DE69535785D1 - Tumornekrosefaktor-rezeptor-assoziierte faktoren - Google Patents
Tumornekrosefaktor-rezeptor-assoziierte faktorenInfo
- Publication number
- DE69535785D1 DE69535785D1 DE69535785T DE69535785T DE69535785D1 DE 69535785 D1 DE69535785 D1 DE 69535785D1 DE 69535785 T DE69535785 T DE 69535785T DE 69535785 T DE69535785 T DE 69535785T DE 69535785 D1 DE69535785 D1 DE 69535785D1
- Authority
- DE
- Germany
- Prior art keywords
- factor receptor
- receptor associated
- associated factors
- nuclear factor
- tnf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/250,858 US5708142A (en) | 1994-05-27 | 1994-05-27 | Tumor necrosis factor receptor-associated factors |
US08/331,394 US5670319A (en) | 1994-05-27 | 1994-10-28 | Assay for tumor necrosis factor receptor-associated factors |
US08/446,915 US5741667A (en) | 1994-05-27 | 1995-05-22 | Tumor necrosis factor receptor-associated factors |
PCT/US1995/006639 WO1995033051A1 (en) | 1994-05-27 | 1995-05-25 | Tumor necrosis factor receptor-associated factors |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69535785D1 true DE69535785D1 (de) | 2008-08-21 |
Family
ID=22949430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69535785T Expired - Fee Related DE69535785D1 (de) | 1994-05-27 | 1995-05-25 | Tumornekrosefaktor-rezeptor-assoziierte faktoren |
Country Status (8)
Country | Link |
---|---|
US (6) | US5708142A (de) |
EP (1) | EP2011873A3 (de) |
JP (2) | JP4187263B2 (de) |
AT (1) | ATE400652T1 (de) |
DE (1) | DE69535785D1 (de) |
DK (1) | DK0760851T3 (de) |
ES (1) | ES2310413T3 (de) |
PT (1) | PT760851E (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5708142A (en) * | 1994-05-27 | 1998-01-13 | Genentech, Inc. | Tumor necrosis factor receptor-associated factors |
US6355780B1 (en) * | 1995-02-22 | 2002-03-12 | Yeda Research And Development Co. Ltd. | Antibodies to the death domain motifs of regulatory proteins |
AU3305197A (en) * | 1996-06-06 | 1998-01-05 | University Of Massachusetts | Non-activated receptor complex proteins and uses thereof |
CA2274987C (en) | 1996-12-23 | 2012-01-24 | Immunex Corporation | Ligand for receptor activator of nf-kappa b, ligand is member of tnf superfamily |
US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
US6143507A (en) * | 1998-10-29 | 2000-11-07 | Boehringer Ingelheim Pharmaceuticals, Inc. | High throughput compatible assay for receptor-TRAF interactions |
US6627199B1 (en) * | 1999-07-09 | 2003-09-30 | Amgen Inc | Isolation, identification and characterization of tmst2, a novel member of the TNF-receptor supergene family |
DE122010000047I1 (de) | 2001-06-26 | 2011-05-05 | Amgen Fremont Inc | Antikörper gegen opgl |
IL160651A0 (en) * | 2001-08-31 | 2004-07-25 | Agensys Inc | Nucleic acid and correspondidng protein entitled 205pib5 and pharmaceutical compositions containing the same |
WO2004060319A2 (en) * | 2002-12-30 | 2004-07-22 | 3M Innovative Properties Company | Immunostimulatory combinations |
WO2005021578A2 (en) * | 2004-08-25 | 2005-03-10 | Amprotein Corporation | A novel chimeric polypeptide and use thereof |
US9081017B2 (en) * | 2005-04-11 | 2015-07-14 | Cambridge Enterprise Limited | Methods for identifying modulators of tumor necrosis factor receptors |
US20100034808A1 (en) * | 2006-11-21 | 2010-02-11 | Toru Nakazawa | Compositions and methods for preserving cells of the eye |
EP2131834A2 (de) * | 2007-04-11 | 2009-12-16 | Alcon Research, Ltd. | Verwendung eines tnfa-hemmers und eines antihistamins zur behandlung von allergischer rhinitis und allergischer konjunktivitis |
US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
BR112012007091A2 (pt) * | 2009-10-01 | 2016-04-19 | Alcon Res Ltd | composições de olopatadina e seus usos |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US3691016A (en) | 1970-04-17 | 1972-09-12 | Monsanto Co | Process for the preparation of insoluble enzymes |
CA1023287A (en) | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
GB1479268A (en) | 1973-07-05 | 1977-07-13 | Beecham Group Ltd | Pharmaceutical compositions |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US3959642A (en) | 1975-02-06 | 1976-05-25 | Lawrence Peska Associates, Inc. | Incense lamp |
US4195128A (en) | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
US4330440A (en) | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
CA1093991A (en) | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
US4229537A (en) | 1978-02-09 | 1980-10-21 | New York University | Preparation of trichloro-s-triazine activated supports for coupling ligands |
US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
DE3169595D1 (en) | 1980-11-10 | 1985-05-02 | Gersonde Klaus | Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application |
US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
JPS58118008A (ja) | 1982-01-06 | 1983-07-13 | Nec Corp | デ−タ処理装置 |
DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
EP0102324A3 (de) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
AU2353384A (en) | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
EP0142641B1 (de) | 1983-09-26 | 1991-01-16 | Udo Dr. Ehrenfeld | Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr |
US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
US4615885A (en) | 1983-11-01 | 1986-10-07 | Terumo Kabushiki Kaisha | Pharmaceutical composition containing urokinase |
US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
WO1987005330A1 (en) | 1986-03-07 | 1987-09-11 | Michel Louis Eugene Bergh | Method for enhancing glycoprotein stability |
US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
DE3613167A1 (de) * | 1986-04-18 | 1987-10-29 | Basf Ag | Verwendung von tnf zur herstellung von arzneimitteln |
GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
EP0266032A1 (de) | 1986-08-29 | 1988-05-04 | Beecham Group Plc | Modifiziertes fibrinolytisches Enzym |
IL87737A (en) | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
PT88641B (pt) | 1987-10-02 | 1993-04-30 | Genentech Inc | Metodo para a preparacao de uma variante de adesao |
GB8724885D0 (en) | 1987-10-23 | 1987-11-25 | Binns M M | Fowlpox virus promotors |
EP0321196A3 (de) | 1987-12-18 | 1990-07-18 | Mycogen Plant Science, Inc. | Transkriptionsaktivator des 780 T-DNA-Gens |
DE68925971T2 (de) | 1988-09-23 | 1996-09-05 | Cetus Oncology Corp | Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte |
AU4660789A (en) | 1988-11-23 | 1990-06-12 | Genentech Inc. | Polypeptide derivatives |
EP0402226A1 (de) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformationsvektoren für Hefe Yarrowia |
EP0739904A1 (de) | 1989-06-29 | 1996-10-30 | Medarex, Inc. | Bispezifische Reagenzien für die AIDS-Therapie |
US5395760A (en) * | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
DE59010933D1 (de) * | 1989-09-12 | 2003-05-08 | Hoffmann La Roche | TFN-bindende Proteine |
EP0502036B1 (de) | 1989-11-22 | 1995-12-20 | Genentech, Inc. | Latenz assoziierte peptide und deren verwendung |
DE69132709T2 (de) | 1990-06-29 | 2002-06-20 | Large Scale Biology Corp | Melaninproduktion durch transformierte mikroorganismen |
WO1992022653A1 (en) | 1991-06-14 | 1992-12-23 | Genentech, Inc. | Method for making humanized antibodies |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
US5708142A (en) * | 1994-05-27 | 1998-01-13 | Genentech, Inc. | Tumor necrosis factor receptor-associated factors |
US5741667A (en) * | 1994-05-27 | 1998-04-21 | Genentech, Inc. | Tumor necrosis factor receptor-associated factors |
IL114418A0 (en) * | 1994-07-07 | 1995-10-31 | Res Dev Foundation | Tumor necrosis factor receptor-II associated protein kinase and methods for its use |
AU2307697A (en) | 1996-04-11 | 1997-10-29 | Mochida Pharmaceutical Co., Ltd. | Novel signal transducer |
-
1994
- 1994-05-27 US US08/250,858 patent/US5708142A/en not_active Expired - Lifetime
- 1994-10-28 US US08/331,394 patent/US5670319A/en not_active Expired - Lifetime
-
1995
- 1995-05-25 EP EP08012298A patent/EP2011873A3/de not_active Withdrawn
- 1995-05-25 AT AT95922112T patent/ATE400652T1/de not_active IP Right Cessation
- 1995-05-25 ES ES95922112T patent/ES2310413T3/es not_active Expired - Lifetime
- 1995-05-25 PT PT95922112T patent/PT760851E/pt unknown
- 1995-05-25 DK DK95922112T patent/DK0760851T3/da active
- 1995-05-25 DE DE69535785T patent/DE69535785D1/de not_active Expired - Fee Related
- 1995-05-25 JP JP50103696A patent/JP4187263B2/ja not_active Expired - Fee Related
-
1996
- 1996-11-05 US US08/744,139 patent/US5869612A/en not_active Expired - Fee Related
-
1997
- 1997-01-07 US US08/779,599 patent/US6500922B1/en not_active Expired - Fee Related
-
2002
- 2002-10-30 US US10/283,500 patent/US7244836B2/en not_active Expired - Fee Related
-
2007
- 2007-06-07 US US11/759,405 patent/US7754858B2/en not_active Expired - Fee Related
-
2009
- 2009-12-25 JP JP2009294770A patent/JP2010131018A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
ATE400652T1 (de) | 2008-07-15 |
US7244836B2 (en) | 2007-07-17 |
US5708142A (en) | 1998-01-13 |
JP4187263B2 (ja) | 2008-11-26 |
US6500922B1 (en) | 2002-12-31 |
US20030120043A1 (en) | 2003-06-26 |
ES2310413T3 (es) | 2009-01-01 |
EP2011873A3 (de) | 2009-07-01 |
DK0760851T3 (da) | 2008-11-10 |
JP2010131018A (ja) | 2010-06-17 |
US7754858B2 (en) | 2010-07-13 |
US5670319A (en) | 1997-09-23 |
US5869612A (en) | 1999-02-09 |
US20070243202A1 (en) | 2007-10-18 |
PT760851E (pt) | 2008-10-21 |
EP2011873A2 (de) | 2009-01-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |