DE69636824D1 - Terminal-sterilisierte osteogene Vorrichtungen und ihre Herstellung - Google Patents

Terminal-sterilisierte osteogene Vorrichtungen und ihre Herstellung

Info

Publication number
DE69636824D1
DE69636824D1 DE69636824T DE69636824T DE69636824D1 DE 69636824 D1 DE69636824 D1 DE 69636824D1 DE 69636824 T DE69636824 T DE 69636824T DE 69636824 T DE69636824 T DE 69636824T DE 69636824 D1 DE69636824 D1 DE 69636824D1
Authority
DE
Germany
Prior art keywords
mammal
devices
disclosed
sterilized
terminally sterilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69636824T
Other languages
English (en)
Other versions
DE69636824T2 (de
Inventor
Marjorie M Tucker
David C Rueger
Kuber T Sampath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stryker Corp
Original Assignee
Stryker Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stryker Corp filed Critical Stryker Corp
Publication of DE69636824D1 publication Critical patent/DE69636824D1/de
Application granted granted Critical
Publication of DE69636824T2 publication Critical patent/DE69636824T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/007—Particle radiation, e.g. electron-beam, alpha or beta radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0035—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/84—Bones; tendons; teeth; cartilage
DE69636824T 1995-06-07 1996-06-07 Terminal-sterilisierte osteogene Vorrichtungen und ihre Herstellung Expired - Lifetime DE69636824T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/478,452 US5674292A (en) 1995-06-07 1995-06-07 Terminally sterilized osteogenic devices and preparation thereof
US478452 1995-06-07

Publications (2)

Publication Number Publication Date
DE69636824D1 true DE69636824D1 (de) 2007-02-15
DE69636824T2 DE69636824T2 (de) 2007-11-08

Family

ID=23900000

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69636824T Expired - Lifetime DE69636824T2 (de) 1995-06-07 1996-06-07 Terminal-sterilisierte osteogene Vorrichtungen und ihre Herstellung
DE69626205T Expired - Lifetime DE69626205T2 (de) 1995-06-07 1996-06-07 Terminal-sterilisierte osteogene vorrichtungen und ihre herstellung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69626205T Expired - Lifetime DE69626205T2 (de) 1995-06-07 1996-06-07 Terminal-sterilisierte osteogene vorrichtungen und ihre herstellung

Country Status (7)

Country Link
US (5) US5674292A (de)
EP (2) EP0837701B1 (de)
JP (2) JP3430474B2 (de)
AT (2) ATE350068T1 (de)
AU (1) AU714963B2 (de)
DE (2) DE69636824T2 (de)
WO (1) WO1996040297A1 (de)

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
ATE142644T1 (de) * 1988-04-08 1996-09-15 Stryker Corp Biosynthetische osteogene proteine und sie enthaltende osteogene vorrichtungen
US6919308B2 (en) * 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US20070166353A1 (en) * 1988-04-08 2007-07-19 Stryker Corporation Osteogenic proteins
US5645591A (en) 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US7056882B2 (en) * 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
JP3504263B2 (ja) 1991-11-04 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 組み換え型骨形態形成蛋白ヘテロダイマー、組成物および使用法
US20080233170A1 (en) * 1992-02-21 2008-09-25 Stryker Corporation Osteogenic Proteins
US20040067157A1 (en) * 1993-07-22 2004-04-08 Clearant, Inc. Methods for sterilizing biological materials
US5362442A (en) * 1993-07-22 1994-11-08 2920913 Canada Inc. Method for sterilizing products with gamma radiation
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
ATE262863T1 (de) * 1996-10-23 2004-04-15 Sdgi Holdings Inc Abstandsstück für wirbel
ES2113834B1 (es) * 1996-11-12 1999-01-01 Univ Vigo Metodo de mejora de la osteointegracion de implantes de fijacion osea.
AU716137B2 (en) * 1997-01-16 2000-02-17 Cohesion Corporation Lyophilized collagen-based biomaterials, process of preparation and uses thereof
JP4388602B2 (ja) * 1997-02-07 2009-12-24 ストライカー コーポレイション マトリクスを含まない骨形成デバイス、移植片、およびその使用方法
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20030032586A1 (en) * 1997-05-15 2003-02-13 David C. Rueger Compositions for morphogen-induced osteogenesis
AU742663B2 (en) 1997-05-30 2002-01-10 Stryker Corporation Methods for evaluating tissue morphogenesis and activity
US20010031254A1 (en) * 1998-11-13 2001-10-18 Bianchi John R. Assembled implant
US6482584B1 (en) 1998-11-13 2002-11-19 Regeneration Technologies, Inc. Cyclic implant perfusion cleaning and passivation process
DE19803673A1 (de) * 1998-01-30 1999-08-05 Norbert M Dr Meenen Biohybrider Gelenkflächenersatz
US20040081704A1 (en) 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
GB9820457D0 (en) 1998-09-18 1998-11-11 Medlogic Global Corp Methods for sterilizing cyanoacrylate compositions
US7572440B2 (en) 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
US6958149B2 (en) * 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
EP1649865B1 (de) * 1998-10-06 2012-06-13 Stryker Corporation GDF-5 zur Verwendung für das Reparieren eines nicht-artikulären Knorpelgewebedefekts in einer Bandscheibe
ES2478257T3 (es) * 1998-10-06 2014-07-21 Stryker Corporation Composición que comprende una proteína osteogénica seleccionada del grupo que consiste en OP-2, OP-3, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-9, BMP-10, BMP-11 , BMP-15, BMP-3B, DPP, Vg-1, Vgr-1, proteína 60A, GDF-1, GDF-2, GDF-3, GDF-6, GDF-7, GDF-8, GDF-9, GDF-10, y GDF-11 para su uso en la reparación de defectos del cartílago no articular
US6677432B1 (en) 1998-10-07 2004-01-13 Stryker Corporation Mutations of the C-terminal portion of TGF-β superfamily proteins
EP1117805A2 (de) 1998-10-07 2001-07-25 STRYKER CORPORATION (a Michigan corporation) Modifizierte proteine der tgf-beta superfamilie
US6846906B1 (en) 1998-10-07 2005-01-25 Stryker Corporation Modified proteins of the TGF-β superfamily, including morphogenic proteins
GB2344519B (en) * 1998-12-07 2004-05-19 Johnson & Johnson Medical Ltd Sterile therapeutic compositions
JP2000169498A (ja) * 1998-12-10 2000-06-20 Natl Food Res Inst タンパク質の溶解性改善方法
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
ATE296643T1 (de) * 1999-02-04 2005-06-15 Sdgi Holdings Inc Osteogene pastenzusammensetzungen und ihre verwendung
EP1027897B1 (de) * 1999-02-10 2005-04-13 IsoTis N.V. Verfahren zur Knorpelgeweberegeneration
WO2000047114A1 (en) * 1999-02-12 2000-08-17 Collagenesis, Inc. Injectable collagen-based delivery system for bone morphogenic proteins
US6698162B2 (en) 2000-03-23 2004-03-02 Teikoku Pharma Usa, Inc. Methods of producing a terminally sterilized topical patch preparation
EP1299131A4 (de) * 2000-03-23 2003-06-18 Clearant Inc Verfahren zum sterilisieren von biologischen materialien
US20040086420A1 (en) * 2000-03-23 2004-05-06 Macphee Martin J. Methods for sterilizing serum or plasma
US6521244B1 (en) * 2000-06-13 2003-02-18 Nozomu Kanesaka Body filling material
US6800245B1 (en) * 2000-11-28 2004-10-05 Vita Special Purpose Corporation Sterile polymerizable systems and kits and methods of their manufacture and use
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
CA2433850A1 (en) 2001-01-04 2002-09-12 Osteotech, Inc. Method for sterilizing bioactive materials
US6682695B2 (en) 2001-03-23 2004-01-27 Clearant, Inc. Methods for sterilizing biological materials by multiple rates
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US6696060B2 (en) * 2001-06-14 2004-02-24 Clearant, Inc. Methods for sterilizing preparations of monoclonal immunoglobulins
US20030031584A1 (en) * 2001-08-10 2003-02-13 Wilson Burgess Methods for sterilizing biological materials using dipeptide stabilizers
US6946098B2 (en) 2001-08-10 2005-09-20 Clearant, Inc. Methods for sterilizing biological materials
US6749851B2 (en) * 2001-08-31 2004-06-15 Clearant, Inc. Methods for sterilizing preparations of digestive enzymes
US7252799B2 (en) * 2001-08-31 2007-08-07 Clearant, Inc. Methods for sterilizing preparations containing albumin
US6783968B2 (en) * 2001-09-24 2004-08-31 Clearant, Inc. Methods for sterilizing preparations of glycosidases
US20030185702A1 (en) * 2002-02-01 2003-10-02 Wilson Burgess Methods for sterilizing tissue
US20030095890A1 (en) * 2001-09-24 2003-05-22 Shirley Miekka Methods for sterilizing biological materials containing non-aqueous solvents
US20110091353A1 (en) * 2001-09-24 2011-04-21 Wilson Burgess Methods for Sterilizing Tissue
DE60239556D1 (de) 2001-11-14 2011-05-05 Durect Corp Katheterinjizierbare depotzusammensetzungen und deren verwendung
CN100446809C (zh) * 2001-11-14 2008-12-31 阿尔扎有限公司 可注射的长效组合物
US20030124023A1 (en) * 2001-12-21 2003-07-03 Wilson Burgess Method of sterilizing heart valves
US7357895B2 (en) 2002-01-04 2008-04-15 Osteotech, Inc. Method for sterilizing bioactive materials
US20030180181A1 (en) * 2002-02-01 2003-09-25 Teri Greib Methods for sterilizing tissue
US7897174B2 (en) * 2002-02-08 2011-03-01 University Of Erlangen-Nurnberg Formulation comprising bioactive agents and method of using same
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US7744597B2 (en) 2002-06-26 2010-06-29 Lifenet Health Device and process for producing fiber products and fiber products produced thereby
US7498040B2 (en) * 2005-10-12 2009-03-03 Lifenet Health Compositions for repair of defects in osseous tissues, and methods of making the same
US6908591B2 (en) * 2002-07-18 2005-06-21 Clearant, Inc. Methods for sterilizing biological materials by irradiation over a temperature gradient
US20040013561A1 (en) * 2002-07-18 2004-01-22 David Mann Methods for sterilizing recombinant or transgenic material
CA2494342A1 (en) 2002-07-31 2004-02-12 Alza Corporation Injectable depot compositions and uses thereof
DK1539101T3 (da) 2002-07-31 2009-04-27 Alza Corp Injicerbare, multi-modale polymere depotsammens tninger og anvendelser deraf
WO2004066876A1 (en) * 2003-01-27 2004-08-12 Medtronic Vascular Connaught Improved packaging for stent delivery systems
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7494811B2 (en) 2003-05-01 2009-02-24 Lifenet Health In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20050003007A1 (en) * 2003-07-02 2005-01-06 Michele Boix Method of sterilization of polymeric microparticles
JP5392981B2 (ja) 2003-09-12 2014-01-22 ワイス・エルエルシー 骨形成蛋白の送達のための注入可能なリン酸カルシウム固体ロッドおよびペースト
US7695674B2 (en) * 2003-09-29 2010-04-13 Medtronic Vascular, Inc. Method of sterilizing balloon with ionizing radiation
ES2396689T3 (es) 2003-12-11 2013-02-25 Isto Technologies Inc. Sistema de cartílago particulado
US7678385B2 (en) * 2004-04-28 2010-03-16 Biomet Manufacturing Corp. Irradiated implantable bone material
US20050244450A1 (en) * 2004-04-28 2005-11-03 Reddi A H Heat-treated implantable bone material
WO2005115438A1 (en) * 2004-05-25 2005-12-08 Stryker Corporation Use of morphogenic proteins for treating cartilage defects
US20060194726A1 (en) * 2004-05-25 2006-08-31 Rueger David C Methods of treating cartilage defects
EP1753396A2 (de) * 2004-06-09 2007-02-21 Scil Technology GmbH Verbundmaterial zur verwendung als proteinträger
US20050288796A1 (en) * 2004-06-23 2005-12-29 Hani Awad Native soft tissue matrix for therapeutic applications
DE102004036881A1 (de) * 2004-07-22 2006-02-16 Ossacur Ag Bioresorbierbares Material zur Füllung von Knochendefekten
DE102004036882A1 (de) * 2004-07-22 2006-02-16 Ossacur Ag Bioresorbierbares Material zur Füllung von Knochendefekten
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
US7837740B2 (en) * 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20080220044A1 (en) * 2007-03-06 2008-09-11 Semler Eric J Cancellous construct with support ring for repair of osteochondral defects
US7993578B2 (en) 2004-10-29 2011-08-09 Depuy Spine, Inc. Methods and kits for aseptic filling of products
US20060166251A1 (en) * 2005-01-26 2006-07-27 Archambault Joanne M Use of sFRPs as markers of BMP activity
MX2007011591A (es) * 2005-03-30 2007-12-10 Wyeth Corp Metodo para estimular el crecimiento de cabello administrando bmps.
US20060280645A1 (en) * 2005-06-02 2006-12-14 Scott Sellers Method for terminal sterilization of transdermal delivery devices
CA2610245A1 (en) * 2005-06-02 2006-12-07 Alza Corporation Method for terminal sterilization of transdermal delivery devices
US7815926B2 (en) * 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US8480757B2 (en) 2005-08-26 2013-07-09 Zimmer, Inc. Implants and methods for repair, replacement and treatment of disease
US8921109B2 (en) 2005-09-19 2014-12-30 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US7498041B2 (en) * 2005-10-12 2009-03-03 Lifenet Health Composition for repair of defects in osseous tissues
US20070083270A1 (en) * 2005-10-12 2007-04-12 Leila Masinaei Orthopedic prosthetic devices containing compositions for repair of defects in osseous tissues
US9005646B2 (en) 2005-10-12 2015-04-14 Lifenet Health Compositions for repair of defects in tissues, and methods of making the same
US20070088404A1 (en) * 2005-10-19 2007-04-19 Allen Wyler Methods and systems for improving neural functioning, including cognitive functioning and neglect disorders
US20100068245A1 (en) * 2006-03-15 2010-03-18 Manders Christian D Preparation and storage of stable, biologically active materials
US20090186332A1 (en) * 2006-03-15 2009-07-23 Manders Ernest K Preparation and storage of stable, antimicrobially active materials
EP1852443A1 (de) 2006-05-05 2007-11-07 Leukocare AG Biokompatible dreidimensionale Matrix für die Immobilisierung von biologischen Substanzen
US7520108B2 (en) 2006-06-13 2009-04-21 Tetra Laval Holdings & Finance Sa Method of sterilizing packages
SE530589C2 (sv) 2006-12-11 2008-07-15 Tetra Laval Holdings & Finance Metod att bestråla föremål
US8048857B2 (en) * 2006-12-19 2011-11-01 Warsaw Orthopedic, Inc. Flowable carrier compositions and methods of use
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US20080154233A1 (en) * 2006-12-20 2008-06-26 Zimmer Orthobiologics, Inc. Apparatus for delivering a biocompatible material to a surgical site and method of using same
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
AU2008240191B2 (en) 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
EP2058335B1 (de) * 2007-11-07 2020-06-24 Leukocare Ag Biologisch verträgliche, dreidimensionale Matrix zur Immobilisierung von biologischen Substanzen
EP2265220A1 (de) * 2008-03-05 2010-12-29 Musculoskeletal Transplant Foundation Spongiosa-konstrukte, knorpelteilchen und kombinationen von spongiosa-konstrukten und knorpelteilchen
US20140031944A1 (en) * 2008-03-18 2014-01-30 Yoh Sawatari Cylindrical graft and method for preparing a recipient site and implanting a cylindrical graft into alveolar jaw bone
US9616153B2 (en) 2008-04-17 2017-04-11 Warsaw Orthopedic, Inc. Rigid bone graft substitute
US20090263507A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Biological markers and response to treatment for pain, inflammation, neuronal or vascular injury and methods of use
WO2010015259A2 (en) * 2008-08-06 2010-02-11 Inmold Biosystems A/S Sterilisation of polymeric products comprising heat and radiation sensitive material
WO2010083051A2 (en) * 2009-01-15 2010-07-22 ProChon Biotech, Ltd. Cartilage particle tissue mixtures optionally combined with a cancellous construct
US20100226959A1 (en) * 2009-03-04 2010-09-09 Warsaw Orthopedic, Inc. Matrix that prolongs growth factor release
DE102009024616A1 (de) 2009-06-08 2010-12-23 Telos Gmbh Sterilisierbare Implantatbeschichtung und Verfahren zu deren Herstellung
US8613938B2 (en) 2010-11-15 2013-12-24 Zimmer Orthobiologics, Inc. Bone void fillers
EP2646065A4 (de) 2010-12-05 2016-03-23 Nanonerve Inc Faserpolymergerüste mit diametral gemusterten polymerfasern
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
WO2014110537A1 (en) * 2013-01-13 2014-07-17 Theracell, Inc. Oxygenated three-dimensional matrix for bone growth
AU2014253753B2 (en) 2013-04-19 2017-03-30 Theracell, Inc. Demineralized bone fibers having controlled geometry and shapes and methods thereof
CN105764491A (zh) 2013-12-09 2016-07-13 度瑞公司 药物活性剂复合物、聚合物复合物，以及包括其的组合物和方法
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
CN113710192B (zh) * 2019-01-31 2024-03-15 细胞医药股份有限公司 无机盐类蛋白复合医疗器械

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4394370A (en) * 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4804744A (en) 1984-01-04 1989-02-14 International Genetic Engineering, Inc. Osteogenic factors
US4578384A (en) * 1984-02-15 1986-03-25 The United States Of America As Represented By The Secretary Of The Army Polylactic-polyglycolic acids combined with an acidic phospholipid-lysozyme complex for healing osseous tissue
MX163953B (es) * 1984-03-27 1992-07-03 Univ New Jersey Med Procedimiento para preparar una matriz biodegradable a base de colageno
US4888366A (en) 1984-10-24 1989-12-19 Collagen Corporation Inductive collagen-based bone repair preparations
US4857456A (en) 1985-04-30 1989-08-15 The Regents Of The University Of California Assay of Bone morphogenetic protein (BMP) and anti-BMP antibody for the diagnosis of bone disorders
US4877864A (en) 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
US4865602A (en) * 1986-11-06 1989-09-12 Collagen Corporation Gamma irradiation of collagen/mineral mixtures
ATE142644T1 (de) 1988-04-08 1996-09-15 Stryker Corp Biosynthetische osteogene proteine und sie enthaltende osteogene vorrichtungen
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5024841A (en) * 1988-06-30 1991-06-18 Collagen Corporation Collagen wound healing matrices and process for their production
US5108436A (en) * 1988-09-29 1992-04-28 Collagen Corporation Implant fixation
US5236456A (en) * 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5645591A (en) 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US6054122A (en) 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6211146B1 (en) * 1991-03-11 2001-04-03 Curis, Inc. 60A protein-induced morphogenesis
US5652337A (en) 1991-03-11 1997-07-29 Creative Biomolecules, Inc. OP-3-induced morphogenesis
US5563124A (en) * 1991-04-22 1996-10-08 Intermedics Orthopedics/ Denver, Inc. Osteogenic product and process
ATE142460T1 (de) * 1991-06-21 1996-09-15 Genetics Inst Osteogene proteine enthaltende arzneimittel
US5270300A (en) 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
JP3504263B2 (ja) 1991-11-04 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 組み換え型骨形態形成蛋白ヘテロダイマー、組成物および使用法
EP0626868A1 (de) * 1992-02-19 1994-12-07 EBERLIN, Jean-Luc Transparant auf basis von kollagen und fibrinkleber zur wiederherstellung von knochen und knorpel und dessen herstellung
CA2093836A1 (en) * 1992-04-24 1993-10-25 Wayne Gombotz Biodegradable tgf-.beta. delivery system for bone regeneration
JPH06296677A (ja) 1993-04-16 1994-10-25 Yamanouchi Pharmaceut Co Ltd 骨形成用移植体
US5522895A (en) 1993-07-23 1996-06-04 Rice University Biodegradable bone templates
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US5514180A (en) * 1994-01-14 1996-05-07 Heggeness; Michael H. Prosthetic intervertebral devices
US5906827A (en) 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
US5520923A (en) * 1994-09-19 1996-05-28 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US5674292A (en) * 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US6040431A (en) 1995-06-07 2000-03-21 Stryker Corporation Single chain analogs of the TGF-β superfamily (morphons)

Also Published As

Publication number Publication date
EP0837701B1 (de) 2003-02-12
US5674292A (en) 1997-10-07
JP3430474B2 (ja) 2003-07-28
US6504079B2 (en) 2003-01-07
EP1334733B1 (de) 2007-01-03
AU714963B2 (en) 2000-01-13
AU6333596A (en) 1996-12-30
DE69636824T2 (de) 2007-11-08
US6461630B1 (en) 2002-10-08
US20020106394A1 (en) 2002-08-08
ATE232401T1 (de) 2003-02-15
US6013856A (en) 2000-01-11
DE69626205T2 (de) 2004-02-12
DE69626205D1 (de) 2003-03-20
ATE350068T1 (de) 2007-01-15
WO1996040297A1 (en) 1996-12-19
EP1334733A2 (de) 2003-08-13
US6028242A (en) 2000-02-22
JPH11506360A (ja) 1999-06-08
EP0837701A1 (de) 1998-04-29
EP1334733A3 (de) 2003-11-19
JP3483870B2 (ja) 2004-01-06
JP2002191686A (ja) 2002-07-09

Similar Documents

Publication Publication Date Title
DE69636824D1 (de) Terminal-sterilisierte osteogene Vorrichtungen und ihre Herstellung
US5676146B1 (en) Surgical implant containing a resorbable radiopaque marker and method of locating such within a body
SE8505518D0 (sv) Implantationslins, forfarande for framsstellning derav och anordning for att utfora forfarandet
ATE211303T1 (de) Miniatur-röntgen röhre mit niedrigem vermögen
ATE307264T1 (de) Anpassung der belichtung der haut
TR200200088T2 (tr) Kondrosit hücre transplantasyonu için metodlar; enstrümanlar ve maddeler
FI883594A0 (fi) Hedelmöitystä ehkäisevä implantti
BR8207625A (pt) Dispositivo de inplantacao recipiente de implantes e sistema de implantacao
NO20003961L (no) Osteoimplantat og fremgangsmÕte for fremstilling derav
DK1330347T3 (da) Behandling med superkritisk fluid af en bestrålet præform af et proteseleje fremstillet af polyethylen
ITBO920452A0 (it) "metodo per la realizzazione di protesi da implantologia e dispositivoper l'attuazione di tale metodo".
FR2746000B1 (fr) Implant intraoculaire souple et ensemble de tels implants
DE69102215T2 (de) Realisierungsverfahren für Implantat-Prothese und hierbei verwendete Elemente.
ATE67094T1 (de) Knochenzement.
ITTO920179A0 (it) Base per impianto endoosseo per protesi odontoiatriche e simili
CA2223049A1 (en) Terminally sterilized osteogenic devices and preparation thereof
CA2129403A1 (en) Ion Implanting Apparatus and Ion Implanting Method
EP0049341A3 (en) Process for conditioning and implanting alloplastic implants and organ grafts, as well as for pretreating the recipient
Khateery et al. The influence of radiation therapy on subperiosteal hydroxyapatite implants in rabbits
GB9112896D0 (en) Process for the manufacture of electron beam irradiated polymeric footwear compositions
DE69104345D1 (de) Bioabsorbierbares implantierbares material und verfahren zur herstellung.
NL192647B (nl) Werkwijze en apparaat voor hoogspanningsbehandeling van elektronenstraalbuizen.
ATE283063T1 (de) Allogene und xenogene transplantation
ITBO930473A0 (it) Dispositivo per la realizzazione di protesi dentarie da implantologia
IT1279984B1 (it) Armatura per la realizzazione di implantoprotesi dentarie, rimovibili, in particolare provvisorie

Legal Events

Date Code Title Description
8364 No opposition during term of opposition