03-03 2015-11-27 Grifols Therapeutics Inc. Procedimientos para la preparación de plasminógeno
EP2403860B1 (de) 2009-03-04 2015-11-04 IDENIX Pharmaceuticals, Inc. Phosphothiophene und phosphothiazole als hcv polymerase inhibitoren
CN102421784B (zh) * 2009-03-11 2015-09-30 杏林制药株式会社 作为gsk-3抑制剂的7-环烷基氨基喹诺酮
CA2754909A1 (en) 2009-03-11 2010-09-16 Ambit Biosciences Corp. Combination of an indazolylaminopyrrolotriazine and taxane for cancer treatment
MX2011010105A (es) 2009-03-27 2012-01-12 Pathway Therapeutics Inc Sulfonamidas de pirimidinilo y 1,3,5-triazinilo benzimidazol y su uso en terapia de cancer.
WO2010110686A1 (en) 2009-03-27 2010-09-30 Pathway Therapeutics Limited Pyrimidinyl and 1,3,5 triazinyl benzimidazoles and their use in cancer therapy
MX2011011141A (es) 2009-04-22 2012-02-13 Axikin Pharmaceuticals Inc Antagonistas ccr3 arisulfonamida.
EP2727908A3 (de) 2009-04-22 2014-08-20 Axikin Pharmaceuticals, Inc. 2,5-disubstituierte Arylsulfonamid-CCR3-Antagonisten
EP2749554B1 (de) 2009-04-22 2017-12-20 SMA Therapeutics, Inc. 2,5-disubstituierte Arylsulfonamid-CCR3-Antagonisten
EP2429452B1 (de) 2009-04-28 2020-01-15 Endologix, Inc. Endoluminales prothesensystem
US20100292641A1 (en) * 2009-05-15 2010-11-18 Bandula Wijay Targeted drug delivery device and method
DK2445571T3 (da) 2009-06-26 2013-02-25 Taris Biomedical Inc Faste lægemiddeltabletter til implanterbare lægemiddelafgivelsesindretninger
WO2011003870A2 (en) 2009-07-06 2011-01-13 Creabilis S.A. Mini-pegylated corticosteroids, compositions including same, and methods of making and using same
DK3072890T3 (en) 2009-07-07 2019-02-11 Mei Pharma Inc Pyrimidinyl and 1,3,5-triazinylbenzimidazoles and their use in cancer therapy
EP3213756A1 (de) 2009-07-08 2017-09-06 Hope Medical Enterprise, Inc. D.b.a. Hope Pharmaceuticals Natriumthiosulfathaltige pharmazeutische zusammensetzungen
US20110022026A1 (en) * 2009-07-21 2011-01-27 Lake Region Manufacturing, Inc. d/b/a Lake Region Medical. Inc. Methods and Devices for Delivering Drugs Using Drug-Delivery or Drug-Coated Guidewires
US8404728B2 (en) 2009-07-30 2013-03-26 Mayo Foundation For Medical Education And Research Small-molecule botulinum toxin inhibitors
US9284307B2 (en) 2009-08-05 2016-03-15 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors
JP2013502429A (ja) 2009-08-19 2013-01-24 アムビト ビオスシエンセス コルポラチオン ビアリール化合物及びその使用方法
US9017312B2 (en) * 2009-09-10 2015-04-28 Taris Biomedical Llc Implantable device for controlled drug delivery
WO2011056566A2 (en) 2009-10-26 2011-05-12 Sunesis Pharmaceuticals, Inc. Compounds and methods for treatment of cancer
WO2011056764A1 (en) 2009-11-05 2011-05-12 Ambit Biosciences Corp. Isotopically enriched or fluorinated imidazo[2,1-b][1,3]benzothiazoles
EP2499282B1 (de) 2009-11-09 2015-04-22 NeuroGenetic Pharmaceuticals, Inc. Gamma-sekretase-modulierende verbindungen, verfahren zu ihrer identifikation und verwendungen dafür
WO2011069002A1 (en) 2009-12-02 2011-06-09 Alquest Therapeutics, Inc. Organoselenium compounds and uses thereof
AU2010330862B2 (en) 2009-12-18 2015-06-25 Idenix Pharmaceuticals, Inc. 5,5-fused arylene or heteroarylene hepatitis C virus inhibitors
WO2011079313A1 (en) * 2009-12-23 2011-06-30 Map Pharmaceuticals, Inc. Novel ergoline analogs
WO2011094890A1 (en) 2010-02-02 2011-08-11 Argusina Inc. Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators
EP2542542B1 (de) 2010-03-02 2015-04-22 Axikin Pharmaceuticals, Inc. Isotopisch angereicherte arylsulfonamid-ccr3-antagonisten
WO2011112689A2 (en) 2010-03-11 2011-09-15 Ambit Biosciences Corp. Saltz of an indazolylpyrrolotriazine
AU2011227232B2 (en) 2010-03-17 2015-07-09 Axikin Pharmaceuticals Inc. Arylsulfonamide CCR3 antagonists
EP2566558B1 (de) * 2010-05-05 2019-04-17 Cook Medical Technologies LLC Intraluminale behandlungsvorrichtung, drahtführung und verfahren zur freisetzung einer behandlungsflüssigkeit
WO2011140186A1 (en) 2010-05-05 2011-11-10 Cook Medical Technologies Llc Treatment fluid delivery method, and turbulator for promoting uptake of a treatment agent
US9265913B2 (en) 2010-09-22 2016-02-23 Vital 5, Llc Catheter assembly
WO2011150198A1 (en) 2010-05-27 2011-12-01 Ambit Biosciences Corporation Azolyl urea compounds and methods of use thereof
WO2011150201A2 (en) 2010-05-27 2011-12-01 Ambit Biosciences Corporation Azolyl amide compounds and methods of use thereof
JP5844354B2 (ja) 2010-06-01 2016-01-13 ビオトヘルイク， インコーポレイテッド ヒドロキシピリドン誘導体、その医薬組成物、及び増殖性疾患治療のためのその治療的使用
JP6019015B2 (ja) 2010-06-01 2016-11-02 ビオトヘルイク， インコーポレイテッド ６−シクロヘキシル−１−ヒドロキシ−４−メチル−２（１ｈ）−ピリドンを使用する血液悪性疾患の治療方法
CN103108868B (zh) 2010-06-07 2015-11-25 诺沃梅迪科斯有限公司 呋喃基化合物及其用途
JP6069661B2 (ja) 2010-06-24 2017-02-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 種々のアミロイドβペプチドアロフォームレベルの調節における組成物及びその使用
NZ605860A (en) 2010-07-19 2015-04-24 Summa Health System Use of vitamin c, and chromium-free vitamin k or 2-methyl-1,4-naphthalendione, and compositions thereof for treating a polycystic disease
AU2011296078B2 (en) 2010-09-01 2015-06-18 Ambit Biosciences Corporation An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof
WO2012030894A1 (en) 2010-09-01 2012-03-08 Ambit Biosciences Corporation Thienopyridine and thienopyrimidine compounds and methods of use thereof
WO2012030912A1 (en) 2010-09-01 2012-03-08 Ambit Biosciences Corporation 7-cyclylquinazoline derivatives and methods of use thereof
EP2611793A1 (de) 2010-09-01 2013-07-10 Ambit Biosciences Corporation 2-cyclochinazolinderivate und verwendungsverfahren dafür
JP5901634B2 (ja) 2010-09-01 2016-04-13 アムビト ビオスシエンセス コルポラチオン キナゾリン化合物及びその使用方法
EP2611809A1 (de) 2010-09-01 2013-07-10 Ambit Biosciences Corporation Azolopyridin- und azolopyrimidinverbindungen sowie verfahren zu ihrer verwendung
WO2012030944A2 (en) 2010-09-01 2012-03-08 Ambit Biosciences Corporation Quinoline and isoquinoline compounds and methods of use thereof
WO2012030918A1 (en) 2010-09-01 2012-03-08 Ambit Biosciences Corporation Adenosine a3 receptor modulating compounds and methods of use thereof
EP2611794A1 (de) 2010-09-01 2013-07-10 Ambit Biosciences Corporation 4--azolylaminochinazolinderivate und verwendungsverfahren dafür
ES2619850T3 (es) 2010-09-01 2017-06-27 Ambit Biosciences Corporation Sales de hidrobromuro de una pirazolilaminoquinazolina
US9446224B2 (en) 2010-09-22 2016-09-20 Vital 5, L.L.C. Barrier catheter
WO2012044641A1 (en) 2010-09-29 2012-04-05 Pathway Therapeutics Inc. 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy
IT1402059B1 (it) * 2010-09-29 2013-08-28 Rand Srl Sistema indossabile per eseguire terapie depurative di fluidi organici con l'impiego di circuiti extracorporei
EP2627635A1 (de) 2010-10-11 2013-08-21 Axikin Pharmaceuticals, Inc. Salze aus arylsulfonamid-ccr3-antagonisten
TWI556849B (zh) 2010-10-21 2016-11-11 美敦力阿福盧森堡公司 用於腎臟神經協調的導管裝置
MX2013004235A (es) 2010-10-25 2013-05-30 Medtronic Ardian Luxembourg Aparatos de cateter que tienen arreglos de multiples electrodos para neuromodulacion renal y sistemas y metodos asociados.
US20120109279A1 (en) 2010-11-02 2012-05-03 Endologix, Inc. Apparatus and method of placement of a graft or graft system
EP2648676A4 (de) 2010-12-06 2016-05-04 Follica Inc Verfahren zur behandlung von kahlköpfigkeit und zur förderung des haarwuchses
WO2012080050A1 (en) 2010-12-14 2012-06-21 F. Hoffmann-La Roche Ag Solid forms of a phenoxybenzenesulfonyl compound
US9114111B2 (en) 2011-01-10 2015-08-25 Allergan, Inc. Methods for sustained treatment of bladder pain and irritative voiding
WO2012103165A2 (en) 2011-01-26 2012-08-02 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies and uses thereof
US10052459B2 (en) * 2011-01-28 2018-08-21 Cook Medical Technologies Llc Catheter assembly and method
CN103338753A (zh) 2011-01-31 2013-10-02 细胞基因公司 胞苷类似物的药物组合物及其使用方法
JP6043730B2 (ja) 2011-02-04 2016-12-14 タリス バイオメディカル エルエルシー 低溶解性薬物の制御された放出のための植込み型装置
AR085352A1 (es) 2011-02-10 2013-09-25 Idenix Pharmaceuticals Inc Inhibidores macrociclicos de serina proteasa, sus composiciones farmaceuticas y su uso para tratar infecciones por hcv
EP2691388A1 (de) 2011-03-28 2014-02-05 MEI Pharma, Inc. (kondensierte arylamino- und heterocyclylamino-)pyrimidynyl und 1,3,5-triazinyl-benzimidazole, pharmazeutische zusammensetzungen daraus und ihre verwendung zur behandlung von proliferativen erkrankungen
EP2691384B1 (de) 2011-03-28 2016-10-26 MEI Pharma, Inc. (alpha-substituierte aralkylamino- und heteroaralkylamino)-pyrimidinyl- und 1,3,5-triazinyl-benzimidazoles, sie enthaltende pharmazeutische zusammensetzungen und diese verbindungen zur verwendung bei der behandlung proliferativer erkrankungen
JP2014509648A (ja) 2011-03-28 2014-04-21 メイ プハルマ，インコーポレーテッド （α−置換シクロアルキルアミノ及びヘテロシクリルアミノ）ピリミジニル及び１，３，５−トリアジニルベンズイミダゾール、その医薬組成物、並びに増殖性疾患の治療におけるそれらの使用
US20120252721A1 (en) 2011-03-31 2012-10-04 Idenix Pharmaceuticals, Inc. Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor
CN103619377B (zh) * 2011-04-05 2017-10-03 法玛森斯股份公司 用于静脉内进入的皮肤固定装置
WO2012161875A1 (en) 2011-04-08 2012-11-29 Tyco Healthcare Group Lp Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
JP5938095B2 (ja) * 2011-04-20 2016-06-22 キナメッド・インコーポレーテッド 手術用ケーブルまたは縫合糸のための形状付与可能なパッサー
JP2014517076A (ja) 2011-06-23 2014-07-17 マップ・ファーマシューティカルズ・インコーポレイテッド 新規のフルオロエルゴリン類似体
CN103702707B (zh) * 2011-08-08 2016-03-30 奥林巴斯株式会社 处理器具
WO2013037482A1 (en) 2011-09-15 2013-03-21 Phenex Pharmaceuticals Ag Farnesoid x receptor agonists for cancer treatment and prevention
USD679804S1 (en) 2011-09-22 2013-04-09 Vital 5, Llc Catheter
US20130085468A1 (en) * 2011-10-03 2013-04-04 Yuri Buydenok Catheter with body wall separator
AU2012322095B2 (en) 2011-10-14 2017-06-29 Ambit Biosciences Corporation Heterocyclic compounds and use thereof as modulators of type III receptor tyrosine kinases
CA2859173A1 (en) 2011-12-19 2013-06-27 Map Pharmaceuticals, Inc. Novel iso-ergoline derivatives
AU2012355983A1 (en) 2011-12-21 2015-01-22 Map Pharmaceuticals, Inc. Novel neuromodulatory compounds
US9611253B2 (en) 2012-02-29 2017-04-04 Ambit Biosciences Corporation Solid forms comprising optically active pyrazolylaminoquinazoline, compositions thereof, and uses therewith
EP2834232A1 (de) 2012-03-16 2015-02-11 Axikin Pharmaceuticals, Inc. 3,5-diaminopyrazol-kinaseinhibitoren
JP6208737B2 (ja) * 2012-03-19 2017-10-04 クック・メディカル・テクノロジーズ・リミテッド・ライアビリティ・カンパニーＣｏｏｋ Ｍｅｄｉｃａｌ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｌｃ 薬剤を体内通路へと送り込むための医療装置、方法、及びキット
US10258791B2 (en) 2012-04-27 2019-04-16 Medtronic Ardian Luxembourg S.A.R.L. Catheter assemblies for neuromodulation proximate a bifurcation of a renal artery and associated systems and methods
CA3086105A1 (en) 2012-05-02 2013-11-07 Boehringer Ingelheim International Gmbh Substituted 3-haloallylamine inhibitors of ssao and uses thereof
ES2614272T3 (es) 2012-05-11 2017-05-30 Medtronic Ardian Luxembourg S.à.r.l. Conjuntos de catéter de múltiples electrodos para neuromodulación renal y sistemas y métodos asociados
EP2861562B1 (de) 2012-06-14 2018-05-09 Mayo Foundation For Medical Education And Research Pyrazolderivate als hemmer von stat3
US9878132B2 (en) 2012-06-15 2018-01-30 W. L. Gore & Associates, Inc. Vascular occlusion and drug delivery devices, systems, and methods
US9012640B2 (en) 2012-06-22 2015-04-21 Map Pharmaceuticals, Inc. Cabergoline derivatives
CA2880007C (en) 2012-07-25 2021-12-28 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies and uses thereof
US9074186B2 (en) 2012-08-15 2015-07-07 Boston Medical Center Corporation Production of red blood cells and platelets from stem cells
JP2015527396A (ja) 2012-09-07 2015-09-17 アクシキン ファーマシューティカルズ インコーポレーテッド 同位体濃縮されたアリールスルホンアミドｃｃｒ３アンタゴニスト
WO2014055647A1 (en) 2012-10-03 2014-04-10 Mei Pharma, Inc. (sulfinyl and sulfonyl benzimidazolyl) pyrimidines and triazines, pharmaceutical compositions thereof, and their use for treating proliferative diseases
US9044575B2 (en) 2012-10-22 2015-06-02 Medtronic Adrian Luxembourg S.a.r.l. Catheters with enhanced flexibility and associated devices, systems, and methods
CA2890177A1 (en) 2012-11-08 2014-05-15 Summa Health System Vitamin c, vitamin k, a polyphenol, and combinations thereof for wound healing
US9095321B2 (en) 2012-11-21 2015-08-04 Medtronic Ardian Luxembourg S.A.R.L. Cryotherapeutic devices having integral multi-helical balloons and methods of making the same
AU2013352106B2 (en) 2012-11-30 2018-04-26 Novomedix, Llc Substituted biaryl sulfonamides and the use thereof
US9409003B2 (en) 2012-12-07 2016-08-09 Cook Medical Technologies, LLC System for reducing local discomfort
EP2934143A4 (de) 2012-12-21 2016-06-15 Map Pharmaceuticals Inc Neuartige methysergidderivate
US9169214B2 (en) 2012-12-21 2015-10-27 The Board Of Trustees Of The Leland Stanford Junior University Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
CA2897665A1 (en) 2013-01-11 2014-07-17 Mayo Foundation For Medical Education And Research Vitamins c and k for treating polycystic diseases
EP3623002A1 (de) * 2013-01-15 2020-03-18 A.V. Medical Technologies, Ltd. Katheter
US20140228801A1 (en) * 2013-02-12 2014-08-14 Gary Keeling Body cavity drainage device and methods for using the same
WO2014165263A1 (en) 2013-03-12 2014-10-09 The Regents Of The University Of California, A California Corporation Gamma-secretase modulators
US9179974B2 (en) 2013-03-15 2015-11-10 Medtronic Ardian Luxembourg S.A.R.L. Helical push wire electrode
JP6517186B2 (ja) 2013-03-15 2019-05-22 タリス バイオメディカル エルエルシー 薬物透過性構成部材を備えた薬物送達デバイス、及び方法
WO2014189794A1 (en) 2013-05-18 2014-11-27 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters with shafts for enhanced flexibility and control and associated devices, systems, and methods
KR101548046B1 (ko) * 2013-06-05 2015-09-04 이근호 감염 방지구조의 소아용 요도 삽입용 카테타
NZ714765A (en) 2013-06-06 2021-12-24 Pf Medicament Anti-c10orf54 antibodies and uses thereof
AU2014309012B2 (en) 2013-08-19 2019-03-14 Taris Biomedical Llc Multi-unit drug delivery devices and methods
CA2922230A1 (en) 2013-08-30 2015-03-05 Ambit Biosciences Corporation Biaryl acetamide compounds and methods of use thereof
US20150073515A1 (en) 2013-09-09 2015-03-12 Medtronic Ardian Luxembourg S.a.r.I. Neuromodulation Catheter Devices and Systems Having Energy Delivering Thermocouple Assemblies and Associated Methods
NZ631142A (en) 2013-09-18 2016-03-31 Axikin Pharmaceuticals Inc Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
WO2015042375A1 (en) 2013-09-20 2015-03-26 Idenix Pharmaceuticals, Inc. Hepatitis c virus inhibitors
US10517892B2 (en) * 2013-10-22 2019-12-31 Medtronic Minimed, Inc. Methods and systems for inhibiting foreign-body responses in diabetic patients
AU2015205391B2 (en) 2014-01-08 2018-11-08 A.V. Medical Technologies, Ltd Devices and methods for imaging and treating blood vessels
EP4059563B1 (de) 2014-01-27 2023-09-27 Medtronic Ireland Manufacturing Unlimited Company Neuromodulationskatheter mit ummantelten neuromodulationselementen und zugehörige vorrichtungen
WO2015123320A1 (en) * 2014-02-11 2015-08-20 All Cape Gynecology Llc Endocyte cannula
EP3110974A4 (de) 2014-02-24 2018-01-24 Celgene Corporation Verfahren zur verwendung eines aktivators von cereblon für neuronale zellexpansion und behandlung von erkrankungen des zentralnervensystems
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
EP3114122A1 (de) 2014-03-05 2017-01-11 Idenix Pharmaceuticals LLC Feste formen einer flaviviridae-virus-hemmerverbindung und salze davon
WO2015143161A1 (en) 2014-03-20 2015-09-24 Capella Therapeutics, Inc. Benzimidazole derivatives as erbb tyrosine kinase inhibitors for the treatment of cancer
TWI683813B (zh) 2014-03-20 2020-02-01 美商卡佩拉醫療公司 苯并咪唑衍生物及其醫藥組合物及使用方法
CN106232043B (zh) 2014-04-24 2019-07-23 美敦力阿迪安卢森堡有限公司 具有编织轴的神经调节导管以及相关的系统和方法
WO2015175381A1 (en) 2014-05-12 2015-11-19 Conatus Pharmaceuticals, Inc. Treatment of the complications of chronic liver disease with caspase inhibitors
US11000658B2 (en) 2014-05-18 2021-05-11 Awair, Inc. Device to reduce discomfort in the upper airway
CA2949998A1 (en) 2014-05-28 2015-12-03 Agenus Inc. Anti-gitr antibodies and methods of use thereof
WO2015195474A1 (en) 2014-06-18 2015-12-23 Biotheryx, Inc. Hydroxypyridone derivatives, pharmaceutical compositions thereof, and their therapeutic use for treating inflammatory, neurodegenerative, or immune-mediated diseases
US9499514B2 (en) 2014-07-11 2016-11-22 Celgene Corporation Antiproliferative compounds and methods of use thereof
WO2016025129A1 (en) 2014-08-14 2016-02-18 Alhamadsheh Mamoun M Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life
CA2960284A1 (en) 2014-09-12 2016-03-17 Tobira Therapeutics, Inc. Cenicriviroc combination therapy for the treatment of fibrosis
EP3209658A1 (de) 2014-10-24 2017-08-30 Biogen MA Inc. Diterpenoidderivate und verfahren zur verwendung
WO2016070107A1 (en) 2014-10-31 2016-05-06 The General Hospital Corporation Potent gamma-secretase modulators
CN108064167A (zh) 2014-12-11 2018-05-22 皮埃尔法布雷医药公司 抗c10orf54抗体及其用途
CA2972048C (en) 2014-12-22 2023-03-07 The Rockefeller University Anti-mertk agonistic antibodies and uses thereof
WO2016106309A1 (en) 2014-12-23 2016-06-30 Axikin Pharmaceuticals, Inc. 3,5-diaminopyrazole kinase inhibitors
JP6856532B2 (ja) 2015-01-20 2021-04-07 エックスオーシー ファーマシューティカルズ インコーポレイテッドＸｏｃ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ エルゴリン化合物およびその使用
MX2017009406A (es) 2015-01-20 2018-01-18 Xoc Pharmaceuticals Inc Compuestos de tipo isoergolina y usos de estos.
US20180002328A1 (en) 2015-01-28 2018-01-04 Jn Therapeutics Substituted imidazo[1, 2-a]pyridin-2-ylamine compounds, and pharmaceutical compositions and methods of use thereof
ES2937020T3 (es) 2015-03-03 2023-03-23 Kymab Ltd Anticuerpos, usos y métodos
JP7425534B2 (ja) 2015-04-23 2024-01-31 タリス バイオメディカル エルエルシー 薬物透過性構成要素を有する薬物送達デバイス及び方法
LT3303394T (lt) 2015-05-29 2020-10-12 Agenus Inc. Anti-ctla-4 antikūnai ir jų naudojimo būdai
MY189806A (en) 2015-06-23 2022-03-08 Neurocrine Biosciences Inc Vmat2 inhibitors for treating neurological diseases or disorders
US11129737B2 (en) 2015-06-30 2021-09-28 Endologix Llc Locking assembly for coupling guidewire to delivery system
US10493232B2 (en) 2015-07-20 2019-12-03 Strataca Systems Limited Ureteral catheters, bladder catheters, systems, kits and methods for inducing negative pressure to increase renal function
US11040180B2 (en) 2015-07-20 2021-06-22 Strataca Systems Limited Systems, kits and methods for inducing negative pressure to increase renal function
US10918827B2 (en) 2015-07-20 2021-02-16 Strataca Systems Limited Catheter device and method for inducing negative pressure in a patient's bladder
US11541205B2 (en) 2015-07-20 2023-01-03 Roivios Limited Coated urinary catheter or ureteral stent and method
US10765834B2 (en) 2015-07-20 2020-09-08 Strataca Systems Limited Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion
US11229771B2 (en) 2015-07-20 2022-01-25 Roivios Limited Percutaneous ureteral catheter
US11040172B2 (en) 2015-07-20 2021-06-22 Strataca Systems Limited Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion
AU2016296866B2 (en) 2015-07-20 2018-07-19 Roivios Limited Ureteral and bladder catheters and methods for inducing negative pressure to increase renal perfusion
US10926062B2 (en) 2015-07-20 2021-02-23 Strataca Systems Limited Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion
US10512713B2 (en) 2015-07-20 2019-12-24 Strataca Systems Limited Method of removing excess fluid from a patient with hemodilution
CN114605548A (zh) 2015-09-01 2022-06-10 艾吉纳斯公司 抗-pd-1抗体及其使用方法
FI3875459T3 (fi) 2015-10-30 2024-02-14 Neurocrine Biosciences Inc Valbenatsiinin dihydrokloridisuoloja ja niiden polymorfeja
WO2017079566A1 (en) 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Caspase inhibitors for use in the treatment of liver cancer
US10112924B2 (en) 2015-12-02 2018-10-30 Astraea Therapeutics, Inc. Piperdinyl nociceptin receptor compounds
RS63170B1 (sr) 2015-12-23 2022-05-31 Neurocrine Biosciences Inc Sintetički postupak za pripremanje (s)-(2r,3r,11br)-3-izobutil-9,10-dimetoksi-2,3,4,6,7,11b-heksahidro-1h-pirido[2,1,-a]izohinolin-2-il 2-amino-3-metilbutanoat di(4-metilbenzensulfonata)
MX2018007964A (es) 2015-12-31 2018-11-09 Conatus Pharmaceuticals Inc Metodos de uso de inhibidores de caspasas en el tratamiento de la enfermedad hepatica.
US10189808B2 (en) 2016-01-08 2019-01-29 Celgene Corporation Solid forms of 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide, and their pharmaceutical compositions and uses
TWI717448B (zh) 2016-01-08 2021-02-01 美商西建公司 抗增生化合物,及其醫藥組合物及用途
US10960013B2 (en) 2016-03-04 2021-03-30 East Carolina University J-series prostaglandin-ethanolamides as novel therapeutics for skin and/or oral disorders
EP3426301A4 (de) 2016-03-08 2019-11-06 Los Gatos Pharmaceuticals, Inc. Verbundnanopartikel und verwendungen davon
EP3426352A4 (de) 2016-03-08 2019-11-13 Los Gatos Pharmaceuticals, Inc. Camptothecin-derivate und verwendungen davon
JP2019513707A (ja) 2016-04-11 2019-05-30 クレキシオ バイオサイエンシーズ エルティーディー． 重水素化ケタミン誘導体
US10047077B2 (en) 2016-04-13 2018-08-14 Skyline Antiinfectives, Inc. Deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams
JP7092680B2 (ja) * 2016-04-15 2022-06-28 テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 注入カテーテル及び使用方法
US20170319818A1 (en) * 2016-05-06 2017-11-09 Cook Medical Technologies Llc Drug delivery device
WO2017194789A1 (en) 2016-05-13 2017-11-16 Institut Pasteur Inhibition of beta-2 nicotinic acetylcholine receptors to treat alzheimer's disease pathology
TWI753910B (zh) 2016-05-16 2022-02-01 美商拜歐斯瑞克斯公司 吡啶硫酮、其醫藥組合物及其治療增生性、炎性、神經退化性或免疫介導疾病之治療用途
KR102543118B1 (ko) 2016-05-27 2023-06-14 아게누스 인코포레이티드 항-tim-3 항체 및 이의 사용 방법
EP3756721B1 (de) * 2016-06-09 2022-09-14 Boston Scientific Scimed Inc. Infusionskatheter
CA3030099A1 (en) 2016-07-08 2018-01-11 Staten Biotechnology B.V. Anti-apoc3 antibodies and methods of use thereof
WO2018035281A1 (en) 2016-08-17 2018-02-22 North Carolina State University Northern-southern route to synthesis of bacteriochlorins
EP3515414B1 (de) 2016-09-19 2022-11-30 MEI Pharma, Inc. Kombinationstherapie
CA3037380A1 (en) 2016-10-11 2018-04-19 Agenus Inc. Anti-lag-3 antibodies and methods of use thereof
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
AU2017353939A1 (en) 2016-11-07 2019-06-06 Neuracle Science Co., Ltd. Anti-family with sequence similarity 19, member A5 antibodies and method of use thereof
US10106521B2 (en) 2016-11-09 2018-10-23 Phloronol, Inc. Eckol derivatives, methods of synthesis and uses thereof
AU2017356926B2 (en) 2016-11-09 2024-01-04 Novomedix, Llc Nitrite salts of 1, 1-dimethylbiguanide, pharmaceutical compositions, and methods of use
US10836774B2 (en) 2016-11-30 2020-11-17 North Carolina State University Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds
CN110191705A (zh) 2016-12-01 2019-08-30 亚尼塔公司 治疗癌症的方法
US20200078352A1 (en) 2016-12-02 2020-03-12 Neurocrine Biosciences, Inc. Use of Valbenazine for Treating Schizophrenia or Schizoaffective Disorder
ES2963226T3 (es) 2016-12-07 2024-03-26 Agenus Inc Anticuerpos ANTI-CTLA-4 y métodos de uso de los mismos
PE20190921A1 (es) 2016-12-07 2019-06-26 Agenus Inc Anticuerpos y metodos de su utilizacion
MY191077A (en) 2017-01-27 2022-05-30 Neurocrine Biosciences Inc Methods for the administration of certain vmat2 inhibitors
IL298196A (en) 2017-02-17 2023-01-01 Eidos Therapeutics Inc Processes for the preparation of ag-10, its intermediates and salts
JP7307681B2 (ja) 2017-02-17 2023-07-12 カムリス インターナショナル インコーポレイテッド 汎用性抗毒素
WO2018164996A1 (en) 2017-03-06 2018-09-13 Neurocrine Biosciences, Inc. Dosing regimen for valbenazine
JP7237848B2 (ja) 2017-03-27 2023-03-13 セルジーン コーポレイション 免疫原性の低下のための方法及び組成物
MA50956A (fr) 2017-04-13 2020-10-14 Agenus Inc Anticorps anti-cd137 et procédés d'utilisation correspondants
WO2018193427A1 (en) 2017-04-21 2018-10-25 Staten Biotechnology B.V. Anti-apoc3 antibodies and methods of use thereof
WO2018200605A1 (en) 2017-04-26 2018-11-01 Neurocrine Biosciences, Inc. Use of valbenazine for treating levodopa-induced dyskinesia
ES2952961T3 (es) 2017-05-01 2023-11-07 Agenus Inc Anticuerpos anti-TIGIT y métodos de uso de los mismos
JOP20190219A1 (ar) 2017-05-09 2019-09-22 Cardix Therapeutics LLC تركيبات صيدلانية وطرق لعلاج أمراض القلب والأوعية الدموية
US10085999B1 (en) 2017-05-10 2018-10-02 Arixa Pharmaceuticals, Inc. Beta-lactamase inhibitors and uses thereof
BR112019025420A2 (pt) 2017-06-01 2020-06-16 Xoc Pharmaceuticals, Inc. Compostos policíclicos e usos destes
JP6904616B2 (ja) 2017-06-27 2021-07-21 ニューラクル サイエンス カンパニー リミテッド 緑内障治療のための配列相同性を有するファミリー、メンバーａ５抗体の用途
CN111344011B (zh) 2017-06-27 2024-01-26 纽洛可科学有限公司 抗fam19a5抗体用于治疗纤维化的用途
AU2018291082A1 (en) 2017-06-27 2020-01-16 Neuracle Science Co., Ltd. Anti-FAM19A5 antibodies and uses thereof
KR20230142819A (ko) 2017-06-27 2023-10-11 주식회사 뉴라클사이언스 암 치료를 위한 항-fam19a5 항체의 용도
US10307566B2 (en) 2017-07-05 2019-06-04 Duke University Drainage or infusion catheter and method of use
EP3675866B1 (de) 2017-09-01 2023-08-02 East Carolina University Ex vivo verfahren zur aktivierung von immunzellen
CN111372567B (zh) 2017-09-21 2024-03-15 纽罗克里生物科学有限公司 高剂量的缬苯那嗪制剂和与其相关的组合物、方法和试剂盒
US10993941B2 (en) 2017-10-10 2021-05-04 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
AU2017435893B2 (en) 2017-10-10 2023-06-29 Neurocrine Biosciences, Inc Methods for the administration of certain VMAT2 inhibitors
JP7039694B2 (ja) 2017-10-31 2022-03-22 スターテン・バイオテクノロジー・ベー・フェー 抗ａｐｏｃ３抗体およびその使用方法
MX2020006274A (es) * 2017-12-28 2020-09-14 Avent Inc Tuneleador de incision.
WO2019139871A1 (en) 2018-01-10 2019-07-18 Cura Therapeutics Llc Pharmaceutical compositions comprising dicarboxylic acids and their therapeutic applications
JP7395480B2 (ja) 2018-01-10 2023-12-11 クラ セラピューティクス， エルエルシー フェニルスルホンアミドを含む薬学的組成物、及びそれらの治療的適用
US11116561B2 (en) 2018-01-24 2021-09-14 Medtronic Ardian Luxembourg S.A.R.L. Devices, agents, and associated methods for selective modulation of renal nerves
MA52137A (fr) 2018-03-23 2021-01-27 Eidos Therapeutics Inc Méthodes de traitement de l'amylose ttr à l'aide d'ag10
CA3097999A1 (en) 2018-04-24 2019-10-31 Neuracle Science Co., Ltd. Use of anti-family with sequence similarity 19, member a5 antibodies for the treatment of neuropathic pain
SG11202011544UA (en) 2018-06-14 2020-12-30 Neurocrine Biosciences Inc Vmat2 inhibitor compounds, compositions, and methods relating thereto
EP3814327A1 (de) 2018-06-29 2021-05-05 Histogen, Inc. (s)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorphenoxy)pentansäure-derivate und verwandte verbindungen als caspase-inhibitoren zur behandlung kardiovaskulärer erkrankungen
AU2019306165A1 (en) 2018-07-20 2021-02-25 Pierre Fabre Medicament Receptor for vista
CN112867491A (zh) 2018-08-15 2021-05-28 纽罗克里生物科学有限公司 施用某些vmat2抑制剂的方法
JP2021534189A (ja) 2018-08-17 2021-12-09 エイドス セラピューティクス，インコーポレイティド Ａｇ１０の製剤
JP2022504287A (ja) 2018-10-03 2022-01-13 スターテン・バイオテクノロジー・ベー・フェー ヒト及びカニクイザルａｐｏｃ３に特異的な抗体、並びにその使用の方法
WO2020102728A1 (en) 2018-11-16 2020-05-22 Neoimmunetech, Inc. Method of treating a tumor with a combination of il-7 protein and an immune checkpoint inhibitor
KR20200071198A (ko) 2018-12-10 2020-06-19 네오이뮨텍, 인코퍼레이티드 Nrf2 발현 조절 기반 T 세포 항암면역치료법
WO2020132071A1 (en) 2018-12-19 2020-06-25 Shy Therapeutics. Llc Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and f1brotic disease
EP3921038A1 (de) 2019-02-06 2021-12-15 Dice Alpha, Inc. Il-17a modulators and uses thereof
EP3930847B1 (de) 2019-02-26 2024-02-14 Inspirna, Inc. Anti-mertk-antikörper mit hoher affinität und ihre verwendung
US11597703B2 (en) 2019-03-07 2023-03-07 Histogen, Inc. Caspase inhibitors and methods of use thereof
EP3959293A4 (de) 2019-05-20 2022-12-28 NIRvana Sciences Inc. Farbstoffe mit geringer emission, zusammensetzungen damit und verfahren zu ihrer herstellung und verwendung
CA3146159A1 (en) 2019-07-11 2021-01-14 Cura Therapeutics, Llc Phenyl compounds and pharmaceutical compositions thereof, and their therapeutic applications
WO2021007478A1 (en) 2019-07-11 2021-01-14 Cura Therapeutics, Llc Sulfone compounds and pharmaceutical compositions thereof, and their therapeutic applications for the treatment of neurodegenerative diseases
US10940141B1 (en) 2019-08-23 2021-03-09 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
TW202122420A (zh) 2019-08-30 2021-06-16 美商艾吉納斯公司 抗ｃｄ９６抗體及其使用方法
CN115103835A (zh) 2019-09-16 2022-09-23 戴斯阿尔法公司 Il-17a调节剂及其用途
IL294663A (en) 2020-01-13 2022-09-01 Neoimmunetech Inc A method for tumor treatment with a combination of il-7 protein and a bispecific antibody
EP4093751A1 (de) 2020-01-22 2022-11-30 Outpace Bio, Inc. Chimäre polypeptide
EP4100045A1 (de) 2020-02-05 2022-12-14 Washington University Verfahren zur behandlung eines festen tumors mit einer kombination aus einem il-7-protein und car-tragenden immunzellen
EP4157271A1 (de) 2020-05-29 2023-04-05 Boulder Bioscience LLC Verfahren zur verbesserten endovaskulären thrombektomie mit 3,3'-diindolylmethan
WO2021257828A1 (en) 2020-06-18 2021-12-23 Shy Therapeutics, Llc Substituted thienopyrimidines that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
TW202227427A (zh) 2020-09-16 2022-07-16 美商拜歐斯瑞克斯公司 Sos1蛋白降解劑、其醫藥組合物及其治療應用
WO2022087335A1 (en) 2020-10-23 2022-04-28 Biotheryx, Inc. Kras protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
US20240101629A1 (en) 2020-11-02 2024-03-28 Neoimmunetech, Inc. Use of interleukin-7 for the treatment of coronavirus
IL302482A (en) 2020-11-05 2023-06-01 Neoimmunetech Inc A method for tumor treatment with a combination of IL-7 protein and a nucleotide vaccine
KR20230157936A (ko) 2020-12-14 2023-11-17 바이오테릭스, 인코포레이티드 Pde4 분해인자, 약제학적 조성물, 및 치료학적 적용
WO2022164997A1 (en) 2021-01-27 2022-08-04 Shy Therapeutics, Llc Methods for the treatment of fibrotic disease
WO2022165000A1 (en) 2021-01-27 2022-08-04 Shy Therapeutics, Llc Methods for the treatment of fibrotic disease
EP4304716A1 (de) 2021-03-10 2024-01-17 Dice Molecules Sv, Inc. Alpha-v-beta-6- und alpha-v-beta-1-integrinhemmer und verwendungen davon
WO2022226166A1 (en) 2021-04-22 2022-10-27 Protego Biopharma, Inc. Spirocyclic imidazolidinones and imidazolidinediones for treatment of light chain amyloidosis
EP4347568A1 (de) 2021-05-27 2024-04-10 Protego Biopharma, Inc. Heteroaryldiamid-ire1/xbp1s-aktivatoren
WO2022251644A1 (en) 2021-05-28 2022-12-01 Lyell Immunopharma, Inc. Nr4a3-deficient immune cells and uses thereof
AU2022286947A1 (en) 2021-06-02 2023-12-14 Lyell Immunopharma, Inc. NR4A-deficient cells expressing c-Jun and uses thereof
IL309349A (en) 2021-06-14 2024-02-01 argenx BV Antibodies against interleukin 9 and methods of using them
CA3222240A1 (en) 2021-06-16 2022-12-22 Biotheryx, Inc. Sos1 protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
WO2022266249A1 (en) 2021-06-16 2022-12-22 Biotheryx, Inc. Kras protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
CN113546277B (zh) * 2021-07-23 2022-07-01 云南省阜外心血管病医院 一种刚度快速调整的医用导管结构
WO2023081923A1 (en) 2021-11-08 2023-05-11 Frequency Therapeutics, Inc. Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof
WO2023130081A1 (en) 2021-12-30 2023-07-06 Neoimmunetech, Inc. Method of treating a tumor with a combination of il-7 protein and vegf antagonist
US11932665B2 (en) 2022-01-03 2024-03-19 Lilac Therapeutics, Inc. Cyclic thiol prodrugs
TW202342070A (zh) 2022-03-30 2023-11-01 美商拜奧馬林製藥公司 肌萎縮蛋白外顯子跳躍寡核苷酸
GB2619907A (en) 2022-04-01 2023-12-27 Kanna Health Ltd Novel crystalline salt forms of mesembrine
US20230331693A1 (en) 2022-04-14 2023-10-19 Bristol-Myers Squibb Company Gspt1 compounds and methods of use of the novel compounds
WO2023215781A1 (en) 2022-05-05 2023-11-09 Biomarin Pharmaceutical Inc. Method of treating duchenne muscular dystrophy
WO2023220640A1 (en) 2022-05-10 2023-11-16 Biotheryx, Inc. Cdk protein degraders, pharmaceutical compositions, and therapeutic applications
WO2023225665A1 (en) 2022-05-19 2023-11-23 Lyell Immunopharma, Inc. Polynucleotides targeting nr4a3 and uses thereof
CN115253019B (zh) * 2022-08-11 2023-06-30 临沂市兴华医用器材有限公司 一种防损伤的加强型麻醉导管
WO2024054832A1 (en) 2022-09-09 2024-03-14 Innovo Therapeutics, Inc. CK1α AND DUAL CK1α / GSPT1 DEGRADING COMPOUNDS

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4693243A (en) * 1983-01-14 1987-09-15 Buras Sharon Y Conduit system for directly administering topical anaesthesia to blocked laryngeal-tracheal areas
US4813925A (en) * 1987-04-21 1989-03-21 Medical Engineering Corporation Spiral ureteral stent
NZ228382A (en) * 1989-03-17 1992-08-26 Carter Holt Harvey Plastic Pro Drug administering coil-like device for insertion in body cavity of animal
US4994033A (en) * 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US5049132A (en) * 1990-01-08 1991-09-17 Cordis Corporation Balloon catheter for delivering therapeutic agents
US5221261A (en) * 1990-04-12 1993-06-22 Schneider (Usa) Inc. Radially expandable fixation member
US5102402A (en) * 1991-01-04 1992-04-07 Medtronic, Inc. Releasable coatings on balloon catheters
US5181911A (en) * 1991-04-22 1993-01-26 Shturman Technologies, Inc. Helical balloon perfusion angioplasty catheter
US5256146A (en) * 1991-10-11 1993-10-26 W. D. Ensminger Vascular catheterization system with catheter anchoring feature

Also Published As

Publication number Publication date
WO1995020416A1 (en) 1995-08-03
US5709874A (en) 1998-01-20
ATE296660T1 (de) 2005-06-15
AU682582B2 (en) 1997-10-09
AU1868395A (en) 1995-08-15
DE69534245T2 (de) 2006-01-26
EP0754072A4 (de) 1998-01-14
ES2243934T3 (es) 2005-12-01
JPH10500028A (ja) 1998-01-06
EP0754072A1 (de) 1997-01-22
DK0754072T3 (da) 2005-09-05
CA2182201A1 (en) 1995-08-03
PT754072E (pt) 2005-10-31
EP0754072B1 (de) 2005-06-01
US5523092A (en) 1996-06-04

Similar Documents

Publication Publication Date Title
ATE296660T1 (de) Vorrichtung zur lokalen verabreichung einer arznei
ATE273024T1 (de) Vorrichtung zur erhöhung der flüssigkeitsdurchflussgeschwindigkeit in einem biologischen gewebe mit mikroporen
ATE298259T1 (de) Vorrichtung zur lokalen verabreichung einer arznei in einer körperhöhle
IL156848A0 (en) Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites
ATE275880T1 (de) Vorrichtung zur umgehung von arteriellen verengungen und/oder zur ausführung anderer transvaskularer eingriffe
ATE90000T1 (de) System zur parenteralen verabreichung eines wirkstoffs.
WO1998049972A3 (en) Differential treatment of prosthetic devices
BR9807916A (pt) Conjunto de dispositivo biomédico, método para inibir substancialmente a reestenose em um vaso sanguìneo de um paciente, método para fabricar um conjunto de dispositivo biomédico.
ATE444042T1 (de) Stent und system aus stent und ballon zur verbesserung des blutflusses
SE8405227D0 (sv) Kateterfestanordning
DK0569552T3 (da) Intramedullær kateter
BR9610869A (pt) Cateter destinado particulamente a ser colocado numa cavidade de corpo para diálise peritoneal
ATE288776T1 (de) Ausdehnbare vorrichtung zur behandlung von tumoren
ATE267032T1 (de) Kathetersystem zur durchführung einer intramyokardialen therapeutischen behandlung
ATE202272T1 (de) Vorrichtung mit mehreren strömungspfaden zur oralen verabreichung von boluseinheiten
ATE226094T1 (de) Verfahren zur arzneistoffabgabe mittels gentherapie
SE0202172L (sv) Anordning och metod för cirkulatorisk isolering och behandling av kroppsdel
ATE87489T1 (de) Vorrichtung zur retroperfusion des koerpers zum zweck der heilung einer krankheit oder einer immunschwaeche.
PT1246662E (pt) Sistema de administracao de um agente benefico ormotico
ATE383883T1 (de) Medizinische vorrichtung für die herstellung und abgabe einer mit gas angereicherten flüssigkeit
IL141117A0 (en) Means for retaining transcutaneous catheters and needles in place
WO2001017582A3 (en) Bifurcated shunt drug delivery system and methods of use
CN2597004Y (zh) 前列腺电液通输治疗仪专用导管探头

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee