DE69601158T2 - Zusammensetzungen enthaltend nsaid-nanopartikel - Google Patents

Zusammensetzungen enthaltend nsaid-nanopartikel

Info

Publication number
DE69601158T2
DE69601158T2 DE69601158T DE69601158T DE69601158T2 DE 69601158 T2 DE69601158 T2 DE 69601158T2 DE 69601158 T DE69601158 T DE 69601158T DE 69601158 T DE69601158 T DE 69601158T DE 69601158 T2 DE69601158 T2 DE 69601158T2
Authority
DE
Germany
Prior art keywords
compositions containing
nanoparticles
containing nsaid
nsaid nanoparticles
maintain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69601158T
Other languages
English (en)
Other versions
DE69601158D1 (de
Inventor
W Eickhoff
David Engers
Karl Mueller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanosystems LLC
Original Assignee
Nanosystems LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanosystems LLC filed Critical Nanosystems LLC
Application granted granted Critical
Publication of DE69601158D1 publication Critical patent/DE69601158D1/de
Publication of DE69601158T2 publication Critical patent/DE69601158T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
DE69601158T 1995-02-09 1996-01-18 Zusammensetzungen enthaltend nsaid-nanopartikel Expired - Lifetime DE69601158T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/385,614 US5518738A (en) 1995-02-09 1995-02-09 Nanoparticulate nsaid compositions
PCT/US1996/000797 WO1996024339A1 (en) 1995-02-09 1996-01-18 Compositions comprising nanoparticles of nsaid

Publications (2)

Publication Number Publication Date
DE69601158D1 DE69601158D1 (de) 1999-01-28
DE69601158T2 true DE69601158T2 (de) 1999-07-22

Family

ID=23522150

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69601158T Expired - Lifetime DE69601158T2 (de) 1995-02-09 1996-01-18 Zusammensetzungen enthaltend nsaid-nanopartikel

Country Status (10)

Country Link
US (1) US5518738A (de)
EP (1) EP0808156B1 (de)
JP (1) JP3710818B2 (de)
AT (1) ATE174506T1 (de)
AU (1) AU4900996A (de)
CA (1) CA2212779C (de)
DE (1) DE69601158T2 (de)
DK (1) DK0808156T3 (de)
ES (1) ES2125099T3 (de)
WO (1) WO1996024339A1 (de)

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US5518738A (en) 1996-05-21
CA2212779C (en) 2003-05-06
DE69601158D1 (de) 1999-01-28
EP0808156A1 (de) 1997-11-26
ATE174506T1 (de) 1999-01-15
AU4900996A (en) 1996-08-27
CA2212779A1 (en) 1996-08-15
JP3710818B2 (ja) 2005-10-26
DK0808156T3 (da) 1999-08-23

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