DE69607907T2 - Substituierte 2,2-Dimethyl-omega-Phenoxysäure und -ester, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen - Google Patents
Substituierte 2,2-Dimethyl-omega-Phenoxysäure und -ester, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische ZusammensetzungenInfo
- Publication number
- DE69607907T2 DE69607907T2 DE69607907T DE69607907T DE69607907T2 DE 69607907 T2 DE69607907 T2 DE 69607907T2 DE 69607907 T DE69607907 T DE 69607907T DE 69607907 T DE69607907 T DE 69607907T DE 69607907 T2 DE69607907 T2 DE 69607907T2
- Authority
- DE
- Germany
- Prior art keywords
- omega
- dimethyl
- ester
- substituted
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9510731A FR2738817B1 (fr) | 1995-09-14 | 1995-09-14 | Nouveaux acides et esters 2,2-dimethyl-omega-phenoxy alcanoiques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69607907D1 DE69607907D1 (de) | 2000-05-31 |
DE69607907T2 true DE69607907T2 (de) | 2001-01-18 |
Family
ID=9482508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69607907T Expired - Fee Related DE69607907T2 (de) | 1995-09-14 | 1996-09-12 | Substituierte 2,2-Dimethyl-omega-Phenoxysäure und -ester, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
Country Status (16)
Country | Link |
---|---|
US (1) | US5734077A (de) |
EP (1) | EP0763527B1 (de) |
JP (1) | JPH09132547A (de) |
CN (1) | CN1064952C (de) |
AT (1) | ATE192143T1 (de) |
AU (1) | AU707127B2 (de) |
CA (1) | CA2185192C (de) |
DE (1) | DE69607907T2 (de) |
DK (1) | DK0763527T3 (de) |
ES (1) | ES2147907T3 (de) |
FR (1) | FR2738817B1 (de) |
GR (1) | GR3033760T3 (de) |
NO (1) | NO306715B1 (de) |
NZ (1) | NZ299378A (de) |
PT (1) | PT763527E (de) |
ZA (1) | ZA967755B (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ528906A (en) | 1997-05-14 | 2005-06-24 | Atherogenics Inc | Compounds and methods for the inhibition of the expression of VCAM-1 |
US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
US6852878B2 (en) | 1998-05-14 | 2005-02-08 | Atherogenics, Inc. | Thioketals and thioethers for inhibiting the expression of VCAM-1 |
EA200000087A1 (ru) | 1997-07-01 | 2000-08-28 | Атеродженикс, Инк. | Повышение эффективности терапии гиперпролиферативных состояний с помощью антиоксиданта |
US20060287254A1 (en) * | 2001-01-26 | 2006-12-21 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
RS51449B (sr) * | 2001-01-26 | 2011-04-30 | Schering Corporation | Kombinacija aktivatora peroksizom proliferator-aktiviranog receptora (ppar) i inhibitora apsorpcije sterola i lečenje vaskularnih indikacija |
US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
DE60216300T2 (de) * | 2001-09-21 | 2007-06-28 | Schering Corp. | Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption |
CN101391972A (zh) | 2003-01-13 | 2009-03-25 | 阿特罗吉尼克斯公司 | 制备普罗布考及其衍生物的酯和醚的方法 |
JP5137228B2 (ja) * | 2003-03-07 | 2013-02-06 | メルク・シャープ・アンド・ドーム・コーポレーション | 高コレステロール血症の処置のための置換アゼチジノン化合物、置換アゼチジノン処方物およびそれらの使用 |
DE602004018617D1 (de) * | 2003-03-07 | 2009-02-05 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
US7459442B2 (en) * | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
JP2007509054A (ja) * | 2003-10-17 | 2007-04-12 | アミリン・ファーマシューティカルズ,インコーポレイテッド | 血管健康を促進するシリルフェノール |
WO2005112914A2 (en) | 2004-04-20 | 2005-12-01 | Atherogenics, Inc. | Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease |
US20070260087A1 (en) | 2004-04-20 | 2007-11-08 | Atherogenics, Inc. | Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof |
AU2008230861A1 (en) | 2007-03-26 | 2008-10-02 | Salutria Pharmaceuticals, Llc | Methods and compositions of derivatives of probucol for the treatment of diabetes |
GB2477944B (en) | 2010-02-18 | 2015-04-01 | Otter Controls Ltd | Cordless electrical appliances |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS518228A (ja) * | 1974-07-10 | 1976-01-23 | Takeda Chemical Industries Ltd | Chikanfuenokishikarubonsanruino seizoho |
DE7505779U (de) * | 1975-02-25 | 1976-09-02 | Rotring-Werke Riepe Kg, 2000 Hamburg | Köcher, insbesondere Verschlußkappe für eine Röhrchenschreiberspitze |
US4351950A (en) * | 1980-01-02 | 1982-09-28 | Warner-Lambert Company | Anti-arteriosclerotic agents |
JPH0729967B2 (ja) * | 1986-03-07 | 1995-04-05 | 三共株式会社 | フエノキシアルカン酸誘導体 |
JP3330282B2 (ja) * | 1996-06-14 | 2002-09-30 | 株式会社神戸製鋼所 | りん酸塩処理性および耐黒変性に優れた溶融亜鉛めっき鋼板 |
-
1995
- 1995-09-14 FR FR9510731A patent/FR2738817B1/fr not_active Expired - Fee Related
-
1996
- 1996-09-10 CA CA002185192A patent/CA2185192C/fr not_active Expired - Fee Related
- 1996-09-12 AT AT96401946T patent/ATE192143T1/de not_active IP Right Cessation
- 1996-09-12 DE DE69607907T patent/DE69607907T2/de not_active Expired - Fee Related
- 1996-09-12 AU AU65603/96A patent/AU707127B2/en not_active Ceased
- 1996-09-12 PT PT96401946T patent/PT763527E/pt unknown
- 1996-09-12 EP EP96401946A patent/EP0763527B1/de not_active Expired - Lifetime
- 1996-09-12 DK DK96401946T patent/DK0763527T3/da active
- 1996-09-12 ES ES96401946T patent/ES2147907T3/es not_active Expired - Lifetime
- 1996-09-13 NO NO963839A patent/NO306715B1/no unknown
- 1996-09-13 US US08/713,665 patent/US5734077A/en not_active Expired - Fee Related
- 1996-09-13 NZ NZ299378A patent/NZ299378A/en unknown
- 1996-09-13 ZA ZA967755A patent/ZA967755B/xx unknown
- 1996-09-13 CN CN961115610A patent/CN1064952C/zh not_active Expired - Fee Related
- 1996-09-17 JP JP8244615A patent/JPH09132547A/ja active Pending
-
2000
- 2000-06-23 GR GR20000401456T patent/GR3033760T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0763527A1 (de) | 1997-03-19 |
NO306715B1 (no) | 1999-12-13 |
US5734077A (en) | 1998-03-31 |
ATE192143T1 (de) | 2000-05-15 |
FR2738817A1 (fr) | 1997-03-21 |
NZ299378A (en) | 1997-04-24 |
NO963839L (no) | 1997-03-17 |
CN1149046A (zh) | 1997-05-07 |
ES2147907T3 (es) | 2000-10-01 |
EP0763527B1 (de) | 2000-04-26 |
JPH09132547A (ja) | 1997-05-20 |
AU6560396A (en) | 1997-03-20 |
GR3033760T3 (en) | 2000-10-31 |
FR2738817B1 (fr) | 1997-10-17 |
NO963839D0 (no) | 1996-09-13 |
CN1064952C (zh) | 2001-04-25 |
PT763527E (pt) | 2000-08-31 |
ZA967755B (en) | 1997-04-16 |
CA2185192A1 (fr) | 1997-03-15 |
DE69607907D1 (de) | 2000-05-31 |
DK0763527T3 (da) | 2000-09-11 |
CA2185192C (fr) | 2001-04-17 |
AU707127B2 (en) | 1999-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de | ||
8370 | Indication related to discontinuation of the patent is to be deleted | ||
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: LES LABORATOIRES SERVIER, NEUILLY SUR SEINE, FR |
|
8339 | Ceased/non-payment of the annual fee |