DE69638159D1 - System zur beförderung mikroskopischer flüssigkeitsmengen - Google Patents

System zur beförderung mikroskopischer flüssigkeitsmengen

Info

Publication number
DE69638159D1
DE69638159D1 DE69638159T DE69638159T DE69638159D1 DE 69638159 D1 DE69638159 D1 DE 69638159D1 DE 69638159 T DE69638159 T DE 69638159T DE 69638159 T DE69638159 T DE 69638159T DE 69638159 D1 DE69638159 D1 DE 69638159D1
Authority
DE
Germany
Prior art keywords
chip
sample
handling system
fluid handling
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69638159T
Other languages
English (en)
Inventor
Barry L Karger
Frantisek Foret
Paul M Zavracky
Nicol E Mcgruer
Qifeng Xue
Yuriy M Dunayevskiy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northeastern University Boston
Original Assignee
Northeastern University Boston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northeastern University Boston filed Critical Northeastern University Boston
Application granted granted Critical
Publication of DE69638159D1 publication Critical patent/DE69638159D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H01J49/0445—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00822—Metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B01J2219/00828—Silicon wafers or plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00831—Glass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00853—Employing electrode arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00925—Irradiation
    • B01J2219/0093—Electric or magnetic energy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00925—Irradiation
    • B01J2219/00932—Sonic or ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
    • B01L2400/027—Drop detachment mechanisms of single droplets from nozzles or pins electrostatic forces between substrate and tip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N2030/285—Control of physical parameters of the fluid carrier electrically driven carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/628—Multiplexing, i.e. several columns sharing a single detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1044—Using pneumatic means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
DE69638159T 1995-07-21 1996-07-19 System zur beförderung mikroskopischer flüssigkeitsmengen Expired - Lifetime DE69638159D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US134995P 1995-07-21 1995-07-21
US08/675,177 US5872010A (en) 1995-07-21 1996-07-03 Microscale fluid handling system
PCT/US1996/011985 WO1997004297A1 (en) 1995-07-21 1996-07-19 Microscale fluid handling system

Publications (1)

Publication Number Publication Date
DE69638159D1 true DE69638159D1 (de) 2010-05-20

Family

ID=26668907

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69638159T Expired - Lifetime DE69638159D1 (de) 1995-07-21 1996-07-19 System zur beförderung mikroskopischer flüssigkeitsmengen

Country Status (7)

Country Link
US (1) US5872010A (de)
EP (1) EP0840886B1 (de)
JP (1) JP4489187B2 (de)
AT (1) ATE463732T1 (de)
CA (1) CA2227331C (de)
DE (1) DE69638159D1 (de)
WO (1) WO1997004297A1 (de)

Families Citing this family (422)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6794127B1 (en) * 1997-06-16 2004-09-21 Diversa Corporation Capillary array-based sample screening
EP0886681A1 (de) * 1996-03-04 1998-12-30 Genetrace Systems, Inc. Verfahren zur suche von nukleinsäuren mit massenspektroskopie
US5965363A (en) 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
WO1998013118A1 (de) * 1996-09-25 1998-04-02 Analyticon Ag Biotechnologie Pharmazie Vorrichtung und verfahren auf hplc-basis zur trennung hochkomplexer substanzgemische
US6110343A (en) * 1996-10-04 2000-08-29 Lockheed Martin Energy Research Corporation Material transport method and apparatus
US6024925A (en) * 1997-01-23 2000-02-15 Sequenom, Inc. Systems and methods for preparing low volume analyte array elements
DK0937096T3 (da) 1996-11-06 2004-06-14 Sequenom Inc Fremgangsmåde til massespektrometri-analyse
DE19782095T1 (de) * 1996-11-06 2000-03-23 Sequenom Inc DNA-Diagnose auf der Basis von Massenspektrometrie
US7285422B1 (en) 1997-01-23 2007-10-23 Sequenom, Inc. Systems and methods for preparing and analyzing low volume analyte array elements
US6379929B1 (en) * 1996-11-20 2002-04-30 The Regents Of The University Of Michigan Chip-based isothermal amplification devices and methods
DE69735445T2 (de) * 1996-12-10 2006-08-10 Sequenom, Inc., San Diego Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
US5994696A (en) * 1997-01-27 1999-11-30 California Institute Of Technology MEMS electrospray nozzle for mass spectroscopy
DE19704477A1 (de) * 1997-02-06 1998-08-13 Solvay Pharm Gmbh Vorrichtung und Verfahren zur Parallel-Chromatographie
US5980719A (en) * 1997-05-13 1999-11-09 Sarnoff Corporation Electrohydrodynamic receptor
WO1998052034A1 (en) * 1997-05-15 1998-11-19 Bio-Rad Laboratories, Inc. Thermal expansion pump for pulse-free liquid flow
US6632619B1 (en) 1997-05-16 2003-10-14 The Governors Of The University Of Alberta Microfluidic system and methods of use
DE69823347T2 (de) 1997-05-16 2005-05-12 Alberta Research Council, Edmonton Mikrofluidisches system und verfahren zu dessen betrieb
US5989402A (en) * 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
US6207954B1 (en) * 1997-09-12 2001-03-27 Analytica Of Branford, Inc. Multiple sample introduction mass spectrometry
WO1999014368A2 (en) * 1997-09-15 1999-03-25 Whitehead Institute For Biomedical Research Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device
CA2301592A1 (en) * 1997-09-19 1999-04-01 David S. Soane Capillary electroflow apparatus and method
US6982431B2 (en) * 1998-08-31 2006-01-03 Molecular Devices Corporation Sample analysis systems
US6902703B2 (en) * 1999-05-03 2005-06-07 Ljl Biosystems, Inc. Integrated sample-processing system
US6838051B2 (en) 1999-05-03 2005-01-04 Ljl Biosystems, Inc. Integrated sample-processing system
US6833242B2 (en) * 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
EP1023742A4 (de) * 1997-10-15 2006-03-22 Analytica Of Branford Inc Gebogene einlassvorrichtung für massenspektrometer
US6139734A (en) * 1997-10-20 2000-10-31 University Of Virginia Patent Foundation Apparatus for structural characterization of biological moieties through HPLC separation
US6685809B1 (en) * 1999-02-04 2004-02-03 Ut-Battelle, Llc Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels
GB9802600D0 (en) * 1998-02-07 1998-04-01 Eastman Kodak Co Liquid separation
US6379971B1 (en) 1998-02-24 2002-04-30 Target Discovery, Inc. Methods for sequencing proteins
US6537432B1 (en) 1998-02-24 2003-03-25 Target Discovery, Inc. Protein separation via multidimensional electrophoresis
US6191418B1 (en) * 1998-03-27 2001-02-20 Synsorb Biotech, Inc. Device for delivery of multiple liquid sample streams to a mass spectrometer
WO1999063332A1 (en) * 1998-06-05 1999-12-09 Sarnoff Corporation Apparatus for separating molecules
US6459080B1 (en) * 1998-06-12 2002-10-01 Agilent Technologies, Inc. Miniaturized device for separating the constituents of a sample and delivering the constituents of the separated sample to a mass spectrometer
US6627446B1 (en) * 1998-07-02 2003-09-30 Amersham Biosciences (Sv) Corp Robotic microchannel bioanalytical instrument
US20030138973A1 (en) * 1998-07-14 2003-07-24 Peter Wagner Microdevices for screening biomolecules
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6794197B1 (en) * 1998-07-14 2004-09-21 Zyomyx, Inc. Microdevice and method for detecting a characteristic of a fluid
GB9815820D0 (en) 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
US6090278A (en) * 1998-08-20 2000-07-18 Dyax Corporation Apparatus and method for sealing a plurality of chromatography columns
US6074880A (en) 1998-08-28 2000-06-13 Transgenomic, Inc. Sample analyte containing solution fraction collection system, and method of use
US6410332B1 (en) 1998-09-08 2002-06-25 Symyx Technologies, Inc. Sampling and analysis of reactions by trapping reaction components on a sorbent
US6103199A (en) * 1998-09-15 2000-08-15 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
EP1876442A3 (de) * 1998-09-17 2008-03-05 Advion BioSciences, Inc. Integriertes monolithisches, auf Mikrobasis hergestelltes System und Verfahren zur Flüssigkeitschromatographie
US6245227B1 (en) 1998-09-17 2001-06-12 Kionix, Inc. Integrated monolithic microfabricated electrospray and liquid chromatography system and method
WO2000019193A1 (en) * 1998-09-28 2000-04-06 Varian Inc Split flow electrospray device for mass spectrometry
DE19846466A1 (de) * 1998-10-08 2000-04-27 Ghs Gesundheits Service Ag Analyseverfahren zur simultanen Bestimmung von Parametern aus unterschiedlichen Medien
US6605472B1 (en) * 1998-10-09 2003-08-12 The Governors Of The University Of Alberta Microfluidic devices connected to glass capillaries with minimal dead volume
US6234167B1 (en) 1998-10-14 2001-05-22 Chrysalis Technologies, Incorporated Aerosol generator and methods of making and using an aerosol generator
DE69913721T2 (de) * 1998-10-16 2004-10-28 Commissariat à l'Energie Atomique Testträger zur chemischen und/oder biochemischen analyse
WO2000030167A1 (en) * 1998-11-19 2000-05-25 California Institute Of Technology Polymer-based electrospray nozzle for mass spectrometry
NL1010833C2 (nl) * 1998-12-17 2000-06-20 Univ Delft Tech Werkwijze voor het gedoseerd aanbrengen van een vloeistof op een oppervlak.
EP1155435A4 (de) * 1999-01-08 2004-08-11 Univ Northeastern Elektropneumatischer verteiler für zeitmultiplexte analytischemicrosystemen
EP1157270A1 (de) * 1999-02-03 2001-11-28 Aclara BioSciences, Inc. Steuerung eines mehrkanal-mikrofluidiksystems
GB9904038D0 (en) * 1999-02-22 1999-04-14 Isis Innovation Improvements in or related to microfluidic sample preparation and mass spectrometry
US6633031B1 (en) * 1999-03-02 2003-10-14 Advion Biosciences, Inc. Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method
US6749814B1 (en) 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
US7150994B2 (en) * 1999-03-03 2006-12-19 Symyx Technologies, Inc. Parallel flow process optimization reactor
US6410914B1 (en) 1999-03-05 2002-06-25 Bruker Daltonics Inc. Ionization chamber for atmospheric pressure ionization mass spectrometry
DE19913076A1 (de) * 1999-03-23 2000-10-19 Hahn Schickard Ges Vorrichtung und Verfahren zum Aufbringen von Mikrotröpfchen auf ein Substrat
US20020164812A1 (en) * 1999-04-06 2002-11-07 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US7214540B2 (en) * 1999-04-06 2007-05-08 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US7247490B2 (en) * 1999-04-06 2007-07-24 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US7250305B2 (en) * 2001-07-30 2007-07-31 Uab Research Foundation Use of dye to distinguish salt and protein crystals under microcrystallization conditions
MXPA01009999A (es) * 1999-04-06 2003-07-14 Uab Research Foundation Metodo para examinar las condiciones de cristalizacion en el crecimiento de cristales en solucion.
US7244396B2 (en) * 1999-04-06 2007-07-17 Uab Research Foundation Method for preparation of microarrays for screening of crystal growth conditions
WO2000062039A1 (en) * 1999-04-09 2000-10-19 Northeastern University System and method for high throughput mass spectrometric analysis
US6368562B1 (en) * 1999-04-16 2002-04-09 Orchid Biosciences, Inc. Liquid transportation system for microfluidic device
US6677114B1 (en) * 1999-04-20 2004-01-13 Target Discovery, Inc. Polypeptide fingerprinting methods and bioinformatics database system
US6818112B2 (en) * 1999-04-20 2004-11-16 Target Discovery, Inc. Protein separation via multidimensional electrophoresis
US6764817B1 (en) * 1999-04-20 2004-07-20 Target Discovery, Inc. Methods for conducting metabolic analyses
WO2000063683A1 (en) * 1999-04-20 2000-10-26 Target Discovery, Inc. Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database
US6716636B1 (en) 1999-04-20 2004-04-06 Target Discovery, Inc. Methods for sequencing proteins
US20030119069A1 (en) * 1999-04-20 2003-06-26 Target Discovery, Inc. Labeling of protein samples
EP1185871A4 (de) 1999-06-01 2003-01-15 Caliper Techn Corp Assays im kleinstformat und mikrofluidische vorrichtungen für aktivitäten von transportern, gradienten und bindungsassays
US6296673B1 (en) 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
US6630006B2 (en) * 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
DE19928412C2 (de) * 1999-06-22 2002-03-21 Agilent Technologies Inc Versorgungselement für einen Labor-Mikrochip
US6533914B1 (en) * 1999-07-08 2003-03-18 Shaorong Liu Microfabricated injector and capillary array assembly for high-resolution and high throughput separation
US6448090B1 (en) * 1999-07-09 2002-09-10 Orchid Biosciences, Inc. Fluid delivery system for a microfluidic device using alternating pressure waveforms
US6395232B1 (en) * 1999-07-09 2002-05-28 Orchid Biosciences, Inc. Fluid delivery system for a microfluidic device using a pressure pulse
DE19933458B4 (de) * 1999-07-15 2015-08-20 Eppendorf Ag Einrichtungen und Systeme zum Handhaben von Flüssigkeitsproben
ATE359502T1 (de) 1999-07-16 2007-05-15 Applera Corp Vorrichtung und verfahren für hochdichte elektrophorese
ATE419384T1 (de) * 1999-07-28 2009-01-15 Merck Serono Biodevelopment Durchfluss-mikroreaktor in dem lokale temperaturzyklen auf eine fliessende probe einwirken
DE19935433A1 (de) * 1999-08-01 2001-03-01 Febit Ferrarius Biotech Gmbh Mikrofluidischer Reaktionsträger
JP3925000B2 (ja) * 1999-09-06 2007-06-06 株式会社日立製作所 噴霧器及びそれを用いた分析装置
DE19964337B4 (de) * 1999-10-01 2004-09-16 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Mikrofluidischer Mikrochip mit abbiegbarem Ansaugrohr
DE19947496C2 (de) 1999-10-01 2003-05-22 Agilent Technologies Inc Mikrofluidischer Mikrochip
WO2001032245A1 (en) * 1999-11-03 2001-05-10 Cornell Research Foundation, Inc. Miniaturized fluid transfer device
US6878255B1 (en) * 1999-11-05 2005-04-12 Arrowhead Center, Inc. Microfluidic devices with thick-film electrochemical detection
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
DE29919506U1 (de) * 1999-11-05 2000-02-24 Creavis Tech & Innovation Gmbh Mikrostruktuierte Pipetten als Dosiersysteme
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
CA2290731A1 (en) * 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
AU2450801A (en) * 1999-12-30 2001-07-16 Advion Biosciences, Inc. Multiple electrospray device, systems and methods
AU2001232805A1 (en) * 2000-01-12 2001-07-24 Ut-Battelle, Llc A microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
AU777273B2 (en) * 2000-01-12 2004-10-07 Zyomyx, Inc. Microdevice and method for detecting a characteristic of a fluid
WO2001053794A1 (en) * 2000-01-18 2001-07-26 Northeastern University Parallel sample loading and injection device for multichannel microfluidic devices
US6939452B2 (en) * 2000-01-18 2005-09-06 Northeastern University Parallel sample loading and injection device for multichannel microfluidic devices
JP2003520962A (ja) * 2000-01-18 2003-07-08 アドビオン バイオサイエンシーズ インコーポレーティッド 分離媒体、複式電気噴霧ノズルシステム、および方法
US6967324B2 (en) * 2000-02-17 2005-11-22 Agilent Technologies, Inc. Micro matrix ion generator for analyzers
CN1444646A (zh) * 2000-02-23 2003-09-24 齐翁米克斯股份有限公司 具有凸起的样品表面的芯片
ATE499988T1 (de) 2000-03-02 2011-03-15 Microchips Inc Mikromechanische geräte und verfahren zur speicherung und zur selektiven exposition von chemikalien
ATE287291T1 (de) 2000-03-07 2005-02-15 Symyx Technologies Inc Prozessoptimierungsreaktor mit parallelem durchfluss
FR2806077B1 (fr) * 2000-03-07 2004-01-30 Solvay Procede pour l'obtention d'un hydrofluoroalcane epure, hydrofluoroalcane epure, utilisation de l'hydrofluoroalcane et methode d'analyse d'un hydrofluoroalcane
US7077960B2 (en) * 2000-03-07 2006-07-18 Solvay (Societe Anonyme) Method for obtaining a purified hydrofluoroalkane, purified hydrofluoroalkane, use of same and method for analysing same
US6569383B1 (en) * 2000-03-11 2003-05-27 Intrinsic Bioprobes, Inc. Bioactive chip mass spectrometry
FR2806646A1 (fr) * 2000-03-22 2001-09-28 Francois Geli Micro-arrays ou macro-arrays multiblocs avec laboratoires sur puces integres
US6905657B2 (en) 2000-04-05 2005-06-14 Bioprocessors Corp. Methods and devices for storing and dispensing liquids
US6561208B1 (en) 2000-04-14 2003-05-13 Nanostream, Inc. Fluidic impedances in microfluidic system
MY136453A (en) * 2000-04-27 2008-10-31 Philip Morris Usa Inc "improved method and apparatus for generating an aerosol"
WO2001091902A2 (en) 2000-05-30 2001-12-06 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
EP1297555A2 (de) * 2000-06-05 2003-04-02 PHARMACIA & UPJOHN COMPANY Mehrquellen-elektrosprühionisation für massenspektrometrie
US6660229B2 (en) 2000-06-13 2003-12-09 The Trustees Of Boston University Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing
AU2001273057A1 (en) * 2000-06-27 2002-01-08 Fluidigm Corporation A microfluidic design automation method and system
US6544477B1 (en) 2000-08-01 2003-04-08 Regents Of The University Of Minnesota Apparatus for generating a temperature gradient
US6701774B2 (en) * 2000-08-02 2004-03-09 Symyx Technologies, Inc. Parallel gas chromatograph with microdetector array
WO2002011888A2 (en) * 2000-08-07 2002-02-14 Nanostream, Inc. Fluidic mixer in microfluidic system
US6890093B2 (en) 2000-08-07 2005-05-10 Nanostream, Inc. Multi-stream microfludic mixers
GB2366793B (en) * 2000-09-13 2005-03-09 Imperial College Chemical processing system and method
US6613224B1 (en) 2000-10-06 2003-09-02 Waters Investments Limited Liquid separation column smart cartridge
US6827095B2 (en) * 2000-10-12 2004-12-07 Nanostream, Inc. Modular microfluidic systems
AU1189702A (en) * 2000-10-13 2002-04-22 Fluidigm Corp Microfluidic device based sample injection system for analytical devices
WO2002066952A2 (en) * 2000-10-19 2002-08-29 Target Discovery, Inc Mass defect labeling for the determination of oligomer sequences
US7033475B2 (en) * 2000-10-25 2006-04-25 Shimadzu Corporation Electrophoretic apparatus
EP1332000B1 (de) 2000-10-30 2012-06-20 Sequenom, Inc. Verfahren zur aufbringung von submikroliter fluid-volumina auf ein substrat
US7514046B2 (en) * 2000-10-31 2009-04-07 Caliper Life Sciences, Inc. Methods and systems for processing microscale devices for reuse
US6879162B2 (en) * 2000-11-07 2005-04-12 Sri International System and method of micro-fluidic handling and dispensing using micro-nozzle structures
DE10154601B4 (de) * 2000-11-13 2007-02-22 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Ein Mikrobauelement mit einem integrierten hervorstehenden Elektrospray-Emitter und ein Verfahren zum Herstellen des Mikrobauelements
US6951632B2 (en) * 2000-11-16 2005-10-04 Fluidigm Corporation Microfluidic devices for introducing and dispensing fluids from microfluidic systems
US6841774B1 (en) 2000-11-28 2005-01-11 Mds Inc. Sample introduction device for mass spectrometry using a fast fluidic system to synchronize multiple parallel liquid sample streams
AU2002223343B2 (en) * 2000-11-28 2007-01-18 Mds Inc. Sample introduction device for mass spectrometry using a fast fluidic system to synchronize multiple parallel liquid sample streams
SE0004574D0 (sv) * 2000-12-08 2000-12-08 Amersham Pharm Biotech Ab Electrospray interface
SE0004594D0 (sv) * 2000-12-12 2000-12-12 Gyros Ab Microscale nozzie
US6701921B2 (en) * 2000-12-22 2004-03-09 Chrysalis Technologies Incorporated Aerosol generator having heater in multilayered composite and method of use thereof
US6799572B2 (en) * 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US6501052B2 (en) 2000-12-22 2002-12-31 Chrysalis Technologies Incorporated Aerosol generator having multiple heating zones and methods of use thereof
US7077130B2 (en) * 2000-12-22 2006-07-18 Chrysalis Technologies Incorporated Disposable inhaler system
US6491233B2 (en) 2000-12-22 2002-12-10 Chrysalis Technologies Incorporated Vapor driven aerosol generator and method of use thereof
US6681998B2 (en) 2000-12-22 2004-01-27 Chrysalis Technologies Incorporated Aerosol generator having inductive heater and method of use thereof
US20040099310A1 (en) * 2001-01-05 2004-05-27 Per Andersson Microfluidic device
US6653625B2 (en) * 2001-03-19 2003-11-25 Gyros Ab Microfluidic system (MS)
CA2434569A1 (en) * 2001-01-26 2002-08-01 Advion Biosciences, Inc. Robotic autosampler for automated electrospray from a microfluidic chip
GB0103516D0 (en) * 2001-02-13 2001-03-28 Cole Polytechnique Federale De Apparatus for dispensing a sample
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
JP2004532392A (ja) * 2001-02-20 2004-10-21 アドヴィオン バイオサイエンシィズ インコーポレイテッド 親和性吸着剤を有するマイクロチップ電子噴霧装置およびカラムならびにそれらの使用法
US7118917B2 (en) * 2001-03-07 2006-10-10 Symyx Technologies, Inc. Parallel flow reactor having improved thermal control
WO2002075775A1 (en) * 2001-03-19 2002-09-26 Gyros Ab A microfluidic system (edi)
EP1384076B1 (de) 2001-03-19 2012-07-25 Gyros Patent Ab Charakterisierung von reaktionsvariablen
US6717136B2 (en) 2001-03-19 2004-04-06 Gyros Ab Microfludic system (EDI)
CA2442345A1 (en) * 2001-03-19 2002-09-26 Gyros Ab A microfluidic system (ms)
JP2004529463A (ja) * 2001-03-19 2004-09-24 ユィロス・アクチボラグ マイクロ流体システム（ｍｓ）
US6610978B2 (en) 2001-03-27 2003-08-26 Agilent Technologies, Inc. Integrated sample preparation, separation and introduction microdevice for inductively coupled plasma mass spectrometry
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7192557B2 (en) * 2001-03-28 2007-03-20 Handylab, Inc. Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
US6852287B2 (en) * 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7270786B2 (en) 2001-03-28 2007-09-18 Handylab, Inc. Methods and systems for processing microfluidic samples of particle containing fluids
US6575188B2 (en) 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7323140B2 (en) * 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7829025B2 (en) * 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7670429B2 (en) * 2001-04-05 2010-03-02 The California Institute Of Technology High throughput screening of crystallization of materials
EP1384022A4 (de) 2001-04-06 2004-08-04 California Inst Of Techn Nukleinsäure-amplifikation verwendende mikrofluidvorrichtungen
WO2002090770A2 (en) * 2001-05-07 2002-11-14 Nanolab Ltd. Method and apparatus for propelling a fluid
US20020166760A1 (en) * 2001-05-11 2002-11-14 Prentiss Mara G. Micromagentic systems and methods for microfluidics
AU2002326304A1 (en) * 2001-05-31 2002-12-16 Massachusetts Institute Of Technology Microchip devices with improved reservoir opening
US6811695B2 (en) * 2001-06-07 2004-11-02 Nanostream, Inc. Microfluidic filter
US20020187557A1 (en) * 2001-06-07 2002-12-12 Hobbs Steven E. Systems and methods for introducing samples into microfluidic devices
US6919046B2 (en) * 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
ATE285756T1 (de) * 2001-06-28 2005-01-15 Microchips Inc Verfahren zum hermetischen versiegeln von mikrochip-reservoir-vorrichtungen
GB0116384D0 (en) * 2001-07-04 2001-08-29 Diagnoswiss Sa Microfluidic chemical assay apparatus and method
US7128876B2 (en) * 2001-07-17 2006-10-31 Agilent Technologies, Inc. Microdevice and method for component separation in a fluid
US7060227B2 (en) * 2001-08-06 2006-06-13 Sau Lan Tang Staats Microfluidic devices with raised walls
US6995024B2 (en) * 2001-08-27 2006-02-07 Sri International Method and apparatus for electrostatic dispensing of microdroplets
US6803568B2 (en) * 2001-09-19 2004-10-12 Predicant Biosciences, Inc. Multi-channel microfluidic chip for electrospray ionization
US6640050B2 (en) 2001-09-21 2003-10-28 Chrysalis Technologies Incorporated Fluid vaporizing device having controlled temperature profile heater/capillary tube
US6568390B2 (en) 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
US20030072682A1 (en) * 2001-10-11 2003-04-17 Dan Kikinis Method and apparatus for performing biochemical testing in a microenvironment
US8440093B1 (en) 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
US6681769B2 (en) 2001-12-06 2004-01-27 Crysalis Technologies Incorporated Aerosol generator having a multiple path heater arrangement and method of use thereof
US6804458B2 (en) * 2001-12-06 2004-10-12 Chrysalis Technologies Incorporated Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
US20030141253A1 (en) * 2001-12-07 2003-07-31 Bihan Thierry Le Apparatus for efficient liquid chromatography/mass spectrometry processing
US6701922B2 (en) 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
US7105810B2 (en) * 2001-12-21 2006-09-12 Cornell Research Foundation, Inc. Electrospray emitter for microfluidic channel
US6877892B2 (en) * 2002-01-11 2005-04-12 Nanostream, Inc. Multi-stream microfluidic aperture mixers
AU2003228205A1 (en) * 2002-01-18 2003-09-02 The Regents Of The University Of Michigan Porous polymers: compositions and uses thereof
US7189370B2 (en) * 2002-02-11 2007-03-13 Microchem Solutions Apparatus and methods for high throughput and high-resolution assays
US7261812B1 (en) 2002-02-13 2007-08-28 Nanostream, Inc. Multi-column separation devices and methods
CA2472945A1 (en) * 2002-02-13 2003-08-21 Nanostream, Inc. Microfluidic separation column devices and fabrication methods
US20050211555A1 (en) * 2002-02-14 2005-09-29 Solus Biosystems, Inc. Method for multiple sample screening using IR spectroscopy
US7033542B2 (en) * 2002-02-14 2006-04-25 Archibald William B High throughput screening with parallel vibrational spectroscopy
US6958119B2 (en) * 2002-02-26 2005-10-25 Agilent Technologies, Inc. Mobile phase gradient generation microfluidic device
EP2581739B1 (de) 2002-03-05 2015-11-04 Caliper Life Sciences, Inc. Mikrofluidisches Trennverfahren mit kombinierter Druck- und Spannungsregelung
US7303727B1 (en) 2002-03-06 2007-12-04 Caliper Life Sciences, Inc Microfluidic sample delivery devices, systems, and methods
WO2004023105A2 (en) * 2002-03-20 2004-03-18 Advanced Sensor Technologies, Inc. Personal monitor to detect exposure to toxic agents
WO2003085379A2 (en) 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
JP4855680B2 (ja) * 2002-05-09 2012-01-18 ザ・ユニバーシティ・オブ・シカゴ 圧力駆動プラグによる輸送と反応のための装置および方法
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
US20030224531A1 (en) * 2002-05-29 2003-12-04 Brennen Reid A. Microplate with an integrated microfluidic system for parallel processing minute volumes of fluids
US20070026528A1 (en) * 2002-05-30 2007-02-01 Delucas Lawrence J Method for screening crystallization conditions in solution crystal growth
AU2003247442A1 (en) * 2002-06-05 2003-12-22 Advanced Research And Technology Institute, Inc. Apparatus and method for relative or quantitative comparison of multiple samples
AU2003234885A1 (en) * 2002-06-07 2003-12-22 Picosep A/S Method and system for multi-stage isoelectric focussing
JP2005531001A (ja) * 2002-06-24 2005-10-13 フルイディグム コーポレイション 再循環流体ネットワークおよびその使用法
WO2004005898A1 (en) * 2002-07-10 2004-01-15 Uab Research Foundation Method for distinguishing between biomolecule and non-biomolecule crystals
US20040018115A1 (en) * 2002-07-29 2004-01-29 Nanostream, Inc. Fault tolerant detection regions in microfluidic systems
JP3610349B2 (ja) * 2002-08-06 2005-01-12 キヤノン株式会社 液体搬送装置
US7132650B1 (en) 2003-09-26 2006-11-07 Nanostream, Inc. High throughput multi-dimensional sample analysis
WO2004015411A1 (en) * 2002-08-08 2004-02-19 Nanostream, Inc. Systems and methods for high-throughput microfluidic sample analysis
US7214320B1 (en) 2002-08-08 2007-05-08 Nanostream, Inc. Systems and methods for high throughput sample analysis
WO2004028955A2 (en) 2002-09-25 2004-04-08 California Institute Of Technology Microfluidic large scale integration
US8871446B2 (en) 2002-10-02 2014-10-28 California Institute Of Technology Microfluidic nucleic acid analysis
US7946982B2 (en) 2002-10-25 2011-05-24 K2M, Inc. Minimal incision maximal access MIS spine instrumentation and method
US7173240B2 (en) 2004-11-05 2007-02-06 Agilent Technologies, Inc. Electrospray devices for mass spectrometry
US6936167B2 (en) * 2002-10-31 2005-08-30 Nanostream, Inc. System and method for performing multiple parallel chromatographic separations
GB0226160D0 (en) * 2002-11-08 2002-12-18 Diagnoswiss Sa Apparatus for dispensing a sample in electrospray mass spectrometers
JP2006507504A (ja) * 2002-11-22 2006-03-02 ソルス バイオシステムズ インコーポレーテッド 並列振動分光法による高スループットのスクリーニング
JP2004354364A (ja) 2002-12-02 2004-12-16 Nec Corp 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法
US20060076482A1 (en) * 2002-12-13 2006-04-13 Hobbs Steven E High throughput systems and methods for parallel sample analysis
US6987263B2 (en) * 2002-12-13 2006-01-17 Nanostream, Inc. High throughput systems and methods for parallel sample analysis
US20040129676A1 (en) * 2003-01-07 2004-07-08 Tan Roy H. Apparatus for transfer of an array of liquids and methods for manufacturing same
DE10302721A1 (de) * 2003-01-23 2004-08-05 Steag Microparts Gmbh Mikrofluidische Anordnung zum Dosieren von Flüssigkeiten
US7413709B2 (en) * 2003-02-12 2008-08-19 Agilent Technologies, Inc. PAEK-based microfluidic device with integrated electrospray emitter
SE0300454D0 (sv) * 2003-02-19 2003-02-19 Aamic Ab Nozzles for electrospray ionization and methods of fabricating them
GB0307403D0 (en) * 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) * 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US7007710B2 (en) * 2003-04-21 2006-03-07 Predicant Biosciences, Inc. Microfluidic devices and methods
WO2004101151A1 (en) * 2003-05-08 2004-11-25 Nanostream, Inc. Sample preparation for parallel chromatography
US6945285B2 (en) * 2003-05-14 2005-09-20 Industrial Technology Research Institute Apparatus and method for collecting fluid fractions
US7425700B2 (en) 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
US20040265519A1 (en) * 2003-06-27 2004-12-30 Pellizzari Roberto O. Fabrication of fluid delivery components
WO2005011867A2 (en) 2003-07-31 2005-02-10 Handylab, Inc. Processing particle-containing samples
AU2004265249B2 (en) * 2003-08-04 2007-07-05 Caliper Life Sciences, Inc. Methods and systems for processing microscale devices for reuse
US7028536B2 (en) * 2004-06-29 2006-04-18 Nanostream, Inc. Sealing interface for microfluidic device
US20050032238A1 (en) * 2003-08-07 2005-02-10 Nanostream, Inc. Vented microfluidic separation devices and methods
US7413712B2 (en) * 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
US7053558B2 (en) * 2003-09-03 2006-05-30 Sri International System and method for controlling emission by a micro-fabricated charge-emission device
FR2860006B1 (fr) * 2003-09-24 2006-12-22 Commissariat Energie Atomique Dispositif pour separer et/ou analyser plusieurs cibles moleculaires en solution dans un melange complexe
US7537807B2 (en) 2003-09-26 2009-05-26 Cornell University Scanned source oriented nanofiber formation
US7282705B2 (en) * 2003-12-19 2007-10-16 Agilent Technologies, Inc. Microdevice having an annular lining for producing an electrospray emitter
WO2005073732A2 (en) * 2004-01-23 2005-08-11 Amgen Inc. Lc/ms method of analyzing high molecular weight proteins
FR2865806B1 (fr) * 2004-01-30 2007-02-02 Commissariat Energie Atomique Laboratoire sur puce comprenant un reseau micro-fluidique et un nez d'electronebulisation coplanaires
CN100340856C (zh) * 2004-02-03 2007-10-03 复旦大学 一种纳升喷雾装置
US7250260B2 (en) * 2004-02-18 2007-07-31 Applera Corporation Multi-step bioassays on modular microfluidic application platforms
US20050221339A1 (en) * 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US20050244973A1 (en) * 2004-04-29 2005-11-03 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
ES2553097T3 (es) * 2004-05-03 2015-12-04 Handylab, Inc. Procesamiento de muestras que contienen polinucleótidos
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
KR100777172B1 (ko) * 2004-06-07 2007-11-28 나노 퓨전 가부시키가이샤 전기 침투류 펌프 시스템 및 전기 침투류 펌프
US20050271560A1 (en) * 2004-06-07 2005-12-08 Bioprocessors Corp. Gas control in a reactor
KR100573926B1 (ko) 2004-07-02 2006-04-26 한국과학기술원 3차원 광학적 에너지 준위를 이용한 연속적인 다종미소입자 분리기
US9477233B2 (en) * 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
US7655470B2 (en) * 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US20060022130A1 (en) * 2004-07-29 2006-02-02 Predicant Biosciences, Inc., A Delaware Corporation Microfluidic devices and methods with integrated electrical contact
CN101073002B (zh) * 2004-09-15 2012-08-08 英特基因有限公司 微流体装置
US20060060769A1 (en) 2004-09-21 2006-03-23 Predicant Biosciences, Inc. Electrospray apparatus with an integrated electrode
US7591883B2 (en) * 2004-09-27 2009-09-22 Cornell Research Foundation, Inc. Microfiber supported nanofiber membrane
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
KR20060058830A (ko) * 2004-11-26 2006-06-01 한국표준과학연구원 개별시료 주입구가 없는 다중채널 전기영동장치에 의한분리방법
US20080074646A1 (en) * 2005-01-18 2008-03-27 Solus Biosystems, Inc. Multiple Sample Screening Using Ir Spectroscopy with Capillary Isoelectric Focusing
CA2611700C (en) * 2005-01-25 2012-08-21 Oscillogy Llc Temperature controller for small fluid samples having different heat capacities
EP1623763A1 (de) * 2005-03-11 2006-02-08 Agilent Technologies, Inc. Chip mit reinigem Hohlraum
JP2008538077A (ja) * 2005-03-16 2008-10-09 ユニバーシティ オブ シカゴ マイクロフルイディックシステム
JP4593507B2 (ja) * 2005-03-30 2010-12-08 ナノフュージョン株式会社 電気浸透流ポンプ及び液体供給装置
JP2006275016A (ja) * 2005-03-30 2006-10-12 Science Solutions International Laboratory Inc 液体輸送装置及び液体輸送システム
GB0511083D0 (en) * 2005-05-31 2005-07-06 Thermo Finnigan Llc Multiple ion injection in mass spectrometry
KR20070074787A (ko) * 2005-06-13 2007-07-18 삼성전자주식회사 계조 전압 발생 장치 및 액정 표시 장치
US7919323B2 (en) 2005-06-15 2011-04-05 Rhodia Operations Microfluidic flow devices for determining parameters of physical and/or chemical transformations
FR2887241B1 (fr) * 2005-06-15 2008-01-11 Rhodia Chimie Sa Dispositif d'ecoulement microfluidique permettant de determiner des parametres d'une transformation physique et/ou chimique, et son utilisation
US20070023677A1 (en) * 2005-06-29 2007-02-01 Perkins Patrick D Multimode ionization source and method for screening molecules
WO2007016432A2 (en) * 2005-07-29 2007-02-08 West Virginia University Research Corporation Apparatus and method for coupling microfluidic systems with a mass spectrometer utilizing rapid voltage switching
EP1945815A4 (de) * 2005-10-11 2009-02-18 Handylab Inc Polynukleotidprobenvorbereitungsvorrichtung
CA2628708C (en) 2005-11-08 2011-11-29 Tohoku University Method of quantifying membrane protein by using mass spectrometer
US20070140918A1 (en) * 2005-12-19 2007-06-21 Hongfeng Yin Fluidic separation devices and methods with reduced sample broadening
US20100137163A1 (en) 2006-01-11 2010-06-03 Link Darren R Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
JP2009528509A (ja) * 2006-01-31 2009-08-06 ユニバーシティ オブ シカゴ 血液凝固をアッセイするための方法及び装置
EP1979079A4 (de) 2006-02-03 2012-11-28 Integenx Inc Mikrofluidische vorrichtungen
FR2897858B1 (fr) * 2006-02-27 2008-06-20 Commissariat Energie Atomique Procede de fabrication d'un reseau de capillaires d'une puce
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US20070221839A1 (en) * 2006-03-24 2007-09-27 Goodley Paul C Analytical system and method
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) * 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
WO2007112114A2 (en) 2006-03-24 2007-10-04 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7495210B2 (en) 2006-05-04 2009-02-24 Agilent Technologies, Inc. Micro fluidic gas assisted ionization device and method
US20080003142A1 (en) 2006-05-11 2008-01-03 Link Darren R Microfluidic devices
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US7629124B2 (en) * 2006-06-30 2009-12-08 Canon U.S. Life Sciences, Inc. Real-time PCR in micro-channels
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
US9892650B2 (en) * 2006-09-11 2018-02-13 Houghton Mifflin Harcourt Publishing Company Recovery of polled data after an online test platform failure
EP2091647A2 (de) 2006-11-14 2009-08-26 Handylab, Inc. Mikrofluidisches system für parallele amplifikation und erkennung von polynukleotiden
WO2008079274A1 (en) * 2006-12-19 2008-07-03 University Of Chicago Spacers for microfludic channels
US20110039303A1 (en) 2007-02-05 2011-02-17 Stevan Bogdan Jovanovich Microfluidic and nanofluidic devices, systems, and applications
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
KR100786622B1 (ko) 2007-02-16 2007-12-21 한국표준과학연구원 개별시료 주입구가 없는 다중채널 전기영동장치 및 이를 이용한 유전자 또는 단백질 분리방법
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
JP5494480B2 (ja) 2007-06-11 2014-05-14 和光純薬工業株式会社 集積リアルタイムｃｅ検出を用いるマイクロチップ大容量ｐｃｒ
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8133671B2 (en) * 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US20090136385A1 (en) * 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8324372B2 (en) 2007-07-13 2012-12-04 Handylab, Inc. Polynucleotide capture materials, and methods of using same
WO2009048673A2 (en) * 2007-07-26 2009-04-16 University Of Chicago Stochastic confinement to detect, manipulate, and utilize molecules and organisms
US20090180931A1 (en) 2007-09-17 2009-07-16 Sequenom, Inc. Integrated robotic sample transfer device
US7825337B2 (en) * 2007-10-23 2010-11-02 Slam Brands, Inc. Cable management apparatuses and systems
US8381169B2 (en) * 2007-10-30 2013-02-19 International Business Machines Corporation Extending unified process and method content to include dynamic and collaborative content
KR20110030415A (ko) * 2008-01-22 2011-03-23 인터젠엑스 인크. 만능 샘플 제조 시스템 및 집적 분석 시스템에서의 용도
WO2009149257A1 (en) * 2008-06-04 2009-12-10 The University Of Chicago The chemistrode: a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
GB0812781D0 (en) * 2008-07-11 2008-08-20 Deltadot Ltd Material separation device
US20100009351A1 (en) * 2008-07-11 2010-01-14 Handylab, Inc. Polynucleotide Capture Materials, and Method of Using Same
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
WO2010009365A1 (en) * 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
US8534307B2 (en) * 2008-08-30 2013-09-17 Corning Incorporated Methods and devices for fluid handling
CN102341691A (zh) * 2008-12-31 2012-02-01 尹特根埃克斯有限公司 具有微流体芯片的仪器
WO2010102199A1 (en) 2009-03-06 2010-09-10 Waters Technologies Corporation Electromechanical and fluidic interface to a microfluidic substrate
EP3415235A1 (de) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation von mikrofluidiktröpfchen
JP5766178B2 (ja) 2009-03-24 2015-08-19 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ ＳｌｉｐＣｈｉｐ装置および方法
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
WO2010141326A1 (en) * 2009-06-02 2010-12-09 Integenx Inc. Fluidic devices with diaphragm valves
AU2010257118B2 (en) * 2009-06-04 2014-08-28 Lockheed Martin Corporation Multiple-sample microfluidic chip for DNA analysis
RU2559541C2 (ru) * 2009-06-05 2015-08-10 Интедженкс Инк. Универсальная система подготовки образцов и применение в интегрированной системе анализа
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
US8584703B2 (en) * 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
WO2011079176A2 (en) 2009-12-23 2011-06-30 Raindance Technologies, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US20110165037A1 (en) * 2010-01-07 2011-07-07 Ismagilov Rustem F Interfaces that eliminate non-specific adsorption, and introduce specific interactions
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
WO2011100604A2 (en) 2010-02-12 2011-08-18 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
EP2606154B1 (de) 2010-08-20 2019-09-25 Integenx Inc. Integriertes analysesystem
EP3447155A1 (de) 2010-09-30 2019-02-27 Raindance Technologies, Inc. Sandwichassays in tröpfchen
CA2814720C (en) 2010-10-15 2016-12-13 Lockheed Martin Corporation Micro fluidic optic design
TWI532530B (zh) * 2010-10-29 2016-05-11 萬國商業機器公司 具有浸入通道之多層微流體探針頭及其製造方法
US8963080B2 (en) * 2011-01-22 2015-02-24 Michael Charles Nyman Substrate compositions and methods of use thereof
US9364803B2 (en) 2011-02-11 2016-06-14 Raindance Technologies, Inc. Methods for forming mixed droplets
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
WO2012125318A2 (en) * 2011-03-11 2012-09-20 The University Of North Carolina At Chapel Hill Microchips with integrated multiple electrospray ionization emitters and related methods, systems and devices
US9396916B2 (en) 2011-03-11 2016-07-19 Waters Technologies Corporation Electrokinetically controlled calibrant delivery
WO2012142516A1 (en) 2011-04-15 2012-10-18 Becton, Dickinson And Company Scanning real-time microfluidic thermo-cycler and methods for synchronized thermocycling and scanning optical detection
WO2012167142A2 (en) 2011-06-02 2012-12-06 Raindance Technolgies, Inc. Enzyme quantification
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US11053535B2 (en) 2011-09-12 2021-07-06 The University Of North Carolina At Chapel Hill Devices with a fluid transport nanochannel intersected by a fluid sensing nanochannel and related methods
ES2825905T3 (es) 2011-09-30 2021-05-17 Becton Dickinson Co Tira reactiva unificada
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
WO2013067202A1 (en) 2011-11-04 2013-05-10 Handylab, Inc. Polynucleotide sample preparation device
CN107881219B (zh) 2012-02-03 2021-09-10 贝克顿·迪金森公司 用于分子诊断测试分配和测试之间兼容性确定的外部文件
US9989515B2 (en) 2012-02-10 2018-06-05 The University Of North Carolina At Chapel Hill Devices with fluidic nanofunnels, associated methods, fabrication and analysis systems
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
AU2013302756C1 (en) 2012-08-14 2018-05-17 10X Genomics, Inc. Microcapsule compositions and methods
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP3567116A1 (de) 2012-12-14 2019-11-13 10X Genomics, Inc. Verfahren und systeme zur verarbeitung von polynukleotiden
KR102190198B1 (ko) 2013-02-08 2020-12-14 10엑스 제노믹스, 인크. 폴리뉴클레오티드 바코드 생성
WO2014134095A1 (en) 2013-02-28 2014-09-04 The University Of North Carolina At Chapel Hill Nanofluidic devices with integrated components for the controlled capture, trapping, and transport of macromolecules and related methods of analysis
US9255288B2 (en) 2013-03-13 2016-02-09 The University Of North Carolina At Chapel Hill Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis
US9653276B2 (en) * 2013-08-07 2017-05-16 DH Technologies Development Pte Ltd. Enhanced spray formation for liquid samples
WO2015051343A1 (en) * 2013-10-03 2015-04-09 Northwestern University High throughput mass spectrometric analysis of proteome samples
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US10191071B2 (en) 2013-11-18 2019-01-29 IntegenX, Inc. Cartridges and instruments for sample analysis
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015092494A1 (en) * 2013-12-20 2015-06-25 Agilent Technologies, Inc. Method of conducting electrospray ionization and method of analyzing an analyte utilizing the same
US10076751B2 (en) 2013-12-30 2018-09-18 General Electric Company Systems and methods for reagent storage
US9399216B2 (en) 2013-12-30 2016-07-26 General Electric Company Fluid transport in microfluidic applications with sensors for detecting fluid presence and pressure
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
DE202015009494U1 (de) 2014-04-10 2018-02-08 10X Genomics, Inc. Fluidische Vorrichtungen und Systeme zur Einkapselung und Partitionierung von Reagenzien, und deren Anwendungen
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
MX2016016902A (es) 2014-06-26 2017-03-27 10X Genomics Inc Metodos para analizar acidos nucleicos de celulas individuales o poblaciones de celulas.
WO2015196303A1 (en) * 2014-06-27 2015-12-30 Uvic Industry Partnerships Inc. System and method for matrix-coating samples for mass spectrometry
EP3209410A4 (de) 2014-10-22 2018-05-02 IntegenX Inc. Systeme und verfahren zur automatisierten vorbereitung, verarbeitung und analyse von proben
CN107002128A (zh) 2014-10-29 2017-08-01 10X 基因组学有限公司 用于靶核酸测序的方法和组合物
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
SG11201705615UA (en) 2015-01-12 2017-08-30 10X Genomics Inc Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
EP3262407B1 (de) 2015-02-24 2023-08-30 10X Genomics, Inc. Partitionsverarbeitungsverfahren und -systeme
AU2016222719B2 (en) 2015-02-24 2022-03-31 10X Genomics, Inc. Methods for targeted nucleic acid sequence coverage
US10734216B2 (en) 2015-05-11 2020-08-04 The University Of North Carolina At Chapel Hill Pressure driven fluidic injection for chemical separations by electrophoresis
US9606082B2 (en) 2015-05-11 2017-03-28 The University Of North Carolina At Chapel Hill Pressure driven microfluidic injection for chemical separations
US9255905B1 (en) 2015-05-11 2016-02-09 The University Of North Carolina At Chapel Hill Pressure driven microfluidic injection for chemical separations
US10471428B2 (en) 2015-05-11 2019-11-12 The University Of North Carolina At Chapel Hill Fluidic devices with nanoscale manifolds for molecular transport, related systems and methods of analysis
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US9728387B2 (en) 2015-10-20 2017-08-08 The University Of North Carolina At Chapel Hill Solid phase extraction with capillary electrophoresis
DK3882357T3 (da) 2015-12-04 2022-08-29 10X Genomics Inc Fremgangsmåder og sammensætninger til analyse af nukleinsyrer
US9733232B1 (en) * 2016-01-25 2017-08-15 International Business Machines Corporation Nanopillar arrays with interfaces for controlled polymer stretching and effective translocation into nanochannels
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
WO2018003046A1 (ja) * 2016-06-30 2018-01-04 株式会社島津製作所 フローコントローラ
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP4029939B1 (de) 2017-01-30 2023-06-28 10X Genomics, Inc. Verfahren und systeme für eine einzelzellbarcodierung auf tröpfchenbasis
CN109526228B (zh) 2017-05-26 2022-11-25 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
US10844372B2 (en) 2017-05-26 2020-11-24 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
CN110603440B (zh) * 2017-05-31 2022-03-29 株式会社岛津制作所 探针电喷雾离子化离子源用样本板
WO2019092640A1 (en) * 2017-11-10 2019-05-16 Perkinelmer Health Sciences Canada, Inc. Multiple analyte ion source
WO2019092269A1 (en) * 2017-11-13 2019-05-16 F. Hoffmann-La Roche Ag Devices for sample analysis using epitachophoresis
EP3625361A1 (de) 2017-11-15 2020-03-25 10X Genomics, Inc. Funktionalisierte gelperlen
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
EP3775271A1 (de) 2018-04-06 2021-02-17 10X Genomics, Inc. Systeme und verfahren zur qualitätskontrolle in einer einzelzellenverarbeitung
CN112090603B (zh) * 2019-06-17 2022-11-08 苏州天健云康信息科技有限公司 微流体器件及其制造方法
AU2020326698A1 (en) 2019-08-05 2022-02-24 Seer, Inc. Systems and methods for sample preparation, data generation, and protein corona analysis

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3538744A (en) * 1967-11-09 1970-11-10 Phillips Petroleum Co Chromatography apparatus
DE1919628C3 (de) * 1969-04-18 1975-04-10 Wolfgang Prof. Dr. Dittrich Anordnung zum automatischen Zählen und/oder Klassifizieren von in einem strömungsfähigen Medium dispergierten Teilchen
US3915652A (en) * 1973-08-16 1975-10-28 Samuel Natelson Means for transferring a liquid in a capillary open at both ends to an analyzing system
DE2521236C3 (de) * 1975-05-10 1978-12-14 Hildegard Dr. 4400 Muenster Goehde Geb. Kuhl Einrichtung zum Zählen und Messen von in einer Flüssigkeit suspendierten Teilchen
JPS55500714A (de) * 1978-06-14 1980-10-02
CA1129498A (en) * 1978-10-25 1982-08-10 Richard L. Columbus Structural configuration and method for transport of a liquid drop through an ingress aperture
EP0028478B1 (de) * 1979-10-31 1985-02-20 The University Of Birmingham Pipettenmittel
EP0028907B1 (de) * 1979-11-08 1984-07-25 Secretary of State for Social Services in Her Britannic Majesty's Gov. of the U.K. of Great Britain and Northern Ireland Vorrichtung zur Prüfung flüssiger Proben
EP0110610B1 (de) * 1982-11-20 1988-07-27 The University Of Birmingham Vorrichtung zum Abgeben von Flüssigkeiten und zum Registrieren von Reaktionen
GB2191110B (en) * 1986-06-06 1989-12-06 Plessey Co Plc Chromatographic separation device
US4708782A (en) * 1986-09-15 1987-11-24 Sepragen Corporation Chromatography column-electrophoresis system
US4983038A (en) * 1987-04-08 1991-01-08 Hitachi, Ltd. Sheath flow type flow-cell device
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5132012A (en) * 1988-06-24 1992-07-21 Hitachi, Ltd. Liquid chromatograph
US5110745A (en) * 1989-06-01 1992-05-05 The Trustees Of The University Of Pennsylvania Methods of detecting glycated proteins
US5302533A (en) * 1989-10-17 1994-04-12 British Technology Group Limited Antibody-enhanced chemiluminescence reactions
JP2977895B2 (ja) * 1989-10-17 1999-11-15 ブリティッシュ・テクノロジー・グループ・リミテッド 増幅化学ルミネセントアッセイ
US5126022A (en) * 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
SE470347B (sv) * 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
HUT60934A (en) * 1990-08-28 1992-11-30 Emil Mincsovics Process, apparatus and sorbent layer for thin-layer chromatography
US5269900A (en) * 1990-09-13 1993-12-14 University Of North Carolina At Chapel Hill Method and device for high speed separation of complex molecules
DE59108006D1 (de) * 1991-01-28 1996-08-22 Ciba Geigy Ag Vorrichtung zur Vorbereitung von Proben insbesondere für Analysezwecke
US5332481A (en) * 1991-01-29 1994-07-26 Beckman Instruments, Inc. Capillary electrophoresis using replaceable gels
DE4104075C1 (de) * 1991-02-11 1992-03-19 Bruker Analytische Messtechnik Gmbh, 7512 Rheinstetten, De
DE4133885C2 (de) * 1991-10-12 1996-03-21 Bosch Gmbh Robert Dreidimensionale Silizium-Struktur
US5245185A (en) * 1991-11-05 1993-09-14 Georgia Tech Research Corporation Interface device and process to couple planar electrophoresis with spectroscopic methods of detection
EP0544969B1 (de) * 1991-12-06 1997-03-05 Ciba-Geigy Ag Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5486335A (en) * 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
WO1993022058A1 (en) * 1992-05-01 1993-11-11 Trustees Of The University Of Pennsylvania Polynucleotide amplification analysis using a microfabricated device
US5744366A (en) * 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5296375A (en) * 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5338427A (en) * 1993-02-26 1994-08-16 Biometric Imaging Inc. Single use separation cartridge for a capillary electrophoresis instrument
US5512451A (en) * 1993-04-01 1996-04-30 British Technology Group Limited Enhancement of chemiluminescent reactions
US5387329A (en) * 1993-04-09 1995-02-07 Ciba Corning Diagnostics Corp. Extended use planar sensors
CA2097257A1 (en) * 1993-05-28 1994-11-29 Norman J. Dovichi Continuous biochemical reactor for analysis of sub-picomole quantities of complex organic molecules and method of operation thereof
DE4318407A1 (de) * 1993-06-03 1994-12-08 Rossendorf Forschzent Mikrokapillare mit integrierten chemischen Mikrosensoren und Verfahren zu ihrer Herstellung
US5328578A (en) * 1993-06-15 1994-07-12 Hewlett-Packard Company Capillary electrophoresis with tracking separation field
US5349186A (en) * 1993-06-25 1994-09-20 The Governors Of The University Of Alberta Electrospray interface for mass spectrometer and method of supplying analyte to a mass spectrometer
US5512131A (en) * 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
US5374834A (en) * 1993-10-12 1994-12-20 Massachusetts Institute Of Technology Ionic liquid-channel charge-coupled device
US5429734A (en) * 1993-10-12 1995-07-04 Massachusetts Institute Of Technology Monolithic capillary electrophoretic device
US5401963A (en) * 1993-11-01 1995-03-28 Rosemount Analytical Inc. Micromachined mass spectrometer
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5500071A (en) * 1994-10-19 1996-03-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5658413A (en) * 1994-10-19 1997-08-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
JP3909859B2 (ja) * 1994-11-14 2007-04-25 トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 中規模ポリヌクレオチド増幅装置
CA2181190C (en) * 1994-11-14 2001-02-06 Peter Wilding Mesoscale sample preparation device and systems for determination and processing of analytes

Also Published As

Publication number Publication date
JP2002515820A (ja) 2002-05-28
CA2227331A1 (en) 1997-02-06
ATE463732T1 (de) 2010-04-15
EP0840886A4 (de) 2005-12-21
EP0840886A1 (de) 1998-05-13
EP0840886B1 (de) 2010-04-07
CA2227331C (en) 2002-04-02
JP4489187B2 (ja) 2010-06-23
WO1997004297A1 (en) 1997-02-06
US5872010A (en) 1999-02-16

Similar Documents

Publication Publication Date Title
DE69638159D1 (de) System zur beförderung mikroskopischer flüssigkeitsmengen
EP0961110A3 (de) Einrichtung zur Herstellung von dünnen Flüssigkeitsproben zur mikroskopischen Untersuchung
EP0964428A3 (de) Miniaturisierte Vorrichtung zur Flüssigkeitsprobenbehandlung und -massenspektrometrie
US6939452B2 (en) Parallel sample loading and injection device for multichannel microfluidic devices
CA2284779A1 (en) Controlled fluid transport in microfabricated polymeric substrates
GB2231150B (en) Liquid transfer devices
WO1993022055A3 (en) Fluid handling in microfabricated analytical devices
CA2233101A1 (en) A device having process, waste and pipette tip parking chambers and a method for transferring liquids
WO2005059512A3 (en) Method for efficient transport of small liquid volumes to, from or within microfluidic devices
EP1391242A3 (de) Mikrosäulenbasierte Anordnung zur Hochdurchsatzanalyse
ES2160236T3 (es) Mejoras en o relacionadas con el procesado de muestras.
WO1999054711A8 (en) Sample-holding devices and systems
WO1999025476A3 (en) Assay work station
DE69532741D1 (de) Miniaturisierte vollintegrierte planare Flüssigkeitsprobenhandhabungs- und -analysevorrichtung
EP0977039A3 (de) Verfahren zur Handhabung von Körperflüssigkeitsproben und Analysevorrichtung. die diese verwendet
DK0925494T3 (da) Mikrostrømningssystem til partikelseparation og analyse
MY132551A (en) Remote-dosing analyte concentration meter
EP0987550A3 (de) Analytische Testvorrichtung und Verfahren zu ihrer Verwendung
EP2299256A3 (de) Miniaturisierte Querstromvorrichtungen und -Verfahren
ATE410686T1 (de) Screening-testsystem mit hohem durchfluss durch mikrofluidische vorrichtungen
DE60035316D1 (de) Vorrichtung und verfahren zur detektion von analyten in flüssigkeiten
NO162535C (no) Innretning for uttrekking og kondisjonering av proever av materialer i fast, flytende eller gassform, for analyse derav.
WO2001053794A1 (en) Parallel sample loading and injection device for multichannel microfluidic devices
EP1577010A3 (de) Mikrosystemplattform und Verwendung davon
KR910700464A (ko) 화학공정의 순차실행을 위한 장치 및 방법

Legal Events

Date Code Title Description
8364 No opposition during term of opposition