DE69636122D1 - Verfahren zur einführung von genen in zielzellen mit hilfe von retroviren - Google Patents
Verfahren zur einführung von genen in zielzellen mit hilfe von retrovirenInfo
- Publication number
- DE69636122D1 DE69636122D1 DE69636122T DE69636122T DE69636122D1 DE 69636122 D1 DE69636122 D1 DE 69636122D1 DE 69636122 T DE69636122 T DE 69636122T DE 69636122 T DE69636122 T DE 69636122T DE 69636122 D1 DE69636122 D1 DE 69636122D1
- Authority
- DE
- Germany
- Prior art keywords
- retrovirus
- target cells
- help
- effective amount
- functional material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
- C12N9/1088—Glutathione transferase (2.5.1.18)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13045—Special targeting system for viral vectors
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP29438295 | 1995-11-13 | ||
JP29438295 | 1995-11-13 | ||
JP5184796 | 1996-03-08 | ||
JP5184796 | 1996-03-08 | ||
PCT/JP1996/003254 WO1997018318A1 (en) | 1995-11-13 | 1996-11-07 | Method for gene introduction into target cells by retrovirus |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69636122D1 true DE69636122D1 (de) | 2006-06-14 |
DE69636122T2 DE69636122T2 (de) | 2006-12-07 |
Family
ID=26392431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69636122T Expired - Lifetime DE69636122T2 (de) | 1995-11-13 | 1996-11-07 | Verfahren zum gentransfer in zielzellen mit einem retrovirus |
Country Status (13)
Country | Link |
---|---|
US (5) | US6472204B1 (de) |
EP (1) | EP0870839B1 (de) |
JP (1) | JP3343357B2 (de) |
KR (2) | KR100395420B1 (de) |
CN (1) | CN100390290C (de) |
AT (1) | ATE325884T1 (de) |
AU (1) | AU709831B2 (de) |
CA (1) | CA2235629A1 (de) |
DE (1) | DE69636122T2 (de) |
EA (3) | EA004928B1 (de) |
ES (1) | ES2259182T3 (de) |
MX (1) | MX9803706A (de) |
WO (1) | WO1997018318A1 (de) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7083979B1 (en) | 1994-03-25 | 2006-08-01 | Indiana University Foundation | Methods for enhanced retroviral-mediated gene transfer |
DK1445322T4 (da) | 1995-06-15 | 2012-09-03 | Crucell Holland Bv | Pakningssystemer for humant rekombinant adenovirus til anvendelse ved genterapi |
CA2233316C (en) * | 1995-09-29 | 2010-12-14 | Indiana University Foundation | Methods for enhanced virus-mediated dna transfer using molecules with virus- and cell-binding domains |
TWI239352B (en) * | 1997-07-23 | 2005-09-11 | Takara Bio Inc | Gene transfer method with the use of serum-free medium |
JP2001523468A (ja) * | 1997-11-14 | 2001-11-27 | セダーシナイ メディカル センター | トランスジェニック種の産生のための雄性生殖細胞のトランスフェクションおよび移入 |
JP3807937B2 (ja) * | 1998-07-01 | 2006-08-09 | タカラバイオ株式会社 | 遺伝子導入方法 |
US7198909B1 (en) * | 1998-10-31 | 2007-04-03 | University Of Medicine & Dentistry Of New Jersey | Myeloid precursor cell useful for gene therapy and for modulation of immune responses |
AU2944100A (en) * | 1999-03-23 | 2000-10-09 | Takara Shuzo Co., Ltd. | Gene therapeutics |
US7309687B1 (en) | 1999-04-13 | 2007-12-18 | The Kenneth S. Warren Institute, Inc. | Methods for treatment and prevention of neuromuscular and muscular conditions by peripherally administered erythropoietin |
US7345019B1 (en) | 1999-04-13 | 2008-03-18 | The Kenneth S. Warren Institute, Inc. | Modulation of excitable tissue function by peripherally administered erythropoietin |
US7604960B2 (en) * | 1999-04-15 | 2009-10-20 | Crucell Holland B.V. | Transient protein expression methods |
US7297680B2 (en) | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
US20050170463A1 (en) * | 1999-04-15 | 2005-08-04 | Abraham Bout | Recombinant protein production in permanent amniocytic cells that comprise nucleic acid encoding adenovirus E1A and E1B proteins |
US20050164386A1 (en) * | 1999-04-15 | 2005-07-28 | Uytdehaag Alphonsus G. | Overexpression of enzymes involved in post-translational protein modifications in human cells |
US6855544B1 (en) * | 1999-04-15 | 2005-02-15 | Crucell Holland B.V. | Recombinant protein production in a human cell |
US8236561B2 (en) * | 1999-04-15 | 2012-08-07 | Crucell Holland B.V. | Efficient production of IgA in recombinant mammalian cells |
GB9912965D0 (en) * | 1999-06-03 | 1999-08-04 | Oxford Biomedica Ltd | In vivo selection method |
AU5958000A (en) * | 1999-07-08 | 2001-01-30 | Connie Jean Eaves | Method to improve viral infection |
US7192759B1 (en) | 1999-11-26 | 2007-03-20 | Crucell Holland B.V. | Production of vaccines |
US7527961B2 (en) * | 1999-11-26 | 2009-05-05 | Crucell Holland B.V. | Production of vaccines |
US7521220B2 (en) * | 1999-11-26 | 2009-04-21 | Crucell Holland B.V. | Production of vaccines |
AU2001285263A1 (en) | 2000-08-25 | 2002-03-13 | The General Hospital Corporation | Selective precipitation of viruses |
PA8536201A1 (es) | 2000-12-29 | 2002-08-29 | Kenneth S Warren Inst Inc | Protección y mejoramiento de células, tejidos y órganos que responden a la eritropoyetina |
US6531121B2 (en) | 2000-12-29 | 2003-03-11 | The Kenneth S. Warren Institute, Inc. | Protection and enhancement of erythropoietin-responsive cells, tissues and organs |
US8742091B2 (en) * | 2001-06-20 | 2014-06-03 | Dainippon Sumitomo Pharma Co., Ltd. | Method of promoting nucleic acid transfer |
JP2005052001A (ja) * | 2001-07-05 | 2005-03-03 | Takara Bio Inc | 遺伝子治療剤 |
KR100888915B1 (ko) | 2001-08-15 | 2009-03-16 | 다카라 바이오 가부시키가이샤 | 항원특이적 세포상해성 t 세포 확대배양방법 |
KR100979025B1 (ko) * | 2001-12-07 | 2010-08-30 | 크루셀 홀란드 비.브이. | 바이러스, 바이러스 단리물 및 백신의 생산 |
CN100591760C (zh) | 2002-03-25 | 2010-02-24 | 宝生物工程株式会社 | 制备细胞毒性淋巴细胞的方法 |
US20100143442A1 (en) | 2003-02-05 | 2010-06-10 | Queensland University Of Technology | Growth factor complexes and modulation of cell migration and growth |
US20040219099A1 (en) * | 2003-05-02 | 2004-11-04 | Jasbir Sandhu | Method for the treatment of tumors |
US20040220085A1 (en) * | 2003-05-02 | 2004-11-04 | Jasbir Sandhu | Compositions for nucleic acid delivery |
ATE414144T1 (de) | 2003-05-09 | 2008-11-15 | Crucell Holland Bv | Kulturen von e1-immortalisierten zellen und verfahren zu deren kultivierung zur erhöhung der produktausbeuten davon |
DK1626992T3 (da) * | 2003-05-23 | 2010-09-20 | Crucell Holland Bv | Produktion af rekombinant IgM i PER.C6-celler |
FR2857598A1 (fr) * | 2003-07-18 | 2005-01-21 | Inst Nat Sante Rech Med | Composes anti-angiogeniques, composition pharmaceutique les comprenant, et leur utilisation |
MXPA06002039A (es) | 2003-08-22 | 2006-05-25 | Takara Bio Inc | Proceso para producir linfocitos citotoxicos. |
GB0410130D0 (en) * | 2004-05-06 | 2004-06-09 | Molmed Spa | Cell preparation |
US9057056B2 (en) * | 2004-09-29 | 2015-06-16 | Takara Bio Inc. | Method for producing retrovirus using human producer cells with increased N-acetylglucosaminyltransferase III activity |
CN101115830B (zh) * | 2005-02-07 | 2012-09-05 | 宝生物工程株式会社 | 逆转录病毒储存方法 |
EP1892294A4 (de) | 2005-06-15 | 2010-04-14 | Takara Bio Inc | Verfahren zum transfer von genen in fettzellen oder vorläuferfettzellen |
CA2616863A1 (en) * | 2005-07-29 | 2007-02-01 | Australian Stem Cell Centre Limited | Compositions and methods for growth of pluripotent cells |
US8889844B2 (en) | 2005-08-16 | 2014-11-18 | Takara Bio Inc. | Nucleic acid for treatment or prevention of immunodeficiency virus infection |
EP1916302A4 (de) | 2005-08-17 | 2009-10-21 | Takara Bio Inc | Verfahren zur herstellung von lymphozyten |
JP4741906B2 (ja) * | 2005-08-31 | 2011-08-10 | タカラバイオ株式会社 | リンパ球の製造方法 |
CA2623735A1 (en) * | 2005-09-30 | 2007-04-12 | Takara Bio Inc. | Method for production of t cell population |
KR20090024782A (ko) * | 2006-06-09 | 2009-03-09 | 다카라 바이오 가부시키가이샤 | 림프구의 제조 방법 |
EP2138580B1 (de) | 2007-04-20 | 2013-03-20 | Takara Bio, Inc. | Vektor für gentherapie |
EP2267118A4 (de) | 2008-03-27 | 2013-08-28 | Takara Bio Inc | Verfahren zur herstellung einer transfizierten zelle |
CN102144027B (zh) * | 2008-07-07 | 2016-04-06 | 宝生物工程株式会社 | 生产多能干细胞的方法 |
WO2010080032A2 (en) * | 2009-01-09 | 2010-07-15 | Stichting Het Nederlands Kanker Instituut | Bead-assisted viral transduction |
WO2011024791A1 (ja) | 2009-08-25 | 2011-03-03 | タカラバイオ株式会社 | レチノイン酸存在下でのt細胞集団の製造方法 |
JP5792622B2 (ja) | 2009-09-11 | 2015-10-14 | タカラバイオ株式会社 | ナチュラルキラー細胞の製造方法 |
CN102725308A (zh) * | 2009-11-30 | 2012-10-10 | 昆士兰技术大学 | 纤连蛋白:生长因子嵌合物 |
US9228206B2 (en) | 2010-06-30 | 2016-01-05 | Takara Bio Inc. | Method for gene transfer |
JP5778147B2 (ja) * | 2010-06-30 | 2015-09-16 | タカラバイオ株式会社 | 遺伝子導入方法 |
US9861681B2 (en) | 2013-04-18 | 2018-01-09 | The United States of America as represented by the Secretary of the Army, on behalf of the United States Army Medical Research Institute of Infectious Diseases | Therapeutic compositions for neutralizing type I interferons, and methods of use |
CN109790536A (zh) | 2016-07-29 | 2019-05-21 | 宝生物工程株式会社 | 用于干细胞产生的纤连蛋白片段 |
US11524988B2 (en) | 2016-09-19 | 2022-12-13 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Artificial antigen presenting cells for genetic engineering of immune cells |
CN108103045B (zh) * | 2016-11-25 | 2022-10-04 | 丰益(上海)生物技术研发中心有限公司 | 脂肪酶及其应用 |
IL292456B (en) | 2017-02-22 | 2022-08-01 | Lumus Ltd | Optical assembly of a light guide |
US20200181260A1 (en) * | 2017-02-22 | 2020-06-11 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Bispecific antibody for cancer immunotherapy |
CN111655842B (zh) | 2018-01-25 | 2023-10-20 | 宝生物工程株式会社 | 淋巴细胞生产方法 |
AU2020211092B2 (en) | 2019-01-24 | 2023-05-11 | Lumus Ltd. | Optical systems including LOE with three stage expansion |
CN114901793A (zh) * | 2019-12-30 | 2022-08-12 | 美国圣戈班性能塑料公司 | 用于细胞转导的容器和方法 |
CN113444167B (zh) * | 2021-07-15 | 2022-09-30 | 陕西巨子生物技术有限公司 | 重组人胶原蛋白多肽及其应用 |
CN114634984A (zh) * | 2022-02-02 | 2022-06-17 | 复旦大学 | 一种脑胶质瘤生物标记物mlkl基因及其应用 |
WO2023213969A1 (en) * | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
CN114965839A (zh) * | 2022-05-11 | 2022-08-30 | 朗肽生物制药股份有限公司 | 人碱性成纤维细胞生长因子的肽图分析方法 |
CN117645664A (zh) * | 2024-01-29 | 2024-03-05 | 英特菲尔(成都)生物制品有限责任公司 | 重组人纤连蛋白标准品及其制备方法、鉴定方法与应用 |
Family Cites Families (13)
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---|---|---|---|---|
GB8516421D0 (en) * | 1985-06-28 | 1985-07-31 | Biotechnology Interface Ltd | Fibronectins |
US4994559A (en) | 1985-12-17 | 1991-02-19 | Synergen, Inc. | Human basic fibroblast growth factor |
US5026839A (en) | 1985-12-17 | 1991-06-25 | Synergen, Inc | DNA encoding a basic fibroblast growth factor |
JP2770926B2 (ja) * | 1985-12-17 | 1998-07-02 | サイナーゲン インコーポレーテッド | 毛管内皮細胞プロテアーゼ合成、dna合成および遊走を促進することの出来るヒト胎盤血管形成誘導因子 |
US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
US5492890A (en) * | 1990-12-03 | 1996-02-20 | The Scripps Research Institute | Polypeptides for promoting cell attachment |
DE4110409C2 (de) * | 1991-03-29 | 1999-05-27 | Boehringer Ingelheim Int | Neue Protein-Polykation-Konjugate |
JP2829405B2 (ja) * | 1991-10-14 | 1998-11-25 | 寳酒造株式会社 | 機能性ポリペプチド |
SE503225C2 (sv) * | 1991-10-30 | 1996-04-22 | Leif Lindholm Konsult Ab | Virus-antikroppskomplex för införing av virus i mammalieceller |
CH685803A5 (fr) * | 1992-06-09 | 1995-10-13 | Francis Verdan | Bâton d'alun fixé dans un étui. |
GB9223084D0 (en) * | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
US5686278A (en) | 1994-03-25 | 1997-11-11 | Indiana University Foundation | Methods for enhanced retrovirus-mediated gene transfer |
JPH1029952A (ja) | 1996-07-16 | 1998-02-03 | Takara Shuzo Co Ltd | ヒト免疫不全ウイルス感染の制御用組成物および制御方法 |
-
1996
- 1996-11-07 EA EA200200837A patent/EA004928B1/ru not_active IP Right Cessation
- 1996-11-07 JP JP51873197A patent/JP3343357B2/ja not_active Expired - Fee Related
- 1996-11-07 EA EA200001110A patent/EA003204B1/ru not_active IP Right Cessation
- 1996-11-07 DE DE69636122T patent/DE69636122T2/de not_active Expired - Lifetime
- 1996-11-07 CA CA002235629A patent/CA2235629A1/en not_active Abandoned
- 1996-11-07 ES ES96937515T patent/ES2259182T3/es not_active Expired - Lifetime
- 1996-11-07 KR KR10-2001-7008355A patent/KR100395420B1/ko not_active IP Right Cessation
- 1996-11-07 KR KR10-1998-0703457A patent/KR100353115B1/ko not_active IP Right Cessation
- 1996-11-07 AT AT96937515T patent/ATE325884T1/de not_active IP Right Cessation
- 1996-11-07 EA EA199800369A patent/EA003195B1/ru not_active IP Right Cessation
- 1996-11-07 EP EP96937515A patent/EP0870839B1/de not_active Expired - Lifetime
- 1996-11-07 US US08/809,156 patent/US6472204B1/en not_active Expired - Fee Related
- 1996-11-07 WO PCT/JP1996/003254 patent/WO1997018318A1/ja active IP Right Grant
- 1996-11-07 CN CNB961996137A patent/CN100390290C/zh not_active Expired - Fee Related
- 1996-11-07 AU AU75058/96A patent/AU709831B2/en not_active Ceased
-
1998
- 1998-05-11 MX MX9803706A patent/MX9803706A/es unknown
-
1999
- 1999-08-02 US US09/366,009 patent/US6426042B1/en not_active Expired - Fee Related
-
2001
- 2001-02-02 US US09/775,964 patent/US6949623B2/en not_active Expired - Fee Related
-
2005
- 2005-07-14 US US11/181,091 patent/US7446170B2/en not_active Expired - Fee Related
-
2008
- 2008-09-30 US US12/241,581 patent/US7790849B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6472204B1 (en) | 2002-10-29 |
KR19990067446A (ko) | 1999-08-16 |
CA2235629A1 (en) | 1997-05-22 |
DE69636122T2 (de) | 2006-12-07 |
US20090209730A1 (en) | 2009-08-20 |
ES2259182T3 (es) | 2006-09-16 |
US20060030046A1 (en) | 2006-02-09 |
EA200200837A1 (ru) | 2002-12-26 |
CN100390290C (zh) | 2008-05-28 |
EA199800369A1 (ru) | 1998-12-24 |
US7446170B2 (en) | 2008-11-04 |
CN1207774A (zh) | 1999-02-10 |
AU7505896A (en) | 1997-06-05 |
EA003195B1 (ru) | 2003-02-27 |
EP0870839A4 (de) | 2000-01-19 |
US6949623B2 (en) | 2005-09-27 |
EA004928B1 (ru) | 2004-10-28 |
US7790849B2 (en) | 2010-09-07 |
WO1997018318A1 (en) | 1997-05-22 |
AU709831B2 (en) | 1999-09-09 |
JP3343357B2 (ja) | 2002-11-11 |
US20030087437A1 (en) | 2003-05-08 |
EA200001110A1 (ru) | 2001-06-25 |
EA003204B1 (ru) | 2003-02-27 |
EP0870839B1 (de) | 2006-05-10 |
KR100353115B1 (ko) | 2003-01-06 |
KR100395420B1 (ko) | 2003-08-21 |
US6426042B1 (en) | 2002-07-30 |
EP0870839A1 (de) | 1998-10-14 |
ATE325884T1 (de) | 2006-06-15 |
MX9803706A (es) | 1998-09-30 |
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