DE69637545D1 - Chimärisches , adenovirales faserprotein und verfahren zu dessen verwendung - Google Patents
Chimärisches , adenovirales faserprotein und verfahren zu dessen verwendungInfo
- Publication number
- DE69637545D1 DE69637545D1 DE69637545T DE69637545T DE69637545D1 DE 69637545 D1 DE69637545 D1 DE 69637545D1 DE 69637545 T DE69637545 T DE 69637545T DE 69637545 T DE69637545 T DE 69637545T DE 69637545 D1 DE69637545 D1 DE 69637545D1
- Authority
- DE
- Germany
- Prior art keywords
- fiber protein
- adenoviral
- chimeric adenoviral
- adenoviral fiber
- chimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101710145505 Fiber protein Proteins 0.000 title abstract 5
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- 241000701161 unidentified adenovirus Species 0.000 abstract 2
- CXURGFRDGROIKG-UHFFFAOYSA-N 3,3-bis(chloromethyl)oxetane Chemical compound ClCC1(CCl)COC1 CXURGFRDGROIKG-UHFFFAOYSA-N 0.000 abstract 1
- 239000000835 fiber Substances 0.000 abstract 1
- 238000005829 trimerization reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
- C12N2810/405—Vectors comprising RGD peptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
- C12N2810/6018—Adenoviridae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/395,381 US5770442A (en) | 1995-02-21 | 1995-02-21 | Chimeric adenoviral fiber protein and methods of using same |
PCT/US1996/001957 WO1996026281A1 (en) | 1995-02-21 | 1996-02-13 | Chimeric adenoviral fiber protein and methods of using same |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69637545D1 true DE69637545D1 (de) | 2008-07-10 |
Family
ID=23562798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69637545T Expired - Lifetime DE69637545D1 (de) | 1995-02-21 | 1996-02-13 | Chimärisches , adenovirales faserprotein und verfahren zu dessen verwendung |
Country Status (8)
Country | Link |
---|---|
US (3) | US5770442A (de) |
EP (1) | EP0811069B1 (de) |
JP (1) | JPH11500315A (de) |
AT (1) | ATE397075T1 (de) |
AU (1) | AU698254B2 (de) |
CA (1) | CA2213343C (de) |
DE (1) | DE69637545D1 (de) |
WO (1) | WO1996026281A1 (de) |
Families Citing this family (130)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5820868A (en) | 1993-12-09 | 1998-10-13 | Veterinary Infectious Disease Organization | Recombinant protein production in bovine adenovirus expression vector system |
US6465253B1 (en) * | 1994-09-08 | 2002-10-15 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
US5998205A (en) * | 1994-11-28 | 1999-12-07 | Genetic Therapy, Inc. | Vectors for tissue-specific replication |
US6127525A (en) * | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
US6783980B2 (en) * | 1995-06-15 | 2004-08-31 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
DE69633565T3 (de) | 1995-06-15 | 2013-01-17 | Crucell Holland B.V. | Verpackungssysteme für humane, menschliche adenoviren, zur verwendung in die gentherapie |
US20020068049A1 (en) * | 1998-09-10 | 2002-06-06 | Henderson Daniel R. | Tissue specific adenoviral vectors |
CA2232669A1 (en) * | 1995-09-27 | 1997-04-03 | Frances Joanne Morling | Recombinant viruses incorporating a protease cleavable protein |
ATE382694T1 (de) * | 1995-11-28 | 2008-01-15 | Genvec Inc | Vektoren und methoden zum gentransfer in zellen |
AU742018B2 (en) * | 1996-08-21 | 2001-12-13 | Genvec, Inc. | Alternatively targeted adenovirus |
US6420629B1 (en) * | 1996-09-09 | 2002-07-16 | B.C. Research Inc. | Process of increasing plant growth and yield and modifying cellulose production in plants |
NZ334827A (en) * | 1996-09-25 | 2001-02-23 | Scripps Research Inst | High-capacity adenoviral vectors suitable for adenoviral-based gene therapy |
US7232899B2 (en) * | 1996-09-25 | 2007-06-19 | The Scripps Research Institute | Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use |
WO1998017322A1 (en) * | 1996-10-24 | 1998-04-30 | Genzyme Corporation And President And Fellows Of Harvard College | Enhanced delivery of adenoviral vectors to lung tissue |
US5877011A (en) * | 1996-11-20 | 1999-03-02 | Genzyme Corporation | Chimeric adenoviral vectors |
AU6442998A (en) * | 1997-03-14 | 1998-10-12 | Uab Research Foundation | Method for the purification of virus |
US6432699B1 (en) * | 1997-03-28 | 2002-08-13 | New York University | Viral vectors having chimeric envelope proteins containing the IgG-binding domain of protein A |
FR2761688A1 (fr) * | 1997-04-02 | 1998-10-09 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
FR2761689B1 (fr) * | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
IL132673A0 (en) * | 1997-05-08 | 2001-03-19 | Genetic Therapy Inc | Gene transfer with adenoviruses having modified fiber proteins |
IL133010A0 (en) * | 1997-05-28 | 2001-03-19 | Genvec Inc | Alternatively targeted adenovirus |
US6319716B1 (en) | 1997-06-23 | 2001-11-20 | University Of Saskatchewan | Bovine adenovirus type 3 genome and vector systems derived therefrom |
US20030045492A1 (en) * | 1997-08-13 | 2003-03-06 | Tang De-Chu C. | Vaccination by topical application of recombinant vectors |
US6706693B1 (en) | 1997-08-13 | 2004-03-16 | The Uab Research Foundation | Vaccination by topical application of genetic vectors |
US20030125278A1 (en) * | 1997-08-13 | 2003-07-03 | Tang De-Chu C. | Immunization of animals by topical applications of a salmonella-based vector |
US6716823B1 (en) | 1997-08-13 | 2004-04-06 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom, and uses thereof |
US6348450B1 (en) * | 1997-08-13 | 2002-02-19 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom and uses thereof |
EP1053013A4 (de) * | 1998-02-06 | 2004-12-22 | Uab Research Foundation | Adenovirus vektor enthaltend ein heterologes peptidepitop in der hi schleife des faserknopfes |
CA2321135A1 (en) * | 1998-02-17 | 1999-08-19 | Uab Research Foundation | Modified adenovirus containing a fiber replacement protein |
US6815200B1 (en) | 1998-02-17 | 2004-11-09 | The Uab Research Foundation | Modified adenovirus containing a fiber replacement protein |
US20050095231A1 (en) * | 1998-02-17 | 2005-05-05 | Curiel David T. | Modified adenovirus containing a fiber replacement protein |
US6670188B1 (en) * | 1998-04-24 | 2003-12-30 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
WO1999055365A1 (en) * | 1998-04-30 | 1999-11-04 | Cornell Research Foundation, Inc. | Adenoviral vectors with tandem fiber proteins |
US20030017138A1 (en) * | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
US20040043489A1 (en) * | 1998-07-08 | 2004-03-04 | Menzo Havenga | Gene delivery vectors provided with a tissue tropism for dendritic cells and methods of use |
AU2003268608B2 (en) * | 1998-07-08 | 2007-01-04 | Crucell Holland B.V. | Chimaeric adenoviruses |
CA2341061A1 (en) | 1998-08-27 | 2000-03-09 | Aventis Pharma S.A. | Targeted adenovirus vectors for delivery of heterologous genes |
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WO2000015823A1 (en) * | 1998-09-11 | 2000-03-23 | Genvec, Inc. | Alternatively targeted adenovirus |
US6929946B1 (en) * | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
IL133032A (en) * | 1998-11-20 | 2007-06-03 | Introgene Bv | Adenoviral gene delivery vectors provided with a tissue tropism for smooth muscle cells and /or endothelial cells |
WO2000052186A1 (en) * | 1999-03-04 | 2000-09-08 | Introgene B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
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ATE540686T1 (de) * | 1999-05-12 | 2012-01-15 | Uab Research Foundation | Adenovirus mit erhöhter infektiosität und konditionaler replikationsfähigkeit und deren verwendungen |
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EP1157999A1 (de) * | 2000-05-24 | 2001-11-28 | Introgene B.V. | Verfahren und Mitteln zur Verbesserung der Haut-Transplantation mittels Genabgabe-Vehikel mit Tropismus für primären Fibroblasten, sowie andere Verwendungsmöglichkeiten für diesen |
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1995
- 1995-02-21 US US08/395,381 patent/US5770442A/en not_active Expired - Lifetime
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1996
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- 1996-02-13 CA CA002213343A patent/CA2213343C/en not_active Expired - Fee Related
- 1996-02-13 EP EP96906417A patent/EP0811069B1/de not_active Expired - Lifetime
- 1996-02-13 AT AT96906417T patent/ATE397075T1/de not_active IP Right Cessation
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1999
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2002
- 2002-06-17 US US10/173,930 patent/US20030166286A1/en not_active Abandoned
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AU4980496A (en) | 1996-09-11 |
US5770442A (en) | 1998-06-23 |
US20030166286A1 (en) | 2003-09-04 |
JPH11500315A (ja) | 1999-01-12 |
AU698254B2 (en) | 1998-10-29 |
US20020099024A1 (en) | 2002-07-25 |
US6576456B2 (en) | 2003-06-10 |
ATE397075T1 (de) | 2008-06-15 |
CA2213343A1 (en) | 1996-08-29 |
EP0811069A1 (de) | 1997-12-10 |
CA2213343C (en) | 2009-09-01 |
WO1996026281A1 (en) | 1996-08-29 |
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