DE69610424D1 - Auf histatin basierende, gegen pilze und bakterien gerichtete peptide - Google Patents

Auf histatin basierende, gegen pilze und bakterien gerichtete peptide

Info

Publication number
DE69610424D1
DE69610424D1 DE69610424T DE69610424T DE69610424D1 DE 69610424 D1 DE69610424 D1 DE 69610424D1 DE 69610424 T DE69610424 T DE 69610424T DE 69610424 T DE69610424 T DE 69610424T DE 69610424 D1 DE69610424 D1 DE 69610424D1
Authority
DE
Germany
Prior art keywords
based peptides
histatine
bacteria
peptides against
histatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69610424T
Other languages
English (en)
Other versions
DE69610424T2 (de
Inventor
G Oppenheim
Tao Xu
Donald Roberts
Peter Spacciapoli
M Friden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston University
Periodontix Inc
Original Assignee
Boston University
Periodontix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston University, Periodontix Inc filed Critical Boston University
Publication of DE69610424D1 publication Critical patent/DE69610424D1/de
Application granted granted Critical
Publication of DE69610424T2 publication Critical patent/DE69610424T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69610424T 1995-06-07 1996-06-07 Auf histatin basierende, gegen pilze und bakterien gerichtete peptide Expired - Fee Related DE69610424T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/481,888 US5631228A (en) 1991-11-01 1995-06-07 Anti-fungal and anti-bacterial histatin-based peptides
PCT/US1996/009374 WO1996040768A2 (en) 1995-06-07 1996-06-07 Anti-fungal and anti-bacterial histatin-based peptides

Publications (2)

Publication Number Publication Date
DE69610424D1 true DE69610424D1 (de) 2000-10-26
DE69610424T2 DE69610424T2 (de) 2001-01-25

Family

ID=23913789

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69610424T Expired - Fee Related DE69610424T2 (de) 1995-06-07 1996-06-07 Auf histatin basierende, gegen pilze und bakterien gerichtete peptide

Country Status (11)

Country Link
US (1) US5631228A (de)
EP (1) EP0832119B1 (de)
JP (1) JPH11508238A (de)
AT (1) ATE196475T1 (de)
AU (1) AU709204B2 (de)
CA (1) CA2223505C (de)
DE (1) DE69610424T2 (de)
DK (1) DK0832119T3 (de)
ES (1) ES2151172T3 (de)
IL (1) IL122386A0 (de)
WO (1) WO1996040768A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025326A (en) * 1995-07-07 2000-02-15 Intrabiotics Pharmaceuticals, Inc. Compositions and methods for the prevention and treatment of oral mucositis
DE69613485T2 (de) * 1995-11-03 2001-10-31 Unilever Nv Natürliche zusammensetzung zum bestreiten von pilzen
US6531573B1 (en) 1997-12-18 2003-03-11 Trustees Of Boston University Antifungal and antibacterial peptides
NL1008745C2 (nl) * 1998-03-30 1999-10-01 Stichting Tech Wetenschapp Therapeutisch werkzame verbinding voor behandeling van gist- en/of schimmelinfecties in de mondholte.
US8283315B2 (en) 1998-08-28 2012-10-09 Lytix Biopharma As Inhibition of tumour growth
GB9818938D0 (en) * 1998-08-28 1998-10-21 Alpharma As Bioactive peptides
US6528488B2 (en) * 1999-01-08 2003-03-04 Demegen, Inc. Method for treating cystic fibrosis
US6800291B1 (en) * 1999-03-24 2004-10-05 Zengen, Inc. Uro-genital condition treatment system
US6833435B2 (en) * 1999-08-23 2004-12-21 Matthew Glenn Compositions isolated from bovine tissues and methods for their use
US20030158111A1 (en) * 1999-10-01 2003-08-21 David Bar-Or Methods and products for oral care
US7632803B2 (en) 1999-10-01 2009-12-15 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US7592304B2 (en) * 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
CA2285673C (en) 1999-10-21 2008-07-29 Gilles Andre Lajoie Cyclic analogs of histatins
CA2412011A1 (en) 2000-06-16 2001-12-27 Hercules Incorporated Chemically-modified antimicrobial peptides, compositions and methods of production and use
US6576226B1 (en) * 2000-11-17 2003-06-10 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US6726898B2 (en) 2000-11-17 2004-04-27 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US7090497B1 (en) 2001-02-21 2006-08-15 Harris David M Method of periodontal laser treatment
US20040127892A1 (en) * 2002-01-31 2004-07-01 Harris David M. Periodontal laser and methods
US7033769B2 (en) 2002-05-23 2006-04-25 The United States Of America As Represented By The Secretary Of The Army Method for discovering one or more peptides adapted for specific binding to a microorganism of interest
US7087228B2 (en) * 2002-07-03 2006-08-08 University Of Southern California Preventing tooth decay and infective endocarditis using natural oligopeptides
EP1616035A4 (de) 2003-04-01 2007-02-21 Univ Southern California Kariesrisikotest zur vorhersage und beurteilung des risikos einer erkrankung
US9127045B2 (en) * 2005-11-17 2015-09-08 University Of Southern California Method of inhibiting bacterial growth and biofilm formation with natural quorum sensing peptides
WO2009005798A2 (en) * 2007-07-03 2009-01-08 Pacgen Biopharmaceuticals Corporation Antifungal formulation and method of preparation
US20130288964A1 (en) 2008-01-07 2013-10-31 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Pa Use of peptides for promoting wound healing
MX2010007442A (es) * 2008-01-07 2010-12-21 Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek En Patientenzorg Uso de peptidos para promover la curacion de heridas.
US20100047734A1 (en) * 2008-08-20 2010-02-25 PathoLase, Inc. Periodontal laser treatment and laser applicator
US8992223B2 (en) * 2010-02-19 2015-03-31 The University Of South Dakota Rechargeable long-term antifungal denture materials
US20130310327A1 (en) 2012-05-18 2013-11-21 Rapid Pathogen Screening, Inc. Histatin for Corneal Wound Healing and Ocular Surface Disease
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US20170022256A1 (en) * 2015-07-23 2017-01-26 General Biologicals Corporation Anti-fungal and anti-bacterial peptide and therapeutic method using same
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN116848129A (zh) * 2021-02-16 2023-10-03 香港大学 抗菌和矿化组合物及其使用方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725576A (en) * 1983-12-29 1988-02-16 Research Foundation Of State University Of New York Fungicidal polypeptide compositions containing L-histidine and methods for use therefore
US5032574A (en) * 1988-05-26 1991-07-16 Invitron Corporation Novel antimicrobial peptide
US5221732A (en) * 1988-12-06 1993-06-22 The United States Of America As Represented By The Department Of Health And Human Services Antimicrobial magainin modified peptides
JP2818056B2 (ja) * 1990-09-07 1998-10-30 森永乳業株式会社 抗菌性ペプチドおよび抗菌剤
US5225399A (en) * 1991-04-15 1993-07-06 The Children's Hospital Of Philadelphia Antimicrobial amphiphilic peptides
US5239059A (en) * 1991-05-10 1993-08-24 The Children's Hospital Of Philadelphia Ion-channel forming peptides
US5324716A (en) * 1991-06-14 1994-06-28 Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
US5486503A (en) * 1991-11-01 1996-01-23 The Trustees Of Boston University Anti-fungal histatin-based peptides
JPH06234653A (ja) * 1993-02-10 1994-08-23 Sunstar Inc 歯周組織再生促進剤および材料
US5459235A (en) * 1993-03-19 1995-10-17 The Regents Of The University Of California Antimicrobial peptides antibodies and nucleic acid molecules from bovine neutrophils
JPH06287146A (ja) * 1993-03-31 1994-10-11 Sunstar Inc 皮膚外用剤

Also Published As

Publication number Publication date
CA2223505C (en) 2003-10-14
IL122386A0 (en) 1998-06-15
ATE196475T1 (de) 2000-10-15
WO1996040768A2 (en) 1996-12-19
DE69610424T2 (de) 2001-01-25
WO1996040768A3 (en) 1997-03-06
JPH11508238A (ja) 1999-07-21
US5631228A (en) 1997-05-20
AU6158596A (en) 1996-12-30
ES2151172T3 (es) 2000-12-16
EP0832119B1 (de) 2000-09-20
EP0832119A2 (de) 1998-04-01
CA2223505A1 (en) 1996-12-19
DK0832119T3 (da) 2000-11-20
AU709204B2 (en) 1999-08-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee