US20020164782A1
(en)
|
1999-02-10 |
2002-11-07 |
Gregory Richard J. |
Adenovirus vectors for gene therapy
|
US5670488A
(en)
*
|
1992-12-03 |
1997-09-23 |
Genzyme Corporation |
Adenovirus vector for gene therapy
|
US7045347B2
(en)
|
1993-06-24 |
2006-05-16 |
Advec, Inc. |
Helper dependent adenovirus vectors based on integrase family site-specific recombinases
|
US20020146392A1
(en)
*
|
1993-06-24 |
2002-10-10 |
Frank L. Graham |
Helper dependent adenovirus vectors based on site-specific recombinases
|
US20020136708A1
(en)
*
|
1993-06-24 |
2002-09-26 |
Graham Frank L. |
System for production of helper dependent adenovirus vectors based on use of endonucleases
|
US6730507B1
(en)
|
1993-06-24 |
2004-05-04 |
Merck & Co., Inc. |
Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration
|
US6379943B1
(en)
*
|
1999-03-05 |
2002-04-30 |
Merck & Co., Inc. |
High-efficiency Cre/loxp based system for construction of adenovirus vectors
|
JP4216350B2
(ja)
*
|
1994-09-19 |
2009-01-28 |
大日本住友製薬株式会社 |
動物細胞感染用の組換えdnaウイルスベクター
|
US6964861B1
(en)
|
1998-11-13 |
2005-11-15 |
Invitrogen Corporation |
Enhanced in vitro recombinational cloning of using ribosomal proteins
|
US7670823B1
(en)
*
|
1999-03-02 |
2010-03-02 |
Life Technologies Corp. |
Compositions for use in recombinational cloning of nucleic acids
|
US6143557A
(en)
*
|
1995-06-07 |
2000-11-07 |
Life Technologies, Inc. |
Recombination cloning using engineered recombination sites
|
US6720140B1
(en)
|
1995-06-07 |
2004-04-13 |
Invitrogen Corporation |
Recombinational cloning using engineered recombination sites
|
US20060110798A1
(en)
*
|
1995-06-07 |
2006-05-25 |
Graham Frank L |
Cells expressing recombinase useful for adenovirus vector production and control of gene expression
|
EP1227147A3
(de)
|
1995-06-07 |
2002-08-14 |
Invitrogen Corporation |
Rekombinatorische Klonierung unter Verwendung genmanipulierter Rekombinationsorte
|
US6783980B2
(en)
*
|
1995-06-15 |
2004-08-31 |
Crucell Holland B.V. |
Packaging systems for human recombinant adenovirus to be used in gene therapy
|
US6265212B1
(en)
|
1995-06-15 |
2001-07-24 |
Introgene B.V. |
Packaging systems for human recombinant adenovirus to be used in gene therapy
|
CA2222140C
(en)
*
|
1995-06-15 |
2010-11-23 |
Introgene B.V. |
Packaging systems for human recombinant adenovirus to be used in gene therapy
|
FR2737501B1
(fr)
*
|
1995-07-31 |
1997-10-24 |
Transgene Sa |
Nouveaux virus auxiliaires pour la preparation de vecteurs viraux recombinants
|
DE19623203A1
(de)
*
|
1995-11-24 |
1997-05-28 |
Max Planck Gesellschaft |
Virusvektor für den Transfer stabiler Episome
|
US20060088938A1
(en)
*
|
1995-12-15 |
2006-04-27 |
Mitchell Lloyd G |
Methods and compositions for use in spliceosome mediated RNA trans-splicing in plants
|
US20030027250A1
(en)
*
|
1995-12-15 |
2003-02-06 |
Mitchell Lloyd G. |
Methods and compositions for use in spliceosome mediated RNA trans-splicing
|
US20020193580A1
(en)
*
|
1995-12-15 |
2002-12-19 |
Mitchell Lloyd G. |
Methods and compositions for use in spliceosome mediated RNA trans-splicing
|
JP2000503534A
(ja)
*
|
1996-01-05 |
2000-03-28 |
ジェネティック セラピー,インコーポレイテッド |
アデノウイルスベクターのリコンビナーゼ媒介生成
|
WO1997032481A1
(en)
*
|
1996-03-07 |
1997-09-12 |
The Regents Of The University Of California |
Helper-free, totally defective adenovirus for gene therapy
|
US6630346B1
(en)
*
|
1996-06-20 |
2003-10-07 |
Merck & Co., Inc. |
Gene therapy for obesity
|
US7232899B2
(en)
|
1996-09-25 |
2007-06-19 |
The Scripps Research Institute |
Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use
|
US6475789B1
(en)
*
|
1996-10-01 |
2002-11-05 |
University Technology Corporation |
Human telomerase catalytic subunit: diagnostic and therapeutic methods
|
DE69723531T3
(de)
|
1996-10-01 |
2012-09-06 |
Geron Corp. |
Katalytische Untereinheit der menschlichen Telomerase
|
US7585622B1
(en)
*
|
1996-10-01 |
2009-09-08 |
Geron Corporation |
Increasing the proliferative capacity of cells using telomerase reverse transcriptase
|
US5994132A
(en)
*
|
1996-10-23 |
1999-11-30 |
University Of Michigan |
Adenovirus vectors
|
EP0953647B1
(de)
|
1996-12-16 |
2008-05-28 |
Eisai R&D Management Co., Ltd. |
Verfahren zur herstellung von retroviralen vektoren für die gentherapie
|
US6403370B1
(en)
|
1997-02-10 |
2002-06-11 |
Genstar Therapeutics Corporation |
Oncolytic/immunogenic complementary-adenoviral vector system
|
US5851808A
(en)
|
1997-02-28 |
1998-12-22 |
Baylor College Of Medicine |
Rapid subcloning using site-specific recombination
|
WO1998039411A1
(en)
*
|
1997-03-04 |
1998-09-11 |
Baxter International Inc. |
Adenovirus e1-complementing cell lines
|
US20050013825A1
(en)
*
|
1997-04-18 |
2005-01-20 |
Geron Corporation |
Vaccine containing the catalytic subunit of telomerase for treating cancer
|
US7413864B2
(en)
*
|
1997-04-18 |
2008-08-19 |
Geron Corporation |
Treating cancer using a telomerase vaccine
|
US7622549B2
(en)
*
|
1997-04-18 |
2009-11-24 |
Geron Corporation |
Human telomerase reverse transcriptase polypeptides
|
WO1999014354A1
(en)
*
|
1997-09-19 |
1999-03-25 |
The Trustees Of The University Of The Pennsylvania |
Methods and vector constructs useful for production of recombinant aav
|
CA2307016A1
(en)
*
|
1997-10-24 |
1999-05-06 |
Life Technologies, Inc. |
Recombinational cloning using nucleic acids having recombination sites
|
US7351578B2
(en)
*
|
1999-12-10 |
2008-04-01 |
Invitrogen Corp. |
Use of multiple recombination sites with unique specificity in recombinational cloning
|
WO1999027101A1
(en)
*
|
1997-11-25 |
1999-06-03 |
Princeton University |
Method for preparing adenovirus vectors, vectors so prepared, and uses thereof
|
DE19807265C2
(de)
*
|
1998-02-20 |
2000-01-05 |
Centeon Pharma Gmbh |
Adenoviraler Transfervektor für den Gentransport einer DNA-Sequenz
|
US6337200B1
(en)
*
|
1998-03-31 |
2002-01-08 |
Geron Corporation |
Human telomerase catalytic subunit variants
|
US6670188B1
(en)
|
1998-04-24 |
2003-12-30 |
Crucell Holland B.V. |
Packaging systems for human recombinant adenovirus to be used in gene therapy
|
EP1108049A2
(de)
|
1998-08-28 |
2001-06-20 |
Duke University |
In iv2a-, 100k- und/oder preterminalen protein- sequenzen deletierte adenoviren
|
US6303362B1
(en)
|
1998-11-19 |
2001-10-16 |
The Board Of Trustees Of The Leland Stanford Junior University |
Adenoviral vector and methods for making and using the same
|
CA2360796A1
(en)
*
|
1999-02-04 |
2000-08-10 |
Merck & Co., Inc. |
Improved helper dependent vector system for gene therapy
|
EP1157103A2
(de)
*
|
1999-02-18 |
2001-11-28 |
Merck & Co., Inc. |
Herstellung von helferabhängigen adenovirusvektoren unter verwendung von endonucleasen
|
CA2366914C
(en)
|
1999-03-05 |
2010-05-11 |
Merck & Co., Inc. |
Enhanced system for construction of adenovirus vectors
|
US20030215423A1
(en)
*
|
1999-04-01 |
2003-11-20 |
Merck & Co., Inc. |
Gene therapy for obesity
|
DK1185615T3
(da)
*
|
1999-04-06 |
2007-11-05 |
Wisconsin Alumni Res Found |
Rekombinante influenzavirus til vacciner og genterapi
|
AU768836B2
(en)
*
|
1999-04-06 |
2004-01-08 |
Advec, Inc. |
Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration
|
US8715940B2
(en)
|
1999-04-06 |
2014-05-06 |
Wisconsin Alumni Research Foundation |
Method of making recombinant influenza virus
|
AU1013601A
(en)
|
1999-10-22 |
2001-05-08 |
Aventis Pasteur Limited |
Method of inducing and/or enhancing an immune response to tumor antigens
|
EP1978098A3
(de)
|
1999-12-10 |
2009-02-18 |
Invitrogen Corporation |
Verwendung von mehrfachen Rekombinationsstellen mit einzigartiger Spezifizität beim Rekombinationsklonen
|
US6867022B1
(en)
|
2000-01-21 |
2005-03-15 |
Regents Of The University Of Michigan |
Replication deficient adenovirus vectors and methods of making and using them
|
US7132277B1
(en)
*
|
2000-01-31 |
2006-11-07 |
Merck & Co., Inc. |
Helper dependent vector system for gene therapy
|
JP4927290B2
(ja)
|
2000-04-14 |
2012-05-09 |
ウィスコンシン アルムニ リサーチ ファンデイション |
変異イオンチャンネルタンパク質を含んで成るウイルス
|
ATE346925T1
(de)
|
2000-05-10 |
2006-12-15 |
Sanofi Pasteur Ltd |
Durch mage minigene kodierte immunogene polypeptide und ihre verwendungen
|
US7244560B2
(en)
*
|
2000-05-21 |
2007-07-17 |
Invitrogen Corporation |
Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
|
AU2001280576A1
(en)
*
|
2000-07-18 |
2002-01-30 |
Uab Research Foundation |
Tissue-specific self-inactivating gene therapy vector
|
US7198924B2
(en)
|
2000-12-11 |
2007-04-03 |
Invitrogen Corporation |
Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
|
JP2004517610A
(ja)
*
|
2000-09-08 |
2004-06-17 |
ザ ジェネラル ホスピタル コーポレーション |
自己再編成性dnaベクター
|
EP1320620B1
(de)
|
2000-09-25 |
2015-01-21 |
The Regents Of The University Of Michigan |
Herstellung viraler vektoren
|
WO2002041922A1
(fr)
*
|
2000-11-24 |
2002-05-30 |
Chugai Seiyaku Kabushiki Kaisha |
Procede servant a reguler l'activite de l'expression d'un produit genetique transfere dans un organisme vivant
|
US20040126774A1
(en)
*
|
2001-01-08 |
2004-07-01 |
Mitchell Lioyd G. |
Correction of factor VIII genetic defects using spliceosome mediated RNA trans splicing
|
US6943012B2
(en)
*
|
2001-03-26 |
2005-09-13 |
The Board Of Trustees Of The Leland Stanford Junor University |
Helper dependent adenoviral vector system and methods for using the same
|
WO2002086144A2
(en)
*
|
2001-04-19 |
2002-10-31 |
Invitrogen Corporation |
Compositions and methods for recombinational cloning of nucleic acid molecules
|
JP2004532636A
(ja)
*
|
2001-05-21 |
2004-10-28 |
インヴィトロジェン コーポレーション |
核酸分子の単離に用いるための組成物および方法
|
EP1402020A2
(de)
*
|
2001-06-28 |
2004-03-31 |
Phenogene Therapeutiques Inc. |
Methoden, vektoren, zelllinien und kits für die identifizierung von nukleinsäuren mit erwünschter eigenschaft
|
CA2460157A1
(en)
|
2001-09-18 |
2003-03-27 |
Clontech Laboratories, Inc. |
Site-specific recombinase based method for producing adenoviral vectors
|
US20040002060A1
(en)
*
|
2002-01-24 |
2004-01-01 |
Novartis Ag |
Fiber shaft modifications for efficient targeting
|
US7399753B2
(en)
*
|
2002-02-25 |
2008-07-15 |
Virxsys Corporation |
Trans-splicing mediated photodynamic therapy
|
ATE517122T1
(de)
|
2002-04-09 |
2011-08-15 |
Sanofi Pasteur Ltd |
Modifizierte cea-nukleinsäure und entsprechende expressionsvektoren
|
CA2485341A1
(en)
*
|
2002-05-08 |
2004-06-17 |
Intronn, Inc. |
Use of spliceosome mediated rna trans-splicing to confer cell selective replication to adenoviruses
|
US8304233B2
(en)
|
2002-06-04 |
2012-11-06 |
Poetic Genetics, Llc |
Methods of unidirectional, site-specific integration into a genome, compositions and kits for practicing the same
|
EP1546347A1
(de)
*
|
2002-09-27 |
2005-06-29 |
PowderJect Research Limited |
Nukleinsäurekonstrukt zur genexpression
|
EP1579004B1
(de)
*
|
2002-10-23 |
2010-06-16 |
VIRxSYS Corporation |
Screening-verfahren zur identifizierung wirksamer prä-trans-spleissmoleküle
|
US20040203133A1
(en)
*
|
2003-01-07 |
2004-10-14 |
Anja Ehrhardt |
Helper dependent adenoviral vector system and methods for using the same
|
KR100869011B1
(ko)
|
2003-04-23 |
2008-11-17 |
위스콘신 얼럼나이 리서어치 화운데이션 |
막횡단 단백질 유전자내 돌연변이를 갖는 재조합인플루엔자 바이러스
|
US20050095615A1
(en)
*
|
2003-06-26 |
2005-05-05 |
Welch Peter J. |
Methods and compositions for detecting promoter activity and expressing fusion proteins
|
US8562970B2
(en)
*
|
2003-10-08 |
2013-10-22 |
Sanofi Pasteur Limited |
Modified CEA/B7 vector
|
ATE469984T1
(de)
|
2003-12-01 |
2010-06-15 |
Life Technologies Corp |
Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon
|
US7968334B2
(en)
*
|
2004-01-23 |
2011-06-28 |
Virxsys Corporation |
Expression of apoAI and variants thereof using spliceosome mediated RNA trans-splicing
|
JP2007518423A
(ja)
*
|
2004-01-23 |
2007-07-12 |
イントロン、インコーポレイテッド |
スプライセオソーム仲介型rnaトランススプライシングを使用するアポa−1及びその変異体の発現
|
WO2005070948A1
(en)
*
|
2004-01-23 |
2005-08-04 |
Intronn, Inc. |
Correction of alpha-1-antitrypsin genetic defects using spliceosome mediated rna trans splicing
|
US20060094110A1
(en)
*
|
2004-07-30 |
2006-05-04 |
Mcgarrity Gerard J |
Use of spliceosome mediated RNA trans-splicing for immunotherapy
|
US20060134658A1
(en)
*
|
2004-08-09 |
2006-06-22 |
Garcia-Blanco Mariano A |
Use of RNA trans-splicing for generation of interfering RNA molecules
|
ES2407859T3
(es)
|
2004-09-13 |
2013-06-14 |
Genzyme Corporation |
Construcciones multiméricas.
|
DE102004047492B4
(de)
*
|
2004-09-23 |
2006-07-20 |
Jost-Werke Gmbh & Co. Kg |
Verfahren zum Übertragen von elektrischer, pneumatischer oder hydraulischer Energie sowie ein Energieübertragungssystem
|
CA2583306A1
(en)
*
|
2004-10-08 |
2006-08-10 |
Intronn, Inc. |
Use of rna trans-splicing for antibody gene transfer and antibody polypeptide production
|
US7871795B2
(en)
|
2004-10-08 |
2011-01-18 |
Virxsys Corporation |
Targeted trans-splicing of highly abundant transcripts for in vivo production of recombinant proteins
|
CN101103103A
(zh)
|
2004-11-19 |
2008-01-09 |
威斯康星旧生研究基金会 |
具有串联转录单位的重组流感病毒载体
|
US7696335B2
(en)
*
|
2005-10-13 |
2010-04-13 |
Bc Cancer Agency |
Kits for multiple non-cross reacting recombination reactions utilizing loxP sequences
|
AR059089A1
(es)
|
2006-01-20 |
2008-03-12 |
Genzyme Corp |
Administracion intraventricular de una enzima para enfermedades de almacenamiento lisosomal
|
SI1988823T1
(sl)
|
2006-02-09 |
2018-12-31 |
Genzyme Corporation |
Počasna intraventrikularna dostava
|
CN101472941B
(zh)
|
2006-03-31 |
2017-08-08 |
沃弗-威斯康星校友研究基金会 |
用于疫苗的高滴度重组流感病毒
|
WO2008156778A2
(en)
|
2007-06-18 |
2008-12-24 |
Tokiko Watanabe |
Influenza m2 protein mutant viruses as live influenza attenuated vaccines
|
ES2337973B8
(es)
*
|
2008-05-16 |
2011-07-21 |
Proyecto De Biomedicina Cima, S.L. |
Adenovirus auxiliares auto-inactivantes para la produccion de adenovirus recombinantes de alta capacidad.
|
ES2813347T3
(es)
|
2009-10-26 |
2021-03-23 |
Wisconsin Alumni Res Found |
Virus recombinantes de la influenza de alto título con replicación mejorada en células Vero
|
US10130697B2
(en)
|
2010-03-23 |
2018-11-20 |
Wisconsin Alumni Research Foundation (Warf) |
Vaccines comprising mutant attenuated influenza viruses
|
SG10201604810UA
(en)
|
2012-02-07 |
2016-08-30 |
Global Bio Therapeutics Inc |
Compartmentalized method of nucleic acid delivery and compositions and uses thereof
|
EP3022296B1
(de)
|
2013-07-15 |
2022-12-28 |
Wisconsin Alumni Research Foundation |
Rekombinante influenzaviren mit hohem titer und erhöhter replikation in mdck- oder vero-zellen oder eiern
|
US11364032B2
(en)
|
2013-08-08 |
2022-06-21 |
Global Bio Therapeutics, Inc. |
Clamp device for minimally invasive procedures and uses thereof
|
EP3561062A1
(de)
|
2013-09-13 |
2019-10-30 |
California Institute of Technology |
Selektive rückgewinnung
|
WO2015196150A2
(en)
|
2014-06-20 |
2015-12-23 |
Wisconsin Alumni Research Foundation (Warf) |
Mutations that confer genetic stability to additional genes in influenza viruses
|
US10633422B2
(en)
|
2015-06-01 |
2020-04-28 |
Wisconsin Alumni Research Foundation (Warf) |
Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
|
WO2017007839A1
(en)
|
2015-07-06 |
2017-01-12 |
Wisconsin Alumni Research Foundation (Warf) |
Improved influenza virus replication for vaccine development
|
WO2017100671A1
(en)
|
2015-12-11 |
2017-06-15 |
California Institute Of Technology |
TARGETING PEPTIDES FOR DIRECTING ADENO-ASSOCIATED VIRUSES (AAVs)
|
JP2019510481A
(ja)
|
2016-02-19 |
2019-04-18 |
ウィスコンシン アルムニ リサーチ ファンデイション |
ワクチン開発のための改善されたb型インフルエンザウイルス複製
|
US11896634B2
(en)
|
2017-04-21 |
2024-02-13 |
Baylor College Of Medicine |
Oncolytic virotherapy with helper-dependent adenoviral-based vectors expressing immunomodulatory molecules
|
CN113966399A
(zh)
|
2018-09-26 |
2022-01-21 |
加州理工学院 |
用于靶向基因疗法的腺相关病毒组合物
|
US11241492B2
(en)
|
2019-01-23 |
2022-02-08 |
Wisconsin Alumni Research Foundation (Warf) |
Mutations that confer genetic stability to genes in influenza viruses
|
JP2022522112A
(ja)
|
2019-02-08 |
2022-04-14 |
ウィスコンシン アルムニ リサーチ ファンデイション |
ヒト化細胞系
|
CN114929269A
(zh)
|
2019-05-01 |
2022-08-19 |
威斯康星校友研究基金会(Warf) |
用于疫苗开发的改进的流感病毒复制
|
WO2021041624A2
(en)
|
2019-08-27 |
2021-03-04 |
Yoshihiro Kawaoka |
Recombinant influenza viruses with stabilized ha for replication in eggs
|
KR20220027164A
(ko)
*
|
2019-10-23 |
2022-03-07 |
주식회사 제넨메드 |
헬퍼 플라스미드 기반 가틀리스 아데노바이러스 생산 시스템
|
KR20220155584A
(ko)
|
2020-03-15 |
2022-11-23 |
프로티니아, 인크. |
곤충에서의 재조합 단백질 생산
|
EP4340855A1
(de)
|
2021-08-13 |
2024-03-27 |
Triovance Holding LLC |
Hautersatzzusammensetzung und verfahren zur herstellung und verwendung davon
|
CN114369623B
(zh)
*
|
2022-01-12 |
2023-07-07 |
中国人民解放军空军军医大学 |
一种基于Cre-lox重组系统的Synaptotagmin2-RNAi及其应用
|
CN114410683B
(zh)
*
|
2022-01-12 |
2023-11-28 |
中国人民解放军空军军医大学 |
一种基于Cre-lox重组系统的RIM3-RNAi及其应用
|