DE69535944D1 - Verfahren und Vorrichtung zur Erzeugung feiner Partikel - Google Patents

Verfahren und Vorrichtung zur Erzeugung feiner Partikel

Info

Publication number
DE69535944D1
DE69535944D1 DE69535944T DE69535944T DE69535944D1 DE 69535944 D1 DE69535944 D1 DE 69535944D1 DE 69535944 T DE69535944 T DE 69535944T DE 69535944 T DE69535944 T DE 69535944T DE 69535944 D1 DE69535944 D1 DE 69535944D1
Authority
DE
Germany
Prior art keywords
fine particles
producing fine
producing
particles
fine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69535944T
Other languages
English (en)
Inventor
Robert E Sievers
Uwe Karst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69535944D1 publication Critical patent/DE69535944D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/04—Specific aggregation state of one or more of the phases to be mixed
    • B01F23/043—Mixing fluids or with fluids in a supercritical state, in supercritical conditions or variable density fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/09—Mixing systems, i.e. flow charts or diagrams for components having more than two different of undetermined agglomeration states, e.g. supercritical states
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/30—Mixing gases with solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/30—Mixing gases with solids
    • B01F23/32—Mixing gases with solids by introducing solids in gas volumes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/30—Mixing gases with solids
    • B01F23/39—Mixing systems, i.e. flow charts or diagrams
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B01F25/28—Jet mixers, i.e. mixers using high-speed fluid streams characterised by the specific design of the jet injector
    • B01F25/281—Jet mixers, i.e. mixers using high-speed fluid streams characterised by the specific design of the jet injector the jet injector being of the explosive rapid expansion of supercritical solutions [RESS] or fluid injection of molecular spray [FIMS] type, i.e. the liquid is jetted in an environment (gas or liquid) by nozzles, in conditions of significant pressure drop, with the possible generation of shock waves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
    • B01J3/008—Processes carried out under supercritical conditions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B12/00—Arrangements for controlling delivery; Arrangements for controlling the spray area
    • B05B12/14—Arrangements for controlling delivery; Arrangements for controlling the spray area for supplying a selected one of a plurality of liquids or other fluent materials or several in selected proportions to a spray apparatus, e.g. to a single spray outlet
    • B05B12/1418—Arrangements for controlling delivery; Arrangements for controlling the spray area for supplying a selected one of a plurality of liquids or other fluent materials or several in selected proportions to a spray apparatus, e.g. to a single spray outlet for supplying several liquids or other fluent materials in selected proportions to a single spray outlet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/24—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
    • B05B7/26—Apparatus in which liquids or other fluent materials from different sources are brought together before entering the discharge device
    • B05B7/28—Apparatus in which liquids or other fluent materials from different sources are brought together before entering the discharge device in which one liquid or other fluent material is fed or drawn through an orifice into a stream of a carrying fluid
    • B05B7/32—Apparatus in which liquids or other fluent materials from different sources are brought together before entering the discharge device in which one liquid or other fluent material is fed or drawn through an orifice into a stream of a carrying fluid the fed liquid or other fluent material being under pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D1/00—Processes for applying liquids or other fluent materials
    • B05D1/02—Processes for applying liquids or other fluent materials performed by spraying
    • B05D1/025—Processes for applying liquids or other fluent materials performed by spraying using gas close to its critical state
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D2401/00—Form of the coating product, e.g. solution, water dispersion, powders or the like
    • B05D2401/90—Form of the coating product, e.g. solution, water dispersion, powders or the like at least one component of the composition being in supercritical state or close to supercritical state
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
DE69535944T 1994-04-08 1995-03-29 Verfahren und Vorrichtung zur Erzeugung feiner Partikel Expired - Lifetime DE69535944D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/224,764 US5639441A (en) 1992-03-06 1994-04-08 Methods for fine particle formation

Publications (1)

Publication Number Publication Date
DE69535944D1 true DE69535944D1 (de) 2009-06-10

Family

ID=22842098

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69525557T Expired - Lifetime DE69525557T2 (de) 1994-04-08 1995-03-29 Verfahren und Apparat zur Erzeugung von feinen Partikeln
DE69535944T Expired - Lifetime DE69535944D1 (de) 1994-04-08 1995-03-29 Verfahren und Vorrichtung zur Erzeugung feiner Partikel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69525557T Expired - Lifetime DE69525557T2 (de) 1994-04-08 1995-03-29 Verfahren und Apparat zur Erzeugung von feinen Partikeln

Country Status (3)

Country Link
US (2) US5639441A (de)
EP (2) EP1160018B1 (de)
DE (2) DE69525557T2 (de)

Families Citing this family (230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063910A (en) * 1991-11-14 2000-05-16 The Trustees Of Princeton University Preparation of protein microparticles by supercritical fluid precipitation
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
DE4445341A1 (de) * 1994-12-19 1996-06-20 Basf Ag Verfahren und Vorrichtung zur Herstellung wirkstoffhaltiger Dispersionen
GB9507768D0 (en) * 1995-04-13 1995-05-31 Glaxo Group Ltd Method of apparatus
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
US5654007A (en) * 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
DE19616573C2 (de) * 1996-04-25 1999-03-04 Pari Gmbh Verwendung unterkritischer Treibmittelmischungen und Aerosole für die Mikronisierung von Arzneimitteln mit Hilfe dichter Gase
US8022095B2 (en) * 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US6395302B1 (en) * 1996-11-19 2002-05-28 Octoplus B.V. Method for the preparation of microspheres which contain colloidal systems
US20030203036A1 (en) 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
WO1999009223A1 (en) * 1997-08-20 1999-02-25 Idaho Research Foundation, Inc. Method for dissociating metals or dissociating metal compounds
US6426136B1 (en) * 1998-02-10 2002-07-30 R & D Technology, Inc. Method of reducing material size
EE200000546A (et) * 1998-03-16 2002-02-15 Inhale Therapeutic Systems, Inc. Aerosoolistatud toimeaine manustamissüsteem
SE9801287D0 (sv) * 1998-04-14 1998-04-14 Astra Ab Incorporation of active substances in carrier matrixes
GB9810559D0 (en) * 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
DE19836723B4 (de) * 1998-08-13 2008-04-24 Deutsches Zentrum für Luft- und Raumfahrt e.V. Verfahren zur Homogenisierung von Staubverteilungen
US6184270B1 (en) 1998-09-21 2001-02-06 Eric J. Beckman Production of power formulations
UA73924C2 (en) * 1998-10-09 2005-10-17 Nektar Therapeutics Device for delivering active agent formulation to lungs of human patient
US6500165B1 (en) * 1998-10-29 2002-12-31 Steven R. Frank Active antisepsis device
US6083565A (en) 1998-11-06 2000-07-04 North Carolina State University Method for meniscus coating with liquid carbon dioxide
US6497921B1 (en) 1998-11-06 2002-12-24 North Carolina State University Method for meniscus coating with liquid carbon dioxide
US6113795A (en) * 1998-11-17 2000-09-05 The University Of Kansas Process and apparatus for size selective separation of micro- and nano-particles
SE9804000D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New composition of matter
SE9804001D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New process
US6864301B2 (en) * 1998-11-30 2005-03-08 The Regents Of The University Of Colorado Preparation and use of photopolymerized microparticles
US6403672B1 (en) * 1998-11-30 2002-06-11 University Technology Corporation Preparation and use of photopolymerized microparticles
GB9828204D0 (en) * 1998-12-21 1999-02-17 Smithkline Beecham Plc Process
US7081133B2 (en) * 1999-01-19 2006-07-25 Carbomedics Inc. Antibiotic treated implantable medical devices
CA2367131C (en) * 1999-04-05 2007-07-03 Solomon S. Steiner Methods for fine powder formation
US6256941B1 (en) 1999-06-04 2001-07-10 Haworth, Inc. Pad for panel
US6630121B1 (en) 1999-06-09 2003-10-07 The Regents Of The University Of Colorado Supercritical fluid-assisted nebulization and bubble drying
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US6606992B1 (en) 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
GB9915975D0 (en) * 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles
US6680284B1 (en) 1999-07-13 2004-01-20 Degussa Ag Method for producing powdery particle-reduced formulations with the aid of compressed gases
CN1167461C (zh) 1999-12-04 2004-09-22 研究发展基金会 吸入治疗的二氧化碳增强
FR2803538B1 (fr) * 1999-12-15 2002-06-07 Separex Sa Procede et dispositif de captage de fines particules par percolation dans un lit de granules
EP1242112A4 (de) * 1999-12-21 2005-02-09 Rxkinetix Inc Partikel-enthaltende medikamente und methode zu deren herstellung
US6761909B1 (en) * 1999-12-21 2004-07-13 Rxkinetix, Inc. Particulate insulin-containing products and method of manufacture
US7029700B2 (en) * 2000-01-14 2006-04-18 Brown University Research Foundation Micronized freeze-dried particles
WO2001087368A1 (en) * 2000-05-16 2001-11-22 Ortho-Mcneil Pharmaceutical, Inc. Process for coating medical devices using super-critical carbon dioxide
NL1015288C2 (nl) * 2000-05-24 2001-12-14 Peter Ferdinand Elbers Preparaat voor het stabiliseren van de beschermlaag op het epitheel van het hoornvlies of de longblaasjes.
US6451287B1 (en) 2000-05-26 2002-09-17 Smithkline Beecham Corporation Fluorinated copolymer surfactants and use thereof in aerosol compositions
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
ES2170008B1 (es) 2000-08-25 2003-05-01 Soc Es Carburos Metalicos Sa Procedimiento para la precipitacion de particulas solidas finamente divididas.
US6443164B1 (en) 2000-09-22 2002-09-03 Spectrum Products, Inc. Apparatus for automatic application of compositions to the skin
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
DE10059167A1 (de) * 2000-11-29 2002-06-06 Bsh Bosch Siemens Hausgeraete Backofen
GB0102075D0 (en) * 2001-01-26 2001-03-14 Astrazeneca Ab Process
US20030072717A1 (en) * 2001-02-23 2003-04-17 Vapotronics, Inc. Inhalation device having an optimized air flow path
US6613280B2 (en) * 2001-03-20 2003-09-02 Therox, Inc. Disposable cartridge for producing gas-enriched fluids
FR2824754B1 (fr) * 2001-05-15 2004-05-28 Separex Sa Procede d'obtention de particules solides a partir d'au moins un produit hydrosoluble
CA2448022C (en) * 2001-05-21 2013-11-12 Injet Digital Aerosols Limited Compositions for protein delivery via the pulmonary route
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7498019B2 (en) 2001-05-24 2009-03-03 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of headache through an inhalation route
US6805853B2 (en) * 2001-11-09 2004-10-19 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US6737042B2 (en) 2001-05-24 2004-05-18 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US6759029B2 (en) * 2001-05-24 2004-07-06 Alexza Molecular Delivery Corporation Delivery of rizatriptan and zolmitriptan through an inhalation route
DE60230035D1 (de) 2001-05-24 2009-01-08 Alexza Pharmaceuticals Inc Verabreichung von alprazolam, estazolam, midazolam oder triazolam durch inhalation
WO2002094231A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of analgesics through an inhalation route
EP1399136B1 (de) * 2001-06-19 2005-03-30 DSM IP Assets B.V. Verfahren zur herstellung von dispersionen
US20060167074A1 (en) * 2001-06-19 2006-07-27 Norbert Muller Methods and compositions for the treatment of psychiatric disorders
DE10129320A1 (de) * 2001-06-19 2003-04-10 Norbert Mueller Verwendung von COX-2 Inhibitoren zur Behandlung von Schizophrenie, wahnhaften Störungen, affektiven Störungen oder Ticstörungen
US7332111B2 (en) * 2001-07-10 2008-02-19 The Regents Of The University Of Colorado Devices and methods for the production of particles
US6595630B2 (en) * 2001-07-12 2003-07-22 Eastman Kodak Company Method and apparatus for controlling depth of deposition of a solvent free functional material in a receiver
CN1525999A (zh) 2001-07-12 2004-09-01 ��˹���´﹫˾ 压缩流体配方
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US7033813B2 (en) * 2001-09-05 2006-04-25 Trevor P Castor Inactivated vaccines for aids and other infectious diseases
US6568390B2 (en) * 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
GB0123013D0 (en) * 2001-09-25 2001-11-14 Upperton Ltd Improvements relating to imaging contrast agents
US7105185B2 (en) 2001-10-03 2006-09-12 Herbalscience, Llc Kavalactone profile
US20050069596A1 (en) * 2001-10-03 2005-03-31 Gow Robert T. Compositions and methods comprising kava and anti-anxiety compounds
US7001620B2 (en) 2001-10-03 2006-02-21 Herbal Science, Llc Kavalactone product
US7029707B2 (en) * 2001-10-03 2006-04-18 Herbalscience, Llc Method of producing a processed kava product having an altered kavalactone distribution and processed kava products produced using the same
US7037524B2 (en) * 2001-10-03 2006-05-02 Herbalscience, Llc Oral delivery of a botanical
US7291352B2 (en) 2001-10-03 2007-11-06 Herbalscience Llc Methods and compositions for oral delivery of Areca and mate' or theobromine
US20050053678A1 (en) * 2001-10-03 2005-03-10 Gow Robert T. Methods and compositions for betel nut chewing gum
EP1435916B1 (de) * 2001-10-10 2006-04-26 Boehringer Ingelheim Pharmaceuticals Inc. Pulververarbeitung mit unter druck stehenden gasförmigen fluids
MXPA04003718A (es) 2001-10-22 2004-07-30 Dompe Spa Procesamiento de fluidos supercriticos: preparacion de microparticulas de proteina y su estabilizacion.
GB0126716D0 (en) * 2001-11-07 2002-01-02 Advanced Phytonics Ltd Method for the production of particles
EP1446102A1 (de) * 2001-11-21 2004-08-18 Alexza Molecular Delivery Corporation Verabreichung von koffein durch inhalation
US20030107614A1 (en) * 2001-12-06 2003-06-12 Eastman Kodak Company Method and apparatus for printing
US6866371B2 (en) * 2002-01-17 2005-03-15 Eastman Kodak Company Method and apparatus for printing and coating
US7086397B2 (en) * 2002-02-16 2006-08-08 Graham Lindley Spruiell Patient usable emergency medical kit
US6832699B2 (en) * 2002-02-22 2004-12-21 Terrasimco Inc. Direct pressure apparatus and method for dispensing coatings
CA2479751C (en) 2002-03-20 2008-06-03 Trent Poole Inhalation apparatus
US7128840B2 (en) 2002-03-26 2006-10-31 Idaho Research Foundation, Inc. Ultrasound enhanced process for extracting metal species in supercritical fluids
WO2003086443A1 (en) * 2002-04-11 2003-10-23 Medimmune Vaccines, Inc. Spray freeze dry of compositions for intranasal administration
US7923029B2 (en) * 2002-04-11 2011-04-12 Medimmune Llc Spray freeze dry of compositions for pulmonary administration
CA2484052C (en) * 2002-04-11 2011-06-14 Medimmune Vaccines, Inc. Preservation of bioactive materials by spray drying
US7582284B2 (en) * 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US6854461B2 (en) * 2002-05-10 2005-02-15 Philip Morris Usa Inc. Aerosol generator for drug formulation and methods of generating aerosol
US7677411B2 (en) 2002-05-10 2010-03-16 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders
CA2483687A1 (en) 2002-05-13 2003-11-20 Alexza Molecular Delivery Corporation Delivery of drug amines through an inhalation route
US7390441B2 (en) * 2002-05-23 2008-06-24 Columbian Chemicals Company Sulfonated conducting polymer-grafted carbon material for fuel cell applications
US7195834B2 (en) * 2002-05-23 2007-03-27 Columbian Chemicals Company Metallized conducting polymer-grafted carbon material and method for making
US7413683B2 (en) 2002-05-23 2008-08-19 Columbian Chemicals Company Sulfonated conducting polymer-grafted carbon material for fuel cell applications
US7459103B2 (en) 2002-05-23 2008-12-02 Columbian Chemicals Company Conducting polymer-grafted carbon material for fuel cell applications
US7241334B2 (en) * 2002-05-23 2007-07-10 Columbian Chemicals Company Sulfonated carbonaceous materials
CA2486765A1 (en) * 2002-05-23 2003-12-04 Columbian Chemicals Company Conducting polymer-grafted carbon material for fuel cell applications
US6756084B2 (en) * 2002-05-28 2004-06-29 Battelle Memorial Institute Electrostatic deposition of particles generated from rapid expansion of supercritical fluid solutions
US6749902B2 (en) * 2002-05-28 2004-06-15 Battelle Memorial Institute Methods for producing films using supercritical fluid
US6780475B2 (en) * 2002-05-28 2004-08-24 Battelle Memorial Institute Electrostatic deposition of particles generated from rapid expansion of supercritical fluid solutions
WO2003101624A1 (en) * 2002-05-28 2003-12-11 Battelle Memorial Institute Electrostatic deposition of particles generated from rapid expansion of supercritical fluid solutions
US7185651B2 (en) * 2002-06-18 2007-03-06 Nektar Therapeutics Flow regulator for aerosol drug delivery and methods
US7056523B1 (en) 2002-06-21 2006-06-06 Advanced Cardiovascular Systems, Inc. Implantable medical devices incorporating chemically conjugated polymers and oligomers of L-arginine
US7033602B1 (en) 2002-06-21 2006-04-25 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of coating implantable medical devices
US7070798B1 (en) 2002-06-21 2006-07-04 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine
US8506617B1 (en) 2002-06-21 2013-08-13 Advanced Cardiovascular Systems, Inc. Micronized peptide coated stent
US7217426B1 (en) 2002-06-21 2007-05-15 Advanced Cardiovascular Systems, Inc. Coatings containing polycationic peptides for cardiovascular therapy
US7011842B1 (en) 2002-06-21 2006-03-14 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of making the same
US7794743B2 (en) 2002-06-21 2010-09-14 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of making the same
US6994867B1 (en) 2002-06-21 2006-02-07 Advanced Cardiovascular Systems, Inc. Biocompatible carrier containing L-arginine
AU2003236808B2 (en) * 2002-06-25 2009-01-15 Aalborg Universitet Method for production of a product having sub-micron primary particle size, product produced by the method and apparatus for use of the method
SI1535349T1 (sl) * 2002-06-27 2014-10-30 Oriel Therapeutics, Inc. Naprave, sistemi in ustrezni postopki za predelavo, izdajo in/ali vrednotenje nefarmacevtskih suhih praškov
US6998051B2 (en) * 2002-07-03 2006-02-14 Ferro Corporation Particles from supercritical fluid extraction of emulsion
US20050037025A1 (en) * 2002-10-03 2005-02-17 Gow Robert T. Methods and compositions comprising kava and mate' or theobromine
US6966990B2 (en) 2002-10-11 2005-11-22 Ferro Corporation Composite particles and method for preparing
US20040073186A1 (en) * 2002-10-15 2004-04-15 Cameron Mickey G. Apparatus for automatic application of compositions to the skin
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
ATE420647T1 (de) 2002-11-26 2009-01-15 Alexza Pharmaceuticals Inc Verwendung von loxapine für die herstellung eines mittels zur behandlung von schmerz
US7550133B2 (en) 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
US7094256B1 (en) 2002-12-16 2006-08-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical device containing polycationic peptides
US20060002862A1 (en) * 2002-12-17 2006-01-05 Medimmune Vaccines, Inc. High pressure spray-dry of bioactive materials
US20040197412A1 (en) * 2002-12-19 2004-10-07 Baxter International, Inc. Process for preparing pharmaceutical formulations using supercritical fluids
CA2508870C (en) * 2002-12-30 2012-10-16 Nektar Therapeutics Prefilming atomizer
US6824079B2 (en) 2003-01-24 2004-11-30 S. C. Johnson & Son, Inc. Aerosol dispenser assembly and method of reducing the particle size of a dispensed product
US20050023368A1 (en) * 2003-01-24 2005-02-03 S.C. Johnson & Son, Inc. Method of designing improved spray dispenser assemblies
US7083748B2 (en) * 2003-02-07 2006-08-01 Ferro Corporation Method and apparatus for continuous particle production using supercritical fluid
US6931888B2 (en) * 2003-02-07 2005-08-23 Ferro Corporation Lyophilization method and apparatus for producing particles
US8142814B2 (en) * 2003-02-07 2012-03-27 Ferro Corporation Method and apparatus for supercritical fluid assisted particle production
US7449136B2 (en) * 2003-02-21 2008-11-11 Ferro Pfanstiehl Laboratories, Inc. Method and apparatus for producing composite particles using supercritical fluid as plasticizing and extracting agent
US7455797B2 (en) * 2003-02-28 2008-11-25 Ferro Corporation Method and apparatus for producing particles using supercritical fluid
US20060008531A1 (en) * 2003-05-08 2006-01-12 Ferro Corporation Method for producing solid-lipid composite drug particles
KR20060015587A (ko) * 2003-05-08 2006-02-17 넥타 쎄라퓨틱스 유케이 리미티드 미립물
US20040234914A1 (en) 2003-05-21 2004-11-25 Alexza Molecular Delivery Corporation Percussively ignited or electrically ingnited self-contained heating unit and drug-supply unit employing same
US7279181B2 (en) * 2003-06-03 2007-10-09 Ferro Corporation Method for preparation of particles from solution-in-supercritical fluid or compressed gas emulsions
US20040263597A1 (en) * 2003-06-24 2004-12-30 Eastman Kodak Company Apparatus and method of producing multiple spectral deposits from a mixture of a compressed fluid and a marking material
WO2005022603A2 (en) * 2003-09-02 2005-03-10 Integral Technologies, Inc. Low cost conductive containers manufactured from conductive loaded resin-based materials
AU2004277419B2 (en) * 2003-09-30 2007-10-11 Brown University Research Foundation Nanoparticulate therapeutic biologically active agents
US7279184B2 (en) * 2003-10-24 2007-10-09 Herbalscience, Llc Methods and compositions comprising Ilex
US7294353B2 (en) * 2003-10-24 2007-11-13 Herbalscience, Llc Methods and compositions comprising ilex
US20090062407A1 (en) * 2004-01-22 2009-03-05 Scf Technologies A/S Method and apparatus for producing micro emulsions
DE102004006135A1 (de) * 2004-02-07 2005-09-01 Henkel Kgaa Herstellung von mikro-/nanoskaligen Duftstoffpartikeln
US6958308B2 (en) * 2004-03-16 2005-10-25 Columbian Chemicals Company Deposition of dispersed metal particles onto substrates using supercritical fluids
US20050218076A1 (en) * 2004-03-31 2005-10-06 Eastman Kodak Company Process for the formation of particulate material
US7223445B2 (en) * 2004-03-31 2007-05-29 Eastman Kodak Company Process for the deposition of uniform layer of particulate material
US7220456B2 (en) * 2004-03-31 2007-05-22 Eastman Kodak Company Process for the selective deposition of particulate material
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US7909263B2 (en) * 2004-07-08 2011-03-22 Cube Technology, Inc. Method of dispersing fine particles in a spray
NO20043150D0 (no) * 2004-07-23 2004-07-23 Ntnu Technology Transfer As "Fremgangsmate og utstyr for varmegjenvining"
ES2385934T3 (es) 2004-08-20 2012-08-03 Mannkind Corporation Catálisis de la síntesis de dicetopiperazina.
KR101644250B1 (ko) 2004-08-23 2016-07-29 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
US20060068987A1 (en) * 2004-09-24 2006-03-30 Srinivas Bollepalli Carbon supported catalyst having reduced water retention
US20060105051A1 (en) * 2004-11-18 2006-05-18 Blair Jackson Manufacture of particles for pulmonary drug delivery by carbon dioxide assisted nebulization
US20060275542A1 (en) * 2005-06-02 2006-12-07 Eastman Kodak Company Deposition of uniform layer of desired material
AU2006259876A1 (en) * 2005-06-13 2006-12-28 Michael H. Gurin Nano-ionic liquids and methods of use
CA2615378C (en) * 2005-07-15 2015-02-17 Map Pharmaceuticals, Inc. Multiple active pharmaceutical ingredients combined in discrete inhalation particles and formulations thereof
US8475845B2 (en) * 2005-07-15 2013-07-02 Map Pharmaceuticals, Inc. Method of particle formation
DK1928423T3 (en) 2005-09-14 2016-02-29 Mannkind Corp A method for drug formulation based on increasing the affinity of the active substances to the crystalline microparticle surfaces
EP1795184A1 (de) * 2005-12-09 2007-06-13 Ludwig-Maximilians-Universität München Verfahren zur Herstelllung von Pulvern mit Kolloidpartikeln
US8147444B2 (en) * 2006-01-20 2012-04-03 Oculus Innovative Sciences, Inc. Methods of treating or preventing peritonitis with oxidative reductive potential water solution
US8039431B2 (en) 2006-02-22 2011-10-18 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
NL1031224C2 (nl) * 2006-02-23 2007-09-03 Friesland Brands Bv Het bereiden van gedroogde deeltjes met behulp van een superkritisch medium.
US8030376B2 (en) 2006-07-12 2011-10-04 Minusnine Technologies, Inc. Processes for dispersing substances and preparing composite materials
TWI318894B (en) * 2006-08-07 2010-01-01 Ind Tech Res Inst System for fabricating nano particles
US7745566B2 (en) * 2007-01-23 2010-06-29 Ferro Corporation Methods for the purification of polymers
US20080260852A1 (en) * 2007-01-23 2008-10-23 Ferro Pfanstiehl Laboratories, Inc. Supercritical fluid extraction produced by in-line homogenization
PL2425820T3 (pl) 2007-02-11 2015-08-31 Map Pharmaceuticals Inc Sposób terapeutycznego stosowania dhe w celu umożliwienia szybkiego złagodzenia migreny przy jednoczesnym zminimalizowaniu profilu działań niepożądanych
US20080216828A1 (en) 2007-03-09 2008-09-11 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
US8815360B2 (en) * 2007-08-28 2014-08-26 Cryovac, Inc. Multilayer film having passive and active oxygen barrier layers
US9452592B2 (en) * 2007-08-28 2016-09-27 Cryovac, Inc. Multilayer film having an active oxygen barrier layer with radiation enhanced active barrier properties
US8268354B2 (en) 2007-11-07 2012-09-18 Aridis Pharmaceuticals Sonic low pressure spray drying
JP5307382B2 (ja) * 2007-11-14 2013-10-02 日機装株式会社 微粒子化方法
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
AU2009257311B2 (en) 2008-06-13 2014-12-04 Mannkind Corporation A dry powder inhaler and system for drug delivery
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
EP2334234A4 (de) 2008-09-19 2013-03-20 Tandem Diabetes Care Inc Vorrichtung zur messung der konzentration eines gelösten stoffs und entsprechende verfahren
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9010329B2 (en) * 2009-02-10 2015-04-21 Aerophase Electronically-controlled, high pressure flow control valve and method of use
JP5667095B2 (ja) 2009-03-11 2015-02-12 マンカインド コーポレイション 吸入器の抵抗を測定するための装置、システムおよび方法
US20100291221A1 (en) * 2009-05-15 2010-11-18 Robert Owen Cook Method of administering dose-sparing amounts of formoterol fumarate-budesonide combination particles by inhalation
CA2764505C (en) 2009-06-12 2018-09-25 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
CA2921304C (en) 2009-07-30 2018-06-05 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US9329951B2 (en) 2009-07-31 2016-05-03 Paypal, Inc. System and method to uniformly manage operational life cycles and service levels
GB0915106D0 (en) 2009-08-28 2009-10-07 Glaxo Group Ltd Process
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
AU2011245476B2 (en) 2010-04-26 2016-05-12 VERO Biotech LLC. Delivery of ultra pure nitric oxide (NO)
RU2571331C1 (ru) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
CO6300119A1 (es) * 2010-11-19 2011-07-21 Univ Del Valle Proceso para la preparacion de suspensiones de sales de calcio y metodo para la incorporacion de calcio en bebidas alimenticias nutraceuticas y farmaceuticas
US9808030B2 (en) 2011-02-11 2017-11-07 Grain Processing Corporation Salt composition
CN105667994B (zh) 2011-04-01 2018-04-06 曼金德公司 用于药物药盒的泡罩包装
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CA2852536A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
CN103565745A (zh) 2012-08-10 2014-02-12 德克萨斯州大学系统董事会 用于治疗中风的神经保护性脂质体组合物和方法
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
ES2754388T3 (es) 2013-03-15 2020-04-17 Mannkind Corp Composiciones y métodos de dicetopiperazina microcristalina
JP6625966B2 (ja) 2013-03-15 2019-12-25 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 希ガスが豊富な液体ならびにその調製及び使用の方法
JP2016518388A (ja) 2013-04-30 2016-06-23 オティトピック インク． 乾燥粉末配合および使用方法
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
EP3030294B1 (de) 2013-08-05 2020-10-07 MannKind Corporation Insufflationsvorrichtung
CN106102748A (zh) 2014-02-20 2016-11-09 奥迪托皮克股份有限公司 用于吸入的干粉制剂
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US20150367038A1 (en) 2014-06-19 2015-12-24 New York University Fabrication of nanowires and hierarchically porous materials through supercritical co2 assisted nebulization
US10610512B2 (en) 2014-06-26 2020-04-07 Island Breeze Systems Ca, Llc MDI related products and methods of use
GB201414820D0 (en) 2014-08-20 2014-10-01 Brown Sebastian M Improvements to anaesthetic recycling methods and systems
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
EP3544724A4 (de) * 2016-11-22 2020-10-14 Elektrofi, Inc Partikel mit einem therapeutischen oder diagnostischen mittel und suspensionen und verfahren zur verwendung davon
CN108993312A (zh) * 2018-06-13 2018-12-14 河南雅利安新材料有限公司 一种节能环保喷雾造粒塔
WO2020160323A2 (en) 2019-01-31 2020-08-06 Elektrofi, Inc. Particle formation and morphology
AU2020344675A1 (en) 2019-09-13 2022-03-31 Elektrofi, Inc. Compositions and methods for the delivery of therapeutic biologics for treatment of disease
WO2021212019A1 (en) * 2020-04-17 2021-10-21 Elektrofi, Inc. Methods of forming particles by continuous droplet formation and dehydration

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2524590A (en) * 1946-04-22 1950-10-03 Carsten F Boe Emulsion containing a liquefied propellant gas under pressure and method of spraying same
US2908442A (en) * 1959-01-16 1959-10-13 Fincase Ind Tiribi Ltda Method for dispersing natural atmospheric fogs and clouds
US3159535A (en) * 1962-01-31 1964-12-01 Johnson & Son Inc S C Aerosol compositions
US3694546A (en) * 1963-09-20 1972-09-26 Geigy Ag J R Two-phase aerosol spraying system
US4066596A (en) * 1971-08-04 1978-01-03 Martin Paint & Chemical Corporation Aerosol dispensed latex paint and package containing the same
US3869070A (en) * 1973-04-10 1975-03-04 Mdt Chemical Corp Aerosol dispensing container for separately stored fluids
US3856185A (en) * 1973-12-26 1974-12-24 Ciba Geigy Corp Single dose, replaceable supply air pressure operated dispenser
GB1599881A (en) * 1977-02-02 1981-10-07 Millington A R Preparation for diagnostic radiology
US4161458A (en) * 1977-08-29 1979-07-17 Scott's Liquid Gold Incorporated Stable aqueous aerosol system with carbon dioxide propellant
DE2837115A1 (de) * 1978-08-25 1980-03-06 Bayer Ag Neues verfahren zur herstellung von sterilen feststoffen
DE3162767D1 (en) * 1980-05-22 1984-04-26 Jan Schmidt Method and apparatus for treatment and hygienisation of sewage sludge and other organic sludges
FR2501644A1 (fr) * 1981-03-11 1982-09-17 Ramis Jean Poche metallique retournable
EP0081014A1 (de) * 1981-12-04 1983-06-15 Clayton Corporation Druckzerstäubervorrichtung
US4536323A (en) * 1983-06-28 1985-08-20 The Drackett Company Non-flammable aerosol propellant microemulsion system
US4582731A (en) * 1983-09-01 1986-04-15 Battelle Memorial Institute Supercritical fluid molecular spray film deposition and powder formation
US4734451A (en) * 1983-09-01 1988-03-29 Battelle Memorial Institute Supercritical fluid molecular spray thin films and fine powders
US4734227A (en) * 1983-09-01 1988-03-29 Battelle Memorial Institute Method of making supercritical fluid molecular spray films, powder and fibers
US4963367A (en) * 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
GB8501015D0 (en) * 1985-01-16 1985-02-20 Riker Laboratories Inc Drug
WO1986006959A1 (en) * 1985-05-22 1986-12-04 Liposome Technology, Inc. Liposome inhalation method and system
US4800903A (en) * 1985-05-24 1989-01-31 Ray Jon P Nicotine dispenser with polymeric reservoir of nicotine
US5013720A (en) * 1986-05-06 1991-05-07 Abbott Laboratories SAP-6-Val proteins and methods
US4790305A (en) * 1986-06-23 1988-12-13 The Johns Hopkins University Medication delivery system
US4845056A (en) * 1987-10-09 1989-07-04 Allied-Signal Inc. Continuous process for production of fine particulate ceramics
SU1591990A1 (ru) * 1987-10-14 1990-09-15 Le Nii Radiatsionnoj Gigieny Уctpoйctbo для bbeдehия лekapctbehhыx пopoшkob
ES2043640T3 (es) * 1987-12-21 1994-01-01 Union Carbide Corp Fluidos supercriticos como diluyentes en la aplicacion por rociada liquida de revestimientos.
US5057342A (en) * 1987-12-21 1991-10-15 Union Carbide Chemicals And Plastics Technology Corporation Methods and apparatus for obtaining a feathered spray when spraying liquids by airless techniques
DE3744329A1 (de) * 1987-12-28 1989-07-06 Schwarz Pharma Gmbh Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung
US5266205A (en) * 1988-02-04 1993-11-30 Battelle Memorial Institute Supercritical fluid reverse micelle separation
US4892232A (en) * 1988-07-25 1990-01-09 Martin James H Unit dose dispenser
SU1577796A1 (ru) * 1988-09-12 1990-07-15 Предприятие П/Я М-5514 Распылитель порошков
AU624421B2 (en) * 1988-10-05 1992-06-11 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
US5707634A (en) * 1988-10-05 1998-01-13 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
US4882107A (en) * 1988-11-23 1989-11-21 Union Carbide Chemicals And Plastics Company Inc. Mold release coating process and apparatus using a supercritical fluid
DK479189D0 (da) * 1989-01-06 1989-09-28 Hans Gernot Schenk Inhalator
FI84698C (fi) * 1989-06-16 1992-01-10 Huhtamaeki Oy Anordning foer finfoerdelning av agglomerat av en enkeldos av ett laekemedelpreparat i pulverform.
US5002048A (en) * 1989-12-12 1991-03-26 Makiej Jr Walter J Inhalation device utilizing two or more aerosol containers
US5056511A (en) * 1989-12-14 1991-10-15 Juergen L. Fischer Method and apparatus for compressing, atomizing, and spraying liquid substances
US5044523A (en) * 1990-02-28 1991-09-03 Photofinish Cosmetics Inc. Method and apparatus for dispensing of volatile fluids
US4970093A (en) * 1990-04-12 1990-11-13 University Of Colorado Foundation Chemical deposition methods using supercritical fluid solutions
US5169433A (en) * 1990-07-18 1992-12-08 Formulogics, Inc. Method of preparing mixtures of active ingredients and excipients using liquid carbon dioxide
US5115803A (en) * 1990-08-31 1992-05-26 Minnesota Mining And Manufacturing Company Aerosol actuator providing increased respirable fraction
US5126126A (en) * 1990-11-20 1992-06-30 Dow Corning Corporation Hair fixatives
CA2093809A1 (en) * 1991-08-15 1993-02-16 Franco Del Bon Inhaler
US5156747A (en) * 1991-10-18 1992-10-20 International Environmental Systems, Inc. Separation of liquids with different boiling points with nebulizing chamber
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
US5301664A (en) * 1992-03-06 1994-04-12 Sievers Robert E Methods and apparatus for drug delivery using supercritical solutions
IT1255256B (it) * 1992-07-24 1995-10-20 Alfonso Caruana Dispositivo di chiusura ermatica autoperforabile per flaconi e simili contenitori
WO1994008599A1 (en) * 1992-10-14 1994-04-28 The Regents Of The University Of Colorado Ion-pairing of drugs for improved efficacy and delivery

Also Published As

Publication number Publication date
EP0677332A3 (de) 1996-10-16
EP1160018A2 (de) 2001-12-05
DE69525557D1 (de) 2002-04-04
US6095134A (en) 2000-08-01
US5639441A (en) 1997-06-17
EP0677332A2 (de) 1995-10-18
EP1160018A3 (de) 2002-01-09
DE69525557T2 (de) 2002-10-31
EP1160018B1 (de) 2009-04-29
EP0677332B1 (de) 2002-02-27

Similar Documents

Publication Publication Date Title
DE69535944D1 (de) Verfahren und Vorrichtung zur Erzeugung feiner Partikel
DE69410408D1 (de) Vorrichtung und Verfahren zur Erzeugung von Aerosols
DE69213967T2 (de) Verfahren und Vorrichtung zur Herstellung von faserförmigen Schleifpartikeln
DE69629478D1 (de) Vorrichtung und verfahren zur erzeugung von gasbläschen optimaler grösse
DE69625455D1 (de) Vorrichtung und verfahren zur erzeugung von virtuellen bildern
DE69634829D1 (de) Verfahren und vorrichtung zur leukozytenfiltration
DE59609111D1 (de) Verfahren und vorrichtung zur erzeugung von resonanzerscheinungen in partikelsuspensionen
DE69501265T2 (de) Verfahren und Vorrichtung zur Erzeugung von Kohlenstoffnanoröhren
DE69127609D1 (de) Vorrichtung und verfahren zur herstellung von diamanten
DE69125054T2 (de) Verfahren und Vorrichtung zur Mustererkennung
DE69515593T2 (de) Verfahren und Vorrichtung zur Oberflächenbehandlung
DE69412059T2 (de) Verfahren und Vorrichtung zur Linsenmontage
DE59604191D1 (de) Verfahren und vorrichtung zur salzgewinnung
DE69317209T2 (de) Verfahren und vorrichtung zur erzeugung formgewickelter ständerspulen
ATA219392A (de) Verfahren und vorrichtung zur filtration
DE69028445D1 (de) Vorrichtung und Verfahren zur Erzeugung von Dünnschichten
ATE200961T1 (de) Verfahren und vorrichtung zur herstellung von borstenwaren und danach hergestellte borstenware
DE69636215D1 (de) Verfahren und vorrichtung zur erzeugung von graviersignalen
DE69511469D1 (de) Verfahren und Vorrichtung zur Herstellung von Diamanten
DE69515001D1 (de) Verfahren und Vorrichtung zur Erzeugung von mehreren Bildern
DE69212550T2 (de) Verfahren und Gerät zur Herstellung von feinen Teilchen
DE69631272D1 (de) Verfahren und Vorrichtung zur Herstellung von Draht
DE69601073D1 (de) Verfahren und vorrichtung zur herstellung und entfernung von feststoffteilchen
DE69315935D1 (de) Verfahren und Vorrichtung zur Herstellung von magnetischen metallischen Teilchen
DE69226781T2 (de) Gerät und verfahren zur erzeugung zugehörigkeitsfunktionen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition