DE69638121D1 - Behandlung und verhütung von neoplasmatischen und infektiösen erkrankungen mit hitzeschock / stress proteinen - Google Patents
Behandlung und verhütung von neoplasmatischen und infektiösen erkrankungen mit hitzeschock / stress proteinenInfo
- Publication number
- DE69638121D1 DE69638121D1 DE69638121T DE69638121T DE69638121D1 DE 69638121 D1 DE69638121 D1 DE 69638121D1 DE 69638121 T DE69638121 T DE 69638121T DE 69638121 T DE69638121 T DE 69638121T DE 69638121 D1 DE69638121 D1 DE 69638121D1
- Authority
- DE
- Germany
- Prior art keywords
- complex
- micrograms
- vivo
- individual
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000002812 Heat-Shock Proteins Human genes 0.000 title abstract 3
- 108010004889 Heat-Shock Proteins Proteins 0.000 title abstract 3
- 208000035473 Communicable disease Diseases 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 4
- 230000000890 antigenic effect Effects 0.000 abstract 3
- 238000001727 in vivo Methods 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 101100016370 Danio rerio hsp90a.1 gene Proteins 0.000 abstract 1
- 101100285708 Dictyostelium discoideum hspD gene Proteins 0.000 abstract 1
- 101100125027 Dictyostelium discoideum mhsp70 gene Proteins 0.000 abstract 1
- 101150031823 HSP70 gene Proteins 0.000 abstract 1
- 101100071627 Schizosaccharomyces pombe (strain 972 / ATCC 24843) swo1 gene Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 101150052825 dnaK gene Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 230000001394 metastastic effect Effects 0.000 abstract 1
- 206010061289 metastatic neoplasm Diseases 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001176—Heat shock proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56977—HLA or MHC typing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6043—Heat shock proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/622—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier non-covalent binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/527,391 US5837251A (en) | 1995-09-13 | 1995-09-13 | Compositions and methods using complexes of heat shock proteins and antigenic molecules for the treatment and prevention of neoplastic diseases |
PCT/US1996/014557 WO1997010001A1 (en) | 1995-09-13 | 1996-09-11 | Treatment or prevention of neoplastic and infectious diseases with heat shock/stress proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69638121D1 true DE69638121D1 (de) | 2010-03-18 |
Family
ID=24101273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69638121T Expired - Lifetime DE69638121D1 (de) | 1995-09-13 | 1996-09-11 | Behandlung und verhütung von neoplasmatischen und infektiösen erkrankungen mit hitzeschock / stress proteinen |
Country Status (10)
Country | Link |
---|---|
US (8) | US5837251A (de) |
EP (1) | EP0859631B9 (de) |
JP (1) | JPH11514985A (de) |
AT (1) | ATE456378T1 (de) |
AU (1) | AU703101B2 (de) |
CA (1) | CA2232048C (de) |
DE (1) | DE69638121D1 (de) |
ES (1) | ES2340558T3 (de) |
WO (1) | WO1997010001A1 (de) |
ZA (1) | ZA967757B (de) |
Families Citing this family (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5750119A (en) * | 1994-01-13 | 1998-05-12 | Mount Sinai School Of Medicine Of The City University Of New York | Immunotherapeutic stress protein-peptide complexes against cancer |
US5997873A (en) * | 1994-01-13 | 1999-12-07 | Mount Sinai School Of Medicine Of The City University Of New York | Method of preparation of heat shock protein 70-peptide complexes |
US5961979A (en) | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
US6761892B1 (en) * | 1995-08-18 | 2004-07-13 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
US6331299B1 (en) | 1995-08-18 | 2001-12-18 | Sloan-Kettering Institute For Cancer Research | Method for treatment of cancer and infectious disease and compositions useful in same |
EP0851764A4 (de) * | 1995-08-18 | 2002-08-07 | Sloan Kettering Inst Cancer | Vakzine basierend auf hitzeschock-proteinen und immuntherapien |
US6773707B1 (en) | 1995-08-18 | 2004-08-10 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
US6719974B1 (en) * | 1995-08-18 | 2004-04-13 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
US5985270A (en) * | 1995-09-13 | 1999-11-16 | Fordham University | Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes |
US5935576A (en) | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
US5837251A (en) | 1995-09-13 | 1998-11-17 | Fordham University | Compositions and methods using complexes of heat shock proteins and antigenic molecules for the treatment and prevention of neoplastic diseases |
US6066716A (en) * | 1996-09-20 | 2000-05-23 | University Of New Mexico | Purified heat shock protein complexes |
US6455493B1 (en) | 1996-09-20 | 2002-09-24 | University Of New Mexico | Methods for using heat shock proteins |
US7157089B1 (en) * | 1996-11-26 | 2007-01-02 | Stressgen Biotechnologies Corporation | Immune responses using compositions containing stress proteins |
US7514232B2 (en) * | 1996-12-06 | 2009-04-07 | Becton, Dickinson And Company | Method for detecting T cell response to specific antigens in whole blood |
US6017540A (en) | 1997-02-07 | 2000-01-25 | Fordham University | Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes |
US6709672B2 (en) * | 1997-03-05 | 2004-03-23 | Biotech Tools S.A. | Pharmaceutical or food composition for treating pathologies associated with graft rejection or an allergic or autoimmune reaction |
CA2290038A1 (en) * | 1997-07-10 | 1999-01-21 | Alan Fersht | Chaperone fragments |
DE69834671T2 (de) | 1997-08-05 | 2007-05-10 | Stressgen Biotechnologies Corp., Victoria | Immunantwort gegen HPV Antigene hervorgerufen von Zusammensetzungen die ein HPV Antigen und ein Stressprotein enthalten oder einem Expressionsvektor fähig zur Expression dieser Proteine |
US6007821A (en) * | 1997-10-16 | 1999-12-28 | Fordham University | Method and compositions for the treatment of autoimmune disease using heat shock proteins |
WO1999022761A1 (en) * | 1997-10-31 | 1999-05-14 | Sloan-Kettering Institute For Cancer Research | Conjugate heat shock protein-binding peptides |
US5948646A (en) | 1997-12-11 | 1999-09-07 | Fordham University | Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes |
CA2321101C (en) * | 1998-02-20 | 2014-12-09 | University Of Miami | Modified heat shock protein-antigenic peptide complex |
WO1999048914A1 (en) * | 1998-03-26 | 1999-09-30 | The University Of New Mexico | Methods for using heat shock proteins |
CA2325735C (en) * | 1998-03-27 | 2013-06-04 | Gabriele Multhoff | Hsp70 protein for the treatment of tumours, cancer or infectious diseases through nk-cell activation |
GB9818133D0 (en) * | 1998-08-19 | 1998-10-14 | Quadrant Holdings Cambridge | Vaccine |
AU2004200711B2 (en) * | 1998-08-19 | 2005-11-10 | Immunobiology Limited | Vaccine Comprising Cytokine-Induced Heat Shock Proteins (HSP) |
US6475490B1 (en) | 1998-10-19 | 2002-11-05 | Fordham University | Compositions and methods for promoting tissue repair using heat shock proteins |
US6495360B1 (en) | 1999-05-28 | 2002-12-17 | Photogen, Inc. | Method for enhanced protein stabilization and for production of cell lines useful for production of such stabilized proteins |
EP1196772A2 (de) * | 1999-07-08 | 2002-04-17 | Stressgen Biotechnologies Corporation | Induktion einer th1-vermittelten immunantwort in vitro |
GB9919733D0 (en) * | 1999-08-19 | 1999-10-20 | Colaco Camilo | Vaccines against intracellular pathogens |
AUPQ233799A0 (en) | 1999-08-19 | 1999-09-09 | Minister For Agriculture, Minister For Land And Water Conservation For And On Behalf Of The State Of New South Wales | Recombinant sub-unit vaccine |
AU7743100A (en) * | 1999-09-30 | 2001-04-30 | Corixa Corporation | Stress protein compositions and methods for prevention and treatment of cancer and infectious disease |
US7378096B2 (en) | 1999-09-30 | 2008-05-27 | Health Research, Inc. | Stress protein compositions and methods for prevention and treatment of cancer and infectious disease |
US8128922B2 (en) * | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
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US20010034042A1 (en) * | 2000-01-20 | 2001-10-25 | Srivastava Pramod K. | Complexes of peptide-binding fragments of heat shock proteins and their use as immunotherapeutic agents |
US7235649B2 (en) * | 2000-03-24 | 2007-06-26 | Duke University | Isolated GRP94 ligand binding domain polypeptide and nucleic acid encoding same, and screening methods employing same |
US7179462B2 (en) | 2000-06-02 | 2007-02-20 | University Of Connecticut Health Center | α (2) macroglobulin receptor as a heat shock protein receptor and uses thereof |
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US7186515B1 (en) | 2000-06-02 | 2007-03-06 | University Of Connecticut Health Center | Alpha(2) macroglobulin receptor as a heat shock protein receptor and uses thereof |
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EP1601756B1 (de) | 2003-02-20 | 2010-12-15 | University of Connecticut Health Center | Verfahren zur herstellung von alpha (2) makroglobulin-antigen-molekül-komplexen |
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-
1995
- 1995-09-13 US US08/527,391 patent/US5837251A/en not_active Expired - Lifetime
-
1996
- 1996-09-11 AT AT96931527T patent/ATE456378T1/de not_active IP Right Cessation
- 1996-09-11 EP EP96931527A patent/EP0859631B9/de not_active Expired - Lifetime
- 1996-09-11 ES ES96931527T patent/ES2340558T3/es not_active Expired - Lifetime
- 1996-09-11 JP JP9512063A patent/JPH11514985A/ja active Pending
- 1996-09-11 AU AU70181/96A patent/AU703101B2/en not_active Ceased
- 1996-09-11 CA CA2232048A patent/CA2232048C/en not_active Expired - Fee Related
- 1996-09-11 DE DE69638121T patent/DE69638121D1/de not_active Expired - Lifetime
- 1996-09-11 WO PCT/US1996/014557 patent/WO1997010001A1/en active Application Filing
- 1996-09-13 ZA ZA967757A patent/ZA967757B/xx unknown
-
1998
- 1998-06-04 US US09/090,754 patent/US7601359B1/en not_active Expired - Fee Related
- 1998-09-09 US US09/150,203 patent/US6143299A/en not_active Expired - Lifetime
- 1998-09-09 US US09/150,040 patent/US6187312B1/en not_active Expired - Lifetime
- 1998-09-09 US US09/150,204 patent/US6136315A/en not_active Expired - Lifetime
- 1998-09-09 US US09/150,039 patent/US6139841A/en not_active Expired - Lifetime
- 1998-09-09 US US09/150,041 patent/US6162436A/en not_active Expired - Fee Related
-
2003
- 2003-08-12 US US10/640,604 patent/US20040047876A1/en not_active Abandoned
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EP0859631B9 (de) | 2010-07-28 |
CA2232048A1 (en) | 1997-03-20 |
US6139841A (en) | 2000-10-31 |
US20040047876A1 (en) | 2004-03-11 |
EP0859631A1 (de) | 1998-08-26 |
ZA967757B (en) | 1997-04-07 |
JPH11514985A (ja) | 1999-12-21 |
US6136315A (en) | 2000-10-24 |
AU7018196A (en) | 1997-04-01 |
US6162436A (en) | 2000-12-19 |
ES2340558T3 (es) | 2010-06-04 |
WO1997010001A1 (en) | 1997-03-20 |
US6187312B1 (en) | 2001-02-13 |
US6143299A (en) | 2000-11-07 |
CA2232048C (en) | 2014-04-29 |
AU703101B2 (en) | 1999-03-18 |
EP0859631A4 (de) | 2002-07-31 |
EP0859631B1 (de) | 2010-01-27 |
US5837251A (en) | 1998-11-17 |
US7601359B1 (en) | 2009-10-13 |
ATE456378T1 (de) | 2010-02-15 |
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