DE69618792D1 - N-benzyldioxothiazolidylbenzamid-derivate und verfahren zu ihrer herstellung - Google Patents

N-benzyldioxothiazolidylbenzamid-derivate und verfahren zu ihrer herstellung

Info

Publication number
DE69618792D1
DE69618792D1 DE69618792T DE69618792T DE69618792D1 DE 69618792 D1 DE69618792 D1 DE 69618792D1 DE 69618792 T DE69618792 T DE 69618792T DE 69618792 T DE69618792 T DE 69618792T DE 69618792 D1 DE69618792 D1 DE 69618792D1
Authority
DE
Germany
Prior art keywords
carbon atoms
groups
group
atoms
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69618792T
Other languages
English (en)
Other versions
DE69618792T2 (de
Inventor
Toshio Maeda
Masahiro Nomura
Katsuya Awano
Susumu Kinoshita
Hiroya Satoh
Koji Murakami
Masaki Tsunoda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69618792D1 publication Critical patent/DE69618792D1/de
Publication of DE69618792T2 publication Critical patent/DE69618792T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
DE69618792T 1995-06-02 1996-05-30 N-benzyldioxothiazolidylbenzamid-derivate und verfahren zu ihrer herstellung Expired - Fee Related DE69618792T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP15978195 1995-06-02
JP15313996A JP3144624B2 (ja) 1995-06-02 1996-05-24 Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法
PCT/JP1996/001459 WO1996038428A1 (fr) 1995-06-02 1996-05-30 Derives de n-benzyldioxothiazolidylbenzamide et leur procede de production

Publications (2)

Publication Number Publication Date
DE69618792D1 true DE69618792D1 (de) 2002-03-14
DE69618792T2 DE69618792T2 (de) 2002-10-10

Family

ID=26481850

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69618792T Expired - Fee Related DE69618792T2 (de) 1995-06-02 1996-05-30 N-benzyldioxothiazolidylbenzamid-derivate und verfahren zu ihrer herstellung

Country Status (15)

Country Link
US (1) US6030990A (de)
EP (1) EP0846693B1 (de)
JP (1) JP3144624B2 (de)
KR (1) KR100456177B1 (de)
CN (2) CN1069901C (de)
AT (1) ATE212341T1 (de)
AU (1) AU698896B2 (de)
CA (1) CA2220698C (de)
DE (1) DE69618792T2 (de)
DK (1) DK0846693T3 (de)
ES (1) ES2170858T3 (de)
HU (1) HU225039B1 (de)
PT (1) PT846693E (de)
TW (1) TW400328B (de)
WO (1) WO1996038428A1 (de)

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US6756360B1 (en) 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
ATE296293T1 (de) 1999-08-23 2005-06-15 Kyorin Seiyaku Kk Substituierte benzylthiazolidin-2,4-dion derivate
HUP0202893A3 (en) 1999-08-23 2004-12-28 Kyorin Seiyaku Kk Substituted benzylthiazolidine-2,4-dione derivatives and pharmaceutical compositions containing them
EP1213287B1 (de) * 1999-08-23 2005-05-25 Kyorin Pharmaceutical Co., Ltd. Substituierte benzylthiazolidin-2,4-dion-derivate
ATE296815T1 (de) * 1999-08-23 2005-06-15 Kyorin Seiyaku Kk Substituierte benzylthiazolidin-2,4-dion derivate
CA2385083C (en) * 1999-09-17 2007-06-05 Kyorin Pharmaceutical Co., Ltd. O-anisamide derivatives
TWI262185B (en) * 1999-10-01 2006-09-21 Eisai Co Ltd Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
TWI271192B (en) 1999-11-11 2007-01-21 Kyorin Pharmaceutical Co Ltd Solid formulation for oral administration
KR100875335B1 (ko) * 1999-12-22 2008-12-22 메타베이시스 테라퓨틱스, 인크. 신규 비스아미데이트 포스포네이트 프로드러그
US6818776B2 (en) * 2000-02-01 2004-11-16 Kyorin Pharmaceutical Co., Ltd. Alkali metal salt of thiazolidine-2,4-dione derivative
AU2001236079A1 (en) * 2000-03-07 2001-09-17 Kyorin Pharmaceutical Co. Ltd. Intermediate compounds
CA2407349A1 (en) 2000-04-25 2002-10-24 Kyorin Pharmaceutical Co., Ltd. Novel stable crystal of thiazolidinedione derivative and process for producing the same
WO2001096321A1 (fr) * 2000-06-14 2001-12-20 Kyorin Pharmaceutical Co., Ltd. Elaboration de derives de thiazolidinedione
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
ATE341343T1 (de) * 2000-12-26 2006-10-15 Sankyo Co Medizinische zusammensetzungen mit diuretischem und die insulinresistenz verbesserndem mittel
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
TW200840563A (en) * 2001-01-26 2008-10-16 Schering Corp Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(S) and treatments for vascular indications
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CZ20032031A3 (cs) * 2001-01-26 2003-12-17 Schering Corporation Farmaceutický prostředek
NZ542090A (en) * 2001-01-26 2006-09-29 Schering Corp Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions
CA2434430A1 (en) * 2001-01-26 2002-08-01 Harry R. Davis The use of substituted azetidinone compounds for the treatment of sitosterolemia
US20030053981A1 (en) * 2001-01-26 2003-03-20 Schering Corporation Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
JP4256166B2 (ja) 2001-03-28 2009-04-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 カルボン酸化合物
US7244861B2 (en) 2001-03-30 2007-07-17 Eisai Co., Ltd. Benzene compound and salt thereof
TWI311133B (en) 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
US20030013699A1 (en) * 2001-05-25 2003-01-16 Davis Harry R. Methods for treating alzheimer's disease and/or regulating levels of amyloid beta peptides in a subject
JPWO2002098840A1 (ja) 2001-06-04 2004-09-16 エーザイ株式会社 カルボン酸誘導体及びその塩もしくはそのエステルからなる医薬
US7371777B2 (en) 2001-08-17 2008-05-13 Eisai Co., Ltd. Cyclic compound and PPAR agonist
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
DE60216300T2 (de) * 2001-09-21 2007-06-28 Schering Corp. Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
WO2003042190A1 (en) 2001-11-12 2003-05-22 Pfizer Products Inc. N-alkyl-adamantyl derivatives as p2x7-receptor antagonists
PA8557501A1 (es) 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
ITRM20020016A1 (it) * 2002-01-15 2003-07-15 Sigma Tau Ind Farmaceuti Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza
AU2003225027A1 (en) * 2002-04-16 2003-11-03 Merck And Co., Inc. Combination therapy using a ppar alpha/gamma agonist
US6821524B2 (en) * 2002-06-03 2004-11-23 Jan Marini Skin Research, Inc. Cosmetic skin care compositions
EP1517882A1 (de) 2002-06-19 2005-03-30 Eli Lilly And Company Amidlinker-modulatoren des peroxisom-proliferator-aktivierten rezeptors
US7071223B1 (en) * 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
PA8591801A1 (es) 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
DE10308351A1 (de) 2003-02-27 2004-11-25 Aventis Pharma Deutschland Gmbh 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10308355A1 (de) 2003-02-27 2004-12-23 Aventis Pharma Deutschland Gmbh Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
DE10308353A1 (de) 2003-02-27 2004-12-02 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10308352A1 (de) 2003-02-27 2004-09-09 Aventis Pharma Deutschland Gmbh Arylcycloalkylderivate mit verzweigten Seitenketten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
US7148246B2 (en) 2003-02-27 2006-12-12 Sanofi-Aventis Deutschland Gmbh Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
DE602004018617D1 (de) * 2003-03-07 2009-02-05 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP5137228B2 (ja) * 2003-03-07 2013-02-06 メルク・シャープ・アンド・ドーム・コーポレーション 高コレステロール血症の処置のための置換アゼチジノン化合物、置換アゼチジノン処方物およびそれらの使用
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BRPI0512781A (pt) * 2004-06-29 2008-04-08 Pfizer Prod Inc método para preparação de derivados de 5-{4-(2-hidroxi-propil)-3,5-dioxo-4,5-diidro-3h-[1,2,4]tria zin-2-il}-benzamida através da desproteção dos precursores de protetores de hidroxila
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FR2680512B1 (fr) * 1991-08-20 1995-01-20 Adir Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
NO302519B1 (no) * 1991-12-26 1998-03-16 Sankyo Co Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat

Also Published As

Publication number Publication date
CN1336366A (zh) 2002-02-20
DE69618792T2 (de) 2002-10-10
EP0846693A4 (de) 1999-03-03
DK0846693T3 (da) 2002-05-06
AU5844696A (en) 1996-12-18
CN1069901C (zh) 2001-08-22
WO1996038428A1 (fr) 1996-12-05
CA2220698C (en) 2003-06-17
HU225039B1 (en) 2006-05-29
AU698896B2 (en) 1998-11-12
EP0846693B1 (de) 2002-01-23
JP3144624B2 (ja) 2001-03-12
CN1186489A (zh) 1998-07-01
CN1133627C (zh) 2004-01-07
US6030990A (en) 2000-02-29
TW400328B (en) 2000-08-01
JPH0948771A (ja) 1997-02-18
CA2220698A1 (en) 1996-12-05
HUP9802565A3 (en) 2000-01-28
EP0846693A1 (de) 1998-06-10
ES2170858T3 (es) 2002-08-16
ATE212341T1 (de) 2002-02-15
KR19990022435A (ko) 1999-03-25
HUP9802565A2 (hu) 1999-04-28
KR100456177B1 (ko) 2004-12-30
PT846693E (pt) 2002-05-31

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