DE69630033D1 - Immunologische kombinationsmittel und dazugehörige verfahren - Google Patents
Immunologische kombinationsmittel und dazugehörige verfahrenInfo
- Publication number
- DE69630033D1 DE69630033D1 DE69630033T DE69630033T DE69630033D1 DE 69630033 D1 DE69630033 D1 DE 69630033D1 DE 69630033 T DE69630033 T DE 69630033T DE 69630033 T DE69630033 T DE 69630033T DE 69630033 D1 DE69630033 D1 DE 69630033D1
- Authority
- DE
- Germany
- Prior art keywords
- lipoprotein
- antigen
- related methods
- compositions
- combination agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6018—Lipids, e.g. in lipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/828—Bacterial vaccine for canidae or mustelidae, e.g. dogs, foxes, minks
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US476656 | 1995-06-07 | ||
US08/476,656 US6251405B1 (en) | 1995-06-07 | 1995-06-07 | Immunological combination compositions and methods |
US588621 | 1996-01-19 | ||
US08/588,621 US6379675B1 (en) | 1995-06-07 | 1996-01-19 | Immunological combination compositions and methods |
PCT/US1996/008866 WO1996040290A1 (en) | 1995-06-07 | 1996-06-05 | Immunological combination compositions and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69630033D1 true DE69630033D1 (de) | 2003-10-23 |
DE69630033T2 DE69630033T2 (de) | 2004-04-01 |
Family
ID=23892726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69630033T Expired - Fee Related DE69630033T2 (de) | 1995-06-07 | 1996-06-05 | Immunologische kombinationsmittel und dazugehörige verfahren |
Country Status (12)
Country | Link |
---|---|
US (5) | US6251405B1 (de) |
EP (1) | EP0831937B1 (de) |
JP (1) | JPH11510370A (de) |
AT (1) | ATE249844T1 (de) |
AU (1) | AU717890B2 (de) |
CA (1) | CA2223041A1 (de) |
DE (1) | DE69630033T2 (de) |
FI (1) | FI118591B (de) |
IL (1) | IL118579A (de) |
NO (1) | NO975620L (de) |
WO (1) | WO1996040290A1 (de) |
ZA (1) | ZA964894B (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7008625B2 (en) | 1993-11-01 | 2006-03-07 | Research Foundation Of The State University Of New York | Recombinant constructs of Borrelia burgdorferi |
ZA964896B (en) * | 1995-06-07 | 1997-01-08 | Connaught Lab | Expression of lipoproteins |
CA2289966A1 (en) * | 1997-05-14 | 1998-11-19 | Galen (Chemicals) Limited | Topical compositions |
CA2304128A1 (en) * | 1997-09-18 | 1999-03-25 | Robert Becker | Improved method of production of pneumococcal surface proteins |
WO2000000218A1 (fr) * | 1998-06-26 | 2000-01-06 | Aventis Pasteur | Immunisation a ciblage mucosal |
KR100629028B1 (ko) | 1998-10-16 | 2006-09-26 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 애쥬번트 시스템 및 백신 |
WO2000039304A2 (en) | 1998-12-31 | 2000-07-06 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
AT407958B (de) | 1999-02-11 | 2001-07-25 | Immuno Ag | Inaktivierte influenza-virus-vakzine zur nasalen oder oralen applikation |
WO2000062800A2 (en) | 1999-04-19 | 2000-10-26 | Smithkline Beecham Biologicals Sa | Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide |
EP1683867B1 (de) | 1999-06-18 | 2014-04-09 | Research Foundation Of State University Of New York | Gruppen von Borrelia burgdorferi und Borrelia afzelii, die Lyme Krankheit in Menschen verursachen |
EP1235588A2 (de) * | 1999-12-09 | 2002-09-04 | Institut Pasteur | Durch mukosale verabreichung ohne adjuvans von polypeptiden mit lipidische ende induzierte systemische immunantwort |
US20030232055A1 (en) * | 2000-07-31 | 2003-12-18 | Ruslan Medzhitov | Innate immune system-directed vaccines |
CA2418036A1 (en) * | 2000-07-31 | 2002-02-07 | Yale University | Innate immune system-directed vaccines |
DE60131982T2 (de) | 2000-08-18 | 2008-12-11 | Brookhaven Science Associates Llc | Veränderte borrelia burgdorferi ospa |
EP1939294A1 (de) | 2000-08-18 | 2008-07-02 | Research Foundation Of State University Of New York | Rekombinante Konstrukte von Borrelia Burgdorferi |
US20030175287A1 (en) * | 2001-01-03 | 2003-09-18 | Yale University | Innate immune system-directed vaccines |
JP5033303B2 (ja) | 2001-07-05 | 2012-09-26 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 抗原性c型hivポリペプチドをコードするポリヌクレオチド、ポリペプチドおよびそれらの使用 |
US7923023B2 (en) * | 2002-02-25 | 2011-04-12 | Astech International LLC | Method and composition for delivery of medicants to animals |
US20080299140A1 (en) * | 2002-05-24 | 2008-12-04 | The Regents Of The University Of California, | Immunogenic Composition and Peptide Sequences for Prevention and Treatment of an Hsv Condition |
FR2846004B1 (fr) * | 2002-10-16 | 2006-06-23 | Maco Pharma Sa | Composition pour culture de cellules notamment animales ou de tissus, comprenant du polyethylene glycol |
US7795223B2 (en) * | 2004-05-27 | 2010-09-14 | Novozymes Biopharma Au Ltd. | Treatment of inflammatory airway disease |
US8029777B2 (en) | 2004-08-13 | 2011-10-04 | Marshall Barry J | Helicobacter system and uses thereof |
CA2576280A1 (en) | 2004-08-13 | 2006-02-16 | Barry J. Marshall | Helicobacter pylori-based delivery system |
EP1991264B1 (de) | 2006-03-07 | 2015-01-07 | Vaxinnate Corporation | Zusammensetzungen mit hämagglutinin, verfahren zu ihrer herstellung und verfahren zu ihrer verwendung |
US8426163B2 (en) * | 2007-12-07 | 2013-04-23 | National Health Research Institutes | Production of lipidated proteins in E. coli |
US8466259B2 (en) * | 2007-12-07 | 2013-06-18 | National Health Research Institutes | Adjuvants |
WO2009131665A1 (en) | 2008-04-22 | 2009-10-29 | Research Foundation Of State University Of New York | Borrelia burgdorferi cell envelope protein array |
US8287880B2 (en) | 2009-06-02 | 2012-10-16 | National Health Research Institutes | Lipidated vaccine against dengue virus infection |
WO2010148496A1 (en) * | 2009-06-22 | 2010-12-29 | National Health Research Institutes | Lipidated tumor- associated antigens and immunotherapeutic compositions |
EP2475385A1 (de) * | 2009-09-10 | 2012-07-18 | Novartis AG | Kombinationsimpfstoffe gegen atemwegserkrankungen |
TWI507413B (zh) | 2010-11-15 | 2015-11-11 | Nat Health Research Institutes | 脂質化多抗原表位疫苗 |
TW201221642A (en) | 2010-11-15 | 2012-06-01 | Nat Health Research Institutes | Method of producing lipidated polypeptides |
KR101948670B1 (ko) | 2010-12-29 | 2019-02-15 | 오션스파 인코퍼레이티드 | 중앙 스파 피쉬 펜 |
RU2737638C2 (ru) * | 2013-12-03 | 2020-12-01 | Вирометикс Аг | ПРОЛИН-БОГАТЫЕ ПЕПТИДЫ, ЗАЩИЩАЮЩИЕ ОТ S.pneumoniae |
JP2017531657A (ja) | 2014-10-07 | 2017-10-26 | ザ リサーチ ファンデーション フォー ザ ステート ユニバーシティ オブ ニューヨーク | 組換えボレリアタンパク質およびその使用のための方法 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK590288D0 (da) * | 1988-10-24 | 1988-10-24 | Symbicom Ab | Kemiske forbindelser |
US4302386A (en) * | 1978-08-25 | 1981-11-24 | The Ohio State University | Antigenic modification of polypeptides |
EP0014815A3 (de) | 1978-12-20 | 1980-10-29 | Ciba-Geigy Ag | Peptidderivate, Verfahren zu deren Herstellung und Zwischenprodukte sowie pharmazeutische Präparate mit einer dieser Verbindungen |
US4258029A (en) | 1979-04-23 | 1981-03-24 | Connaught Laboratories Limited | Synthetic adjuvants for stimulation of antigenic responses |
US4455142A (en) | 1980-07-07 | 1984-06-19 | Alza Corporation | Method of coadministering an antigen and an immunopotentiator |
US4484923A (en) * | 1982-03-25 | 1984-11-27 | Alza Corporation | Method for administering immunopotentiator |
DE3521994A1 (de) | 1985-06-20 | 1987-01-02 | Bayer Ag | N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
US4839293A (en) * | 1986-02-24 | 1989-06-13 | The Trustees Of Columbia University In The City Of New York | DNA encoding streptavidin, streptavidin produced therefrom, fused polypeptides which include amino acid sequences present in streptavidin and uses thereof |
US4721617A (en) | 1986-08-14 | 1988-01-26 | Regents Of The University Of Minnesota | Vaccine against lyme disease |
EP0270295A3 (de) * | 1986-12-03 | 1989-08-02 | Connaught Laboratories Limited | Konjugat-Impfstoff |
US4879213A (en) * | 1986-12-05 | 1989-11-07 | Scripps Clinic And Research Foundation | Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse |
US5098997A (en) * | 1987-12-11 | 1992-03-24 | Praxis Biologics, Inc. | Vaccines for Haemophilus influenzae |
WO1990003441A1 (en) | 1988-09-20 | 1990-04-05 | Marvin Murray | Accelerated microdilution determination of bacteria susceptibility to antibiotics |
DK0506868T4 (da) | 1989-12-22 | 2004-04-26 | Mikrogen Molekularbiol Entw | Immunologisk aktive proteiner fra Borrelia burgdorferi, tilhørende testkits og vaccine |
CA2032914A1 (en) * | 1989-12-26 | 1991-06-27 | Peter C.K. Lau | Use of bacterial lipoprotein amino terminus in fusion plasmids for in vivo expression of lipid modified polypeptides |
ZA921025B (en) | 1991-02-15 | 1992-11-25 | Uab Research Foundation | Structural gene of pneumococcal protein |
WO1993004175A1 (en) * | 1991-08-15 | 1993-03-04 | Smithkline Beecham Biologicals (S.A.) | Osp a proteins of borrelia burgdorferi subgroups, encoding genes and vaccines |
WO1993007897A1 (en) * | 1991-10-21 | 1993-04-29 | Medimmune, Inc. | Bacterial expression vectors containing dna encoding secretion signals of lipoproteins |
EP0540457A1 (de) * | 1991-10-22 | 1993-05-05 | Symbicom Ab | Verbesserungen der Diagnose und der Prophylaxe von Borrelia burgdorferi |
CA2105629A1 (en) * | 1992-09-14 | 1994-03-15 | Robert S. Becker | Potentiation of immunogenic response |
WO1994014318A1 (en) * | 1992-12-24 | 1994-07-07 | Medimmune, Inc. | Method of protection against streptococcus pneumoniae with transformed mycobacteria |
FR2708622B1 (fr) * | 1993-08-02 | 1997-04-18 | Raymond Hamers | Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides. |
-
1995
- 1995-06-07 US US08/476,656 patent/US6251405B1/en not_active Expired - Fee Related
-
1996
- 1996-01-19 US US08/588,621 patent/US6379675B1/en not_active Expired - Fee Related
- 1996-06-05 IL IL118579A patent/IL118579A/en not_active IP Right Cessation
- 1996-06-05 WO PCT/US1996/008866 patent/WO1996040290A1/en active IP Right Grant
- 1996-06-05 AT AT96919085T patent/ATE249844T1/de not_active IP Right Cessation
- 1996-06-05 EP EP96919085A patent/EP0831937B1/de not_active Expired - Lifetime
- 1996-06-05 AU AU61519/96A patent/AU717890B2/en not_active Ceased
- 1996-06-05 CA CA002223041A patent/CA2223041A1/en not_active Abandoned
- 1996-06-05 DE DE69630033T patent/DE69630033T2/de not_active Expired - Fee Related
- 1996-06-05 JP JP9501336A patent/JPH11510370A/ja not_active Ceased
- 1996-06-07 ZA ZA9604894A patent/ZA964894B/xx unknown
-
1997
- 1997-12-04 NO NO975620A patent/NO975620L/no unknown
- 1997-12-05 FI FI974423A patent/FI118591B/fi active IP Right Grant
-
2002
- 2002-03-12 US US10/096,687 patent/US6984385B2/en not_active Expired - Fee Related
-
2005
- 2005-07-01 US US11/173,364 patent/US7235243B2/en not_active Expired - Fee Related
-
2007
- 2007-05-18 US US11/804,446 patent/US20080089911A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
FI974423A (fi) | 1998-02-04 |
CA2223041A1 (en) | 1996-12-19 |
EP0831937B1 (de) | 2003-09-17 |
FI118591B (fi) | 2008-01-15 |
JPH11510370A (ja) | 1999-09-14 |
WO1996040290A1 (en) | 1996-12-19 |
EP0831937A1 (de) | 1998-04-01 |
AU717890B2 (en) | 2000-04-06 |
EP0831937A4 (de) | 2001-09-19 |
NO975620D0 (no) | 1997-12-04 |
IL118579A (en) | 2007-12-03 |
AU6151996A (en) | 1996-12-30 |
US6984385B2 (en) | 2006-01-10 |
US20080089911A1 (en) | 2008-04-17 |
US20060110408A1 (en) | 2006-05-25 |
FI974423A0 (fi) | 1997-12-05 |
IL118579A0 (en) | 1996-10-16 |
ATE249844T1 (de) | 2003-10-15 |
US20020131983A1 (en) | 2002-09-19 |
NO975620L (no) | 1998-02-04 |
DE69630033T2 (de) | 2004-04-01 |
US7235243B2 (en) | 2007-06-26 |
ZA964894B (en) | 1997-02-24 |
US6379675B1 (en) | 2002-04-30 |
US6251405B1 (en) | 2001-06-26 |
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