DE69535883D1 - Muteine von ifn-beta - Google Patents
Muteine von ifn-betaInfo
- Publication number
- DE69535883D1 DE69535883D1 DE69535883T DE69535883T DE69535883D1 DE 69535883 D1 DE69535883 D1 DE 69535883D1 DE 69535883 T DE69535883 T DE 69535883T DE 69535883 T DE69535883 T DE 69535883T DE 69535883 D1 DE69535883 D1 DE 69535883D1
- Authority
- DE
- Germany
- Prior art keywords
- ifn
- beta
- those
- muteins
- recombinant dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/213,448 US5545723A (en) | 1994-03-15 | 1994-03-15 | Muteins of IFN-β |
PCT/US1995/003206 WO1995025170A1 (en) | 1994-03-15 | 1995-03-13 | NOVEL MUTEINS OF IFN-$g(b) |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69535883D1 true DE69535883D1 (de) | 2008-12-24 |
Family
ID=22795174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69535883T Expired - Lifetime DE69535883D1 (de) | 1994-03-15 | 1995-03-13 | Muteine von ifn-beta |
Country Status (12)
Country | Link |
---|---|
US (2) | US5545723A (de) |
EP (1) | EP0750668B1 (de) |
JP (2) | JP3822903B2 (de) |
AT (1) | ATE414152T1 (de) |
AU (1) | AU695208B2 (de) |
CA (1) | CA2185352C (de) |
DE (1) | DE69535883D1 (de) |
DK (1) | DK0750668T3 (de) |
FI (1) | FI120356B (de) |
NO (1) | NO318989B1 (de) |
NZ (2) | NZ283217A (de) |
WO (1) | WO1995025170A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE270899T1 (de) * | 1996-12-24 | 2004-07-15 | Biogen Inc | Stabile flüssige interferon-zubereitungen |
IL142350A0 (en) * | 1998-10-16 | 2002-03-10 | Biogen Inc | Interferon-beta fusion proteins and pharmaceutical compositions containing the same |
SG2008070138A (en) * | 1998-10-16 | 2017-08-30 | Biogen Ma Inc | Polymer conjugates of interferon beta- 1a and their uses |
US6514729B1 (en) | 1999-05-12 | 2003-02-04 | Xencor, Inc. | Recombinant interferon-beta muteins |
US7144574B2 (en) * | 1999-08-27 | 2006-12-05 | Maxygen Aps | Interferon β variants and conjugates |
US6531122B1 (en) * | 1999-08-27 | 2003-03-11 | Maxygen Aps | Interferon-β variants and conjugates |
US7431921B2 (en) * | 2000-04-14 | 2008-10-07 | Maxygen Aps | Interferon beta-like molecules |
AU783208B2 (en) * | 1999-12-09 | 2005-10-06 | Novartis Vaccines And Diagnostics, Inc. | Method for administering a cytokine to the central nervous system and the lymphatic system |
US20020169290A1 (en) * | 2000-11-02 | 2002-11-14 | Claus Bornaes | New multimeric interferon beta polypeptides |
MXPA03007619A (es) | 2001-02-27 | 2003-12-04 | Maxygen Aps | Nuevas moleculas similares a interferon beta. |
WO2002072019A2 (en) * | 2001-03-13 | 2002-09-19 | Vical Incorporated | Interferon-beta polynucleotide therapy for autoimmune and inflammatory diseases |
US6887462B2 (en) | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
AU2002326991A1 (en) * | 2001-09-18 | 2003-04-01 | Chiron Corporation | Methods for treating multiple sclerosis |
EP2279755B1 (de) | 2001-10-10 | 2014-02-26 | ratiopharm GmbH | Neumodulierung und Glykokonjugation von Fibroblasten-Wachstumsfaktor (FGF) |
WO2004099231A2 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
EP2322229B1 (de) | 2001-10-10 | 2016-12-21 | Novo Nordisk A/S | Neumodulierung und Glykokonjugation von Faktor IX |
ATE466085T1 (de) * | 2002-09-09 | 2010-05-15 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
MXPA05003243A (es) * | 2002-09-27 | 2005-09-12 | Biogen Idec Inc | Terapias para polineuropatia desmielinizante inflamatoria cronica usando interferon-beta. |
EP1581631A4 (de) * | 2002-10-01 | 2007-09-05 | Xencor Inc | Interferonvarianten mit verbesserteneigenschaften |
US20040175359A1 (en) * | 2002-11-12 | 2004-09-09 | Desjarlais John Rudolph | Novel proteins with antiviral, antineoplastic, and/or immunomodulatory activity |
CN103755800B (zh) | 2004-02-02 | 2016-02-24 | Ambrx公司 | 经修饰的人类生长激素多肽与其用途 |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
US20070179113A1 (en) * | 2005-05-19 | 2007-08-02 | Schering Aktiengesellachaft | GM-CSF gene therapy for Crohn's disease using an improved regulated expression system |
DOP2006000117A (es) * | 2005-05-19 | 2007-11-30 | Schering Ag | Terapia génica de interferon-beta usando un sistema mejorado de expresión regulada |
GT200600209A (es) * | 2005-05-19 | 2007-01-03 | Schering Ag | Tratamiento de enfermedades usando un sistema mejorado de expresion regulada |
US20080076729A1 (en) * | 2005-05-19 | 2008-03-27 | Schering Aktiengesellachaft | Interferon-beta gene therapy using an improved, regulated expression system |
EP1917276B1 (de) * | 2005-08-26 | 2018-03-21 | Ares Trading S.A. | Verfahren zur herstellung von glykosyliertem interferon-beta |
US20080038224A1 (en) * | 2006-03-28 | 2008-02-14 | Thierry Guyon | Modified interferon-beta (IFN-beta) polypeptides |
WO2008125222A2 (en) * | 2007-04-11 | 2008-10-23 | Bayer Schering Pharma Aktiengesellschaft | New modulation molecules for an improved regulated expression system |
WO2008134406A1 (en) * | 2007-04-25 | 2008-11-06 | The Board Of Trustees Of The Leland Stanford Junior University | Ischemia-induced neovascularization is enhanced by hcns-sc transplantation |
BRPI0810622A2 (pt) * | 2007-05-02 | 2020-10-13 | Ambrx, Inc. | polipeptídeos de interferon beta modificados e seus usos |
US8273561B2 (en) * | 2007-10-05 | 2012-09-25 | Nuron Biotech, Inc. | High pressure treatment of aggregated interferons |
WO2010075500A1 (en) | 2008-12-23 | 2010-07-01 | Stemcells California, Inc | Target populations of oligodendrocyte precursor cells and methods of making and using same |
WO2019073315A1 (en) | 2017-10-09 | 2019-04-18 | Mansour Poorebrahim | ANALOGUE PEPTIDE OF INTERFERON-BETA |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI88175C (fi) * | 1980-04-03 | 1993-04-13 | Biogen Inc | Rekombinant-dna-molekyler och foerfaranden foer framstaellning av polypeptider liknande humant -interferon |
US4992271A (en) * | 1982-09-23 | 1991-02-12 | Cetus Corporation | Formulation for lipophilic IL-2 proteins |
FI82266C (fi) * | 1982-10-19 | 1991-02-11 | Cetus Corp | Foerfarande foer framstaellning av il-2 -mutein. |
US4737462A (en) * | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
US4853332A (en) * | 1982-10-19 | 1989-08-01 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins |
US4588585A (en) * | 1982-10-19 | 1986-05-13 | Cetus Corporation | Human recombinant cysteine depleted interferon-β muteins |
US4518584A (en) * | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
GB8317880D0 (en) * | 1983-07-01 | 1983-08-03 | Searle & Co | Structure and synthesis of interferons |
GB8334102D0 (en) * | 1983-12-21 | 1984-02-01 | Searle & Co | Interferons with cysteine pattern |
US4530787A (en) * | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
GB8412564D0 (en) * | 1984-05-17 | 1984-06-20 | Searle & Co | Structure and properties |
US4959314A (en) * | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
US4572798A (en) * | 1984-12-06 | 1986-02-25 | Cetus Corporation | Method for promoting disulfide bond formation in recombinant proteins |
US4816440A (en) * | 1985-09-26 | 1989-03-28 | Cetus Corporation | Stable formulation of biologically active proteins for parenteral injection |
DE3683910D1 (de) * | 1986-09-05 | 1992-03-26 | Cetus Corp | Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate. |
US5183746A (en) * | 1986-10-27 | 1993-02-02 | Schering Aktiengesellschaft | Formulation processes for pharmaceutical compositions of recombinant β- |
IL92124A (en) * | 1988-10-28 | 1996-10-31 | Sidney Pestka | Recombinant proteins modified to contain post-phosphorylation that do not occur in nature |
CA2131550A1 (en) * | 1992-02-05 | 1993-08-19 | Andrew Zalewski | Interferon gene therapy for the treatment of vascular disorders |
-
1994
- 1994-03-15 US US08/213,448 patent/US5545723A/en not_active Expired - Lifetime
-
1995
- 1995-03-13 EP EP95914045A patent/EP0750668B1/de not_active Expired - Lifetime
- 1995-03-13 AT AT95914045T patent/ATE414152T1/de not_active IP Right Cessation
- 1995-03-13 CA CA002185352A patent/CA2185352C/en not_active Expired - Lifetime
- 1995-03-13 NZ NZ283217A patent/NZ283217A/en not_active IP Right Cessation
- 1995-03-13 JP JP52414595A patent/JP3822903B2/ja not_active Expired - Lifetime
- 1995-03-13 DK DK95914045T patent/DK0750668T3/da active
- 1995-03-13 DE DE69535883T patent/DE69535883D1/de not_active Expired - Lifetime
- 1995-03-13 AU AU21202/95A patent/AU695208B2/en not_active Expired
- 1995-03-13 WO PCT/US1995/003206 patent/WO1995025170A1/en active Application Filing
- 1995-03-13 NZ NZ329970A patent/NZ329970A/xx not_active IP Right Cessation
-
1996
- 1996-09-13 FI FI963630A patent/FI120356B/fi not_active IP Right Cessation
- 1996-09-13 NO NO19963837A patent/NO318989B1/no not_active IP Right Cessation
-
1997
- 1997-08-18 US US08/912,768 patent/US6127332A/en not_active Expired - Lifetime
-
2006
- 2006-04-17 JP JP2006113870A patent/JP2006199711A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
NZ283217A (en) | 1998-05-27 |
NZ329970A (en) | 2000-01-28 |
US5545723A (en) | 1996-08-13 |
NO318989B1 (no) | 2005-05-30 |
FI120356B (fi) | 2009-09-30 |
US6127332A (en) | 2000-10-03 |
CA2185352A1 (en) | 1995-09-21 |
ATE414152T1 (de) | 2008-11-15 |
FI963630A (fi) | 1996-09-13 |
CA2185352C (en) | 2005-02-22 |
JPH10500563A (ja) | 1998-01-20 |
NO963837D0 (no) | 1996-09-13 |
EP0750668B1 (de) | 2008-11-12 |
FI963630A0 (fi) | 1996-09-13 |
DK0750668T3 (da) | 2009-03-02 |
MX9604073A (es) | 1997-12-31 |
EP0750668A1 (de) | 1997-01-02 |
JP3822903B2 (ja) | 2006-09-20 |
NO963837L (no) | 1996-11-14 |
WO1995025170A1 (en) | 1995-09-21 |
AU2120295A (en) | 1995-10-03 |
JP2006199711A (ja) | 2006-08-03 |
AU695208B2 (en) | 1998-08-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |