DE69629591D1 - Formulierung zur intranasalen verabreichung - Google Patents
Formulierung zur intranasalen verabreichungInfo
- Publication number
- DE69629591D1 DE69629591D1 DE69629591T DE69629591T DE69629591D1 DE 69629591 D1 DE69629591 D1 DE 69629591D1 DE 69629591 T DE69629591 T DE 69629591T DE 69629591 T DE69629591 T DE 69629591T DE 69629591 D1 DE69629591 D1 DE 69629591D1
- Authority
- DE
- Germany
- Prior art keywords
- analgesic
- formulation
- tramadol
- intranasal administration
- intranasal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US557279 | 1995-11-14 | ||
US08/557,279 US6017963A (en) | 1995-11-14 | 1995-11-14 | Formulation for intranasal administration |
PCT/US1996/018904 WO1997017948A1 (en) | 1995-11-14 | 1996-11-14 | Formulation for respiratory tract administration |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69629591D1 true DE69629591D1 (de) | 2003-09-25 |
DE69629591T2 DE69629591T2 (de) | 2004-07-01 |
Family
ID=24224765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69629591T Expired - Lifetime DE69629591T2 (de) | 1995-11-14 | 1996-11-14 | Formulierung zur intranasalen verabreichung |
Country Status (8)
Country | Link |
---|---|
US (3) | US6017963A (de) |
EP (1) | EP0877609B1 (de) |
JP (1) | JP3152437B2 (de) |
AT (1) | ATE247461T1 (de) |
AU (1) | AU714303B2 (de) |
CA (1) | CA2234847C (de) |
DE (1) | DE69629591T2 (de) |
WO (1) | WO1997017948A1 (de) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9726916D0 (en) * | 1997-12-19 | 1998-02-18 | Danbiosyst Uk | Nasal formulation |
US6509005B1 (en) * | 1998-10-27 | 2003-01-21 | Virginia Commonwealth University | Δ9 Tetrahydrocannabinol (Δ9 THC) solution metered dose inhaler |
CA2354576C (en) * | 1998-12-11 | 2008-10-14 | Pharmachemie B.V. | Pharmaceutical preparation for inhalation of an opioid |
US7640062B2 (en) | 2000-05-08 | 2009-12-29 | Brainsgate Ltd. | Methods and systems for management of alzheimer's disease |
US6610271B2 (en) * | 2000-05-10 | 2003-08-26 | University Of Kentucky Research Foundation | System and method for intranasal administration of lorazepam |
US20060083691A1 (en) * | 2000-05-10 | 2006-04-20 | Wermeling Daniel P | Intranasal opioid compositions, delivery devices and methods of using same |
US20040115133A1 (en) * | 2000-05-10 | 2004-06-17 | Wermeling Daniel P. | Intranasal opioid compositions |
CA2417727C (en) * | 2000-07-31 | 2009-09-01 | Nycomed Danmark A/S | Fentanyl composition for nasal administration |
WO2002013886A2 (en) * | 2000-08-15 | 2002-02-21 | University Of Kentucky Research Foundation | Programmable multi-dose intranasal drug delivery device |
DE10049483A1 (de) * | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte 1-Aminobutan-3-ol-Derivate |
AU2001294808A1 (en) * | 2000-09-29 | 2002-04-08 | Board Of Trustees Operating Michigan State University | Catecholamine pharmaceutical compositions and methods |
EP1367970A1 (de) * | 2001-01-24 | 2003-12-10 | Summanus Pharma, Inc. | Alkylarylpolyether-alkohol-polymere zur verbesserung der nasenatmung |
US20040176359A1 (en) * | 2001-02-20 | 2004-09-09 | University Of Kentucky Research Foundation | Intranasal Benzodiazepine compositions |
EP1397126B9 (de) * | 2001-03-16 | 2007-02-21 | DMI Biosciences, Inc. | Verwendung von Tramadol zur Verzögerung der Ejakulation |
JP2005503425A (ja) | 2001-05-24 | 2005-02-03 | アレックザ モレキュラー デリヴァリー コーポレイション | 所定の吸入ルートによる薬剤エステルの送出 |
WO2002094231A1 (en) * | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Delivery of analgesics through an inhalation route |
US20030051728A1 (en) | 2001-06-05 | 2003-03-20 | Lloyd Peter M. | Method and device for delivering a physiologically active compound |
US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
HUP0401022A3 (en) * | 2001-08-14 | 2006-11-28 | Biotie Therapies Corp | Method for the preparation of pharmaceutical compositions containing opioid antagonist for treating alcoholism or alcohol abuse |
US6780891B2 (en) | 2001-11-30 | 2004-08-24 | Sepracor Inc. | Tramadol analogs and uses thereof |
IL164828A0 (en) * | 2002-04-25 | 2005-12-18 | Brainsgate Ltd | Methods and apparatus for modifying properties of the bbb and cerebral circulation by using the neuroexcitatory and/or neuroinhibitory effects of odorants on nerves in the head |
GB2389530B (en) * | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
ATE426460T1 (de) * | 2002-08-06 | 2009-04-15 | Glaxo Group Ltd | Ausgabevorrichtung |
GB0219511D0 (en) * | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Method of preparing dry powder inhalation compositions |
MXPA05001903A (es) * | 2002-08-21 | 2005-04-28 | Norton Healthcare Ltd | Composicion para inhalacion. |
DE10248601B4 (de) * | 2002-10-17 | 2006-05-24 | Goldstein, Naum, Dr.habil.nat. | Pharmazeutisches Mittel zur endonasalen Applikation bei der Behandlung von Krankheiten und Störungen des zentralen Nervensystems |
ES2370395T3 (es) | 2003-05-21 | 2011-12-15 | Alexza Pharmaceuticals, Inc. | Utilización de una capa de combustible sólido, procedimiento para fabricarla y unidad de calefacción correspondiente. |
GB0400804D0 (en) | 2004-01-14 | 2004-02-18 | Innoscience Technology Bv | Pharmaceutical compositions |
US8055347B2 (en) | 2005-08-19 | 2011-11-08 | Brainsgate Ltd. | Stimulation for treating brain events and other conditions |
US8010189B2 (en) * | 2004-02-20 | 2011-08-30 | Brainsgate Ltd. | SPG stimulation for treating complications of subarachnoid hemorrhage |
US9233245B2 (en) | 2004-02-20 | 2016-01-12 | Brainsgate Ltd. | SPG stimulation |
US20060045849A1 (en) * | 2004-08-24 | 2006-03-02 | Farhan Taghizadeh | Method of customizing the fragrance of nasal medications |
TWI436991B (zh) | 2004-11-22 | 2014-05-11 | Euro Celtique Sa | 用於純化反-(-)-△9-四氫大麻酚與反-(+)-△9-四氫大麻酚之方法 |
US20070020330A1 (en) | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
US8758816B2 (en) * | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
LT2486942T (lt) | 2004-11-24 | 2019-01-25 | Meda Pharmaceuticals Inc. | Kompozicijos, apimančios azelastiną ir jų panaudojimo būdai |
TWI366460B (en) | 2005-06-16 | 2012-06-21 | Euro Celtique Sa | Cannabinoid active pharmaceutical ingredient for improved dosage forms |
US20100272769A1 (en) * | 2005-08-03 | 2010-10-28 | Amcol International | Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use |
US20070031512A1 (en) * | 2005-08-03 | 2007-02-08 | Amcol International Corporation | Virus-interacting layered phyllosilicates and methods of inactivating viruses |
US20080184618A1 (en) * | 2005-08-03 | 2008-08-07 | Amcol International | Virus-Interacting Layered Phyllosilicates and Methods of Use |
US20070111964A1 (en) * | 2005-08-17 | 2007-05-17 | Fleming And Company, Pharmaceuticals | Vitamin B12 nasal spray and method of use |
ES2385513T3 (es) * | 2005-10-11 | 2012-07-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Composición para administración nasal |
US8911751B2 (en) * | 2005-10-11 | 2014-12-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions for nasal delivery |
AU2007208681B2 (en) * | 2006-01-27 | 2010-04-08 | Asahi Kasei Pharma Corporation | Medicine for transnasal administration |
US20080319083A1 (en) * | 2006-01-27 | 2008-12-25 | Asahi Kasei Pharma Corporation | Medicine for transnasal administration |
WO2008011596A2 (en) * | 2006-07-21 | 2008-01-24 | Lab International Srl | Hydrophilic abuse deterrent delivery system |
US20080275030A1 (en) * | 2007-01-19 | 2008-11-06 | Sveinbjorn Gizurarson | Methods and Compositions for the Delivery of a Therapeutic Agent |
WO2008100926A1 (en) * | 2007-02-12 | 2008-08-21 | Dmi Biosciences, Inc. | Treatment of comorbid premature ejaculation and erectile dysfunction |
CA2677691C (en) | 2007-02-12 | 2012-07-31 | David Bar-Or | Reducing side effects of tramadol |
WO2008112661A2 (en) | 2007-03-09 | 2008-09-18 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
ATE530178T1 (de) | 2007-05-23 | 2011-11-15 | Amcol International Corp | Mit cholesterin interagierende phyllosilikate und verfahren zur reduktion von hypercholesterinämie bei einem säuger |
CN102014636A (zh) | 2008-02-27 | 2011-04-13 | 安姆科尔国际公司 | 治疗和动脉粥样硬化有关的心血管障碍的方法 |
CN103687594A (zh) | 2011-04-05 | 2014-03-26 | 奥普托索夫有限公司 | 眼科治疗 |
US10702485B2 (en) | 2011-07-09 | 2020-07-07 | Syntrix Biosystems Inc. | Compositions and methods for overcoming resistance to tramadol |
EP2668945A1 (de) * | 2012-06-01 | 2013-12-04 | Bayer Technology Services GmbH | Genotyp- bzw. Phänotyp-basierte Arzeimittelformulierungen |
CN104208044A (zh) * | 2013-05-29 | 2014-12-17 | 天津金耀集团有限公司 | 盐酸曲马多吸入制剂 |
ES2604816B1 (es) | 2015-09-09 | 2018-01-29 | Farmalider, S.A. | Composición farmacéutica de tramadol para uso oftálmico |
US11844859B2 (en) | 2017-08-20 | 2023-12-19 | Nasus Pharma Ltd. | Dry powder compositions for intranasal delivery |
AU2018319592A1 (en) | 2017-08-20 | 2020-02-13 | Nasus Pharma Ltd. | Dry powder compositions for intranasal delivery |
RU2667808C1 (ru) * | 2017-12-19 | 2018-09-24 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский технологический университет "МИСиС" | Способ акустико-эмиссионной диагностики ответственных деталей тележек грузовых вагонов при эксплуатации |
RU2697159C1 (ru) * | 2018-06-18 | 2019-08-12 | Общество с ограниченной ответственностью "МЕЖДУНАРОДНЫЙ ЦЕНТР МОНИТОРИНГА НА ОСНОВЕ ВОЛНОВЫХ ПРОЦЕССОВ" | Способ мониторинга технического состояния колес подвижного состава во время движения |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3652589A (en) * | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
US4464378A (en) * | 1981-04-28 | 1984-08-07 | University Of Kentucky Research Foundation | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same |
US4440777A (en) * | 1981-07-07 | 1984-04-03 | Merck & Co., Inc. | Use of eucalyptol for enhancing skin permeation of bio-affecting agents |
US4749700A (en) * | 1984-10-23 | 1988-06-07 | Nastech Pharmaceutical Co, Inc. | Novel methods of administering antihistamines, antinausea and antiemetic pharmaceutical agents and novel dosage forms containing same |
US4624965A (en) * | 1984-11-15 | 1986-11-25 | Nastech Pharmaceutical Co., Inc. | Novel method of administering anti-nausea and anti-emetic pharmaceutical agents and novel dosage forms containing same |
EP0189861A3 (de) * | 1985-01-26 | 1988-02-17 | Showa Denko Kabushiki Kaisha | Transdermaler Absorptionsbeschleuniger für ionische wasserlösliche Arzneistoffe |
US4729997A (en) * | 1985-10-15 | 1988-03-08 | Nastech Pharmaceutical Co., Inc. | Novel method of administering meclizine type pharmaceutical agents and novel dosage forms containing same |
US5066648A (en) * | 1985-11-29 | 1991-11-19 | Merck & Co., Inc. | Pyroglutamic acid esters used as dermal penetration enhancers for drugs |
DE3602370A1 (de) * | 1986-01-27 | 1987-08-06 | Chrubasik Sigrun | Verwendung von analgetica durch inhalation |
US4778810A (en) * | 1987-01-08 | 1988-10-18 | Nastech Pharmaceutical Co., Inc. | Nasal delivery of caffeine |
US5446070A (en) * | 1991-02-27 | 1995-08-29 | Nover Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
US4973596A (en) * | 1988-05-20 | 1990-11-27 | Barr Laboratories, Inc. | Method of administering a narcotic analgesic and dosage forms therefor |
US4880813A (en) * | 1988-07-22 | 1989-11-14 | Baker Cummins Pharmaceuticals, Inc. | Method of treatment for allergic rhinitis |
JP2875611B2 (ja) * | 1990-08-29 | 1999-03-31 | エーザイ株式会社 | ケイ酸カルシウム含有外用剤 |
CA2095523C (en) | 1991-09-06 | 2004-06-22 | Robert B. Raffa | Composition comprising a tramadol material and acetaminophen and its use |
EP0534628B1 (de) * | 1991-09-06 | 1996-11-20 | Mcneilab, Inc. | Zusammensetzungen, die Tramadol und irgendein Kodein, Oxykoden oder Hydrokoden enthalten, und deren Verwendung |
US5223541A (en) * | 1991-09-13 | 1993-06-29 | Mcneilab, Inc. | Tramadol n-oxide material, enantiomers and compositions thereof, and their use |
US5516803A (en) | 1991-10-30 | 1996-05-14 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
GB9202464D0 (en) * | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
DE69327432T2 (de) | 1992-02-07 | 2000-05-18 | Kaken Pharma Co Ltd | Heilmittel für wunden und hämorrhoiden |
DE4221256C2 (de) * | 1992-06-26 | 1997-07-10 | Lancaster Group Ag | Galenische Zusammensetzung für die topische Anwendung |
GB2269992A (en) * | 1992-08-14 | 1994-03-02 | Rh Ne Poulenc Rorer Limited | Powder inhalation formulations |
WO1994004139A1 (en) | 1992-08-21 | 1994-03-03 | Dana Farber Cancer Institute | Treatment of human viral infections |
WO1994010987A1 (en) * | 1992-11-09 | 1994-05-26 | Pharmetrix Corporation | Combined analgesic delivery methods for pain management |
JPH06199701A (ja) * | 1992-12-29 | 1994-07-19 | Lion Corp | 外用消炎鎮痛剤 |
DE69434304T2 (de) * | 1993-03-26 | 2005-12-29 | Merkus, Franciscus Wilhelmus H.M. | Pharmazeutische Zusammensetzungen zur intranasalen Verabreichung von Dihydroergotamin |
CA2159359A1 (en) | 1993-04-07 | 1994-10-13 | Seiichi Araki | Immunopotentiative and infection-protective agent, containing two or more bacillus, egg white and garlic |
US5451408A (en) * | 1994-03-23 | 1995-09-19 | Liposome Pain Management, Ltd. | Pain management with liposome-encapsulated analgesic drugs |
-
1995
- 1995-11-14 US US08/557,279 patent/US6017963A/en not_active Expired - Fee Related
-
1996
- 1996-11-14 AU AU10604/97A patent/AU714303B2/en not_active Ceased
- 1996-11-14 WO PCT/US1996/018904 patent/WO1997017948A1/en active IP Right Grant
- 1996-11-14 EP EP96941475A patent/EP0877609B1/de not_active Expired - Lifetime
- 1996-11-14 DE DE69629591T patent/DE69629591T2/de not_active Expired - Lifetime
- 1996-11-14 AT AT96941475T patent/ATE247461T1/de active
- 1996-11-14 CA CA002234847A patent/CA2234847C/en not_active Expired - Fee Related
- 1996-11-14 JP JP51917797A patent/JP3152437B2/ja not_active Expired - Fee Related
-
1999
- 1999-11-05 US US09/435,009 patent/US20010049391A1/en not_active Abandoned
-
2001
- 2001-08-16 US US09/930,927 patent/US6642275B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU714303B2 (en) | 1999-12-23 |
CA2234847C (en) | 2002-06-25 |
EP0877609A4 (de) | 2000-06-07 |
AU1060497A (en) | 1997-06-05 |
JP3152437B2 (ja) | 2001-04-03 |
WO1997017948A1 (en) | 1997-05-22 |
US20010049391A1 (en) | 2001-12-06 |
CA2234847A1 (en) | 1997-05-22 |
US6642275B2 (en) | 2003-11-04 |
DE69629591T2 (de) | 2004-07-01 |
US20020022663A1 (en) | 2002-02-21 |
US6017963A (en) | 2000-01-25 |
EP0877609B1 (de) | 2003-08-20 |
ATE247461T1 (de) | 2003-09-15 |
EP0877609A1 (de) | 1998-11-18 |
JPH11500148A (ja) | 1999-01-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: EURO-CELTIQUE S.A., LUXEMBURG/LUXEMBOURG, LU |
|
8364 | No opposition during term of opposition |