DE69630881D1 - Fernprogrammierbare matrizen mit speichern und verwendungen davon - Google Patents

Fernprogrammierbare matrizen mit speichern und verwendungen davon

Info

Publication number
DE69630881D1
DE69630881D1 DE69630881T DE69630881T DE69630881D1 DE 69630881 D1 DE69630881 D1 DE 69630881D1 DE 69630881 T DE69630881 T DE 69630881T DE 69630881 T DE69630881 T DE 69630881T DE 69630881 D1 DE69630881 D1 DE 69630881D1
Authority
DE
Germany
Prior art keywords
molecules
substrate
support matrix
storage
particle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69630881T
Other languages
English (en)
Other versions
DE69630881T2 (de
Inventor
P Nova
E Senyei
Zahra Parandoosh
S David
Xiao-Yi Xiao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Discovery Partners International Inc
Original Assignee
Discovery Partners International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/428,662 external-priority patent/US5741462A/en
Priority claimed from US08/480,196 external-priority patent/US5925562A/en
Priority claimed from US08/480,147 external-priority patent/US6352854B1/en
Priority claimed from US08/473,660 external-priority patent/US6331273B1/en
Priority claimed from US08/484,486 external-priority patent/US6416714B1/en
Priority claimed from US08/484,504 external-priority patent/US5751629A/en
Priority claimed from US08/538,387 external-priority patent/US5874214A/en
Priority claimed from US08/567,746 external-priority patent/US6025129A/en
Application filed by Discovery Partners International Inc filed Critical Discovery Partners International Inc
Publication of DE69630881D1 publication Critical patent/DE69630881D1/de
Publication of DE69630881T2 publication Critical patent/DE69630881T2/de
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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    • B82—NANOTECHNOLOGY
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • G01N15/149—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742—Type of codes
    • G01N2035/00782—Type of codes reprogrammmable code
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
    • G11C13/02—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using elements whose operation depends upon chemical change
    • G11C13/025—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using elements whose operation depends upon chemical change using fullerenes, e.g. C60, or nanotubes, e.g. carbon or silicon nanotubes
DE69630881T 1995-04-25 1996-04-25 Fernprogrammierbare matrizen mit speichern und verwendungen davon Expired - Lifetime DE69630881T2 (de)

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US428662 1995-04-25
US08/428,662 US5741462A (en) 1995-04-25 1995-04-25 Remotely programmable matrices with memories
US480147 1995-06-07
US08/480,147 US6352854B1 (en) 1995-04-25 1995-06-07 Remotely programmable matrices with memories
US08/473,660 US6331273B1 (en) 1995-04-25 1995-06-07 Remotely programmable matrices with memories
US08/484,486 US6416714B1 (en) 1995-04-25 1995-06-07 Remotely programmable matrices with memories
US08/484,504 US5751629A (en) 1995-04-25 1995-06-07 Remotely programmable matrices with memories
US484504 1995-06-07
US08/480,196 US5925562A (en) 1995-04-25 1995-06-07 Remotely programmable matrices with memories
US480196 1995-06-07
US473660 1995-06-07
US484486 1995-06-07
US08/538,387 US5874214A (en) 1995-04-25 1995-10-03 Remotely programmable matrices with memories
US538387 1995-10-03
US567746 1995-12-05
US08/567,746 US6025129A (en) 1995-04-25 1995-12-05 Remotely programmable matrices with memories and uses thereof
US63981396A 1996-04-02 1996-04-02
US639813 1996-04-02
PCT/US1996/006145 WO1996036436A1 (en) 1995-04-25 1996-04-25 Remotely programmable matrices with memories and uses thereof

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Families Citing this family (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100973A (en) * 1994-03-18 2000-08-08 Spectra Science Corporation Methods and apparatus for performing microanalytical techniques using photolithographically fabricated substrates having narrow band optical emission capability
US6100026A (en) * 1995-04-25 2000-08-08 Irori Matrices with memories and uses thereof
US5925562A (en) * 1995-04-25 1999-07-20 Irori Remotely programmable matrices with memories
US5961923A (en) * 1995-04-25 1999-10-05 Irori Matrices with memories and uses thereof
KR19990008052A (ko) * 1995-04-25 1999-01-25 마이클 피 노바 기억 장치를 갖는 원격적으로 프로그램 가능한 매트릭스 및 이의 용도
US6284459B1 (en) 1995-04-25 2001-09-04 Discovery Partners International Solid support matrices with memories and combinatorial libraries therefrom
US5736332A (en) * 1995-11-30 1998-04-07 Mandecki; Wlodek Method of determining the sequence of nucleic acids employing solid-phase particles carrying transponders
US6001571A (en) 1995-11-30 1999-12-14 Mandecki; Wlodek Multiplex assay for nucleic acids employing transponders
JP2000502887A (ja) * 1995-11-30 2000-03-14 ウロデック マンデッキ 生体分子の電子的固相アッセイ
US6051377A (en) * 1995-11-30 2000-04-18 Pharmaseq, Inc. Multiplex assay for nucleic acids employing transponders
US5641634A (en) 1995-11-30 1997-06-24 Mandecki; Wlodek Electronically-indexed solid-phase assay for biomolecules
WO1997019958A1 (en) 1995-11-30 1997-06-05 Wlodek Mandecki Screening of drugs from chemical combinatorial libraries employing transponders
AU4976797A (en) * 1996-10-07 1998-05-05 Irori Matrices with memories in automated drug discovery and units therefor
US6136274A (en) * 1996-10-07 2000-10-24 Irori Matrices with memories in automated drug discovery and units therefor
US5981166A (en) * 1997-04-23 1999-11-09 Pharmaseq, Inc. Screening of soluble chemical compounds for their pharmacological properties utilizing transponders
US7160687B1 (en) * 1997-05-29 2007-01-09 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6096496A (en) 1997-06-19 2000-08-01 Frankel; Robert D. Supports incorporating vertical cavity emitting lasers and tracking apparatus for use in combinatorial synthesis
EP0950114A4 (de) * 1997-07-22 2004-07-28 Symyx Technologies Inc Kodierung von organometallischen bibliotheken
DE19736470C2 (de) * 1997-08-21 2001-02-22 Ulrich Schenck Datenverarbeitungsfähiger Mikroskopie-Probenträger und Verfahren zur Analyse von mikroskopierbaren Proben
AU2583899A (en) * 1998-02-04 1999-08-23 Invitrogen Corporation Microarrays and uses therefor
US6027695A (en) * 1998-04-01 2000-02-22 Dupont Pharmaceuticals Company Apparatus for holding small volumes of liquids
WO1999049974A1 (en) * 1998-04-01 1999-10-07 The Du Pont Merck Pharmaceutical Company Plate apparatus for holding small volumes of liquids
GB9808783D0 (en) * 1998-04-25 1998-06-24 Central Research Lab Ltd Labelling of small articles
GB9812783D0 (en) 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
EP2045334A1 (de) 1998-06-24 2009-04-08 Illumina, Inc. Dekodierung von Arraysensoren mit Mikrosphären
US7384733B1 (en) 1998-12-05 2008-06-10 Xention Discovery Limited Interface patch clamping
EP1151302B1 (de) * 1999-02-09 2010-03-31 Illumina, Inc. Screeningverfahren mit porösen mikrokügelchen und zusammensetzungen
US6432719B1 (en) * 1999-02-16 2002-08-13 Pe Corporation (Ny) Matrix storage and dispensing system
US7101510B2 (en) 1999-02-16 2006-09-05 Applera Corporation Matrix storage and dispensing system
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US7253435B2 (en) 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
AU4245900A (en) * 1999-04-15 2000-11-02 Virtual Arrays, Inc. Combinatorial chemical library supports having indicia at coding positions and methods of use
IL145970A0 (en) * 1999-04-16 2002-07-25 Tibotec Nv Encoding of microcarriers
US6759235B2 (en) 2000-04-06 2004-07-06 Quantum Dot Corporation Two-dimensional spectral imaging system
DE10059890A1 (de) * 2000-12-01 2002-06-20 Hte Ag Verfahren zur Herstellung einer Vielzahl von Bausteinen einer Materialbibliothek
US7189800B2 (en) 2001-03-27 2007-03-13 Samuel Bogoch Replikin peptides in rapid replication of glioma cells and in influenza epidemics
NZ592340A (en) 2001-03-27 2012-12-21 Elenore S Bogoch A method for making a virus vaccine compising Replikin peptides
US7774144B2 (en) 2001-10-26 2010-08-10 Samuel Bogoch System and method for identifying complex patterns of amino acids
US7572642B2 (en) 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
CN100485032C (zh) * 2001-05-11 2009-05-06 松下电器产业株式会社 生物分子基底,使用它的检验和诊断方法及装置
US6800491B2 (en) 2001-06-08 2004-10-05 Nalge Nunc International Corporation Robotic reservoir without liquid hangup
GB2387903A (en) * 2002-04-24 2003-10-29 Smartbead Technologies Ltd Multiparameter analysis using tagged molecules
JP4409426B2 (ja) * 2002-05-28 2010-02-03 オウトジエノミクス・インコーポレーテツド マイクロアレイ検出器および方法
GB2391230A (en) * 2002-07-26 2004-02-04 Smartbead Technologies Ltd Multiparameter assays using coded supports
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7164533B2 (en) * 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
CA2498916A1 (en) * 2002-09-12 2004-03-25 Cyvera Corporation Chemical synthesis using diffraction grating-based encoded optical elements
WO2004065000A1 (en) 2003-01-21 2004-08-05 Illumina Inc. Chemical reaction monitor
US8494781B2 (en) 2003-06-06 2013-07-23 Samuel Bogoch Systems and methods for identifying replikin scaffolds and uses of said replikin scaffolds
NZ580449A (en) * 2003-09-11 2011-06-30 Theranos Inc Ingestible medical device with biocompatible polymer coating, device with microarray to interact with disease marker
US7187286B2 (en) 2004-03-19 2007-03-06 Applera Corporation Methods and systems for using RFID in biological field
SG151298A1 (en) 2004-04-08 2009-04-30 Biomatrica Inc Integration of sample storage and sample management for life science
KR101270934B1 (ko) * 2004-04-28 2013-06-21 엘레노어 에스 보고치 아미노산의 복합 패턴을 확인하는 시스템 및 방법
US9254315B2 (en) 2004-04-28 2016-02-09 Samuel Bogoch Systems and methods for identifying replikin scaffolds and uses of said replikin scaffolds
WO2006055736A1 (en) 2004-11-16 2006-05-26 Illumina, Inc. And methods and apparatus for reading coded microbeads
EP1856525A4 (de) 2005-03-10 2015-12-09 Raustech Pty Ltd Diskettensubstrate für kombinatorische chemie
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
EP2639579B1 (de) * 2006-12-14 2016-11-16 Life Technologies Corporation Vorrichtung zur Messung von Analyten mithilfe großer FET-Arrays
KR100842730B1 (ko) * 2007-01-16 2008-07-01 삼성전자주식회사 멀티 비트 전기 기계적 메모리 소자 및 그의 제조방법
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
US8080372B2 (en) * 2007-04-11 2011-12-20 Canon Kabushiki Kaisha Method for detecting nucleic acid in sample, method for designing probes, system for designing probes therefor
AU2008266702A1 (en) 2007-05-30 2008-12-24 Elenore S. Bogoch Synthetic replikin peptides against pathogenic infection of invertebrates in aquaculture
WO2009064843A1 (en) * 2007-11-13 2009-05-22 Bayer Healthcare Llc Method to measure amino acid concentrations
WO2009064425A1 (en) * 2007-11-13 2009-05-22 Rational Affinity Devices, L.L.C. Multistate affinity ligands for the separation and purification of antibodies, antibody fragments and conjugates of antibodies and antibody fragments
JP5043810B2 (ja) * 2007-12-26 2012-10-10 パナソニック株式会社 生体試料測定装置およびこれを備えた生体試料測定システム
ES2312290B1 (es) * 2008-05-14 2009-09-22 Grifols, S.A. Dispositivo lector de microtubos para analisis de muestras de sangre.
ES2442024T3 (es) 2008-07-15 2014-02-07 Academia Sinica Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados
US8405379B1 (en) 2008-09-18 2013-03-26 Luc Montagnier System and method for the analysis of DNA sequences in biological fluids
US9233148B2 (en) 2009-01-09 2016-01-12 Samuel Bogoch Replikin-based compounds for prevention and treatment of influenza and methods of differentiating infectivity and lethality in influenza
US8741591B2 (en) 2009-10-09 2014-06-03 The Research Foundation For The State University Of New York pH-insensitive glucose indicator protein
EP2494353B1 (de) 2009-10-30 2017-09-27 Illumina Inc. Vorrichtung mit einer Mehrzahl von codierten Mikrogefäßen und einer Vielzahl von Fächern und ein Verfahren zum Lesen einer Mehrzahl von codierten Mikrogefäßen
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
US9845489B2 (en) 2010-07-26 2017-12-19 Biomatrica, Inc. Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
JP5933544B2 (ja) 2010-07-26 2016-06-08 バイオマトリカ， インコーポレーテッド 外界温度で出荷および貯蔵中の血中ｄｎａ、ｒｎａおよびタンパク質ならびに他の生体試料を安定化させるための組成物
US8668886B2 (en) * 2011-04-24 2014-03-11 Therapeutic Proteins International, LLC Separative bioreactor
US9057712B1 (en) 2011-10-27 2015-06-16 Copilot Ventures Fund Iii Llc Methods of delivery of encapsulated perfluorocarbon taggants
CN104271767B (zh) 2012-02-03 2017-08-25 加州理工学院 多路生化测定中信号的编码和解码
EP2820174B1 (de) 2012-02-27 2019-12-25 The University of North Carolina at Chapel Hill Verfahren und verwendung für molekulare tags
EP3321378B1 (de) 2012-02-27 2021-11-10 Becton, Dickinson and Company Zusammensetzungen für molekularen zählung
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
US9914956B2 (en) 2012-08-18 2018-03-13 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
WO2014100755A2 (en) 2012-12-20 2014-06-26 Biomatrica, Inc. Formulations and methods for stabilizing pcr reagents
KR101397599B1 (ko) * 2012-12-28 2014-05-30 한국기계연구원 전자후방산란회절 맵핑 결과 상의 상인식 오류의 필터링 방법
JP5898119B2 (ja) * 2013-03-28 2016-04-06 シスメックス株式会社 分析装置
CN104156739B (zh) * 2013-05-14 2019-09-10 上海亨臻实业有限公司 电子标签亲和配体库及用途
WO2014210397A1 (en) 2013-06-26 2014-12-31 Academia Sinica Rm2 antigens and use thereof
US9981030B2 (en) 2013-06-27 2018-05-29 Academia Sinica Glycan conjugates and use thereof
KR102536833B1 (ko) 2013-08-28 2023-05-26 벡톤 디킨슨 앤드 컴퍼니 대량의 동시 단일 세포 분석
AU2014317889B2 (en) 2013-09-06 2020-03-05 Academia Sinica Human iNKT cell activation using glycolipids with altered glycosyl groups
CN105745528A (zh) 2013-10-07 2016-07-06 赛卢拉研究公司 用于以数字方式对阵列上的特征进行计数的方法和系统
US9208864B2 (en) * 2013-10-14 2015-12-08 Toshiba America Electronic Components, Inc. Semiconductor memory with integrated biologic element
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
WO2015184009A1 (en) 2014-05-27 2015-12-03 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
CA2937123A1 (en) 2014-01-16 2015-07-23 Academia Sinica Compositions and methods for treatment and detection of cancers
WO2015148915A1 (en) 2014-03-27 2015-10-01 Academia Sinica Reactive labelling compounds and uses thereof
US10005847B2 (en) 2014-05-27 2018-06-26 Academia Sinica Anti-HER2 glycoantibodies and uses thereof
JP2017518989A (ja) 2014-05-27 2017-07-13 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 抗ｃｄ２０糖操作抗体群およびその使用
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
US11332523B2 (en) 2014-05-28 2022-05-17 Academia Sinica Anti-TNF-alpha glycoantibodies and uses thereof
ES2786373T3 (es) 2014-06-10 2020-10-09 Biomatrica Inc Estabilización de trombocitos a temperaturas ambiente
AU2015315294B2 (en) 2014-09-08 2020-09-17 Academia Sinica Human iNKT cell activation using glycolipids
CN106999929A (zh) * 2014-09-11 2017-08-01 克忧公司 用于检测和量化分析物的系统和方法
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
EP3653292A1 (de) * 2015-01-19 2020-05-20 Hitachi Chemical Company, Ltd. Trennmaterial
EP3789766A1 (de) 2015-01-24 2021-03-10 Academia Sinica Neuartige glycankonjugate und verfahren zur verwendung davon
WO2016134078A1 (en) 2015-02-19 2016-08-25 Becton, Dickinson And Company High-throughput single-cell analysis combining proteomic and genomic information
CN107208158B (zh) 2015-02-27 2022-01-28 贝克顿迪金森公司 空间上可寻址的分子条形编码
EP4180535A1 (de) 2015-03-30 2023-05-17 Becton, Dickinson and Company Verfahren und zusammensetzungen für kombinatorische barcodierung
WO2016172373A1 (en) 2015-04-23 2016-10-27 Cellular Research, Inc. Methods and compositions for whole transcriptome amplification
US11124823B2 (en) 2015-06-01 2021-09-21 Becton, Dickinson And Company Methods for RNA quantification
CN108026524A (zh) 2015-09-11 2018-05-11 赛卢拉研究公司 用于核酸文库标准化的方法和组合物
EP3387411B1 (de) 2015-12-08 2023-05-10 Biomatrica, INC. Verringerung der erythrozytensedimentationsrate
US10336784B2 (en) 2016-03-08 2019-07-02 Academia Sinica Methods for modular synthesis of N-glycans and arrays thereof
AU2017261189B2 (en) 2016-05-02 2023-02-09 Becton, Dickinson And Company Accurate molecular barcoding
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
US11397882B2 (en) 2016-05-26 2022-07-26 Becton, Dickinson And Company Molecular label counting adjustment methods
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
WO2017218777A1 (en) 2016-06-17 2017-12-21 California Institute Of Technology Nucleic acid reactions and related methods and compositions
US10391495B2 (en) * 2016-08-22 2019-08-27 Wisconsin Alumni Research Foundation Deformable well and method
KR102588027B1 (ko) 2016-08-22 2023-10-12 초 파마 인크. 항체, 결합 단편 및 사용 방법
US11460468B2 (en) 2016-09-26 2022-10-04 Becton, Dickinson And Company Measurement of protein expression using reagents with barcoded oligonucleotide sequences
KR102060306B1 (ko) * 2016-10-05 2019-12-30 서울대학교산학협력단 저장, 보존 및 색인이 가능한 생화학 물질 운반체 및 이의 제조방법
EP3523043A1 (de) * 2016-10-07 2019-08-14 Boehringer Ingelheim Vetmedica GmbH Verfahren zur steuerung einer analysevorrichtung und analysesystem
KR20190077062A (ko) 2016-11-08 2019-07-02 셀룰러 리서치, 인크. 발현 프로파일 분류 방법
EP3538672A1 (de) 2016-11-08 2019-09-18 Cellular Research, Inc. Verfahren zur klassifizierung von zellmarkern
CN110573253B (zh) 2017-01-13 2021-11-02 赛卢拉研究公司 流体通道的亲水涂层
US11319583B2 (en) 2017-02-01 2022-05-03 Becton, Dickinson And Company Selective amplification using blocking oligonucleotides
US10676779B2 (en) 2017-06-05 2020-06-09 Becton, Dickinson And Company Sample indexing for single cells
US11946095B2 (en) 2017-12-19 2024-04-02 Becton, Dickinson And Company Particles associated with oligonucleotides
SG11202007070VA (en) 2018-01-30 2020-08-28 Life Technologies Corp Instruments, devices and consumables for use in a workflow of a smart molecular analysis system
WO2019213237A1 (en) 2018-05-03 2019-11-07 Becton, Dickinson And Company Molecular barcoding on opposite transcript ends
CA3097976A1 (en) 2018-05-03 2019-11-07 Becton, Dickinson And Company High throughput multiomics sample analysis
JP2022511398A (ja) 2018-10-01 2022-01-31 ベクトン・ディキンソン・アンド・カンパニー ５’転写物配列の決定
US11932849B2 (en) 2018-11-08 2024-03-19 Becton, Dickinson And Company Whole transcriptome analysis of single cells using random priming
CN113195717A (zh) 2018-12-13 2021-07-30 贝克顿迪金森公司 单细胞全转录组分析中的选择性延伸
WO2020150356A1 (en) 2019-01-16 2020-07-23 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
WO2020154247A1 (en) 2019-01-23 2020-07-30 Cellular Research, Inc. Oligonucleotides associated with antibodies
CN114051534A (zh) 2019-07-22 2022-02-15 贝克顿迪金森公司 单细胞染色质免疫沉淀测序测定
US11591591B2 (en) * 2019-08-21 2023-02-28 New England Biolabs, Inc. Isolation of high molecular weight DNA using beads
EP4055160B1 (de) 2019-11-08 2024-04-10 Becton Dickinson and Company Verwendung von random-rpiming zur gewinnung von v(d)j-informationen in voller länge für immunrepertoiresequenzierung
US11649497B2 (en) 2020-01-13 2023-05-16 Becton, Dickinson And Company Methods and compositions for quantitation of proteins and RNA
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
CN115605614A (zh) 2020-05-14 2023-01-13 贝克顿迪金森公司（Us） 用于免疫组库谱分析的引物
CN111724841B (zh) * 2020-06-04 2022-06-10 中国科学院上海微系统与信息技术研究所 一种基于生物蛋白的信息存储方法
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
CN112490685B (zh) * 2020-10-13 2023-03-07 日月光半导体制造股份有限公司 天线封装结构及封装方法
EP4247967A1 (de) 2020-11-20 2023-09-27 Becton, Dickinson and Company Profilierung von stark exprimierten und schwach exprimierten proteinen

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3772200A (en) 1971-04-30 1973-11-13 Minnesota Mining & Mfg Method of tagging with microparticles
AT315542B (de) 1972-09-27 1974-05-27 Johannes Bancsich Dr Probenträger und Vorrichtung zum Einschreiben und Auslesen desselben
US4053433A (en) 1975-02-19 1977-10-11 Minnesota Mining And Manufacturing Company Method of tagging with color-coded microparticles
US4131064A (en) 1977-07-15 1978-12-26 Westinghouse Electric Corp. Tagging particles which are easily detected by luminescent response, or magnetic pickup, or both
US4390452A (en) 1979-08-20 1983-06-28 Minnesota Mining & Manufacturing Company Microparticles with visual identifying means
US4372745A (en) * 1979-12-19 1983-02-08 Electro-Nucleonics, Inc. Chemical luminescence amplification substrate system for immunochemistry involving microencapsulated fluorescer
GB2097144A (en) * 1981-03-23 1982-10-27 Tno New method for identifying algae in water samples and apparatus for use in that method
JPS58189558A (ja) * 1982-04-28 1983-11-05 Mochida Pharmaceut Co Ltd 免疫学的測定用容器
FR2555744B1 (fr) * 1983-11-30 1986-05-09 Philips Ind Commerciale Eprouvette avec moyens de memorisation des resultats d'analyse
US4727020A (en) * 1985-02-25 1988-02-23 Becton, Dickinson And Company Method for analysis of subpopulations of blood cells
US4631211A (en) * 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4857893A (en) * 1986-07-18 1989-08-15 Bi Inc. Single chip transponder device
WO1989008264A1 (fr) * 1988-03-04 1989-09-08 Ballies Uwe W Procede d'analyse automatique entierement selective du sang ou des composants du sang
US4891254A (en) * 1988-06-17 1990-01-02 Bianco James S Article with embedded optically-readable identification means and method for making same
GB8816982D0 (en) * 1988-07-16 1988-08-17 Probus Biomedical Ltd Bio-fluid assay apparatus
DE3932428A1 (de) * 1989-09-28 1991-04-11 Argumens Gmbh Vorrichtung zur drahtlosen messung einer lokalen physikalischen groesse
US5092184A (en) * 1989-12-22 1992-03-03 Medical Research Institute Of The Mary Imogene Bassett Hospital Cell staining system for flow cytometry
AU8868091A (en) * 1990-10-17 1992-05-20 Jack Love Identification and paternity determination by detecting presence or absence of multiple nucleic acid sequences
US5228001A (en) * 1991-01-23 1993-07-13 Syracuse University Optical random access memory
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
DE69217497T2 (de) * 1991-09-18 1997-06-12 Affymax Tech Nv Verfahren zur synthese der verschiedenen sammlungen von oligomeren
DE69220888T2 (de) * 1991-11-05 1998-01-29 Perkin Elmer Corp Vorrichtung und Verfahren zur Herstellung von Biopolymeren
US5213960A (en) * 1992-03-09 1993-05-25 Tanox Biosystems, Inc. Methods for selecting low frequency antigen-specific single B lymphocytes
JP3164403B2 (ja) * 1992-03-27 2001-05-08 オリンパス光学工業株式会社 自動分析装置
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
DE4213065A1 (de) * 1992-04-21 1993-10-28 Norbert H L Dr Ing Koster Selbstidentifizierende Telemetrievorrichtung
US5288291A (en) * 1992-08-12 1994-02-22 Datapet, Inc. Method and apparatus for simultaneously injecting a liquid and a transponder into an animal
JP2541081B2 (ja) * 1992-08-28 1996-10-09 日本電気株式会社 バイオセンサ及びバイオセンサの製造・使用方法
US5585275A (en) * 1992-09-02 1996-12-17 Arris Pharmaceutical Corporation Pilot apparatus for peptide synthesis and screening
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
DE4306563A1 (de) * 1993-03-03 1994-09-08 Jan Lichtenberg Probenbehälter für zu analysierende Proben
CA2139409C (en) * 1993-05-17 2005-01-04 Neil David Cook Devices and methods for the measurement of cellular biochemical processes
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
DE4326342A1 (de) * 1993-08-05 1995-02-09 Boehringer Mannheim Gmbh Verfahren zur Analyse von Probenflüssigkeiten
US6315953B1 (en) * 1993-11-01 2001-11-13 Nanogen, Inc. Devices for molecular biological analysis and diagnostics including waveguides
US5384025A (en) * 1994-03-07 1995-01-24 Applied Biosystems, Inc. Notched spacer for slab-gel electrophoresis
JPH07286953A (ja) * 1994-04-19 1995-10-31 Toa Medical Electronics Co Ltd イメージングフローサイトメータ
US5501954A (en) * 1994-06-13 1996-03-26 Genzyme Corporation Method of detecting cellular material
US5639428A (en) * 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
DE9416270U1 (de) * 1994-10-10 1994-12-08 Grieb Reinhard Laborprobenbehälter
US5985356A (en) 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
US6100026A (en) 1995-04-25 2000-08-08 Irori Matrices with memories and uses thereof
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US6340588B1 (en) 1995-04-25 2002-01-22 Discovery Partners International, Inc. Matrices with memories
US5741462A (en) 1995-04-25 1998-04-21 Irori Remotely programmable matrices with memories
US6352854B1 (en) 1995-04-25 2002-03-05 Discovery Partners International, Inc. Remotely programmable matrices with memories
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US5961923A (en) 1995-04-25 1999-10-05 Irori Matrices with memories and uses thereof
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
KR19990008052A (ko) * 1995-04-25 1999-01-25 마이클 피 노바 기억 장치를 갖는 원격적으로 프로그램 가능한 매트릭스 및 이의 용도
US6284459B1 (en) 1995-04-25 2001-09-04 Discovery Partners International Solid support matrices with memories and combinatorial libraries therefrom
US6319668B1 (en) 1995-04-25 2001-11-20 Discovery Partners International Method for tagging and screening molecules
US6025129A (en) 1995-04-25 2000-02-15 Irori Remotely programmable matrices with memories and uses thereof
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US6416714B1 (en) 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US5925562A (en) 1995-04-25 1999-07-20 Irori Remotely programmable matrices with memories
WO1996037777A1 (en) * 1995-05-23 1996-11-28 Nelson Randall W Mass spectrometric immunoassay
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US20030203390A1 (en) 1995-10-26 2003-10-30 Kaye Paul H. Coded particles for process sequence tracking in combinatorial compound library preparation
GB9521943D0 (en) 1995-10-26 1996-01-03 Univ Hertfordshire Coded particles for process sequence tracking in combinatorial compound library preparation
US5641634A (en) * 1995-11-30 1997-06-24 Mandecki; Wlodek Electronically-indexed solid-phase assay for biomolecules
JP2001519763A (ja) 1996-03-22 2001-10-23 オントジエン・コーポレイシヨン 空間分散位置コード化組み合わせライブラリー合成方法
US6136274A (en) 1996-10-07 2000-10-24 Irori Matrices with memories in automated drug discovery and units therefor
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5858648A (en) 1996-11-04 1999-01-12 Sienna Biotech, Inc. Assays using reference microparticles
US6005691A (en) 1996-12-11 1999-12-21 Hewlett-Packard Company High-security machine-readable holographic card
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US20020119580A1 (en) 1997-04-17 2002-08-29 Corless Anthony Robert Radiofrequency encoded chemical library synthesis particles method
US20020084329A1 (en) 1997-07-16 2002-07-04 Kaye Paul H. Coded items for labeling objects
JP3468750B2 (ja) 1998-01-22 2003-11-17 ルミネックス コーポレイション 多数の蛍光シグナルを有する微小粒子
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US20030134330A1 (en) 1999-04-15 2003-07-17 Ilya Ravkin Chemical-library composition and method
US20040018485A1 (en) 1999-04-15 2004-01-29 Ilya Ravkin Multiplexed analysis of cells
US20030129654A1 (en) 1999-04-15 2003-07-10 Ilya Ravkin Coded particles for multiplexed analysis of biological samples
US7253435B2 (en) 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US6649414B1 (en) 1999-08-17 2003-11-18 Luminex Corporation Microparticles with multiple fluorescent signals and methods of using same
US7338773B2 (en) 2000-04-14 2008-03-04 Millipore Corporation Multiplexed assays of cell migration
JP2004537712A (ja) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
US20040069857A1 (en) * 2000-10-19 2004-04-15 Leblans Marc Jan Rene Method and device for the manipulation of microcarriers for an identification purpose
US7842246B2 (en) * 2001-06-29 2010-11-30 Meso Scale Technologies, Llc Assay plates, reader systems and methods for luminescence test measurements

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US7935659B2 (en) 2011-05-03
US20090226891A2 (en) 2009-09-10
EP0822861B1 (de) 2003-11-26
CN1181720A (zh) 1998-05-13
AU707444B2 (en) 1999-07-08
US20110237459A1 (en) 2011-09-29
KR19990008052A (ko) 1999-01-25
US20110212857A1 (en) 2011-09-01
WO1996036436A1 (en) 1996-11-21
CA2216645A1 (en) 1996-11-21
US8219327B2 (en) 2012-07-10
US20120238466A1 (en) 2012-09-20
US20070248957A1 (en) 2007-10-25
US20130090260A1 (en) 2013-04-11
DE69630881T2 (de) 2004-09-02
ATE254965T1 (de) 2003-12-15
AU5918596A (en) 1996-11-29
EP0822861A1 (de) 1998-02-11

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